DK3578179T3 - Process for the preparation of cyclic depsipeptides - Google Patents
Process for the preparation of cyclic depsipeptides Download PDFInfo
- Publication number
- DK3578179T3 DK3578179T3 DK19185579.0T DK19185579T DK3578179T3 DK 3578179 T3 DK3578179 T3 DK 3578179T3 DK 19185579 T DK19185579 T DK 19185579T DK 3578179 T3 DK3578179 T3 DK 3578179T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- cyclic depsipeptides
- depsipeptides
- cyclic
- Prior art date
Links
- 108010002156 Depsipeptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462003369P | 2014-05-27 | 2014-05-27 | |
| EP15800006.7A EP3148540B1 (en) | 2014-05-27 | 2015-05-27 | Process for the preparation of cyclic depsipeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3578179T3 true DK3578179T3 (da) | 2021-03-15 |
Family
ID=54699686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19185579.0T DK3578179T3 (da) | 2014-05-27 | 2015-05-27 | Process for the preparation of cyclic depsipeptides |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US10100089B2 (da) |
| EP (2) | EP3148540B1 (da) |
| JP (4) | JP6522120B2 (da) |
| KR (3) | KR102368235B1 (da) |
| CN (2) | CN106456613B (da) |
| CA (1) | CA2950315C (da) |
| DK (1) | DK3578179T3 (da) |
| ES (1) | ES2866104T3 (da) |
| HU (1) | HUE053677T2 (da) |
| PL (1) | PL3578179T3 (da) |
| PT (2) | PT3148540T (da) |
| TW (4) | TWI711627B (da) |
| WO (1) | WO2015183897A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015183897A1 (en) * | 2014-05-27 | 2015-12-03 | Onkure, Inc. | Process for the preparation of cyclic depsipeptides |
| US11203602B2 (en) * | 2016-05-20 | 2021-12-21 | Onkure, Inc. | Thioester prodrugs of macrocycles as inhibitors of histone deacetylases |
| CN109134511B (zh) * | 2017-06-16 | 2021-07-02 | 复旦大学 | C19位氟代的Largazole类似物、其制备方法和用途 |
| CN109134512B (zh) * | 2017-06-16 | 2021-07-02 | 复旦大学 | C-18位氟代的Laragzole类似物、其制备方法和制备抗肿瘤剂的用途 |
| US11643438B2 (en) | 2018-07-20 | 2023-05-09 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
| CA3205814A1 (en) * | 2020-12-21 | 2022-06-30 | Colorado State University Research Foundation | Synthesis of structural analogs of largazole and associated compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080003334A (ko) | 2005-03-11 | 2008-01-07 | 더 리젠트스 오브 더 유니버시티 오브 콜로라도 | 암 세포를 표피 성장 인자 억제제에 대해 감작화시키는히스톤 데아세틸라제 억제제 |
| US8759512B2 (en) * | 2008-02-24 | 2014-06-24 | University Of Florida Research Foundation, Inc. | Methods of preparation of macrocyclic compounds |
| WO2010009334A1 (en) * | 2008-07-17 | 2010-01-21 | Colorado State University Research Foundation | Method for preparing largazole analogs and uses thereof |
| CN101781321B (zh) * | 2010-02-08 | 2012-12-26 | 中国科学院广州生物医药与健康研究院 | 拉格唑拉(Largazole)及其类似物的合成方法 |
| ES2594500T3 (es) | 2010-05-27 | 2016-12-20 | The Regents Of The University Of Colorado, A Body Corporate | Compuestos macrocíclicos útiles como inhibidores de histonas desacetilasas |
| CN102391359B (zh) * | 2011-11-17 | 2014-07-16 | 南京优科生物医药研究有限公司 | 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途 |
| WO2013148324A1 (en) * | 2012-03-26 | 2013-10-03 | The Regents Of The University Of California | Anti-cancer polyketide compounds |
| CN103232474A (zh) * | 2013-04-16 | 2013-08-07 | 中国药科大学 | 组蛋白去乙酰化酶抑制剂 |
| WO2015183897A1 (en) * | 2014-05-27 | 2015-12-03 | Onkure, Inc. | Process for the preparation of cyclic depsipeptides |
-
2015
- 2015-05-27 WO PCT/US2015/032590 patent/WO2015183897A1/en not_active Ceased
- 2015-05-27 PT PT158000067T patent/PT3148540T/pt unknown
- 2015-05-27 TW TW108116572A patent/TWI711627B/zh active
- 2015-05-27 CN CN201580027121.8A patent/CN106456613B/zh active Active
- 2015-05-27 KR KR1020207014187A patent/KR102368235B1/ko active Active
- 2015-05-27 TW TW109138257A patent/TWI775203B/zh active
- 2015-05-27 JP JP2017514999A patent/JP6522120B2/ja active Active
- 2015-05-27 TW TW111135538A patent/TWI837833B/zh active
- 2015-05-27 PL PL19185579T patent/PL3578179T3/pl unknown
- 2015-05-27 EP EP15800006.7A patent/EP3148540B1/en active Active
- 2015-05-27 KR KR1020167036444A patent/KR102366527B1/ko active Active
- 2015-05-27 ES ES19185579T patent/ES2866104T3/es active Active
- 2015-05-27 CN CN201910227308.2A patent/CN110156874B/zh active Active
- 2015-05-27 TW TW104117108A patent/TWI683823B/zh active
- 2015-05-27 DK DK19185579.0T patent/DK3578179T3/da active
- 2015-05-27 EP EP19185579.0A patent/EP3578179B1/en active Active
- 2015-05-27 US US15/313,800 patent/US10100089B2/en active Active
- 2015-05-27 PT PT191855790T patent/PT3578179T/pt unknown
- 2015-05-27 KR KR1020227005999A patent/KR102432263B1/ko active Active
- 2015-05-27 HU HUE19185579A patent/HUE053677T2/hu unknown
- 2015-05-27 CA CA2950315A patent/CA2950315C/en active Active
-
2018
- 2018-09-11 US US16/127,399 patent/US10689419B2/en active Active
-
2019
- 2019-03-12 JP JP2019044425A patent/JP6892471B2/ja active Active
-
2020
- 2020-02-04 US US16/781,233 patent/US11053284B2/en active Active
-
2021
- 2021-01-15 JP JP2021004695A patent/JP7033677B2/ja active Active
- 2021-06-07 US US17/340,731 patent/US11739123B2/en active Active
-
2022
- 2022-02-28 JP JP2022029025A patent/JP7269398B2/ja active Active
-
2023
- 2023-07-14 US US18/222,170 patent/US12252511B2/en active Active
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