DK3851537T3 - Behandling af hyperbilirubinæmi - Google Patents

Behandling af hyperbilirubinæmi Download PDF

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Publication number
DK3851537T3
DK3851537T3 DK21151019.3T DK21151019T DK3851537T3 DK 3851537 T3 DK3851537 T3 DK 3851537T3 DK 21151019 T DK21151019 T DK 21151019T DK 3851537 T3 DK3851537 T3 DK 3851537T3
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DK
Denmark
Prior art keywords
hyperbilirubinamia
treatment
Prior art date
Application number
DK21151019.3T
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English (en)
Other versions
DK3851537T5 (da
Inventor
Federico Mingozzi
Giuseppe Ronzitti
Fanny Collaud
Andrés Muro
Giulia Bortolussi
Original Assignee
Genethon
Int Centre For Genetic Engineering And Biotechnology
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Publication of DK3851537T3 publication Critical patent/DK3851537T3/da
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Publication of DK3851537T5 publication Critical patent/DK3851537T5/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK21151019.3T 2014-04-25 2015-04-27 Behandling af hyperbilirubinæmi DK3851537T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14305622 2014-04-25
EP14196400 2014-12-04
EP19172023.4A EP3546585B1 (en) 2014-04-25 2015-04-27 Nucleic acids comprising a modified intron for use in the treatment of hyperbilirubinemia

Publications (2)

Publication Number Publication Date
DK3851537T3 true DK3851537T3 (da) 2024-03-18
DK3851537T5 DK3851537T5 (da) 2024-08-19

Family

ID=53039406

Family Applications (3)

Application Number Title Priority Date Filing Date
DK19172023.4T DK3546585T3 (da) 2014-04-25 2015-04-27 Nukleinsyrer med en modificeret intron til brug i behandlingen af hyperbilirubinæmi
DK21151019.3T DK3851537T5 (da) 2014-04-25 2015-04-27 Behandling af hyperbilirubinæmi
DK15719677.5T DK3134530T3 (da) 2014-04-25 2015-04-27 Behandling af hyperbilirubinæmi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK19172023.4T DK3546585T3 (da) 2014-04-25 2015-04-27 Nukleinsyrer med en modificeret intron til brug i behandlingen af hyperbilirubinæmi

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK15719677.5T DK3134530T3 (da) 2014-04-25 2015-04-27 Behandling af hyperbilirubinæmi

Country Status (11)

Country Link
US (3) US10471132B2 (da)
EP (4) EP3851537B1 (da)
JP (3) JP6730193B2 (da)
CN (2) CN114395559A (da)
AU (1) AU2015250770B2 (da)
CA (2) CA3205555A1 (da)
DK (3) DK3546585T3 (da)
ES (3) ES2744565T3 (da)
FI (2) FI3546585T3 (da)
PL (1) PL3851537T3 (da)
WO (1) WO2015162302A2 (da)

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Also Published As

Publication number Publication date
DK3546585T3 (da) 2025-11-03
JP2022088645A (ja) 2022-06-14
EP4643946A2 (en) 2025-11-05
EP3134530B1 (en) 2019-06-12
FI3851537T3 (fi) 2024-03-21
EP3851537B1 (en) 2023-12-27
FI3546585T3 (fi) 2025-11-20
DK3851537T5 (da) 2024-08-19
CA3205555A1 (en) 2015-10-29
WO2015162302A2 (en) 2015-10-29
ES3050307T3 (en) 2025-12-19
JP2017513501A (ja) 2017-06-01
EP3546585B1 (en) 2025-09-10
CA2942451A1 (en) 2015-10-29
AU2015250770B2 (en) 2020-10-01
JP7349931B2 (ja) 2023-09-25
US20170028036A1 (en) 2017-02-02
CN106459932B (zh) 2022-01-11
CN114395559A (zh) 2022-04-26
CN106459932A (zh) 2017-02-22
DK3134530T3 (da) 2019-09-09
EP3851537A1 (en) 2021-07-21
EP3546585A1 (en) 2019-10-02
EP3134530A2 (en) 2017-03-01
US20230414724A1 (en) 2023-12-28
ES2744565T3 (es) 2020-02-25
JP6730193B2 (ja) 2020-07-29
EP4643946A3 (en) 2026-03-04
ES2971434T3 (es) 2024-06-05
US10471132B2 (en) 2019-11-12
AU2015250770A1 (en) 2016-09-29
CA2942451C (en) 2024-09-10
US20190374619A1 (en) 2019-12-12
PL3851537T3 (pl) 2024-09-16
WO2015162302A3 (en) 2015-12-30
JP2020103300A (ja) 2020-07-09

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