DK3094626T3 - Substituerede bicykliske heteroaryl-forbindelser som rxr-agonister - Google Patents

Substituerede bicykliske heteroaryl-forbindelser som rxr-agonister Download PDF

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Publication number
DK3094626T3
DK3094626T3 DK15714964.2T DK15714964T DK3094626T3 DK 3094626 T3 DK3094626 T3 DK 3094626T3 DK 15714964 T DK15714964 T DK 15714964T DK 3094626 T3 DK3094626 T3 DK 3094626T3
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heteroaryl compounds
rxr agonists
substituted bicycle
bicycle heteroaryl
substituted
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DK15714964.2T
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Madhavan Gurram Ranga
Jagannath Madanahalli Ranganath Rao
Chandra Sekhar Gudla
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Connexios Life Sciences Pvt Ltd
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    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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DK15714964.2T 2014-01-14 2015-01-09 Substituerede bicykliske heteroaryl-forbindelser som rxr-agonister DK3094626T3 (da)

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IN161CH2014 2014-01-14
PCT/IN2015/000010 WO2015107549A1 (en) 2014-01-14 2015-01-09 Substituted bicyclic heteroaryl compounds as rxr agonists

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US (1) US9862713B2 (da)
EP (1) EP3094626B1 (da)
JP (1) JP6625057B2 (da)
KR (1) KR102372599B1 (da)
CN (1) CN107074800B (da)
AU (1) AU2015207690B2 (da)
BR (1) BR112016016348B1 (da)
CA (1) CA2936162C (da)
CL (1) CL2016001803A1 (da)
DK (1) DK3094626T3 (da)
ES (1) ES2795660T3 (da)
MA (1) MA39253B1 (da)
MX (1) MX381643B (da)
MY (1) MY192609A (da)
PH (1) PH12016501393B1 (da)
PL (1) PL3094626T3 (da)
PT (1) PT3094626T (da)
RU (1) RU2721283C2 (da)
SG (1) SG11201605721XA (da)
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CN106565761A (zh) * 2016-11-15 2017-04-19 贵州大学 一种4‑羧基苯硼酸的制备工艺
US12257248B2 (en) 2020-09-01 2025-03-25 University Of South Florida Bronchodilators for treating obstructive lung disease
CN112047901B (zh) * 2020-09-21 2023-01-24 自然资源部第三海洋研究所 苯并噻唑杂萜类化合物及其衍生物以及制备方法与应用
US11919873B1 (en) 2023-08-29 2024-03-05 King Faisal University 1,3-benzothiazol-2-yl-N′-(benzoyloxy)ethanimidamide as an antitumor and antimicrobial compound
US11851413B1 (en) 2023-08-29 2023-12-26 King Faisal University 1,3-benzothiazol-2-yl-N'-[(naphthalene-1-carbonyl)oxy]ethanimidamide as an antitumor and antimicrobial compound
US11912676B1 (en) 2023-08-29 2024-02-27 King Faisal University N'-[(4-chlorobenzoyl)oxy]-1,3-benzothiazole-2-carboximidamide as an antitumor and antimicrobial compound

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78888B (da) * 1982-07-06 1984-10-02 Hoffmann La Roche
DK158947C (da) 1982-07-06 1991-01-21 Hoffmann La Roche Tetrahydronaphthalin-,benzofuran- og benzothiophenderivater, fremstilling og anvendelse deraf samt rodenticid indeholdende saadanne derivater
US5420145A (en) * 1993-03-22 1995-05-30 Koichi Shudo Carboxylic acid derivative
AU700706B2 (en) * 1992-11-25 1999-01-14 Ligand Pharmaceuticals, Inc. RXR homodimer formation and bridged bicyclic aromatic compounds and their use in modulating gene expression
WO1997010813A1 (en) * 1995-09-18 1997-03-27 Ligand Pharmaceuticals Incorporated Ppar gamma antagonists for treating obesity
BR9610875A (pt) * 1995-10-06 1999-07-13 Ligand Pharm Inc Modulares rxr seletivos - dimeros e processos para seu uso
JPH10338658A (ja) * 1997-04-08 1998-12-22 Hoechst Marion Roussel Kk レチノイド作用調節剤
US6624154B1 (en) * 1999-04-23 2003-09-23 Bristol-Myers Squibb Company Compositions and methods for treatment of hyperproliferative diseases
ATE365158T1 (de) * 1999-04-28 2007-07-15 Inst Med Molecular Design Inc Pyrimidincarbonsäurederivate
DE102004026532A1 (de) * 2004-05-29 2006-01-05 Sanofi-Aventis Deutschland Gmbh Substituierte Oxazol-Benzoisothiazoldioxidderivate, Verfahren zu deren Herstellung und deren Verwendung
EP1924546A1 (en) * 2005-09-14 2008-05-28 Amgen, Inc Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
CN101316822A (zh) * 2005-09-30 2008-12-03 詹森药业有限公司 作为RXR激动剂用于治疗异常脂肪血症、高胆固醇血症和糖尿病的1,2,3,5-四氢-环戊烯并[c]喹啉-4-酮衍生物
JP2009513570A (ja) * 2005-09-30 2009-04-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 異常脂血症、高コレステロール血症及び糖尿病の処置のためのｒｘｒアゴニストとしての複素環式アミド誘導体
CN101316821A (zh) * 2005-09-30 2008-12-03 詹森药业有限公司 作为rxr激动剂用于治疗异常脂肪血症、高胆固醇血症和糖尿病的二氢-[1h]-喹啉-2-酮衍生物
CL2007001597A1 (es) * 2006-06-05 2008-05-16 Novartis Ag Xenon Pharmaceutic Compuestos derivados de 2-oxo-piridin-1(2h)-il-tiazol, imidazol o tiofen-carboxamida; composicion farmaceutica; y uso para el tratamiento de una enfermedad mediada por la estearoil-coa-desaturasa, tal como sindrome metabolico, hipertension y diabetes
US7687526B2 (en) * 2006-09-07 2010-03-30 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
JP5255994B2 (ja) * 2008-11-04 2013-08-07 国立大学法人 岡山大学 核内受容体リガンド
JP2010280585A (ja) * 2009-06-02 2010-12-16 Okayama Univ Ｒｘｒ作動性物質を有効成分とする鎮痛剤
US20130324520A1 (en) * 2011-02-14 2013-12-05 Sloan-Kettering Institute For Cancer Research Rxrg modulators for the treatment of cancer

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