DK3145517T3 - Funktionelle oligodendrocytter afledt fra pluripotente stamceller og fremgangsmåder til fremstilling og anvendelse deraf - Google Patents

Funktionelle oligodendrocytter afledt fra pluripotente stamceller og fremgangsmåder til fremstilling og anvendelse deraf Download PDF

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DK3145517T3
DK3145517T3 DK15796034.5T DK15796034T DK3145517T3 DK 3145517 T3 DK3145517 T3 DK 3145517T3 DK 15796034 T DK15796034 T DK 15796034T DK 3145517 T3 DK3145517 T3 DK 3145517T3
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oligodendrocyts
derived
functional
manufacture
methods
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DK15796034.5T
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Valentina Fossati
Panagiotis Douvaras
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New York Stem Cell Found Inc
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DK15796034.5T 2014-05-22 2015-05-22 Funktionelle oligodendrocytter afledt fra pluripotente stamceller og fremgangsmåder til fremstilling og anvendelse deraf DK3145517T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462002048P 2014-05-22 2014-05-22
PCT/US2015/032274 WO2015179822A1 (en) 2014-05-22 2015-05-22 Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same

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DK3145517T3 true DK3145517T3 (da) 2020-11-30

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DK15796034.5T DK3145517T3 (da) 2014-05-22 2015-05-22 Funktionelle oligodendrocytter afledt fra pluripotente stamceller og fremgangsmåder til fremstilling og anvendelse deraf

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US (3) US10301592B2 (da)
EP (1) EP3145517B1 (da)
JP (2) JP6873705B2 (da)
KR (2) KR102324714B1 (da)
CN (1) CN106456672B (da)
AU (1) AU2015263951B2 (da)
DK (1) DK3145517T3 (da)
ES (1) ES2846860T3 (da)
PL (1) PL3145517T3 (da)
WO (1) WO2015179822A1 (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10301592B2 (en) * 2014-05-22 2019-05-28 New York Stem Cell Foundation, Inc. Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same
CN105567642B (zh) * 2016-02-01 2019-07-12 中国科学院生物物理研究所 一种着色性干皮病人多能干细胞的制备方法
JP2019509744A (ja) * 2016-03-30 2019-04-11 アステリアス バイオセラピューティクス インコーポレイテッド オリゴデンドロサイト前駆細胞組成物
KR102598310B1 (ko) * 2017-04-13 2023-11-07 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 인간 희소돌기아교세포 생성 및 시험관내 수초화 연구를 위한 개인화된 3d 신경 배양 시스템
EP3652200A4 (en) * 2017-07-13 2021-04-28 Allele Biotechnology And Pharmaceuticals, Inc. INDUCTION OF NEURAL PRECURSOR CELLS, OLIGODENDROCYT PRECURSOR CELLS AND OLIGODENDROCYTE BY STEM CELL DIFFERENTIATION USING REFERENCE POINT TRANSCRIPTION FACTORS
WO2019023793A1 (en) * 2017-08-04 2019-02-07 University Health Network GENERATION OF OLIGODENDROGENIC NEURON PROGENITOR CELLS
CA3006897A1 (en) * 2017-08-04 2019-02-04 University Health Network Generation of oligodendrogenic neural progenitor cells
CN107858331B (zh) * 2017-11-02 2021-01-15 北京全式金生物技术有限公司 一种诱导人多能性干细胞分化为脊髓运动神经前体细胞的方法
EP3717654A4 (en) 2017-12-01 2021-11-10 President And Fellows Of Harvard College METHODS AND COMPOSITIONS FOR PRODUCING OLIGODENDROCYTE PRECURSOR CELLS
CN108384755A (zh) * 2018-02-08 2018-08-10 北京呈诺医学科技有限公司 一种高效、快捷的诱导性多能干细胞向神经干细胞分化的方法
WO2019204309A1 (en) * 2018-04-17 2019-10-24 Case Western Reserve University Induction of myelinating oligodendrocytes in human cortical spheroids
CN108624560B (zh) * 2018-06-01 2022-04-08 南京艾尔普再生医学科技有限公司 一种分化培养基及少突胶质前体细胞的制备方法
WO2019241620A1 (en) * 2018-06-14 2019-12-19 Academia Sinica Method to generate induced oligodendrocyte-lineage cells and treatment using such cells
AU2019342741B2 (en) 2018-09-19 2025-12-11 Lineage Cell Therapeutics, Inc. Methods for differentiating pluripotent stem cells in dynamic suspension culture
EP3660145A1 (en) * 2018-11-30 2020-06-03 Assistance Publique, Hopitaux De Paris Use of oligodendrocytes from oral neuroectodermal stem cells in the repair of the nervous system
JP7469317B2 (ja) 2019-01-23 2024-04-16 アステリアス バイオセラピューティクス インコーポレイテッド ヒト多能性幹細胞からの背側由来オリゴデンドロサイト前駆細胞
US20220251504A1 (en) * 2019-05-29 2022-08-11 New York Stem Cell Foundation, Inc. Functional astrocytes derived from pluripotent stem cells and methods of making and using the same
WO2020243392A1 (en) * 2019-05-31 2020-12-03 President And Fellows Of Harvard College Sox9-induced oligodendrocyte progenitor cells
KR20220068222A (ko) 2019-08-23 2022-05-25 사나 바이오테크놀로지, 인크. Cd24 발현 세포 및 이의 용도
US12533383B2 (en) 2019-09-06 2026-01-27 Keio University Method for producing cell aggregate including glial progenitor cells
CN110716595A (zh) * 2019-09-11 2020-01-21 合肥众建翔新能源有限公司 一种基于新能源的养殖系统
US20230293593A1 (en) 2020-03-25 2023-09-21 Sana Biotechnology, Inc. Hypoimmunogenic neural cells for the treatment of neurological disorders and conditions
KR102657342B1 (ko) * 2020-05-20 2024-04-15 고려대학교 산학협력단 희소돌기아교세포로 분화가 특화된 신경줄기세포로부터 희소돌기아교세포를 포함하는 오가노이드의 제조방법, 상기 방법으로 제조된 오가노이드 및 이의 용도
IL300516A (en) 2020-08-13 2023-04-01 Sana Biotechnology Inc Methods for treating susceptible patients with hypoimmunogenic cells, and related methods and compounds
KR102568532B1 (ko) * 2021-01-13 2023-08-18 건국대학교 산학협력단 3차원 배양을 통한 신경줄기세포 제조 방법
EP4314256A1 (en) 2021-03-30 2024-02-07 Trailhead Biosystems Inc. Methods and compositions for generating oligodendrocyte progenitor cells
US20240226164A1 (en) 2021-05-27 2024-07-11 Sana Biotechnology, Inc. Hypoimmunogenic cells comprising engineered hla-e or hla-g
AU2022309875A1 (en) 2021-07-14 2024-01-25 Sana Biotechnology, Inc. Altered expression of y chromosome-linked antigens in hypoimmunogenic cells
CN113564122B (zh) * 2021-08-05 2022-04-08 呈诺再生医学科技(珠海横琴新区)有限公司 人诱导性多能干细胞向少突胶质细胞分化的方法，试剂盒以及应用
WO2023019226A1 (en) 2021-08-11 2023-02-16 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
AU2022325955A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
AU2022325231A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
WO2023019203A1 (en) 2021-08-11 2023-02-16 Sana Biotechnology, Inc. Inducible systems for altering gene expression in hypoimmunogenic cells
CN113699117B (zh) * 2021-09-03 2023-06-30 呈诺再生医学科技(北京)有限公司 经基因改造的少突胶质祖细胞在多发性硬化症中的应用
CN114262686B (zh) * 2022-03-02 2022-06-24 深圳市夏同生物医药科技有限公司 一种少突胶质细胞的制备方法及应用
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
KR102898110B1 (ko) * 2022-06-13 2025-12-12 고려대학교 산학협력단 키나아제 저해제를 유효성분으로 포함하는 탈수초성 질환 예방 또는 치료용 약학적 조성물
US20240043798A1 (en) * 2022-08-08 2024-02-08 Trailhead Biosystems Inc. Methods and compositions for generating oligodendrocyte progenitor cells
US20240052321A1 (en) * 2022-08-15 2024-02-15 Cellino Biotech, Inc. Systems and methods for cell manufacturing
CN115322965B (zh) * 2022-08-19 2024-01-30 同济大学 一种体外获得后脑底板细胞的方法、成套培养基及应用
WO2025054202A1 (en) 2023-09-05 2025-03-13 Sana Biotechnology, Inc. Method of screening a sample comprising a transgene with a unique barcode
WO2025151838A1 (en) 2024-01-12 2025-07-17 Sana Biotechnology, Inc. Safety switches to control in vitro and in vivo proliferation of cell therapy products

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003295089A1 (en) * 2002-12-06 2004-06-30 Singapore General Hospital Pte Ltd Nogo, Caspr, F3 NB-3 useful in the treatment of injury and disease to the central nervous system
US8809052B2 (en) * 2006-08-28 2014-08-19 Yeda Research And Development Co. Ltd. Methods of generating mature oligodendrocytes
US8227247B2 (en) * 2007-12-20 2012-07-24 Wisconsin Alumni Research Foundation Method of generating myelinating oligodendrocytes
WO2015124725A1 (en) * 2014-02-21 2015-08-27 Johan Ericson Late born central nervous system cell types
US10301592B2 (en) 2014-05-22 2019-05-28 New York Stem Cell Foundation, Inc. Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same

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KR102324714B1 (ko) 2021-11-11
US20190256820A1 (en) 2019-08-22
EP3145517A1 (en) 2017-03-29
US10676716B2 (en) 2020-06-09
US20200399595A1 (en) 2020-12-24
CN106456672B (zh) 2020-03-13
KR20170005844A (ko) 2017-01-16
AU2015263951B2 (en) 2020-07-02
CN106456672A (zh) 2017-02-22
US20170183627A1 (en) 2017-06-29
PL3145517T3 (pl) 2021-04-06
US10301592B2 (en) 2019-05-28
AU2015263951A1 (en) 2016-12-01
JP2017524340A (ja) 2017-08-31
ES2846860T3 (es) 2021-07-29
JP7410903B2 (ja) 2024-01-10
JP6873705B2 (ja) 2021-05-19
KR102585909B1 (ko) 2023-10-05
EP3145517A4 (en) 2017-11-15
JP2021118718A (ja) 2021-08-12
WO2015179822A1 (en) 2015-11-26
KR20210138783A (ko) 2021-11-19
US11814648B2 (en) 2023-11-14
EP3145517B1 (en) 2020-08-26

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