DK3124610T3 - Hbv-behandling - Google Patents

Hbv-behandling Download PDF

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Publication number
DK3124610T3
DK3124610T3 DK16188642.9T DK16188642T DK3124610T3 DK 3124610 T3 DK3124610 T3 DK 3124610T3 DK 16188642 T DK16188642 T DK 16188642T DK 3124610 T3 DK3124610 T3 DK 3124610T3
Authority
DK
Denmark
Prior art keywords
hbv treatment
hbv
treatment
Prior art date
Application number
DK16188642.9T
Other languages
English (en)
Inventor
Michael Wayne Graham
Peter French
Yixiang Lu
Tiejun Li
Yuncheng Sun
Xiaojun Tang
Li Shan
York Yuan Yuan Zhu
Original Assignee
Benitec Biopharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201010522005.2A external-priority patent/CN101979558B/zh
Priority claimed from CN201010521972.7A external-priority patent/CN102021170B/zh
Priority claimed from CN201010521990.5A external-priority patent/CN101979556B/zh
Priority claimed from CN201010521975.0A external-priority patent/CN101979555B/zh
Priority claimed from CN201010522003.3A external-priority patent/CN101979557B/zh
Priority claimed from CN201010521948.3A external-priority patent/CN101979553B/zh
Priority claimed from CN201010521962.3A external-priority patent/CN101979554B/zh
Priority claimed from PCT/CN2011/071107 external-priority patent/WO2012109798A1/en
Application filed by Benitec Biopharma Ltd filed Critical Benitec Biopharma Ltd
Application granted granted Critical
Publication of DK3124610T3 publication Critical patent/DK3124610T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Control Of Eletrric Generators (AREA)
DK16188642.9T 2010-10-28 2011-10-27 Hbv-behandling DK3124610T3 (da)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN201010522005.2A CN101979558B (zh) 2010-10-28 2010-10-28 一种靶向乙型肝炎病毒基因的siRNA分子及其应用
CN201010521972.7A CN102021170B (zh) 2010-10-28 2010-10-28 一种干扰乙型肝炎病毒基因的siRNA分子及其应用
CN201010521990.5A CN101979556B (zh) 2010-10-28 2010-10-28 一种siRNA靶向分子及其应用
CN201010521975.0A CN101979555B (zh) 2010-10-28 2010-10-28 一种小干扰rna分子及其应用
CN201010522003.3A CN101979557B (zh) 2010-10-28 2010-10-28 一种siRNA分子及其在抗病毒药物中的应用
CN201010521948.3A CN101979553B (zh) 2010-10-28 2010-10-28 一种干扰HBV基因的siRNA分子及其抗病毒应用
CN201010521962.3A CN101979554B (zh) 2010-10-28 2010-10-28 一种干扰HBV基因的siRNA分子及其应用
PCT/CN2011/071107 WO2012109798A1 (en) 2011-02-18 2011-02-18 Hbv treatment
EP11835635.1A EP2633051B1 (en) 2010-10-28 2011-10-27 Hbv treatment

Publications (1)

Publication Number Publication Date
DK3124610T3 true DK3124610T3 (da) 2019-06-11

Family

ID=45993174

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16188642.9T DK3124610T3 (da) 2010-10-28 2011-10-27 Hbv-behandling

Country Status (21)

Country Link
US (2) US9080174B2 (da)
EP (2) EP3124610B1 (da)
KR (2) KR20180110186A (da)
CN (1) CN103370415B (da)
AU (1) AU2011320437B2 (da)
BR (1) BR112013010525A2 (da)
CA (1) CA2853613C (da)
CY (1) CY1121894T1 (da)
DK (1) DK3124610T3 (da)
ES (1) ES2730393T3 (da)
HR (1) HRP20190995T1 (da)
HU (1) HUE044426T2 (da)
LT (1) LT3124610T (da)
PL (1) PL3124610T3 (da)
PT (1) PT3124610T (da)
RS (1) RS58982B1 (da)
RU (1) RU2620966C2 (da)
SI (1) SI3124610T1 (da)
SM (1) SMT201900317T1 (da)
TR (1) TR201908127T4 (da)
WO (1) WO2012055362A1 (da)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
SI3505528T1 (sl) 2011-04-21 2021-04-30 Glaxo Group Limited Modulacija izražanja virusa hepatitisa B (HBV)
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
CN105002214B (zh) * 2015-04-08 2018-07-17 许中伟 用于载体表达的复合多联gRNA和RNAi的表达框架
CN107683336A (zh) * 2015-05-06 2018-02-09 贝尼泰克生物制药有限公司 用于治疗乙型肝炎病毒(hbv)感染的试剂及其用途
CN115957337A (zh) 2015-08-07 2023-04-14 箭头药业股份有限公司 乙型肝炎病毒感染的RNAi疗法
CA3013683C (en) 2016-03-14 2021-07-13 F. Hoffmann-La Roche Ag Oligonucleotides for reduction of pd-l1 expression
AU2017260580B2 (en) * 2016-05-05 2022-07-28 Benitec IP Holdings Inc. Reagents for treatment of hepatitis B virus (HBV) infection and use thereof
AU2017285350A1 (en) 2016-06-17 2018-12-20 F. Hoffmann-La Roche Ag Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection
JOP20190015A1 (ar) 2016-08-04 2019-02-04 Arrowhead Pharmaceuticals Inc عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب
CN108929870B (zh) * 2017-05-19 2020-01-24 百奥迈科生物技术有限公司 抑制HBV的siRNA分子及其应用
KR20200030594A (ko) 2017-10-16 2020-03-20 에프. 호프만-라 로슈 아게 B형 간염 감염을 치료하기 위한 PAPD5 및 PAPD7 mRNA의 감소용 핵산 분자
MA52661A (fr) 2018-04-05 2021-02-17 Centre Leon Berard Utilisation d'inhibiteurs de fubp1 dans le traitement d'une infection par le virus de l'hépatite b
TWI862501B (zh) 2018-07-03 2024-11-21 瑞士商赫孚孟拉羅股份公司 用於調制 Tau 表現之寡核苷酸
BR112021000538A2 (pt) 2018-07-13 2021-04-06 F. Hoffmann-La Roche Ag Oligonucleotídeos para modular a expressão de rtel1
WO2021122921A1 (en) 2019-12-19 2021-06-24 F. Hoffmann-La Roche Ag Use of cops3 inhibitors for treating hepatitis b virus infection
CN114867856A (zh) 2019-12-19 2022-08-05 豪夫迈·罗氏有限公司 Saraf抑制剂用于治疗乙型肝炎病毒感染的用途
JP7634542B2 (ja) 2019-12-19 2025-02-21 エフ． ホフマン－ラ ロシュ アーゲー Ｂ型肝炎ウイルス感染症を処置するためのｓｅｐｔ９阻害剤の使用
WO2021122910A1 (en) 2019-12-19 2021-06-24 F. Hoffmann-La Roche Ag Use of sbds inhibitors for treating hepatitis b virus infection
AR122731A1 (es) 2020-06-26 2022-10-05 Hoffmann La Roche Oligonucleótidos mejorados para modular la expresión de fubp1
JP2023538630A (ja) 2020-08-21 2023-09-08 エフ． ホフマン－ラ ロシュ アーゲー Ｂ型肝炎ウイルス感染症を処置するためのａ１ｃｆ阻害剤の使用
TW202246500A (zh) 2021-02-02 2022-12-01 瑞士商赫孚孟拉羅股份公司 用於抑制 ｒｔｅｌ１ 表現之增強型寡核苷酸
CN119095603A (zh) 2021-12-17 2024-12-06 豪夫迈·罗氏有限公司 用于调节rtel1和fubp1的寡核苷酸的组合
US20240309383A1 (en) * 2023-02-24 2024-09-19 Suzhou Sanegene Bio Inc. Small interfering rna targeting hbv and uses thereof
CN118995698A (zh) * 2023-05-17 2024-11-22 南京晖丽生物科技有限公司 小核酸在制备治疗猫传染性腹膜炎药物中的应用

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US20030206887A1 (en) * 1992-05-14 2003-11-06 David Morrissey RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
US6218181B1 (en) 1998-03-18 2001-04-17 The Salk Institute For Biological Studies Retroviral packaging cell line
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
CN101818145A (zh) 1998-03-20 2010-09-01 联邦科学和工业研究组织 控制基因表达
JP2003526367A (ja) 2000-03-16 2003-09-09 ジェネティカ インコーポレイテッド Ｒｎａ干渉の方法とｒｎａ干渉組成物
CA2457282C (en) 2001-09-13 2015-01-13 California Institute Of Technology Method for expression of small antiviral rna molecules within a cell
EP2801614B1 (en) 2002-08-29 2019-05-15 The Board of Trustees of the Leland Stanford Junior University Circular nucleic acid vectors and methods for making and using the same
US20050059044A1 (en) 2003-06-03 2005-03-17 Graham Michael Wayne Double-stranded nucleic acid
ATE508190T1 (de) 2004-03-05 2011-05-15 Benitec Inc Mehrfachpromotor-expressionskassetten zurgleichzeitigen zuführung von rnai-agentien
US7803611B2 (en) 2005-02-03 2010-09-28 Benitec, Inc. RNAi expression constructs
US8008468B2 (en) * 2005-02-16 2011-08-30 Benitec, Inc. RNAi expression constructs with liver-specific enhancer/promoter
AR057252A1 (es) * 2005-12-27 2007-11-21 Alcon Mfg Ltd Inhibicion de rho quinasa mediada por arni para el tratamiento de trastornos oculares
WO2007120533A2 (en) 2006-03-30 2007-10-25 The Board Of Trustees Of The Leland Stanford Junior University Minigene expression cassette
CN101684478B (zh) * 2009-06-26 2012-02-29 武汉大学 一种串联表达小干扰rna重组慢病毒载体的构建方法
CN101979556B (zh) * 2010-10-28 2015-01-21 百奥迈科生物技术有限公司 一种siRNA靶向分子及其应用

Also Published As

Publication number Publication date
US9410154B2 (en) 2016-08-09
PT3124610T (pt) 2019-06-14
EP2633051B1 (en) 2016-09-14
CN103370415B (zh) 2017-05-31
HUE044426T2 (hu) 2019-10-28
RU2620966C2 (ru) 2017-05-30
ES2730393T3 (es) 2019-11-11
CY1121894T1 (el) 2020-10-14
CN103370415A (zh) 2013-10-23
BR112013010525A2 (pt) 2016-08-02
KR20140071949A (ko) 2014-06-12
KR20180110186A (ko) 2018-10-08
RS58982B1 (sr) 2019-08-30
KR101903778B1 (ko) 2018-10-04
CA2853613C (en) 2020-03-24
AU2011320437B2 (en) 2017-03-16
EP3124610A1 (en) 2017-02-01
LT3124610T (lt) 2019-08-12
US20130296401A1 (en) 2013-11-07
SI3124610T1 (sl) 2019-08-30
PL3124610T3 (pl) 2019-09-30
TR201908127T4 (tr) 2019-06-21
HRP20190995T1 (hr) 2019-08-09
RU2013124422A (ru) 2014-12-10
EP2633051A1 (en) 2013-09-04
SMT201900317T1 (it) 2019-09-09
US9080174B2 (en) 2015-07-14
EP2633051A4 (en) 2014-04-23
US20150344885A1 (en) 2015-12-03
EP3124610B1 (en) 2019-03-06
AU2011320437A1 (en) 2013-06-13
WO2012055362A1 (en) 2012-05-03
CA2853613A1 (en) 2012-05-03

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