DK3237621T5 - Varianter af human alpha-galactosidase - Google Patents

Varianter af human alpha-galactosidase Download PDF

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Publication number
DK3237621T5
DK3237621T5 DK15874075.3T DK15874075T DK3237621T5 DK 3237621 T5 DK3237621 T5 DK 3237621T5 DK 15874075 T DK15874075 T DK 15874075T DK 3237621 T5 DK3237621 T5 DK 3237621T5
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DK
Denmark
Prior art keywords
galactosidase
variants
human alpha
alpha
human
Prior art date
Application number
DK15874075.3T
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English (en)
Other versions
DK3237621T3 (da
Inventor
Nicholas J Agard
Mathew G Miller
Xiyun Zhang
Gjalt W Huisman
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Codexis Inc filed Critical Codexis Inc
Publication of DK3237621T3 publication Critical patent/DK3237621T3/da
Application granted granted Critical
Publication of DK3237621T5 publication Critical patent/DK3237621T5/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01022—Alpha-galactosidase (3.2.1.22)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK15874075.3T 2014-12-22 2015-12-02 Varianter af human alpha-galactosidase DK3237621T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462095313P 2014-12-22 2014-12-22
US201562216452P 2015-09-10 2015-09-10
PCT/US2015/063329 WO2016105889A1 (en) 2014-12-22 2015-12-02 Human alpha-galactosidase variants

Publications (2)

Publication Number Publication Date
DK3237621T3 DK3237621T3 (da) 2023-06-19
DK3237621T5 true DK3237621T5 (da) 2024-10-14

Family

ID=56151383

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15874075.3T DK3237621T5 (da) 2014-12-22 2015-12-02 Varianter af human alpha-galactosidase

Country Status (19)

Country Link
US (6) US20170360900A1 (da)
EP (2) EP4234699A1 (da)
JP (5) JP6650943B2 (da)
KR (2) KR102438885B1 (da)
AU (2) AU2015370125B2 (da)
BR (1) BR112017013300A2 (da)
CA (1) CA2970638A1 (da)
DK (1) DK3237621T5 (da)
ES (1) ES2944889T3 (da)
FI (1) FI3237621T3 (da)
HR (1) HRP20230468T1 (da)
HU (1) HUE062016T2 (da)
IL (1) IL252479B (da)
LT (1) LT3237621T (da)
PL (1) PL3237621T3 (da)
PT (1) PT3237621T (da)
RS (1) RS64574B1 (da)
SI (1) SI3237621T1 (da)
WO (1) WO2016105889A1 (da)

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* Cited by examiner, † Cited by third party
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DK3237621T5 (da) 2014-12-22 2024-10-14 Codexis Inc Varianter af human alpha-galactosidase
GB201508025D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Fabry disease gene therapy
JP6956417B2 (ja) 2015-12-24 2021-11-02 オキシレイン ユーケー リミテッド ヒトα−Ｎ−アセチルガラクトサミニダーゼポリペプチド
EP3784695B1 (en) 2018-04-27 2023-08-09 The Medical College of Wisconsin, Inc. Use of lentivector-transduced t-rapa cells for amelioration of lysosomal storage disorders
US11708569B2 (en) 2018-08-29 2023-07-25 University Of Copenhagen Modified recombinant lysosomal alpha-galactosidase A and aspartylglucoaminidase having low mannose-6-phosphate and high sialic acid
JP2022515742A (ja) * 2018-12-20 2022-02-22 コデクシス， インコーポレイテッド α－ガラクトシダーゼバリアント
WO2021041809A1 (en) 2019-08-30 2021-03-04 Codexis, Inc. Engineered lipase variants
WO2021055801A1 (en) * 2019-09-18 2021-03-25 The Medical College Of Wisconsin, Inc. Improved alpha-galactosidase protein for enzyme replacement therapy (ert) and methods of use
PE20221266A1 (es) 2019-12-20 2022-08-16 Codexis Inc Variantes de alfa-glucosidasa acida disenadas por ingenieria
TW202146648A (zh) * 2020-02-28 2021-12-16 美商克迪科思股份有限公司 人類α-半乳糖苷酶變異體

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Also Published As

Publication number Publication date
JP6650943B2 (ja) 2020-02-19
JP2018500907A (ja) 2018-01-18
US20210244804A1 (en) 2021-08-12
DK3237621T3 (da) 2023-06-19
KR20220123342A (ko) 2022-09-06
KR102438885B1 (ko) 2022-09-01
PL3237621T3 (pl) 2023-10-30
HRP20230468T1 (hr) 2023-11-10
JP2022097653A (ja) 2022-06-30
US12263207B2 (en) 2025-04-01
US11497798B2 (en) 2022-11-15
US20250041388A1 (en) 2025-02-06
IL252479A0 (en) 2017-07-31
AU2022202939A1 (en) 2022-05-26
US11278600B2 (en) 2022-03-22
SI3237621T1 (sl) 2023-11-30
EP4234699A1 (en) 2023-08-30
US10973888B2 (en) 2021-04-13
KR102702200B1 (ko) 2024-09-02
AU2022202939B2 (en) 2025-03-06
JP2024150549A (ja) 2024-10-23
JP2019076110A (ja) 2019-05-23
WO2016105889A1 (en) 2016-06-30
PT3237621T (pt) 2023-07-20
KR20170093976A (ko) 2017-08-16
US20170360900A1 (en) 2017-12-21
LT3237621T (lt) 2023-09-25
CA2970638A1 (en) 2016-06-30
EP3237621A4 (en) 2018-12-05
US20200405826A1 (en) 2020-12-31
JP7785315B2 (ja) 2025-12-15
EP3237621B1 (en) 2023-04-19
AU2015370125B2 (en) 2022-02-03
JP7675443B2 (ja) 2025-05-13
RS64574B1 (sr) 2023-10-31
FI3237621T3 (fi) 2023-06-01
BR112017013300A2 (pt) 2018-02-27
US12257291B2 (en) 2025-03-25
NZ732171A (en) 2021-01-29
EP3237621A1 (en) 2017-11-01
US20200360490A1 (en) 2020-11-19
IL252479B (en) 2021-03-25
HUE062016T2 (hu) 2023-09-28
AU2015370125A1 (en) 2017-06-22
JP2021003129A (ja) 2021-01-14
US20200360489A1 (en) 2020-11-19
ES2944889T3 (es) 2023-06-26

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