ATE365158T1 - Pyrimidincarbonsäurederivate - Google Patents

Pyrimidincarbonsäurederivate

Info

Publication number
ATE365158T1
ATE365158T1 AT00922876T AT00922876T ATE365158T1 AT E365158 T1 ATE365158 T1 AT E365158T1 AT 00922876 T AT00922876 T AT 00922876T AT 00922876 T AT00922876 T AT 00922876T AT E365158 T1 ATE365158 T1 AT E365158T1
Authority
AT
Austria
Prior art keywords
group
hydrogen atom
alkyl group
carboxylic acid
acid derivatives
Prior art date
Application number
AT00922876T
Other languages
English (en)
Inventor
Hiroyuki Kagechika
Original Assignee
Inst Med Molecular Design Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Med Molecular Design Inc filed Critical Inst Med Molecular Design Inc
Application granted granted Critical
Publication of ATE365158T1 publication Critical patent/ATE365158T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT00922876T 1999-04-28 2000-04-26 Pyrimidincarbonsäurederivate ATE365158T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12159299 1999-04-28

Publications (1)

Publication Number Publication Date
ATE365158T1 true ATE365158T1 (de) 2007-07-15

Family

ID=14815077

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00922876T ATE365158T1 (de) 1999-04-28 2000-04-26 Pyrimidincarbonsäurederivate

Country Status (7)

Country Link
US (1) US6869959B1 (de)
EP (1) EP1180520B1 (de)
JP (1) JP4693247B2 (de)
AT (1) ATE365158T1 (de)
AU (1) AU4314000A (de)
DE (1) DE60035271D1 (de)
WO (1) WO2000066595A1 (de)

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AR038368A1 (es) 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
AU2003227454B2 (en) * 2002-04-22 2009-07-30 Research Foundation Itsuu Laboratory Medicament for therapeutic treatment of vascular disease
WO2005099759A1 (ja) * 2004-04-16 2005-10-27 Institute Of Medicinal Molecular Design. Inc. 動脈硬化症の予防及び／又は治療のための医薬
WO2006043515A1 (ja) * 2004-10-22 2006-04-27 Kyorin Pharmaceutical Co., Ltd. ピリミジン－５－カルボン酸誘導体
JPWO2007037188A1 (ja) * 2005-09-27 2009-04-09 北海道公立大学法人 札幌医科大学 血管透過性亢進に起因する眼疾患の予防及び治療のための医薬
EP2116523B1 (de) 2007-02-27 2015-05-06 National University Corporation Okayama University Rexinoidverbindung mit alkoxygruppe
JP5211322B2 (ja) * 2008-03-07 2013-06-12 国立医薬品食品衛生研究所長 ピリミジン−５−カルボン酸誘導体の抗肥満剤としての新規用途
WO2011055843A1 (ja) * 2009-11-09 2011-05-12 国立大学法人 岡山大学 レチノイド化合物
CA2848540A1 (en) 2011-09-15 2013-03-21 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Therapeutic compounds
EP3094626B1 (de) * 2014-01-14 2020-02-19 Connexios Life Sciences Pvt. Ltd. Substituierte bicyclische heteroaryl-verbindungen als rxr-agonisten
WO2015109318A2 (en) 2014-01-17 2015-07-23 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Therapeutic methods
US9908856B2 (en) 2014-02-26 2018-03-06 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds

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US3466373A (en) 1963-12-19 1969-09-09 Lab U P S A Analgesic and anti-inflammatory composition consisting essentially of 2-(2,3-xylylamino)-nicotinic acid
DE1670536B2 (de) * 1966-11-09 1975-05-28 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Neue 2-Anilino-5-acylamino-pyrimidlne
US4207330A (en) 1978-07-03 1980-06-10 The Dow Chemical Company Method for treating hyperglycemia in mammals using arylamino benzoic acids
US4143151A (en) 1978-07-03 1979-03-06 The Dow Chemical Company Method for treating hyperglycemia in mammals using arylamino benzoic acids
JPS60100559A (ja) * 1983-11-05 1985-06-04 Morishita Seiyaku Kk ２−アニリノ−１，６−ジヒドロ−６−オキソ−５−ピリミジンカルボン酸誘導体，その製法及び該化合物を含有する抗アレルギ−剤
JPS6122047A (ja) 1984-07-07 1986-01-30 Koichi Shiyudo 安息香酸誘導体
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AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
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FR2719043B1 (fr) 1994-04-26 1996-05-31 Cird Galderma Nouveaux composés bicycliques-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
US6162815A (en) 1994-04-26 2000-12-19 Centre International De Recherches Dermatologiques Galderma RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof
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JP2000511558A (ja) 1996-06-21 2000-09-05 アラーガン・セイルズ・インコーポレイテッド レチノイドおよび／またはレチノイド拮抗剤様生物学的活性を有する置換テトラヒドロナフタレンおよびジヒドロナフタレン誘導体
US5739338A (en) 1996-11-05 1998-04-14 Allergan N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
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US5760276A (en) 1997-03-06 1998-06-02 Allergan Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity
JPH10338658A (ja) 1997-04-08 1998-12-22 Hoechst Marion Roussel Kk レチノイド作用調節剤
US6037488A (en) 1997-04-19 2000-03-14 Allergan Sales, Inc. Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
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Also Published As

Publication number Publication date
EP1180520A4 (de) 2002-06-05
US6869959B1 (en) 2005-03-22
EP1180520B1 (de) 2007-06-20
WO2000066595A1 (en) 2000-11-09
AU4314000A (en) 2000-11-17
JP4693247B2 (ja) 2011-06-01
EP1180520A1 (de) 2002-02-20
DE60035271D1 (en) 2007-08-02

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