ATE365158T1 - Pyrimidincarbonsäurederivate - Google Patents

Pyrimidincarbonsäurederivate

Info

Publication number
ATE365158T1
ATE365158T1 AT00922876T AT00922876T ATE365158T1 AT E365158 T1 ATE365158 T1 AT E365158T1 AT 00922876 T AT00922876 T AT 00922876T AT 00922876 T AT00922876 T AT 00922876T AT E365158 T1 ATE365158 T1 AT E365158T1
Authority
AT
Austria
Prior art keywords
group
hydrogen atom
alkyl group
carboxylic acid
acid derivatives
Prior art date
Application number
AT00922876T
Other languages
English (en)
Inventor
Hiroyuki Kagechika
Original Assignee
Inst Med Molecular Design Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Med Molecular Design Inc filed Critical Inst Med Molecular Design Inc
Application granted granted Critical
Publication of ATE365158T1 publication Critical patent/ATE365158T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT00922876T 1999-04-28 2000-04-26 Pyrimidincarbonsäurederivate ATE365158T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12159299 1999-04-28

Publications (1)

Publication Number Publication Date
ATE365158T1 true ATE365158T1 (de) 2007-07-15

Family

ID=14815077

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00922876T ATE365158T1 (de) 1999-04-28 2000-04-26 Pyrimidincarbonsäurederivate

Country Status (7)

Country Link
US (1) US6869959B1 (de)
EP (1) EP1180520B1 (de)
JP (1) JP4693247B2 (de)
AT (1) ATE365158T1 (de)
AU (1) AU4314000A (de)
DE (1) DE60035271D1 (de)
WO (1) WO2000066595A1 (de)

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AR038368A1 (es) 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
NZ536493A (en) * 2002-04-22 2007-03-30 Res Found Itsuu Lab Medicament comprising a retinoid for therapeutic treatment of vascular disease
WO2005099759A1 (ja) * 2004-04-16 2005-10-27 Institute Of Medicinal Molecular Design. Inc. 動脈硬化症の予防及び／又は治療のための医薬
WO2006043515A1 (ja) * 2004-10-22 2006-04-27 Kyorin Pharmaceutical Co., Ltd. ピリミジン－５－カルボン酸誘導体
EP1938815A1 (de) * 2005-09-27 2008-07-02 Sapporo Medical University Pharmazeutisches mittel zur prävention und behandlung von ophthalmischen erkrankungen durch zunahme der vasopermeabilität
JP4691619B2 (ja) 2007-02-27 2011-06-01 国立大学法人 岡山大学 アルコキシ基を有するレキシノイド化合物
JP5211322B2 (ja) * 2008-03-07 2013-06-12 国立医薬品食品衛生研究所長 ピリミジン−５−カルボン酸誘導体の抗肥満剤としての新規用途
JPWO2011055843A1 (ja) * 2009-11-09 2013-03-28 国立大学法人 岡山大学 レチノイド化合物
EP2910549A1 (de) * 2011-09-15 2015-08-26 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University 1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalenderivate als rxr-modulatoren zur behandlung von alzheimer-krankheit und krebs
CN107074800B (zh) * 2014-01-14 2019-11-12 康内克斯生命科学私人有限公司 经取代的双环杂芳基化合物作为rxr促效剂
US10328040B2 (en) 2014-01-17 2019-06-25 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic methods
WO2015130973A1 (en) * 2014-02-26 2015-09-03 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof

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GB1064259A (en) 1963-12-19 1967-04-05 Union Pharma Scient Appl New derivatives of 2-anilino-nicotinic acid and process for their preparation
US3466373A (en) 1963-12-19 1969-09-09 Lab U P S A Analgesic and anti-inflammatory composition consisting essentially of 2-(2,3-xylylamino)-nicotinic acid
DE1670537A1 (de) 1966-11-09 1970-10-29 Degussa Verfahren zur Herstellung neuer substituierter Aminopyrimidine
US4143151A (en) 1978-07-03 1979-03-06 The Dow Chemical Company Method for treating hyperglycemia in mammals using arylamino benzoic acids
US4207330A (en) 1978-07-03 1980-06-10 The Dow Chemical Company Method for treating hyperglycemia in mammals using arylamino benzoic acids
JPS60100559A (ja) 1983-11-05 1985-06-04 Morishita Seiyaku Kk ２−アニリノ−１，６−ジヒドロ−６−オキソ−５−ピリミジンカルボン酸誘導体，その製法及び該化合物を含有する抗アレルギ−剤
JPS6176440A (ja) 1984-09-19 1986-04-18 Koichi Shiyudo 安息香酸誘導体
JPS6122047A (ja) 1984-07-07 1986-01-30 Koichi Shiyudo 安息香酸誘導体
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
FR2581063B1 (fr) * 1985-04-30 1987-07-17 Chauvin Blache Lab Amino-2 thiazoles n-substitues, leur procede de preparation et leur application en therapeutique
JPS62123180A (ja) * 1985-11-21 1987-06-04 Otsuka Pharmaceut Factory Inc ｐ−アミノフエノ−ル誘導体
US4788195A (en) * 1986-01-13 1988-11-29 American Cyanamid Company 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
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EP0254259A3 (de) 1986-07-21 1989-11-23 Otsuka Pharmaceutical Factory, Inc. p-Aminophenol-Derivate
ATE186724T1 (de) 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
JPH03204813A (ja) 1989-09-27 1991-09-06 Otsuka Pharmaceut Factory Inc 抗活性酸素剤
US5119033A (en) 1989-09-29 1992-06-02 Rosemount Inc. Vernier voltage-to-digital converter with a storage capacitance selectable in magnitude
JPH03127790A (ja) * 1989-10-11 1991-05-30 Morishita Pharmaceut Co Ltd Ｎ―（１ｈ―テトラゾール―５―イル）―２―アニリノ―５―ピリミジンカルボキシアミド類及びその合成中間体
US6162815A (en) 1994-04-26 2000-12-19 Centre International De Recherches Dermatologiques Galderma RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof
FR2719043B1 (fr) 1994-04-26 1996-05-31 Cird Galderma Nouveaux composés bicycliques-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
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JP3964478B2 (ja) 1995-06-30 2007-08-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬
US5776699A (en) 1995-09-01 1998-07-07 Allergan, Inc. Method of identifying negative hormone and/or antagonist activities
US5958954A (en) 1995-09-01 1999-09-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
WO1997011061A1 (en) 1995-09-21 1997-03-27 Nikken Chemicals Co., Ltd. Compounds potentiating retinoid
JPH09100270A (ja) 1995-10-03 1997-04-15 Koichi Shudo レチノイドアンタゴニスト
BR9610875A (pt) 1995-10-06 1999-07-13 Ligand Pharm Inc Modulares rxr seletivos - dimeros e processos para seu uso
AU7598596A (en) 1995-11-01 1997-05-22 Allergan, Inc. Sulfides, sulfoxides and sulfones disubstituted with a tetrahydronaphthalenyl, chromanyl, thiochromanyl or tetrahydroquinolinyl and substituted phenyl or heteroaryl group, having retinoid-like biological activity
US6121309A (en) 1996-03-18 2000-09-19 Eisai Co., Ltd. Fused-ring carboxylic acid derivatives
WO1997048672A2 (en) 1996-06-21 1997-12-24 Allergan Sales, Inc. Substituted tetrahydronaphthalene and dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5739338A (en) 1996-11-05 1998-04-14 Allergan N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
US5728846A (en) 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
US5760276A (en) 1997-03-06 1998-06-02 Allergan Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity
JPH10338658A (ja) * 1997-04-08 1998-12-22 Hoechst Marion Roussel Kk レチノイド作用調節剤
US6037488A (en) 1997-04-19 2000-03-14 Allergan Sales, Inc. Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
US6093838A (en) 1999-08-16 2000-07-25 Allergan Sales, Inc. Amines substituted with a dihydro-benzofuranyl or with a dihydro-isobenzofuranyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity

Also Published As

Publication number Publication date
DE60035271D1 (en) 2007-08-02
EP1180520B1 (de) 2007-06-20
WO2000066595A1 (en) 2000-11-09
EP1180520A1 (de) 2002-02-20
EP1180520A4 (de) 2002-06-05
JP4693247B2 (ja) 2011-06-01
US6869959B1 (en) 2005-03-22
AU4314000A (en) 2000-11-17

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