DK3257943T3 - Fremgangsmåder og vektorer til celleimmortalisering - Google Patents

Fremgangsmåder og vektorer til celleimmortalisering

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Publication number
DK3257943T3
DK3257943T3 DK17180843.9T DK17180843T DK3257943T3 DK 3257943 T3 DK3257943 T3 DK 3257943T3 DK 17180843 T DK17180843 T DK 17180843T DK 3257943 T3 DK3257943 T3 DK 3257943T3
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Denmark
Prior art keywords
vectors
methods
cell immortalization
immortalization
cell
Prior art date
Application number
DK17180843.9T
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English (en)
Inventor
Tobias May
Hansjörg HAUSER
Franziska Schuller
Jeannette Zauers
Roland Schucht
Original Assignee
Helmholtz Zentrum Infektionsforschung Gmbh
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Publication of DK3257943T3 publication Critical patent/DK3257943T3/da

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
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    • C12N2740/10011Retroviridae
    • C12N2740/15011Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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DK17180843.9T 2010-11-02 2011-11-02 Fremgangsmåder og vektorer til celleimmortalisering DK3257943T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40950310P 2010-11-02 2010-11-02
EP10014200 2010-11-02
EP11778807.5A EP2635682B1 (en) 2010-11-02 2011-11-02 Methods and vectors for cell immortalisation

Publications (1)

Publication Number Publication Date
DK3257943T3 true DK3257943T3 (da) 2019-10-21

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DK17180843.9T DK3257943T3 (da) 2010-11-02 2011-11-02 Fremgangsmåder og vektorer til celleimmortalisering

Country Status (8)

Country Link
US (1) US9453203B2 (da)
EP (2) EP3257943B1 (da)
JP (2) JP6147191B2 (da)
CN (1) CN103282498A (da)
AU (1) AU2011325439B2 (da)
CA (1) CA2814704C (da)
DK (1) DK3257943T3 (da)
WO (1) WO2012059223A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3257943T3 (da) * 2010-11-02 2019-10-21 Helmholtz Zentrum Infektionsforschung Gmbh Fremgangsmåder og vektorer til celleimmortalisering
WO2014109696A1 (en) * 2013-01-10 2014-07-17 Alf Grandien Method for immortalization of b cells and uses thereof
CN104630136B (zh) * 2013-11-15 2019-10-01 中国科学院广州生物医药与健康研究院 一种制备诱导多能性干细胞的方法以及该方法中所使用的组合物及其应用
CN105960455B (zh) * 2013-11-27 2020-02-04 株式会社钟化 细胞培养基及使用其的培养方法
SG11201606934SA (en) * 2014-03-04 2016-09-29 Fate Therapeutics Inc Improved reprogramming methods and cell culture platforms
KR102334203B1 (ko) * 2017-08-09 2021-12-02 가부시키가이샤 만다무 불사화(不死化) 땀샘 근상피 세포
CN119033819A (zh) 2017-11-22 2024-11-29 迈索布拉斯特国际有限公司 细胞组合物及治疗方法
CN109097335B (zh) * 2018-08-29 2022-08-19 刘卫辉 正常肝干细胞向肝癌干细胞恶性转化的诱导方法
CN109486769A (zh) * 2018-10-16 2019-03-19 山东农业大学 一种对prrsv易感的猪子宫内膜上皮细胞系及其构建方法
BR112022001912A2 (pt) 2019-08-05 2022-04-19 Mesoblast Int Sarl Composições celulares compreendendo vetores virais e métodos de tratamento
WO2021060467A1 (ja) * 2019-09-25 2021-04-01 国立大学法人東京大学 巨核球前駆細胞および巨核球細胞の製造方法並びに得られた巨核球前駆細胞および巨核球細胞
JP7659784B2 (ja) * 2019-10-17 2025-04-10 国立大学法人千葉大学 巨核球前駆細胞又は巨核球細胞の製造方法
WO2021090594A1 (ja) * 2019-11-04 2021-05-14 国立大学法人 東京大学 好中球前駆細胞及びその製造方法
CN110699326A (zh) * 2019-11-04 2020-01-17 郭津生 一种永生化人肝星状细胞株及其制备方法
CN111154807B (zh) * 2020-01-17 2023-03-24 山东农业大学 一种分泌型的崂山奶山羊乳腺上皮细胞系的构建方法
JP6989859B2 (ja) * 2020-04-10 2022-01-12 有限会社バラエティーエム・ワン 情報コード、情報コード生成装置、情報コード読取装置、プログラムおよび情報コード利用システム
WO2022034506A1 (en) 2020-08-10 2022-02-17 Mesoblast International Sárl Cellular compositions and methods of treatment
CN112574946B (zh) * 2020-12-28 2023-12-12 中国科学院昆明动物研究所 一种原代分离培养土狗多个组织来源的成纤维细胞及其永生化的构建方法
JP7670269B2 (ja) * 2021-01-14 2025-04-30 学校法人日本医科大学 不死化間葉系細胞を含む細胞集団を製造する方法及び不死化間葉系細胞を含む細胞集団
JP2024508797A (ja) * 2021-02-22 2024-02-28 ヴィトロラブズ インコーポレイテッド 人工合成皮革のための不死化細胞株
CN118176292A (zh) * 2021-10-14 2024-06-11 北京干细胞与再生医学研究院 年轻化非多能性细胞及其制备方法和应用
WO2023090901A1 (ko) * 2021-11-18 2023-05-25 의료법인 성광의료재단 기계 학습을 이용한 세포 노화의 마커를 선별하는 방법, 세포 노화 바이오 마커, 및 이를 이용한 세놀리틱 제제를 스크리닝 하는 방법
WO2023096380A1 (ko) * 2021-11-26 2023-06-01 한양대학교 산학협력단 유전자 과발현을 이용해 조건부 성숙이 가능한 적혈구 전구세포주 확립
CN114525238A (zh) * 2022-02-14 2022-05-24 中国农业科学院兰州兽医研究所 一株牛皮肤成纤维永生化细胞系的建立方法及应用
WO2024122579A1 (ja) * 2022-12-06 2024-06-13 北山ラベス株式会社 不死化細胞の製造方法
AU2023415203A1 (en) * 2022-12-28 2025-08-07 National University Corporation Chiba University Method for regulating degree of cell differentiation
WO2025070651A1 (ja) * 2023-09-29 2025-04-03 国立大学法人千葉大学 造血幹細胞及び造血前駆細胞の増殖を促進する方法。
WO2025106446A1 (en) * 2023-11-13 2025-05-22 Memorial Sloan-Kettering Cancer Center Monocyte or macrophage compositions with enhanced anti- tumor activity and uses thereof
CN119662736A (zh) * 2024-12-16 2025-03-21 西南民族大学 一种牦牛肌内前体脂肪永生化细胞系及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE311466T1 (de) * 1995-02-10 2005-12-15 Univ California Menschliche pancreas zellinien: entwicklungen und anwendungen
US6303289B1 (en) * 1999-03-23 2001-10-16 Elenor Roosevelt Institute Composition and methods for the treatment of cancer and viral infections
GB0005856D0 (en) * 2000-03-10 2000-05-03 Reneuron Ltd Genetic constructs
WO2003001198A1 (en) * 2001-06-21 2003-01-03 Regents Of The University Of California Immortalization of human cells by the ectopic expression of human telomerase reverse transcriptase
GB0125773D0 (en) * 2001-10-26 2001-12-19 Reneuron Ltd Constructs
GB0316882D0 (en) * 2003-07-18 2003-08-20 Consejo Superior Investigacion Reversible immortalization of OEG from human olfactory bulbs as a tool to promote spinal cord regeneration
CN1590539A (zh) * 2003-09-02 2005-03-09 中国人民解放军第四军医大学口腔医学院 一种使皮肤成纤维细胞永生化的方法
EP1528101A1 (en) 2003-11-03 2005-05-04 ProBioGen AG Immortalized avian cell lines for virus production
EP1652932A1 (en) * 2004-11-02 2006-05-03 GBF Gesellschaft für Biotechnologische Forschung mbH Method for the generation of virus producing cell lines and cell lines
US20100190250A1 (en) * 2005-10-14 2010-07-29 Jifan Hu Methods of Rejuvenating Cells In Vitro and In Vivo
EP2141241A1 (en) * 2008-07-03 2010-01-06 Helmholtz-Zentrum für Infektionsforschung GmbH Senescence cells and methods for its production
CN102105488A (zh) * 2008-07-18 2011-06-22 朱志强 真核细胞的长期培养方法及其应用
DK3257943T3 (da) * 2010-11-02 2019-10-21 Helmholtz Zentrum Infektionsforschung Gmbh Fremgangsmåder og vektorer til celleimmortalisering

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