DK3218509T3 - Mutante mikroorganismer, der er resistente over for lactose-drab - Google Patents
Mutante mikroorganismer, der er resistente over for lactose-drab Download PDFInfo
- Publication number
- DK3218509T3 DK3218509T3 DK15797912.1T DK15797912T DK3218509T3 DK 3218509 T3 DK3218509 T3 DK 3218509T3 DK 15797912 T DK15797912 T DK 15797912T DK 3218509 T3 DK3218509 T3 DK 3218509T3
- Authority
- DK
- Denmark
- Prior art keywords
- mutant microorganisms
- microorganisms resistant
- lactose killing
- killing
- lactose
- Prior art date
Links
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 title 1
- 239000008101 lactose Substances 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01022—Lactose synthase (2.4.1.22)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14193151 | 2014-11-14 | ||
| PCT/EP2015/076449 WO2016075243A1 (en) | 2014-11-14 | 2015-11-12 | Mutant microorganisms resistant to lactose killing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3218509T3 true DK3218509T3 (da) | 2024-05-21 |
Family
ID=51893928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15797912.1T DK3218509T3 (da) | 2014-11-14 | 2015-11-12 | Mutante mikroorganismer, der er resistente over for lactose-drab |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10858684B2 (da) |
| EP (1) | EP3218509B1 (da) |
| JP (2) | JP6765372B2 (da) |
| KR (1) | KR102579346B1 (da) |
| CN (2) | CN114015714A (da) |
| AU (2) | AU2015345073B9 (da) |
| BR (1) | BR112017006295B1 (da) |
| CA (1) | CA2958786A1 (da) |
| DK (1) | DK3218509T3 (da) |
| ES (1) | ES2985061T3 (da) |
| RU (2) | RU2746410C2 (da) |
| SG (1) | SG11201701585VA (da) |
| WO (1) | WO2016075243A1 (da) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11773423B2 (en) * | 2015-08-17 | 2023-10-03 | Zuchem, Inc. | Production of activated TDP-deoxysugars in recombinant microorganisms |
| KR101731263B1 (ko) * | 2016-04-25 | 2017-05-02 | 서울대학교 산학협력단 | 코리네박테리움 글루타미쿰을 이용한 2'-푸코실락토오스의 생산방법 |
| ES2856749T3 (es) | 2016-10-29 | 2021-09-28 | Chr Hansen Hmo Gmbh | Proceso para la producción de oligosacáridos fucosilados |
| EP3562951A1 (en) | 2016-12-27 | 2019-11-06 | Inbiose N.V. | In vivo synthesis of sialylated compounds |
| WO2019106147A1 (en) * | 2017-12-01 | 2019-06-06 | Nestec S.A. | Human milk fortifier composition |
| WO2019209245A1 (en) * | 2018-04-23 | 2019-10-31 | Dupont Nutrition Biosciences Aps | Increasing activity of 2' fucosyllactose transporters endogenous to microbial cells |
| EP3784791A1 (en) | 2018-04-23 | 2021-03-03 | DuPont Nutrition Biosciences ApS | Increasing export of 2' fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
| US10519475B1 (en) * | 2018-11-21 | 2019-12-31 | Amyris, Inc. | Biosynthesis of compounds in yeast |
| JP2022514743A (ja) | 2018-12-18 | 2022-02-15 | インバイオス エン．フェー． | ３－フコシルラクトースの産生およびラクトース変換α－１，３－フコシルトランスフェラーゼ酵素 |
| CN109735479B (zh) * | 2019-01-30 | 2022-04-01 | 光明乳业股份有限公司 | 一种合成2’-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法与应用 |
| KR20220035247A (ko) | 2019-07-19 | 2022-03-21 | 인바이오스 엔.브이. | 숙주 세포에서 푸코실락토스의 제조 |
| CN114829592A (zh) | 2019-12-17 | 2022-07-29 | 因比奥斯公司 | 转化乳糖的α-1,2-岩藻糖基转移酶 |
| AU2020409590A1 (en) | 2019-12-18 | 2022-05-19 | Inbiose N.V. | Production of sialylated oligosaccharide in host cells |
| US20220403431A1 (en) | 2020-02-14 | 2022-12-22 | Inbiose N.V. | Glycominimized bacterial host cells |
| BR112022016042A2 (pt) | 2020-02-14 | 2022-10-11 | Inbiose Nv | Produção de produto glicosilado em células hospedeiras |
| EP3954769A1 (en) | 2020-08-10 | 2022-02-16 | Inbiose N.V. | Production of oligosaccharide mixtures by a cell |
| US20230313252A1 (en) | 2020-08-10 | 2023-10-05 | Inbiose N.V. | Cellular production of sialylated di and/or oligosaccharides |
| CN116171328A (zh) | 2020-08-10 | 2023-05-26 | 因比奥斯公司 | 藉由细胞培养或微生物发酵产生的不同寡糖的纯化混合物的制造方法 |
| US12077788B2 (en) | 2020-08-10 | 2024-09-03 | Inbiose N.V. | Production of a mixture of neutral non-fucosylated oligosaccharides by a cell |
| EP4192946A1 (en) | 2020-08-10 | 2023-06-14 | Inbiose N.V. | Cellular production of di- and/or oligosaccharides |
| WO2022034079A2 (en) | 2020-08-10 | 2022-02-17 | Inbiose N.V. | Process for purification of an oligosaccharide solution produced by cell cultivation or microbial fermentation |
| JP2023546022A (ja) | 2020-10-08 | 2023-11-01 | ジーバイオティクス カンパニー | 腸内での繊維合成酵素の発現のための操作されたプロバイオティクス |
| US20240035004A1 (en) | 2020-12-18 | 2024-02-01 | Inbiose N.V. | Variant sucrose permease polypeptides |
| EP4019534A1 (en) * | 2020-12-22 | 2022-06-29 | Chr. Hansen HMO GmbH | Microbial cells possessing a reduced lactose internalization for producing an oligosaccharide |
| EP4281577A1 (en) | 2021-01-20 | 2023-11-29 | Inbiose N.V. | Production of oligosaccharides comprising ln3 as core structure in host cells |
| CN117157394A (zh) | 2021-04-16 | 2023-12-01 | 因比奥斯公司 | 发酵生产 |
| AU2022258874A1 (en) | 2021-04-16 | 2023-11-30 | Inbiose N.V. | Cellular production of sialylated di- and/or oligosaccharides |
| US20240294959A1 (en) | 2021-04-16 | 2024-09-05 | Inbiose N.V. | Cellular production of bioproducts |
| WO2023285650A1 (en) | 2021-07-16 | 2023-01-19 | Inbiose N.V. | Lacto-n-biose converting fucosyltransferases |
| CN113881586B (zh) * | 2021-09-27 | 2023-03-10 | 四川大学 | 耐高温、耐高糖、耐高盐酿酒酵母菌株及构建方法和应用 |
| KR102477273B1 (ko) * | 2021-11-24 | 2022-12-16 | (주)에이피테크놀로지 | 효소 처리를 통한 2'-푸코실락토오스의 생산성 증대 방법 |
| AU2022409554A1 (en) | 2021-12-14 | 2024-08-01 | Inbiose N.V. | Production of alpha-1,3-fucosylated compounds |
| AU2022415533A1 (en) | 2021-12-14 | 2024-08-01 | Inbiose N.V. | Production of alpha-1,4-fucosylated compounds |
| CN114645070B (zh) * | 2022-02-28 | 2022-12-20 | 北京焉支山科技有限公司 | 一种己糖-6-磷酸组合物的制备方法及其在化妆品中的应用 |
| WO2024017987A1 (en) | 2022-07-20 | 2024-01-25 | Inbiose N.V. | Production of oligosaccharides in host cells |
| CN117551680A (zh) * | 2022-08-03 | 2024-02-13 | 国投生物科技投资有限公司 | 提高酿酒酵母对木糖的利用效率的方法及其应用 |
| WO2024165525A1 (en) | 2023-02-06 | 2024-08-15 | Inbiose N.V. | Production of a saccharide, lactobionic acid and/or glycosylated forms of lactobionic acid |
| WO2024165524A1 (en) | 2023-02-06 | 2024-08-15 | Inbiose N.V. | Production of a saccharide by a cell with reduced synthesis of lactobionic acid |
| CN120641559A (zh) | 2023-02-07 | 2025-09-12 | 因比奥斯公司 | 由具有降低的UDP-GlcNAc合成的细胞来产生二糖和/或乳寡糖 |
| WO2024223815A1 (en) | 2023-04-26 | 2024-10-31 | Inbiose N.V. | Production of a negatively charged oligosaccharide by a cell |
| WO2025224348A1 (en) | 2024-04-26 | 2025-10-30 | Inbiose N.V. | Production of a milk oligosaccharide mixture |
| WO2026052789A1 (en) | 2024-09-05 | 2026-03-12 | Inbiose N.V. | Fucosyltransferase mutants |
| LU508746B1 (en) | 2024-10-30 | 2026-04-30 | Inbiose Nv | Production of a 6'sialylated oligosaccharide |
| EP4752218A1 (en) | 2024-11-29 | 2026-06-03 | OligoScience Biotechnology GmbH | Mutant galactosidase permease and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858752A (en) | 1995-06-07 | 1999-01-12 | The General Hospital Corporation | Fucosyltransferase genes and uses thereof |
| PL1991690T3 (pl) * | 2006-03-09 | 2014-07-31 | Centre Nat Rech Scient | Sposób wytwarzania sialilowanych oligosacharydów |
| JP5998130B2 (ja) * | 2010-07-12 | 2016-09-28 | ユニヴェルシテイト ヘントＵｎｉｖｅｒｓｉｔｅｉｔ Ｇｅｎｔ | 付加価値バイオ生成物の生成のための代謝操作された生物 |
| EP2675899A4 (en) * | 2011-02-16 | 2014-09-10 | Glycosyn LLC | BIOSYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES IN MANIPULATED BACTERIA |
| DK2791367T3 (da) * | 2011-12-16 | 2019-07-01 | Inbiose Nv | Mutante mikroorganismer til syntetisering af colansyre, mannosylerede og/eller fucosylerede oligosaccharider |
| CN102604849B (zh) * | 2012-03-23 | 2013-08-14 | 天津科技大学 | 一株高效利用乳糖生产燃料乙醇的酿酒酵母工程菌 |
| US20140308702A1 (en) * | 2012-03-23 | 2014-10-16 | Silab | Yeast recombinant cell capable of producing gdp-fucose |
| US9816122B2 (en) * | 2012-09-25 | 2017-11-14 | Glycom A/S | Glycoconjugate synthesis |
-
2015
- 2015-11-12 BR BR112017006295-0A patent/BR112017006295B1/pt active IP Right Grant
- 2015-11-12 JP JP2017525844A patent/JP6765372B2/ja active Active
- 2015-11-12 WO PCT/EP2015/076449 patent/WO2016075243A1/en not_active Ceased
- 2015-11-12 US US15/505,809 patent/US10858684B2/en active Active
- 2015-11-12 ES ES15797912T patent/ES2985061T3/es active Active
- 2015-11-12 EP EP15797912.1A patent/EP3218509B1/en active Active
- 2015-11-12 KR KR1020177007250A patent/KR102579346B1/ko active Active
- 2015-11-12 CN CN202111280441.8A patent/CN114015714A/zh active Pending
- 2015-11-12 DK DK15797912.1T patent/DK3218509T3/da active
- 2015-11-12 SG SG11201701585VA patent/SG11201701585VA/en unknown
- 2015-11-12 RU RU2017120211A patent/RU2746410C2/ru active
- 2015-11-12 CN CN201580053480.0A patent/CN107075506B/zh active Active
- 2015-11-12 CA CA2958786A patent/CA2958786A1/en active Pending
- 2015-11-12 AU AU2015345073A patent/AU2015345073B9/en active Active
- 2015-11-12 RU RU2021109889A patent/RU2021109889A/ru unknown
-
2020
- 2020-09-15 JP JP2020154738A patent/JP2021000116A/ja active Pending
- 2020-10-30 US US17/085,380 patent/US20210095321A1/en active Pending
-
2021
- 2021-06-17 AU AU2021204038A patent/AU2021204038B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20180066294A1 (en) | 2018-03-08 |
| CN107075506A (zh) | 2017-08-18 |
| RU2021109889A (ru) | 2021-05-06 |
| RU2746410C2 (ru) | 2021-04-13 |
| EP3218509B1 (en) | 2024-02-28 |
| SG11201701585VA (en) | 2017-05-30 |
| BR112017006295B1 (pt) | 2023-10-17 |
| AU2015345073A1 (en) | 2017-03-23 |
| JP6765372B2 (ja) | 2020-10-07 |
| RU2017120211A3 (da) | 2019-04-25 |
| AU2015345073B2 (en) | 2021-04-08 |
| US10858684B2 (en) | 2020-12-08 |
| AU2021204038B2 (en) | 2024-03-14 |
| CN107075506B (zh) | 2022-06-03 |
| KR102579346B1 (ko) | 2023-09-15 |
| BR112017006295A2 (pt) | 2017-12-12 |
| WO2016075243A1 (en) | 2016-05-19 |
| CA2958786A1 (en) | 2016-05-19 |
| AU2021204038A1 (en) | 2021-07-08 |
| EP3218509A1 (en) | 2017-09-20 |
| KR20170076650A (ko) | 2017-07-04 |
| ES2985061T3 (es) | 2024-11-04 |
| CN114015714A (zh) | 2022-02-08 |
| AU2015345073B9 (en) | 2021-04-29 |
| RU2017120211A (ru) | 2018-12-14 |
| JP2017534292A (ja) | 2017-11-24 |
| JP2021000116A (ja) | 2021-01-07 |
| US20210095321A1 (en) | 2021-04-01 |
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