DK3204357T3 - Fluorescerende, syntetiske retinoider - Google Patents

Fluorescerende, syntetiske retinoider Download PDF

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Publication number
DK3204357T3
DK3204357T3 DK15798539.1T DK15798539T DK3204357T3 DK 3204357 T3 DK3204357 T3 DK 3204357T3 DK 15798539 T DK15798539 T DK 15798539T DK 3204357 T3 DK3204357 T3 DK 3204357T3
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Prior art keywords
fluorescent
synthetic retinoids
retinoids
synthetic
Prior art date
Application number
DK15798539.1T
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English (en)
Inventor
Andrew Whiting
Todd Marder
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High Force Res Limited
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Publication date
Priority claimed from GB201417957A external-priority patent/GB201417957D0/en
Priority claimed from GB201419496A external-priority patent/GB201419496D0/en
Application filed by High Force Res Limited filed Critical High Force Res Limited
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Publication of DK3204357T3 publication Critical patent/DK3204357T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18Halogen atoms or nitro radicals
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
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    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P35/00Antineoplastic agents
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C09K11/00Luminescent materials, e.g. electroluminescent or chemiluminescent
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
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    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N21/643Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" non-biological material
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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DK15798539.1T 2014-10-10 2015-10-09 Fluorescerende, syntetiske retinoider DK3204357T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201417957A GB201417957D0 (en) 2014-10-10 2014-10-10 Fluorescent synthetic retinoids
GB201419496A GB201419496D0 (en) 2014-10-31 2014-10-31 Fluorescent synthetic retinoids
PCT/GB2015/052956 WO2016055800A2 (en) 2014-10-10 2015-10-09 Fluorescent synthetic retinoids

Publications (1)

Publication Number Publication Date
DK3204357T3 true DK3204357T3 (da) 2022-04-04

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ID=54697607

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Application Number Title Priority Date Filing Date
DK15798539.1T DK3204357T3 (da) 2014-10-10 2015-10-09 Fluorescerende, syntetiske retinoider

Country Status (12)

Country Link
US (1) US10759762B2 (da)
EP (1) EP3204357B1 (da)
JP (1) JP7178781B2 (da)
CN (1) CN107250112B (da)
AU (2) AU2015329798C1 (da)
CA (1) CA2962150C (da)
DK (1) DK3204357T3 (da)
ES (1) ES2909874T3 (da)
PL (1) PL3204357T3 (da)
PT (1) PT3204357T (da)
SI (1) SI3204357T1 (da)
WO (1) WO2016055800A2 (da)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
CN107176945B (zh) 2016-03-11 2021-06-08 中国科学院上海有机化学研究所 一种视黄酸类化合物、其制备方法、中间体及应用
ES3066492T3 (en) 2016-08-09 2026-05-13 Univ Of Durham Synthetic retinoids (in cell modulation)
GB201910239D0 (en) * 2019-07-17 2019-08-28 Lightox Ltd Fluorescent systems for biological imaging and uses thereof
JP7657223B2 (ja) 2019-12-19 2025-04-04 オルファゲン ファーマシューティカルズ,インク. 炎症性疾患および男性避妊用rarアルファ化合物
CN112479998B (zh) * 2020-11-16 2022-03-15 广州中医药大学(广州中医药研究院) 一种二氢喹啉类荧光探针及其制备方法与应用

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US20170217893A1 (en) 2017-08-03
EP3204357A2 (en) 2017-08-16
JP7178781B2 (ja) 2022-11-28
CA2962150C (en) 2023-07-04
AU2015329798C1 (en) 2019-10-24
SI3204357T1 (sl) 2022-05-31
WO2016055800A3 (en) 2016-06-16
PT3204357T (pt) 2022-03-31
AU2019203709A1 (en) 2019-06-20
AU2019203709B2 (en) 2020-10-22
CN107250112B (zh) 2021-04-23
JP2017537140A (ja) 2017-12-14
US10759762B2 (en) 2020-09-01
PL3204357T3 (pl) 2022-04-25
CN107250112A (zh) 2017-10-13
AU2015329798B2 (en) 2019-07-11
WO2016055800A2 (en) 2016-04-14
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AU2015329798A1 (en) 2017-05-11
EP3204357B1 (en) 2022-01-19

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