DK325583A - Fremgangsmaade til fremstilling af lavmolekylaere hepariner ved depolymerisation af normal heparin - Google Patents

Fremgangsmaade til fremstilling af lavmolekylaere hepariner ved depolymerisation af normal heparin Download PDF

Info

Publication number: DK325583A
Authority: DK; Denmark
Prior art keywords: heparines; depolymerization; procedure; preparation; low molecular
Prior art date: 1982-07-19

Application number

DK325583A

Other languages

English (en)

Other versions

DK325583D0 (da

DK172798B1 (da

Inventor

Milton R Smith

Eduardo Amaya

Fernando Fussi

Original Assignee

Hepar Ind Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-07-19

Filing date

1983-07-14

Publication date

1984-01-20

1983-07-14 Application filed by Hepar Ind Inc filed Critical Hepar Ind Inc

1983-07-14 Publication of DK325583D0 publication Critical patent/DK325583D0/da

1984-01-20 Publication of DK325583A publication Critical patent/DK325583A/da

1999-07-19 Application granted granted Critical

1999-07-19 Publication of DK172798B1 publication Critical patent/DK172798B1/da

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title 1
229960002897 heparin Drugs 0.000 title 1
229920000669 heparin Polymers 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Materials Engineering (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

DK198303255A 1982-07-19 1983-07-14 Fremgangsmåde til fremstilling af lavmolekylære hepariner ved depolymerisation af normal heparin DK172798B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39921782A	1982-07-19	1982-07-19
US39921782		1982-07-19

Publications (3)

Publication Number	Publication Date
DK325583D0 DK325583D0 (da)	1983-07-14
DK325583A true DK325583A (da)	1984-01-20
DK172798B1 DK172798B1 (da)	1999-07-19

Family

ID=23578637

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198303255A DK172798B1 (da)	1982-07-19	1983-07-14	Fremgangsmåde til fremstilling af lavmolekylære hepariner ved depolymerisation af normal heparin

Country Status (10)

Country	Link
EP (1)	EP0101141A3 (da)
JP (1)	JPS5920302A (da)
AR (1)	AR231644A1 (da)
AU (1)	AU1033183A (da)
CA (1)	CA1195322A (da)
DK (1)	DK172798B1 (da)
ES (1)	ES8402319A1 (da)
NZ (1)	NZ202996A (da)
PT (1)	PT76111A (da)
ZA (1)	ZA829463B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1214609B (it) *	1985-05-17	1990-01-18	Opocrin Spa	Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
US4745106A (en) *	1986-08-20	1988-05-17	Griffin Charles C	Heparin derivatives having improved anti-Xa specificity
EP0256880B1 (en) *	1986-08-20	1995-05-03	Miami University	Alkanoyl esters of heparin of low molecular weight
US4942156A (en) *	1986-08-20	1990-07-17	Hepar Industries, Inc.	Low molecular weight heparin derivatives having improved anti-Xa specificity
US5744457A (en) *	1995-03-31	1998-04-28	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US6001820A (en) *	1995-03-31	1999-12-14	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5763427A (en) *	1995-03-31	1998-06-09	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5767269A (en) *	1996-10-01	1998-06-16	Hamilton Civic Hospitals Research Development Inc.	Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
FR2763848B1 (fr)	1997-05-28	2000-01-28	Rhone Poulenc Rorer Sa	Utilisation des heparines de bas poids moleculaire pour la prevention et le traitement du trauma du systeme nerveux central
JP2003504428A (ja) *	1999-06-30	2003-02-04	ハミルトンシビックホスピタルズリサーチディベロップメントインコーポレイテッド	クロット関連凝固因子を阻害するヘパリン組成物
JP2002293804A (ja) *	2001-03-28	2002-10-09	Itoham Foods Inc	低分子量ヘパリンの製造法
WO2022015794A1 (en)	2020-07-14	2022-01-20	Optimvia, Llc	Methods for synthesizing non-anticoagulant heparan sulfate
CA3144968A1 (en)	2019-07-09	2021-01-14	Optimvia Llc	Methods for synthesizing anticoagulant polysaccharides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3179566A (en) *	1963-05-16	1965-04-20	Canada Packers Ltd	Purification of heparin
US3482014A (en) *	1966-06-29	1969-12-02	Canada Packers Ltd	Orally active heparin and method for making and using same
CA1136620A (en) *	1979-01-08	1982-11-30	Ulf P.F. Lindahl	Heparin fragments having selective anticoagulation activity
JPS56120704A (en) *	1980-01-28	1981-09-22	Hepar Ind Inc	Method of obtaining low molecular weight heparin having heightened pharmacologic property* product manufactured thereby and its use
US4281108A (en) *	1980-01-28	1981-07-28	Hepar Industries, Inc.	Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained

1982
- 1982-12-23 ZA ZA829463A patent/ZA829463B/xx unknown
- 1982-12-23 CA CA000418428A patent/CA1195322A/en not_active Expired
1983
- 1983-01-12 EP EP83300155A patent/EP0101141A3/en not_active Withdrawn
- 1983-01-12 AU AU10331/83A patent/AU1033183A/en not_active Abandoned
- 1983-01-12 JP JP58003271A patent/JPS5920302A/ja active Granted
- 1983-01-12 NZ NZ202996A patent/NZ202996A/en unknown
- 1983-01-14 ES ES519015A patent/ES8402319A1/es not_active Expired
- 1983-01-19 PT PT76111A patent/PT76111A/pt unknown
- 1983-01-21 AR AR291924A patent/AR231644A1/es active
- 1983-07-14 DK DK198303255A patent/DK172798B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0101141A3 (en)	1985-05-22
NZ202996A (en)	1985-10-11
PT76111A (en)	1983-02-01
DK325583D0 (da)	1983-07-14
ES519015A0 (es)	1984-02-01
EP0101141A2 (en)	1984-02-22
AU1033183A (en)	1984-01-26
ZA829463B (en)	1983-10-26
AR231644A1 (es)	1985-01-31
ES8402319A1 (es)	1984-02-01
JPH0442401B2 (da)	1992-07-13
JPS5920302A (ja)	1984-02-02
DK172798B1 (da)	1999-07-19
CA1195322A (en)	1985-10-15

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Legal Events

Date	Code	Title	Description
2003-07-28	PUP	Patent expired