DK319886A - Kemiske forbindelser - Google Patents

Kemiske forbindelser Download PDF

Info

Publication number: DK319886A
Authority: DK; Denmark
Prior art keywords: 4alkyl; compounds; hydroxy; hydrogen; optionally substituted
Prior art date: 1985-07-05

Application number

DK319886A

Other languages

English (en)

Other versions

DK319886D0 (da

Inventor

William John Coates

John Colin Emmett

Robert Antony Slater

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-05

Filing date

1986-07-04

Publication date

1987-01-06

1985-07-05 Priority claimed from GB858517054A external-priority patent/GB8517054D0/en

1985-07-05 Priority claimed from GB858517052A external-priority patent/GB8517052D0/en

1985-07-05 Priority claimed from GB858517053A external-priority patent/GB8517053D0/en

1985-07-05 Priority claimed from GB858517055A external-priority patent/GB8517055D0/en

1986-07-04 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1986-07-04 Publication of DK319886D0 publication Critical patent/DK319886D0/da

1987-01-06 Publication of DK319886A publication Critical patent/DK319886A/da

Links

150000001875 compounds Chemical class 0.000 title abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
229910052799 carbon Inorganic materials 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
-1 C1 -4alkoxy Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000003182 bronchodilatating effect Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000000297 inotrophic effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
229940124549 vasodilator Drugs 0.000 abstract 1
239000003071 vasodilator agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

DK319886A 1985-07-05 1986-07-04 Kemiske forbindelser DK319886A (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB858517054A GB8517054D0 (en)	1985-07-05	1985-07-05	Chemical compounds
GB858517052A GB8517052D0 (en)	1985-07-05	1985-07-05	Chemical compounds
GB858517053A GB8517053D0 (en)	1985-07-05	1985-07-05	Chemical compounds
GB858517055A GB8517055D0 (en)	1985-07-05	1985-07-05	Chemical compounds

Publications (2)

Publication Number	Publication Date
DK319886D0 DK319886D0 (da)	1986-07-04
DK319886A true DK319886A (da)	1987-01-06

Family

ID=27449675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK319886A DK319886A (da)	1985-07-05	1986-07-04	Kemiske forbindelser

Country Status (9)

Country	Link
US (1)	US4946842A (da)
EP (1)	EP0208518B1 (da)
AT (1)	ATE67193T1 (da)
AU (1)	AU581324B2 (da)
DE (1)	DE3681359D1 (da)
DK (1)	DK319886A (da)
ES (1)	ES2000312A6 (da)
GR (1)	GR861718B (da)
PT (1)	PT82897B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8400863D0 (en) *	1984-01-13	1984-02-15	Smith Kline French Lab	Chemical compounds
GB8603780D0 (en) *	1986-02-15	1986-03-19	Smith Kline French Lab	Chemical compounds
ATE110071T1 (de) *	1988-01-23	1994-09-15	Kyowa Hakko Kogyo Kk	Pyridazinon-derivate und diese enthaltende pharmazeutische zubereitungen.
DE3814057A1 (de) *	1988-04-26	1989-11-09	Heumann Pharma Gmbh & Co	6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5185332A (en) *	1989-02-11	1993-02-09	Orion-Yhtyma Oy	Thiadiazines and pharmaceutical compositions thereof as well as method of use
GB8903130D0 (en) *	1989-02-11	1989-03-30	Orion Yhtymae Oy	Substituted pyridazinones
GB2251615B (en) *	1991-01-03	1995-02-08	Orion Yhtymae Oy	(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB9606474D0 (en)	1996-03-27	1996-06-05	Orion Yhytmo Oy	Method for obtaining pure enantiomers of a pyridazinone derivative
US7049273B2 (en) *	2002-07-17	2006-05-23	Afton Chemical Intangibles Llc	Hybridized olefin copolymer additives
DE10356717A1 (de) *	2003-12-02	2005-07-07	Aventis Pharma Deutschland Gmbh	Verfahren zur Herstellung von (3-Oxo-2,3-dihydro-1H-isoindol-1-yl)-acetylguanidin-Derivaten
US7531569B2 (en)	2003-12-02	2009-05-12	Sanofi-Aventis Deutschland Gmbh	Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
EP2454241B1 (en)	2009-07-14	2014-04-02	Cipla Limited	Process for preparing levosimendan and intermediates for use in the process
CA2879454A1 (en)	2012-07-19	2014-01-23	Drexel University	Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same
EP3424908A1 (en)	2017-07-07	2019-01-09	Melody Healthcare Pvt. Ltd.	Process for preparation of levosimendan
WO2019089902A1 (en)	2017-11-01	2019-05-09	Drexel University	Compounds, compositions, and methods for treating diseases
CN110117257B (zh)	2018-02-05	2022-12-06	安徽省新星药物开发有限责任公司	一种含胍基的p2y12受体拮抗剂、制备方法及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE791539A (fr) *	1971-11-19	1973-05-17	Basf Ag	Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
US4171325A (en) *	1974-09-02	1979-10-16	Smith Kline & French Laboratories Limited	Chemical process
US4233302A (en) *	1977-12-23	1980-11-11	Glaxo Group Limited	Amine derivatives and pharmaceutical compositions containing them
FR2446829A1 (fr) *	1978-11-16	1980-08-14	Glaxo Group Ltd	Derives de polymethylene disubstitues en alpha, omega, procede pour leur preparation et compositions pharmaceutiques les contenant
US4332822A (en) *	1980-02-05	1982-06-01	John Wyeth & Brother Limited	Guanidine derivatives
DE3014353A1 (de) *	1980-04-15	1982-01-21	Bayer Ag, 5090 Leverkusen	Trisubstituierte cyanguanidine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
JPS58113180A (ja) *	1981-12-28	1983-07-05	Mitsui Toatsu Chem Inc	ピリダジノン誘導体
JPS58140076A (ja) *	1982-02-09	1983-08-19	Mitsubishi Chem Ind Ltd	ピリダジノン誘導体又はその塩類
DE3209159A1 (de) *	1982-03-13	1983-09-15	Basf Ag, 6700 Ludwigshafen	Neue 6-aryl-4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung, diese verbindungen enthaltende therapeutische mittel und deren verwendung
DE3302021A1 (de) *	1983-01-22	1984-07-26	Basf Ag, 6700 Ludwigshafen	6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
GB8400863D0 (en) *	1984-01-13	1984-02-15	Smith Kline French Lab	Chemical compounds
CA1251448A (en) *	1985-03-27	1989-03-21	William J. Coates	Pyridazinone derivatives

1986
- 1986-06-30 US US06/880,372 patent/US4946842A/en not_active Expired - Fee Related
- 1986-06-30 AU AU59381/86A patent/AU581324B2/en not_active Ceased
- 1986-07-01 PT PT82897A patent/PT82897B/pt not_active IP Right Cessation
- 1986-07-01 GR GR861718A patent/GR861718B/el unknown
- 1986-07-04 DK DK319886A patent/DK319886A/da not_active Application Discontinuation
- 1986-07-04 AT AT86305188T patent/ATE67193T1/de not_active IP Right Cessation
- 1986-07-04 EP EP86305188A patent/EP0208518B1/en not_active Expired
- 1986-07-04 DE DE8686305188T patent/DE3681359D1/de not_active Expired - Lifetime
- 1986-07-04 ES ES8600128A patent/ES2000312A6/es not_active Expired

Also Published As

Publication number	Publication date
EP0208518A3 (en)	1988-04-20
US4946842A (en)	1990-08-07
DK319886D0 (da)	1986-07-04
ES2000312A6 (es)	1988-02-16
PT82897B (pt)	1989-01-30
AU581324B2 (en)	1989-02-16
EP0208518B1 (en)	1991-09-11
EP0208518A2 (en)	1987-01-14
AU5938186A (en)	1987-01-08
PT82897A (en)	1986-08-01
DE3681359D1 (de)	1991-10-17
GR861718B (en)	1986-11-04
ATE67193T1 (de)	1991-09-15

Legal Events

Date	Code	Title	Description
1992-01-20	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
FI850140A0 (fi)	1985-01-11	Kemiska foereningar.
DK319886D0 (da)	1986-07-04	Kemiske forbindelser
CY1252A (en)	1984-08-31	(piperidinylalkyl)quinazoline derivatives and intermediates,process for their preparation and pharmaceutical compositions containing them
RU95108329A (ru)	1996-12-20	Замещенные производные тиазолидиндиона, способ их получения, фармкомпозиция
RU2000127751A (ru)	2002-09-20	Противоопухолевое средство
ES2030735T3 (es)	1992-11-16	Procedimientos para preparar derivados de acido glutamico.
MX9202975A (es)	1992-07-01	Nuevos compuestos biciclicos y sus sales farmaceuticamente aceptables y procedimiento para su preparacion.
ES2010284A6 (es)	1989-11-01	Procedimiento para preparar derivados de tiourea.
NO802925L (no)	1981-04-06	Nitrosoureaderivater og fremgangsmaate ved fremstilling derav
EA200200379A3 (ru)	2002-12-26	Новые соединения пиримидин-4-она, способ их получения и содержащие их фармацевтические композиции
EP0197664A3 (en)	1987-09-23	2-aminopyrimidinone derivatives
DE3772850D1 (de)	1991-10-17	Thiadiazinon-derivate.