DK3177313T5 - Telomerase revers transkriptase-baserede terapier til behandling af tilstande associeret med myokardieinfarkt - Google Patents

Telomerase revers transkriptase-baserede terapier til behandling af tilstande associeret med myokardieinfarkt Download PDF

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Publication number
DK3177313T5
DK3177313T5 DK15747463.6T DK15747463T DK3177313T5 DK 3177313 T5 DK3177313 T5 DK 3177313T5 DK 15747463 T DK15747463 T DK 15747463T DK 3177313 T5 DK3177313 T5 DK 3177313T5
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Prior art keywords
treatment
reverse transcriptase
myocardial infarction
conditions associated
based therapies
Prior art date
Application number
DK15747463.6T
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English (en)
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DK3177313T3 (da
Inventor
Maria Bobadilla
Jacques Mizrahi
De Jesus Bruno Bernardes
Christian Baer
Marhuenda Maria Antonia Blasco
Ruiz Rosa María Serrano
I Tubert Fàtima Bosch
Eduard Ayuso
Ivan Formentini
Original Assignee
Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio
UNIV AUTòNOMA DE BARCELONA
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Application filed by Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio, UNIV AUTòNOMA DE BARCELONA filed Critical Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio
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Publication of DK3177313T3 publication Critical patent/DK3177313T3/da
Publication of DK3177313T5 publication Critical patent/DK3177313T5/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • C12N9/1276RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07Nucleotidyltransferases (2.7.7)
    • C12Y207/07049RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DK15747463.6T 2014-08-08 2015-08-04 Telomerase revers transkriptase-baserede terapier til behandling af tilstande associeret med myokardieinfarkt DK3177313T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14382311 2014-08-08
PCT/EP2015/067875 WO2016020346A1 (en) 2014-08-08 2015-08-04 Telomerase reverse transcriptase-based therapies for treatment of conditions associated with myocardial infarction

Publications (2)

Publication Number Publication Date
DK3177313T3 DK3177313T3 (da) 2023-01-23
DK3177313T5 true DK3177313T5 (da) 2024-10-14

Family

ID=51454633

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15747463.6T DK3177313T5 (da) 2014-08-08 2015-08-04 Telomerase revers transkriptase-baserede terapier til behandling af tilstande associeret med myokardieinfarkt

Country Status (7)

Country Link
US (1) US11261434B2 (da)
EP (1) EP3177313B1 (da)
JP (1) JP6695856B2 (da)
DK (1) DK3177313T5 (da)
ES (1) ES2936383T3 (da)
FI (1) FI3177313T3 (da)
WO (1) WO2016020346A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017147132A1 (en) * 2016-02-22 2017-08-31 The Board Of Trustees Of The Leland Stanford Junior University Identification of telomere length as a diagnostic biomarker for heritable cardiomyopathies
CN112063601B (zh) * 2020-09-22 2023-06-02 浙江愈方生物科技有限公司 一种灭活性端粒酶、具有其的腺病毒和人造mRNA及应用
EP4089171A1 (en) 2021-05-12 2022-11-16 Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Recombinant tert-encoding viral genomes and vectors
CN118946266A (zh) * 2022-01-24 2024-11-12 卡洛斯三世肿瘤研究中心国家公共部门基金会(F.S.P.Cnio) 用于肾纤维化的端粒酶逆转录酶治疗及其非人动物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001048151A1 (en) * 1999-12-28 2001-07-05 Kyowa Hakko Kogyo Co., Ltd. Cells capable of differentiating into heart muscle cells
WO2004092395A2 (en) 2003-04-08 2004-10-28 Baylor College Of Medicine Modulators of telomere stability
ES2590461T3 (es) * 2010-07-02 2016-11-22 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii La transcriptasa inversa de la telomerasa como protección frente al envejecimiento
EP2875826B1 (en) 2012-05-11 2017-08-23 KAEL-GemVax Co.,Ltd Composition for preventing or treating sepsis
WO2014105870A1 (en) * 2012-12-27 2014-07-03 Sierra Sciences, Inc. Enhancing health in mammals using telomerase reverse transcriptase gene therapy

Also Published As

Publication number Publication date
US11261434B2 (en) 2022-03-01
FI3177313T3 (fi) 2023-02-28
WO2016020346A1 (en) 2016-02-11
EP3177313B1 (en) 2022-11-02
ES2936383T3 (es) 2023-03-16
JP6695856B2 (ja) 2020-05-20
DK3177313T3 (da) 2023-01-23
JP2017524370A (ja) 2017-08-31
US20170191045A1 (en) 2017-07-06
EP3177313A1 (en) 2017-06-14

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