PT3690060T - Método de identificação e quantificação relativa da expressão de sequências de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação utilizando reações combinadas de nuclease, ligação e polimerase com prevenção de arraste - Google Patents

Método de identificação e quantificação relativa da expressão de sequências de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação utilizando reações combinadas de nuclease, ligação e polimerase com prevenção de arraste

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Publication number
PT3690060T
PT3690060T PT201503547T PT20150354T PT3690060T PT 3690060 T PT3690060 T PT 3690060T PT 201503547 T PT201503547 T PT 201503547T PT 20150354 T PT20150354 T PT 20150354T PT 3690060 T PT3690060 T PT 3690060T
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Prior art keywords
translocation
copies
drawback
prevention
binding
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PT201503547T
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English (en)
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Univ Cornell
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Publication of PT3690060T publication Critical patent/PT3690060T/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/331—Methylation site specific nuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
PT201503547T 2014-10-08 2015-10-08 Método de identificação e quantificação relativa da expressão de sequências de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação utilizando reações combinadas de nuclease, ligação e polimerase com prevenção de arraste PT3690060T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462061376P 2014-10-08 2014-10-08
US201562103894P 2015-01-15 2015-01-15

Publications (1)

Publication Number Publication Date
PT3690060T true PT3690060T (pt) 2022-01-27

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PT158493015T PT3204520T (pt) 2014-10-08 2015-10-08 Método de identificação e quantificação da expressão de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação
PT201503547T PT3690060T (pt) 2014-10-08 2015-10-08 Método de identificação e quantificação relativa da expressão de sequências de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação utilizando reações combinadas de nuclease, ligação e polimerase com prevenção de arraste

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PT158493015T PT3204520T (pt) 2014-10-08 2015-10-08 Método de identificação e quantificação da expressão de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação

Country Status (13)

Country Link
US (2) US10344321B2 (pt)
EP (3) EP4026914A1 (pt)
JP (3) JP6871160B2 (pt)
CN (2) CN113481281B (pt)
AU (2) AU2015330844B2 (pt)
BR (1) BR112017007033B1 (pt)
CA (2) CA3187713A1 (pt)
DK (2) DK3204520T3 (pt)
ES (2) ES2784342T3 (pt)
IL (3) IL296204B2 (pt)
PT (2) PT3204520T (pt)
SG (2) SG11201702831XA (pt)
WO (1) WO2016057832A2 (pt)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
WO2011146632A1 (en) 2010-05-18 2011-11-24 Gene Security Network Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
CN103608466B (zh) 2010-12-22 2020-09-18 纳特拉公司 非侵入性产前亲子鉴定方法
RU2671980C2 (ru) 2011-02-09 2018-11-08 Натера, Инк. Способы неинвазивного пренатального установления плоидности
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
CA2945962C (en) 2014-04-21 2023-08-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
PT3204520T (pt) * 2014-10-08 2020-04-16 Univ Cornell Método de identificação e quantificação da expressão de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US20220042086A1 (en) * 2017-03-11 2022-02-10 Yan Wang Methods and Devices for Performing Real Time Digital PCR
DK3607086T3 (da) * 2017-04-03 2021-10-04 Qiagen Gmbh Fremgangsmåde til analyse af ekspressionen af et eller flere rna-biomarkørmolekyler
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
CN108179176B (zh) * 2018-02-08 2021-08-03 斯格特生物 一种基于miRNA搭桥对两个互不重叠的扩增引物进行双向延伸检测miRNA的方法
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US20190390282A1 (en) * 2018-05-22 2019-12-26 Biochain Institute, Inc. Target enrichment and sequencing of modified nucleic acids for human cancer detection
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN109385464A (zh) * 2018-07-27 2019-02-26 中山大学附属第六医院 一种dna甲基化检测试剂盒及方法
CN109161594A (zh) * 2018-08-17 2019-01-08 中山大学达安基因股份有限公司 一种检测braf基因突变的方法及其试剂盒
CN108998535B (zh) * 2018-09-11 2021-09-10 广州市宝创生物技术有限公司 一种kras基因多重突变位点检测试剂盒
US11421216B2 (en) 2018-12-21 2022-08-23 Illumina, Inc. Nuclease-based RNA depletion
JP2022530920A (ja) * 2019-05-03 2022-07-04 コーネル ユニバーシティー 核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー
US20220205050A1 (en) * 2019-05-03 2022-06-30 Cornell University Method and markers for identifying and quantifying of nucleic acid sequence, mutation, copy number, or methylation changes
US12305235B2 (en) 2019-06-06 2025-05-20 Natera, Inc. Methods for detecting immune cell DNA and monitoring immune system
US11680290B2 (en) * 2019-12-19 2023-06-20 Chapter Diagnostics, Inc. Efficient methods and compositions for multiplex target amplification PCR
CN113046421B (zh) * 2019-12-26 2022-09-30 厦门大学 一种不对称扩增靶核酸的方法
BR112022022179A2 (pt) * 2020-05-01 2022-12-13 Univ Cornell Método e marcadores para identificação e quantificação relativa de sequência de ácido nucleico, mutação, número de cópia ou alterações de metilação usando combinações de nuclease, ligação, desaminação, reparo de dna e reações de polimerase com prevenção de tranferência
US20240093300A1 (en) * 2020-06-19 2024-03-21 Grail, Llc Methylated dna fragment enrichment, methods, compositions and kits
JPWO2022149575A1 (pt) * 2021-01-06 2022-07-14
US20240182955A1 (en) * 2021-02-17 2024-06-06 Act Genomics (ip) Limited Dna fragment joining detecting method and kit thereof
CN117015617B (zh) 2021-02-23 2025-04-04 10X基因组学有限公司 基于探针的核酸和蛋白质分析
KR20250019610A (ko) 2022-03-21 2025-02-10 빌리언투원, 인크. 치료 모니터링을 위한 메틸화된 세포 유리 dna의 분자 계수
CN115386659B (zh) * 2022-09-05 2025-06-27 江苏海洋大学 一种新冠病毒s蛋白e484q突变的基因分型检测方法
WO2025166072A1 (en) * 2024-02-01 2025-08-07 10X Genomics, Inc. Compositions and methods for sample analysis

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493896A (en) * 1982-10-14 1985-01-15 Bio-Rad Laboratories, Inc. Dual chamber microplate washer
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5683896A (en) 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5035996A (en) 1989-06-01 1991-07-30 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
DK0528882T3 (da) 1990-05-03 2008-01-14 Cornell Res Foundation Inc DNA-amplifikationssystem til påvisning af genetiske sygdomme ved hjælp af termostabil ligase
CA2073298C (en) 1991-07-12 2007-04-17 James L. Hartley Process for controlling contamination of nucleic acid amplification reactions
GB9609441D0 (en) 1996-05-04 1996-07-10 Zeneca Ltd Process
EP2369007B1 (en) * 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6312892B1 (en) 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
EP1385629A2 (en) * 2001-05-11 2004-02-04 Allegro Research Limited A method and device for dispensing of droplets
US20030119004A1 (en) 2001-12-05 2003-06-26 Wenz H. Michael Methods for quantitating nucleic acids using coupled ligation and amplification
EP1552001A4 (en) 2002-09-19 2006-01-04 Applera Corp METHODS AND COMPOSITIONS FOR TARGET DETECTION
US20040219565A1 (en) * 2002-10-21 2004-11-04 Sakari Kauppinen Oligonucleotides useful for detecting and analyzing nucleic acids of interest
DE10337484B4 (de) * 2003-08-14 2005-05-25 Zengerle, Roland, Prof. Dr. Mikrodosiervorrichtung und Verfahren zur dosierten Abgabe von Flüssigkeiten
CN1632132A (zh) * 2003-12-22 2005-06-29 华东理工大学 一种探针及其在关联检测基因多态性位点中的应用
CN100434181C (zh) * 2004-02-17 2008-11-19 纳斯申特生物科学公司 计量一定剂量的样品液体
WO2005092038A2 (en) 2004-03-22 2005-10-06 The Johns Hopkins University Methods for the detection of nucleic acid differences
JP2007530051A (ja) 2004-03-24 2007-11-01 アプレラ コーポレイション 標的分子を決定するためのライゲーション反応および増幅反応
CA2562390C (en) * 2004-04-07 2014-12-02 Exiqon A/S Novel methods for quantification of micrornas and small interfering rnas
DE602005024987D1 (de) * 2004-08-24 2011-01-05 Cornell Res Foundation Inc Detektion von nucleinsäureunterschieden mit hilfe von endonucleasespaltungs-/ligaseabgabereaktionen und kapillarelektrophoresen oder mikroarrays
AU2007281535A1 (en) * 2006-08-01 2008-02-07 Applied Biosystems, Llc. Detection of analytes and nucleic acids
KR100882711B1 (ko) * 2007-03-12 2009-02-06 성균관대학교산학협력단 사이크로박터 스피시스 ｈｊ147 균주 유래의 우라실-ｄｎａ글리코실라제 및 이의 용도
WO2008135512A2 (en) * 2007-05-02 2008-11-13 Jerzy Paszkowski Dna amplification method
CN101329250B (zh) * 2007-06-20 2011-11-30 上海翼和应用生物技术有限公司 一种荧光标记探针的pcr-ldr基因多态性检测测序方法
US20100248228A1 (en) * 2008-03-27 2010-09-30 The Curators Of The University Of Missouri Method for detecting DNA methylation in cancer cells
US8669061B2 (en) * 2008-06-26 2014-03-11 Roche Molecular Systems, Inc. Method for the prevention of carryover contamination in nucleic acid amplification technologies
US8940487B2 (en) 2010-02-09 2015-01-27 UmiTaq Bio Methods and compositions for universal detection of nucleic acids
US8752732B2 (en) * 2011-02-01 2014-06-17 Sakura Finetek U.S.A., Inc. Fluid dispensing system
SG11201404899VA (en) 2012-02-14 2014-10-30 Univ Cornell Method for relative quantification of nucleic acid sequence, expression, or copy changes, using combined nuclease, ligation, and polymerase reactions
CN202533360U (zh) * 2012-02-24 2012-11-14 珠海美华医疗科技有限公司 自加样微孔板
ES2746237T3 (es) * 2013-03-14 2020-03-05 Univ Cornell Método para la cuantificación relativa de cambios en la metilación del ADN, usando reacciones combinadas de nucleasa, ligamiento, y polimerasa
CN103394380B (zh) * 2013-07-31 2016-05-25 中国科学院上海微系统与信息技术研究所 一种高通量微量液体样品分配装置及使用方法
PT3204520T (pt) * 2014-10-08 2020-04-16 Univ Cornell Método de identificação e quantificação da expressão de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação

Also Published As

Publication number Publication date
AU2015330844B2 (en) 2022-02-03
ES2784342T3 (es) 2020-09-24
EP4026914A1 (en) 2022-07-13
BR112017007033A2 (pt) 2017-12-12
WO2016057832A3 (en) 2016-06-16
IL251513A0 (en) 2017-05-29
IL296204B2 (en) 2024-08-01
DK3690060T3 (da) 2022-01-17
JP2023040174A (ja) 2023-03-22
US11466311B2 (en) 2022-10-11
JP2017533697A (ja) 2017-11-16
EP3690060B1 (en) 2021-12-08
EP3204520A4 (en) 2018-03-07
ES2904909T3 (es) 2022-04-06
US20180265917A1 (en) 2018-09-20
CA2963687A1 (en) 2016-04-14
JP2021106608A (ja) 2021-07-29
EP3204520B1 (en) 2020-02-12
CA2963687C (en) 2023-03-28
AU2015330844A1 (en) 2017-04-27
IL296204B1 (en) 2024-04-01
EP3690060A1 (en) 2020-08-05
IL296204A (en) 2022-11-01
BR112017007033B1 (pt) 2023-10-31
PT3204520T (pt) 2020-04-16
JP6871160B2 (ja) 2021-05-12
CN107002145B (zh) 2021-07-30
SG11201702831XA (en) 2017-05-30
IL286496A (en) 2021-10-31
DK3204520T3 (da) 2020-04-20
JP7209762B2 (ja) 2023-01-20
JP7548607B2 (ja) 2024-09-10
CN107002145A (zh) 2017-08-01
CN113481281A (zh) 2021-10-08
US20190316187A1 (en) 2019-10-17
AU2022200229A1 (en) 2022-02-10
US10344321B2 (en) 2019-07-09
IL251513B (en) 2021-10-31
SG10202008961UA (en) 2020-10-29
CA3187713A1 (en) 2016-04-14
EP3204520A2 (en) 2017-08-16
WO2016057832A2 (en) 2016-04-14
CN113481281B (zh) 2026-03-24

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