ES2000312A6 - Un procedimiento para preparar derivados de dihidroperidaazinona - Google Patents

Un procedimiento para preparar derivados de dihidroperidaazinona

Info

Publication number
ES2000312A6
ES2000312A6 ES8600128A ES8600128A ES2000312A6 ES 2000312 A6 ES2000312 A6 ES 2000312A6 ES 8600128 A ES8600128 A ES 8600128A ES 8600128 A ES8600128 A ES 8600128A ES 2000312 A6 ES2000312 A6 ES 2000312A6
Authority
ES
Spain
Prior art keywords
alkyl
substituted
hydrogen
dihydroperida
azinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600128A
Other languages
English (en)
Inventor
William John Coates
Johnn Colin Emmett
Robert Antony Slater
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858517055A external-priority patent/GB8517055D0/en
Priority claimed from GB858517053A external-priority patent/GB8517053D0/en
Priority claimed from GB858517052A external-priority patent/GB8517052D0/en
Priority claimed from GB858517054A external-priority patent/GB8517054D0/en
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES2000312A6 publication Critical patent/ES2000312A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PREPARAN COMPUESTOS DE FORMULA (I) O SUS SALES FARMACEUTICAS, DONDE R1 ES HIDROGENO O METILO, R2 ES ALQUILO C1-4 SUSTITUIDO CON UNO O DOS GRUPOS SELECCIONADOS DE HIDROXI, ALCOXI C1-4, CARBAMOILO, ALCOXICARBAMOILO C1-4 Y TRIFLUOROMETILO, SIEMPRE QUE EL ATOMO DE CARBONO ADYACENTE AL ATOMO DE NITROGENO NO ESTE SUSTITUIDO CON HIDROXI Y NINGUN ATOMO DE CARBONO ESTE DISUSTITUIDO CON HIDROXI, O-A-R4, DONDE A ES ALQUILENO C1-4 Y R4 ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO, R3 ES CIANO, -COR5 O -SO2R6, DONDE R5 ES ALQUILO C1-4,ALCOXI C1-4 O FENILO OPCIONALMENTE SUSTITUIDO Y R6 ES NHR7, ALQUILO C1-4 O ARILO OPCIONALMENTE SUSTITUIDO; Y R7 ES HIDROGENO O ALQUILO C1-4, R2 PUEDE SER TAMBIEN CICLOALQUILO C3-6, ALILO O PROPARGILO CUANDO R3 ES CIANO, Y R2 PUEDE SER TAMBIEN HIDROGENO O ALQUILO C1-4 CUANDO R3 ES -COR3 O -SO2R6. ESTOS COMPUESTOS TIENEN PROPIEDADES IONOTROPICAS, VASODILATADORAS, BRONCODILATADORAS E INHIBIDORAS DE AGREGACION PLAQUETARIA.
ES8600128A 1985-07-05 1986-07-04 Un procedimiento para preparar derivados de dihidroperidaazinona Expired ES2000312A6 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858517055A GB8517055D0 (en) 1985-07-05 1985-07-05 Chemical compounds
GB858517053A GB8517053D0 (en) 1985-07-05 1985-07-05 Chemical compounds
GB858517052A GB8517052D0 (en) 1985-07-05 1985-07-05 Chemical compounds
GB858517054A GB8517054D0 (en) 1985-07-05 1985-07-05 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2000312A6 true ES2000312A6 (es) 1988-02-16

Family

ID=27449675

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600128A Expired ES2000312A6 (es) 1985-07-05 1986-07-04 Un procedimiento para preparar derivados de dihidroperidaazinona

Country Status (9)

Country Link
US (1) US4946842A (es)
EP (1) EP0208518B1 (es)
AT (1) ATE67193T1 (es)
AU (1) AU581324B2 (es)
DE (1) DE3681359D1 (es)
DK (1) DK319886A (es)
ES (1) ES2000312A6 (es)
GR (1) GR861718B (es)
PT (1) PT82897B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8400863D0 (en) * 1984-01-13 1984-02-15 Smith Kline French Lab Chemical compounds
GB8603780D0 (en) * 1986-02-15 1986-03-19 Smith Kline French Lab Chemical compounds
EP0326307B1 (en) * 1988-01-23 1994-08-17 Kyowa Hakko Kogyo Co., Ltd. Novel pyridazinone derivatives and pharmaceutical preparations containing them
DE3814057A1 (de) * 1988-04-26 1989-11-09 Heumann Pharma Gmbh & Co 6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5185332A (en) * 1989-02-11 1993-02-09 Orion-Yhtyma Oy Thiadiazines and pharmaceutical compositions thereof as well as method of use
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB9606474D0 (en) 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
US7049273B2 (en) * 2002-07-17 2006-05-23 Afton Chemical Intangibles Llc Hybridized olefin copolymer additives
US7531569B2 (en) 2003-12-02 2009-05-12 Sanofi-Aventis Deutschland Gmbh Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
DE10356717A1 (de) * 2003-12-02 2005-07-07 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von (3-Oxo-2,3-dihydro-1H-isoindol-1-yl)-acetylguanidin-Derivaten
AU2010272364B2 (en) 2009-07-14 2014-04-10 Cipla Limited Process for preparing levosimendan and intermediates for use in the process
WO2014015157A2 (en) 2012-07-19 2014-01-23 Philadelphia Health & Education Corporation Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same
EP3424908A1 (en) 2017-07-07 2019-01-09 Melody Healthcare Pvt. Ltd. Process for preparation of levosimendan
WO2019089902A1 (en) 2017-11-01 2019-05-09 Drexel University Compounds, compositions, and methods for treating diseases
CN110117257B (zh) * 2018-02-05 2022-12-06 安徽省新星药物开发有限责任公司 一种含胍基的p2y12受体拮抗剂、制备方法及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791539A (fr) * 1971-11-19 1973-05-17 Basf Ag Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
US4171325A (en) * 1974-09-02 1979-10-16 Smith Kline & French Laboratories Limited Chemical process
US4233302A (en) * 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
FR2446829A1 (fr) * 1978-11-16 1980-08-14 Glaxo Group Ltd Derives de polymethylene disubstitues en alpha, omega, procede pour leur preparation et compositions pharmaceutiques les contenant
US4332822A (en) * 1980-02-05 1982-06-01 John Wyeth & Brother Limited Guanidine derivatives
DE3014353A1 (de) * 1980-04-15 1982-01-21 Bayer Ag, 5090 Leverkusen Trisubstituierte cyanguanidine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
JPS58140076A (ja) * 1982-02-09 1983-08-19 Mitsubishi Chem Ind Ltd ピリダジノン誘導体又はその塩類
DE3209159A1 (de) * 1982-03-13 1983-09-15 Basf Ag, 6700 Ludwigshafen Neue 6-aryl-4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung, diese verbindungen enthaltende therapeutische mittel und deren verwendung
DE3302021A1 (de) * 1983-01-22 1984-07-26 Basf Ag, 6700 Ludwigshafen 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
GB8400863D0 (en) * 1984-01-13 1984-02-15 Smith Kline French Lab Chemical compounds
CA1251448A (en) * 1985-03-27 1989-03-21 William J. Coates Pyridazinone derivatives

Also Published As

Publication number Publication date
EP0208518A2 (en) 1987-01-14
AU581324B2 (en) 1989-02-16
ATE67193T1 (de) 1991-09-15
GR861718B (en) 1986-11-04
PT82897B (pt) 1989-01-30
EP0208518B1 (en) 1991-09-11
DE3681359D1 (de) 1991-10-17
DK319886D0 (da) 1986-07-04
EP0208518A3 (en) 1988-04-20
PT82897A (en) 1986-08-01
US4946842A (en) 1990-08-07
DK319886A (da) 1987-01-06
AU5938186A (en) 1987-01-08

Similar Documents

Publication Publication Date Title
ES2000312A6 (es) Un procedimiento para preparar derivados de dihidroperidaazinona
ES8604964A1 (es) Un procedimiento para la preparacion de derivados de imida- zodiacepina
BR0010366A (pt) Composto, composição farmacêutica, método de preparar um composto, e, composto para uso em terapia
ES2066875T3 (es) Aminoalquilindoles, procedimiento para su obtencion y preparados farmaceuticos que los contienen.
ES8607914A1 (es) Un procedimiento de preparar un derivado de trans-1,2-diaminociclohexil-amida.
FR2398718A1 (fr) Nouvelles amines primaires utiles a la preparation de derives d'aminoalkyl benzenes
ES416037A1 (es) Procedimiento para la preparacion de 2-(heteroaril-metil)- 5,9b-dialcohil-6,7-benzomorfanos.
FI860369A0 (fi) Imidazolderivat, deras framstaellning och anvaendning samt dessa derivat innehaollande farmaceutiska kompositioner.
ES2000456A6 (es) Procedimiento para preparar deirvados de acido eicosatriinoico-5,8,11 y utilizacion de estos en composiciones farmaceuticas y cosmeticas.
FI862909A0 (fi) Foerfarande foer framstaellning av nya indolkarboxamidderivat och deras salter.
ES2055804T3 (es) Procedimiento de preparacion de nuevas meta-fenilendiaminas sustituidas con trialcoxi.
ITMI913399A1 (it) Copoliestere lineare contenente fosforo, procedimento di preparazione e uso quale addittivo antifiamma
ES2033242T3 (es) Compuestos organicos y su uso farmaceutico.
ES417559A1 (es) Procedimiento de preparacion de compuestos ciclisados que llevan un grupo urea.
ES2001641A6 (es) Procedimiento para la obtencion de nuevas dihidropiridin-2-hidroxiaminas.
ES2003100A6 (es) Un procedimiento para preparar imidazoles
ES476241A1 (es) Procedimiento para la preparacion de derivados de tetraciclonomano.
MX174146B (es) Nuevos derivados de 1-arisulfonil-2-piperidinona y procedimiento para su preparacion
ES445944A1 (es) Procedimiento de preparacion de derivados de 8-amino-teofi- lina.
ATE18993T1 (de) Dibenzocycloheptenyliden-verbindungen zur verwendung bei der modulation der immunreaktion.
ES2036528T3 (es) Procedimiento para la obtencion de derivados aromaticos.
MX173423B (es) DERIVADOS DE 1-ARILSULFINIL-2-PIRROLIDINONA Y P ROCEDIMIENTO PARA SU PREPARACION R1, donde R1, en cualquier posición sobre el núcleR3 donde R2 y R3, identicos o difernetes represent
ES8501741A1 (es) Procedimiento para la obtencion de fenetil-sulfenamidas n-sulfeniladas
ES474002A1 (es) Procedimiento de preparacion de nuevos derivados de acidos arilalcanoicos y de sus sales con una base mineral u organi-ca
ATE66475T1 (de) Aromatische thioaether.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000601