DK3059307T5 - Anvendelse af et laminin til differentiering af pluripotente celler i hepatocytcellelinier - Google Patents

Anvendelse af et laminin til differentiering af pluripotente celler i hepatocytcellelinier Download PDF

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Publication number
DK3059307T5
DK3059307T5 DK15305265.9T DK15305265T DK3059307T5 DK 3059307 T5 DK3059307 T5 DK 3059307T5 DK 15305265 T DK15305265 T DK 15305265T DK 3059307 T5 DK3059307 T5 DK 3059307T5
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laminin
differentiation
cell lines
pluripotent cells
hepatocyte cell
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DK15305265.9T
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DK3059307T4 (da
DK3059307T3 (da
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Angélique Fourrier
Tuan Huy Nguyen
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Inst Nat Sante Rech Med
Univ Nantes
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/237—Oncostatin M [OSM]
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
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  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK15305265.9T 2015-02-20 2015-02-20 Anvendelse af et laminin til differentiering af pluripotente celler i hepatocytcellelinier DK3059307T5 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15305265.9A EP3059307B2 (en) 2015-02-20 2015-02-20 Use of a laminin for differentiating pluripotent cells into hepatocyte lineage cells

Publications (3)

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DK3059307T3 DK3059307T3 (da) 2019-01-14
DK3059307T4 DK3059307T4 (da) 2022-08-01
DK3059307T5 true DK3059307T5 (da) 2022-08-29

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DK15305265.9T DK3059307T5 (da) 2015-02-20 2015-02-20 Anvendelse af et laminin til differentiering af pluripotente celler i hepatocytcellelinier
DK16705202.6T DK3259345T5 (da) 2015-02-20 2016-02-19 Anvendelse af laminin til differentiering af pluripotente celler i hepatocyt-linie-celler

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US (2) US20180030415A1 (da)
EP (2) EP3059307B2 (da)
JP (2) JP6840084B2 (da)
CN (2) CN107532144A (da)
CY (1) CY1121243T1 (da)
DK (2) DK3059307T5 (da)
ES (2) ES2703167T5 (da)
FI (1) FI3259345T3 (da)
HR (2) HRP20182119T4 (da)
HU (2) HUE041518T2 (da)
LT (2) LT3059307T (da)
PL (2) PL3059307T5 (da)
PT (2) PT3059307T (da)
RS (2) RS58070B2 (da)
SI (2) SI3059307T2 (da)
SM (2) SMT201900005T1 (da)
WO (1) WO2016131959A1 (da)

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CN108884438B (zh) * 2015-10-30 2022-12-23 拜奥拉米那公司 肝细胞的生产方法
WO2018019780A1 (en) * 2016-07-28 2018-02-01 F. Hoffmann-La Roche Ag Non-human primate induced pluripotent stem cell derived hepatocytes and uses thereof
BR112019009746A2 (pt) * 2016-11-16 2019-09-03 Cynata Therapeutics Limited ensaio de células-tronco pluripotentes
EP3583201B1 (en) * 2017-02-14 2024-01-17 University of Pittsburgh - Of the Commonwealth System of Higher Education Methods of engineering human induced pluripotent stem cells to produce liver tissue
JP6950887B2 (ja) * 2017-04-28 2021-10-13 米満　吉和 体外型の人工肝臓、及び体外型の人工肝臓用又は肝細胞培養用の器具
JP7271440B2 (ja) * 2017-05-05 2023-05-11 ナショナル ユニバーシティ オブ シンガポール ヒト角化細胞を培養するための方法
MX2020007071A (es) 2018-01-05 2020-11-11 Platelet Biogenesis Inc Composiciones y metodos para producir megacariocitos.
EP3794107B1 (en) * 2018-05-16 2026-04-29 Institut National de la Santé et de la Recherche Médicale (INSERM) Method of culturing proliferative hepatocytes
KR20240033089A (ko) * 2018-06-06 2024-03-12 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 신경 줄기 세포 조성물 및 신경변성 장애를 치료하는 방법
EP3813853A4 (en) 2018-06-29 2022-04-06 Platelet Biogenesis, Inc. DELIVERY COMPOSITIONS AND METHODS OF USE
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CN117802031A (zh) * 2018-09-30 2024-04-02 中国科学院分子细胞科学卓越创新中心 肝细胞的体外扩增培养方法及应用
WO2020097555A1 (en) * 2018-11-09 2020-05-14 Children's Hospital Medical Center In vitro cell culture system for producing hepatocyte-like cells and uses thereof
US12492380B2 (en) 2019-05-09 2025-12-09 FUJIFILM Cellular Dynamics, Inc. Methods for the production of hepatocytes
EP3980527A4 (en) * 2019-06-04 2023-09-27 University Health Network Methods of making and using liver cells
US20230407264A1 (en) * 2020-03-13 2023-12-21 Goliver Therapeutics Hepatic Stem-Like Cells for the Treatment and/or the Prevention of Liver Disorders
CN111621467A (zh) * 2020-06-12 2020-09-04 青岛大学 一种诱导人脂肪间充质干细胞分化为肝脏样细胞的方法
CN115851578B (zh) * 2022-12-23 2023-11-21 华南理工大学 一种3d悬浮诱导持续扩增肝祖细胞类器官和/或肝细胞类器官的试剂盒及其应用
KR20260003527A (ko) * 2024-06-28 2026-01-07 재단법인 아산사회복지재단 파수딜과 젤라틴을 이용한 줄기세포 유래 간세포 분화 방법
WO2026071075A1 (ja) * 2024-09-30 2026-04-02 国立研究開発法人国立成育医療研究センター 幹細胞由来肝細胞、当該幹細胞由来肝細胞を含む肝移植用組成物、凍結耐性を有する多能性幹細胞由来肝細胞の製造方法、凍結耐性を有する肝細胞を選別するための分子マーカーの使用、ならびに肝前駆細胞または肝細胞の純化方法

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SMT201900005T1 (it) * 2015-02-20 2019-05-10 Inst Nat Sante Rech Med Uso di una laminina per la differenziazione di cellule pluripotenti in cellule di lignaggio epatocitario

Also Published As

Publication number Publication date
ES2703167T5 (es) 2022-09-30
PL3059307T3 (pl) 2019-05-31
SMT202300078T1 (it) 2023-05-12
RS58070B2 (sr) 2022-10-31
PT3059307T (pt) 2019-01-23
EP3259345B1 (en) 2023-02-08
HUE041518T2 (hu) 2019-05-28
EP3059307B1 (en) 2018-10-17
CN111548985A (zh) 2020-08-18
SI3059307T1 (sl) 2019-03-29
DK3259345T3 (da) 2023-03-27
JP2021006054A (ja) 2021-01-21
PT3259345T (pt) 2023-03-15
HUE061457T2 (hu) 2023-06-28
HRP20230302T1 (hr) 2023-05-12
CA2986830A1 (en) 2016-08-25
PL3059307T5 (pl) 2023-04-03
CN107532144A (zh) 2018-01-02
FI3259345T3 (fi) 2023-04-03
RS64062B1 (sr) 2023-04-28
EP3059307B2 (en) 2022-05-04
RS58070B1 (sr) 2019-02-28
JP2018508207A (ja) 2018-03-29
LT3059307T (lt) 2019-01-10
SI3259345T1 (sl) 2023-08-31
LT3259345T (lt) 2023-03-27
DK3059307T4 (da) 2022-08-01
ES2703167T3 (es) 2019-03-07
JP7132463B2 (ja) 2022-09-07
CY1121243T1 (el) 2020-05-29
US20180030415A1 (en) 2018-02-01
DK3259345T5 (da) 2024-10-14
US20240150721A1 (en) 2024-05-09
SI3059307T2 (sl) 2022-08-31
EP3259345A1 (en) 2017-12-27
WO2016131959A1 (en) 2016-08-25
DK3059307T3 (da) 2019-01-14
SMT201900005T1 (it) 2019-05-10
JP6840084B2 (ja) 2021-03-17
ES2940191T3 (es) 2023-05-04
HRP20182119T1 (hr) 2019-03-08
PL3259345T3 (pl) 2023-05-02
HRP20182119T4 (hr) 2022-09-02
EP3059307A1 (en) 2016-08-24

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