DK3144325T3 - Heparin med høj renhed og fremstillingsfremgangsmåde dertil - Google Patents

Heparin med høj renhed og fremstillingsfremgangsmåde dertil Download PDF

Info

Publication number: DK3144325T3
Authority: DK; Denmark
Prior art keywords: high purity; manufacturing procedure; purity heparin; heparin; procedure
Prior art date: 2010-09-14

Application number

DK16191158.1T

Other languages

English (en)

Inventor

Michio Muguruma

Hiroshi Murata

Original Assignee

Univ Miyazaki

Fuso Pharmaceutical Ind

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-09-14

Filing date

2011-09-13

Publication date

2021-01-25

2011-09-13 Application filed by Univ Miyazaki, Fuso Pharmaceutical Ind filed Critical Univ Miyazaki

2021-01-25 Application granted granted Critical

2021-01-25 Publication of DK3144325T3 publication Critical patent/DK3144325T3/da

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title 1
229960002897 heparin Drugs 0.000 title 1
229920000669 heparin Polymers 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
- G01N30/14—Preparation by elimination of some components
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Physics & Mathematics (AREA)
Sustainable Development (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Hematology (AREA)
Diabetes (AREA)

DK16191158.1T 2010-09-14 2011-09-13 Heparin med høj renhed og fremstillingsfremgangsmåde dertil DK3144325T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2010205310		2010-09-14
EP11825154.5A EP2617737B1 (en)	2010-09-14	2011-09-13	High purity heparin and production method therefor

Publications (1)

Publication Number	Publication Date
DK3144325T3 true DK3144325T3 (da)	2021-01-25

Family

ID=45831611

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK16191158.1T DK3144325T3 (da)	2010-09-14	2011-09-13	Heparin med høj renhed og fremstillingsfremgangsmåde dertil
DK11825154.5T DK2617737T3 (da)	2010-09-14	2011-09-13	Heparin med høj renhedsgrad og fremstillingsfremgangsmåde dertil

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK11825154.5T DK2617737T3 (da)	2010-09-14	2011-09-13	Heparin med høj renhedsgrad og fremstillingsfremgangsmåde dertil

Country Status (9)

Country	Link
US (2)	US8932867B2 (da)
EP (2)	EP3144325B1 (da)
JP (5)	JPWO2012036152A1 (da)
KR (3)	KR101794877B1 (da)
CN (1)	CN103209997B (da)
AU (1)	AU2011303081B2 (da)
CA (3)	CA3020369C (da)
DK (2)	DK3144325T3 (da)
WO (1)	WO2012036152A1 (da)

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CN105504096A (zh) *	2012-12-08	2016-04-20	青岛九龙生物医药有限公司	正丙醇萃取法降低肝素钠中的半乳糖胺含量的方法
CN103923230A (zh) *	2013-01-11	2014-07-16	青岛亚博生物科技有限公司	一种肝素钠的精制方法
KR102298179B1 (ko)	2017-11-27	2021-09-06	(주)우리비앤비	비분획 헤파린의 제조방법
CN116879411B (zh) *	2018-07-24	2025-11-11	深圳市天道医药有限公司	一种达肝素钠亚硝酸降解产物的分析方法及其应用
CN109232773A (zh) *	2018-11-29	2019-01-18	淮安麦德森制药有限公司	肝素锂的制备方法
KR102104367B1 (ko)	2019-09-02	2020-04-24	팜앤바이오 주식회사	헤파린나트륨의 제조장치 및 제조방법
KR20220147996A (ko)	2021-04-28	2022-11-04	주식회사 휴메딕스	고순도 헤파린나트륨의 제조방법
CN117362479B (zh) *	2023-10-24	2026-02-24	河北常山生化药业股份有限公司	一种羊源依诺肝素钠的制备方法

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FR2845686B1 (fr) *	2002-10-10	2013-08-30	Aventis Pharma Sa	Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
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CN101575385B (zh) *	2008-05-09	2011-01-12	青岛九龙生物医药有限公司	萃取法分离肝素钠中的多硫酸软骨素的方法
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GB0818255D0 (en) *	2008-10-06	2008-11-12	Agency Science Tech & Res	Isolation and identification of glycosaminoglycans
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2011
- 2011-09-13 DK DK16191158.1T patent/DK3144325T3/da active
- 2011-09-13 AU AU2011303081A patent/AU2011303081B2/en not_active Ceased
- 2011-09-13 US US13/822,825 patent/US8932867B2/en active Active
- 2011-09-13 CA CA3020369A patent/CA3020369C/en not_active Expired - Fee Related
- 2011-09-13 CA CA2811186A patent/CA2811186C/en not_active Expired - Fee Related
- 2011-09-13 EP EP16191158.1A patent/EP3144325B1/en active Active
- 2011-09-13 KR KR1020177007476A patent/KR101794877B1/ko active Active
- 2011-09-13 CA CA2974062A patent/CA2974062C/en not_active Expired - Fee Related
- 2011-09-13 JP JP2012534011A patent/JPWO2012036152A1/ja active Pending
- 2011-09-13 KR KR1020137007805A patent/KR101847846B1/ko active Active
- 2011-09-13 EP EP11825154.5A patent/EP2617737B1/en active Active
- 2011-09-13 KR KR1020187009094A patent/KR102082276B1/ko active Active
- 2011-09-13 DK DK11825154.5T patent/DK2617737T3/da active
- 2011-09-13 CN CN201180054488.0A patent/CN103209997B/zh active Active
- 2011-09-13 WO PCT/JP2011/070851 patent/WO2012036152A1/ja not_active Ceased
2014
- 2014-12-10 US US14/565,671 patent/US9540454B2/en active Active
2015
- 2015-03-09 JP JP2015046245A patent/JP6082416B2/ja active Active
2016
- 2016-08-05 JP JP2016154813A patent/JP6511418B2/ja active Active
2019
- 2019-01-22 JP JP2019008602A patent/JP2019065306A/ja active Pending
- 2019-01-22 JP JP2019008601A patent/JP6755980B2/ja active Active

Also Published As

Publication number	Publication date
AU2011303081A1 (en)	2013-04-04
EP3144325B1 (en)	2020-11-04
WO2012036152A1 (ja)	2012-03-22
JP6511418B2 (ja)	2019-05-15
EP3144325A1 (en)	2017-03-22
KR101794877B1 (ko)	2017-11-07
JP6755980B2 (ja)	2020-09-16
DK2617737T3 (da)	2017-04-03
KR101847846B1 (ko)	2018-04-11
KR20180037622A (ko)	2018-04-12
JP2019065306A (ja)	2019-04-25
US9540454B2 (en)	2017-01-10
JP2015111156A (ja)	2015-06-18
AU2011303081B2 (en)	2015-08-13
EP2617737B1 (en)	2017-03-01
CA3020369C (en)	2019-11-26
CN103209997A (zh)	2013-07-17
KR102082276B1 (ko)	2020-02-27
KR20170033915A (ko)	2017-03-27
US20130183764A1 (en)	2013-07-18
CA2974062A1 (en)	2012-03-22
EP2617737A1 (en)	2013-07-24
JP2019056717A (ja)	2019-04-11
CA2811186A1 (en)	2012-03-22
KR20130118307A (ko)	2013-10-29
CN103209997B (zh)	2016-03-16
JP6082416B2 (ja)	2017-02-15
EP2617737A4 (en)	2014-04-02
US20150094460A1 (en)	2015-04-02
JP2016206204A (ja)	2016-12-08
CA2811186C (en)	2018-12-04
CA2974062C (en)	2018-07-17
CA3020369A1 (en)	2012-03-22
US8932867B2 (en)	2015-01-13
JPWO2012036152A1 (ja)	2014-02-03

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