DK3152296T3 - Human hepatisk 3d-samkulturmodel og anvendelser deraf - Google Patents
Human hepatisk 3d-samkulturmodel og anvendelser deraf Download PDFInfo
- Publication number
- DK3152296T3 DK3152296T3 DK15726971.3T DK15726971T DK3152296T3 DK 3152296 T3 DK3152296 T3 DK 3152296T3 DK 15726971 T DK15726971 T DK 15726971T DK 3152296 T3 DK3152296 T3 DK 3152296T3
- Authority
- DK
- Denmark
- Prior art keywords
- applications
- human hepatic
- cultural model
- cultural
- model
- Prior art date
Links
- 230000002440 hepatic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5067—Liver cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/04—Screening or testing on artificial tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1410048.1A GB201410048D0 (en) | 2014-06-06 | 2014-06-06 | Human hepatic 3d co-culture model and uses thereof |
| GBGB1505012.3A GB201505012D0 (en) | 2015-03-25 | 2015-03-25 | Human hepatic 3D co-culture model and uses thereof |
| PCT/EP2015/062551 WO2015185714A1 (en) | 2014-06-06 | 2015-06-05 | Human hepatic 3d co-culture model and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3152296T3 true DK3152296T3 (da) | 2021-11-08 |
Family
ID=53284272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15726971.3T DK3152296T3 (da) | 2014-06-06 | 2015-06-05 | Human hepatisk 3d-samkulturmodel og anvendelser deraf |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20170166870A1 (da) |
| EP (1) | EP3152296B1 (da) |
| CA (1) | CA2950470A1 (da) |
| DK (1) | DK3152296T3 (da) |
| ES (1) | ES2897553T3 (da) |
| WO (1) | WO2015185714A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP3712254A1 (en) | 2014-05-28 | 2020-09-23 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| CA2963704A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| RU2661105C2 (ru) * | 2016-01-21 | 2018-07-11 | Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" | СПОСОБ ПОЛУЧЕНИЯ СФЕРОИДОВ КЛЕТОК HepaRG В СРЕДЕ БЕЗ ДИМЕТИЛСУЛЬФОКСИДА |
| EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| SG11201903697WA (en) * | 2016-11-04 | 2019-05-30 | Childrens Hospital Med Ct | Liver organoid compositions and methods of making and using same |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| CN109423472B (zh) * | 2017-08-22 | 2026-03-27 | 中国食品药品检定研究院 | 体外3d肝脏模型和肠肝共培养模型及其建立方法和应用 |
| US12297457B2 (en) | 2017-10-10 | 2025-05-13 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| US12421500B2 (en) | 2018-07-26 | 2025-09-23 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| JP2021535753A (ja) | 2018-09-12 | 2021-12-23 | チルドレンズ ホスピタル メディカル センター | 造血幹細胞およびその派生体の生成のためのオルガノイド組成物 |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| JP7595939B2 (ja) * | 2019-02-22 | 2024-12-09 | 株式会社サイフューズ | ヒト肝臓様立体構造体、肝毒性を評価する方法およびヒト肝臓様複合体 |
| CA3141814A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| CN114174494A (zh) | 2019-05-31 | 2022-03-11 | 儿童医院医学中心 | 产生和扩增造血干细胞的方法 |
| CN111826338B (zh) * | 2019-12-27 | 2022-03-29 | 四川大学华西医院 | 一种快速培养肝芽类器官的方法 |
| KR20250080793A (ko) | 2023-11-28 | 2025-06-05 | 부산대학교 산학협력단 | 간 전구세포주의 분화를 촉진하는 스페로이드 제조방법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0030584D0 (en) * | 2000-12-15 | 2001-01-31 | Univ Nottingham | Hepatocyte Co-Culture |
| TWI294461B (en) * | 2004-12-28 | 2008-03-11 | Ind Tech Res Inst | Cell culture and method for screening for a compound useful in the treatment or prevention of hepatic cirrhosis |
-
2015
- 2015-06-05 DK DK15726971.3T patent/DK3152296T3/da active
- 2015-06-05 WO PCT/EP2015/062551 patent/WO2015185714A1/en not_active Ceased
- 2015-06-05 US US15/316,199 patent/US20170166870A1/en not_active Abandoned
- 2015-06-05 EP EP15726971.3A patent/EP3152296B1/en active Active
- 2015-06-05 CA CA2950470A patent/CA2950470A1/en not_active Abandoned
- 2015-06-05 ES ES15726971T patent/ES2897553T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3152296B1 (en) | 2021-08-04 |
| EP3152296A1 (en) | 2017-04-12 |
| WO2015185714A1 (en) | 2015-12-10 |
| US20170166870A1 (en) | 2017-06-15 |
| CA2950470A1 (en) | 2015-12-10 |
| ES2897553T3 (es) | 2022-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FIC20230014I1 (fi) | Foslevodopa ja foskarbidopa | |
| EP3496074A4 (en) | MEDICAL SIMULATOR | |
| MA40933A (fr) | Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines | |
| IL248979B (en) | Syntac polypeptides and uses thereof | |
| DK3210977T3 (da) | Hidtil ukendt aminoalkylbenzothiazepinderivat og anvendelse deraf | |
| DK3229838T3 (da) | Anti-C10orf54-antistoffer og anvendelser deraf | |
| DK3212255T3 (da) | Selvorienterende sprøjte og sprøjtegrænseflade | |
| DK3126388T3 (da) | Anti-EGFRvIII-antistoffer og anvendelser deraf | |
| DK3235830T3 (da) | Interleukin-15-proteinkompleks og anvendelse deraf | |
| HUE036281T2 (hu) | Önbeálló fecskendõ és fecskendõcsatlakozás | |
| IL248781B (en) | Pesticidal compositions and related methods | |
| IL250952A0 (en) | Mir-29 mimics and uses thereof | |
| SI3129018T1 (sl) | Zdravljenje nafld in nash | |
| DK3161139T3 (da) | Tlr-4-specifikke aptamerer og anvendelser heraf | |
| DK3015526T3 (da) | Hydrofluorolefinbaseret sammensætning og anvendelse deraf | |
| DK3209773T3 (da) | Prolintolerante tripeptidylpeptidaser og anvendelser deraf | |
| EP3879472C0 (en) | COMPARISON AND SIMULATION OF WASHES FOR CIP | |
| IL259202A (en) | Modified immune cells and uses thereof | |
| DK3321279T3 (da) | Exenatidmodificeringsmiddel og anvendelse deraf | |
| EP3535617A4 (en) | VISUAL AID DEVICE | |
| DK3365321T3 (da) | Solabegron-zwitterion og anvendelser deraf | |
| PT3337506T (pt) | Combinações e suas utilizações | |
| EP3424705A4 (en) | LAMINATE AND APPLICATION THEREOF | |
| MA49905A (fr) | Polyesteramines et polyesterquats | |
| DE112015003841A5 (de) | Di- und triphosphat-propharmaka |