DK3240892T3 - Rpe-cellepopulationer og fremgangsmåder til dannelse deraf - Google Patents

Rpe-cellepopulationer og fremgangsmåder til dannelse deraf Download PDF

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DK3240892T3
DK3240892T3 DK15832827.8T DK15832827T DK3240892T3 DK 3240892 T3 DK3240892 T3 DK 3240892T3 DK 15832827 T DK15832827 T DK 15832827T DK 3240892 T3 DK3240892 T3 DK 3240892T3
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procedures
creating
cell populations
rpe cell
rpe
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DK15832827.8T
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DK3240892T5 (da
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Osnat Bohana-Kashtan
Belmaker Lior Ann Rosenberg
Ofer Wiser
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Cell Cure Neurosciences Ltd
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    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

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  • Ophthalmology & Optometry (AREA)
  • Developmental Biology & Embryology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK15832827.8T 2014-12-30 2015-12-30 Rpe-cellepopulationer og fremgangsmåder til dannelse deraf DK3240892T5 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462097753P 2014-12-30 2014-12-30
US201562116972P 2015-02-17 2015-02-17
US201562195309P 2015-07-22 2015-07-22
PCT/IL2015/051269 WO2016108239A1 (en) 2014-12-30 2015-12-30 Rpe cell populations and methods of generating same

Publications (2)

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DK3240892T3 true DK3240892T3 (da) 2020-02-17
DK3240892T5 DK3240892T5 (da) 2020-10-19

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US (6) US11891622B2 (da)
EP (2) EP3674397A1 (da)
JP (4) JP6882981B2 (da)
KR (1) KR20170115514A (da)
CN (1) CN107406830A (da)
AU (3) AU2015373050B2 (da)
BR (1) BR112017014345A2 (da)
CA (1) CA2972575A1 (da)
DK (1) DK3240892T5 (da)
EA (1) EA201791416A1 (da)
ES (1) ES2774456T3 (da)
HK (1) HK1246348A1 (da)
IL (4) IL273405B2 (da)
MX (1) MX2017008737A (da)
PH (1) PH12017501218A1 (da)
SG (1) SG11201705379VA (da)
WO (1) WO2016108239A1 (da)

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SG11201705379VA (en) 2017-08-30
IL321407A (en) 2025-08-01
AU2015373050B2 (en) 2022-09-29
EP3240892A1 (en) 2017-11-08
DK3240892T5 (da) 2020-10-19
EP3674397A1 (en) 2020-07-01
US11891622B2 (en) 2024-02-06
AU2025237944A1 (en) 2025-10-16
AU2015373050A9 (en) 2017-09-07
IL273405B1 (en) 2023-09-01
US20180016553A1 (en) 2018-01-18
PH12017501218A1 (en) 2018-01-29
US20220154141A1 (en) 2022-05-19
US20220169981A1 (en) 2022-06-02
JP7608192B2 (ja) 2025-01-06
IL273405A (en) 2020-05-31
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EP3240892B9 (en) 2020-07-22
US20210332325A1 (en) 2021-10-28
EP3240892B1 (en) 2019-11-06
MX2017008737A (es) 2018-01-25
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AU2022291539A1 (en) 2023-02-02
IL253238B (en) 2020-04-30
JP6882981B2 (ja) 2021-06-02
US20220169982A1 (en) 2022-06-02
IL273405B2 (en) 2024-01-01
CN107406830A (zh) 2017-11-28
EA201791416A1 (ru) 2017-11-30
IL305070B1 (en) 2025-07-01
JP2025111765A (ja) 2025-07-30
HK1246348A1 (zh) 2018-09-07
IL305070B2 (en) 2025-11-01
JP2021072832A (ja) 2021-05-13
IL253238A0 (en) 2017-08-31
BR112017014345A2 (pt) 2018-01-02
ES2774456T3 (es) 2020-07-21
WO2016108239A1 (en) 2016-07-07
US11987810B2 (en) 2024-05-21
US20240301351A1 (en) 2024-09-12
JP2023052646A (ja) 2023-04-11
KR20170115514A (ko) 2017-10-17
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