DK3204520T3 - Fremgangsmåde til identificering og kvantificering af nukleinsyreekspression, splejsningsvariant, translokation, kopiantal eller methyleringsændringer - Google Patents

Fremgangsmåde til identificering og kvantificering af nukleinsyreekspression, splejsningsvariant, translokation, kopiantal eller methyleringsændringer Download PDF

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Publication number
DK3204520T3
DK3204520T3 DK15849301.5T DK15849301T DK3204520T3 DK 3204520 T3 DK3204520 T3 DK 3204520T3 DK 15849301 T DK15849301 T DK 15849301T DK 3204520 T3 DK3204520 T3 DK 3204520T3
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Prior art keywords
translocation
identifying
nucleic acid
copy number
acid expression
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DK15849301.5T
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English (en)
Inventor
Francis Barany
John William Efcavitch
Jianmin Huang
Philip B Feinberg
Rueda Cristian Ruiz
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Univ Cornell
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/331—Methylation site specific nuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
DK15849301.5T 2014-10-08 2015-10-08 Fremgangsmåde til identificering og kvantificering af nukleinsyreekspression, splejsningsvariant, translokation, kopiantal eller methyleringsændringer DK3204520T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462061376P 2014-10-08 2014-10-08
US201562103894P 2015-01-15 2015-01-15
PCT/US2015/054759 WO2016057832A2 (en) 2014-10-08 2015-10-08 Method for identification and relative quantification of nucleic acid sequence expression, splice variant, translocation, copy number, or methylation changes using combined nuclease, ligation, and polymerase reactions with carryover prevention

Publications (1)

Publication Number Publication Date
DK3204520T3 true DK3204520T3 (da) 2020-04-20

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK15849301.5T DK3204520T3 (da) 2014-10-08 2015-10-08 Fremgangsmåde til identificering og kvantificering af nukleinsyreekspression, splejsningsvariant, translokation, kopiantal eller methyleringsændringer
DK20150354.7T DK3690060T3 (da) 2014-10-08 2015-10-08 Method for identification and relative quantification of nucleic acid sequence expression, splice variant, translocation, copy number, or methylation changes using combined nuclease, ligation, and polymerase reactions with carryover prevention

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DK20150354.7T DK3690060T3 (da) 2014-10-08 2015-10-08 Method for identification and relative quantification of nucleic acid sequence expression, splice variant, translocation, copy number, or methylation changes using combined nuclease, ligation, and polymerase reactions with carryover prevention

Country Status (13)

Country Link
US (2) US10344321B2 (da)
EP (3) EP4026914A1 (da)
JP (3) JP6871160B2 (da)
CN (2) CN107002145B (da)
AU (2) AU2015330844B2 (da)
BR (1) BR112017007033B1 (da)
CA (2) CA2963687C (da)
DK (2) DK3204520T3 (da)
ES (2) ES2904909T3 (da)
IL (3) IL296204B2 (da)
PT (2) PT3690060T (da)
SG (2) SG11201702831XA (da)
WO (1) WO2016057832A2 (da)

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Also Published As

Publication number Publication date
EP3204520A4 (en) 2018-03-07
IL286496A (en) 2021-10-31
JP2023040174A (ja) 2023-03-22
SG11201702831XA (en) 2017-05-30
EP4026914A1 (en) 2022-07-13
BR112017007033A2 (pt) 2017-12-12
US20180265917A1 (en) 2018-09-20
EP3204520B1 (en) 2020-02-12
CA3187713A1 (en) 2016-04-14
JP6871160B2 (ja) 2021-05-12
IL251513A0 (en) 2017-05-29
EP3204520A2 (en) 2017-08-16
CN107002145B (zh) 2021-07-30
ES2904909T3 (es) 2022-04-06
SG10202008961UA (en) 2020-10-29
IL296204B1 (en) 2024-04-01
AU2015330844A1 (en) 2017-04-27
CN113481281B (zh) 2026-03-24
CN113481281A (zh) 2021-10-08
BR112017007033B1 (pt) 2023-10-31
CN107002145A (zh) 2017-08-01
PT3204520T (pt) 2020-04-16
IL296204B2 (en) 2024-08-01
IL296204A (en) 2022-11-01
US20190316187A1 (en) 2019-10-17
JP2021106608A (ja) 2021-07-29
EP3690060A1 (en) 2020-08-05
AU2015330844B2 (en) 2022-02-03
WO2016057832A2 (en) 2016-04-14
JP2017533697A (ja) 2017-11-16
ES2784342T3 (es) 2020-09-24
WO2016057832A3 (en) 2016-06-16
AU2022200229A1 (en) 2022-02-10
EP3690060B1 (en) 2021-12-08
JP7548607B2 (ja) 2024-09-10
PT3690060T (pt) 2022-01-27
DK3690060T3 (da) 2022-01-17
IL251513B (en) 2021-10-31
US10344321B2 (en) 2019-07-09
CA2963687A1 (en) 2016-04-14
US11466311B2 (en) 2022-10-11
JP7209762B2 (ja) 2023-01-20
CA2963687C (en) 2023-03-28

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