DK3280405T3 - Inhibitorer og anvendelser deraf - Google Patents

Inhibitorer og anvendelser deraf Download PDF

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Publication number
DK3280405T3
DK3280405T3 DK16717688.2T DK16717688T DK3280405T3 DK 3280405 T3 DK3280405 T3 DK 3280405T3 DK 16717688 T DK16717688 T DK 16717688T DK 3280405 T3 DK3280405 T3 DK 3280405T3
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DK
Denmark
Prior art keywords
inhibitors
Prior art date
Application number
DK16717688.2T
Other languages
English (en)
Inventor
Anne Bertolotti
Agnieszka Krzyzosiak
Kim Schneider
Adrien Rousseau
Anna Gudny Sigurdardottir
Indrajit Das
Original Assignee
Res & Innovation Uk
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Filing date
Publication date
Priority claimed from GBGB1505975.1A external-priority patent/GB201505975D0/en
Priority claimed from GBGB1505971.0A external-priority patent/GB201505971D0/en
Application filed by Res & Innovation Uk filed Critical Res & Innovation Uk
Application granted granted Critical
Publication of DK3280405T3 publication Critical patent/DK3280405T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/14Enzymes or microbial cells immobilised on or in an inorganic carrier
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/916Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
DK16717688.2T 2015-04-08 2016-04-08 Inhibitorer og anvendelser deraf DK3280405T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1505975.1A GB201505975D0 (en) 2015-04-08 2015-04-08 Inhibitors and their uses
GBGB1505971.0A GB201505971D0 (en) 2015-04-08 2015-04-08 Inhibitors and their uses
PCT/GB2016/050991 WO2016162689A1 (en) 2015-04-08 2016-04-08 Inhibitors and their uses

Publications (1)

Publication Number Publication Date
DK3280405T3 true DK3280405T3 (da) 2021-09-06

Family

ID=55759894

Family Applications (2)

Application Number Title Priority Date Filing Date
DK16717688.2T DK3280405T3 (da) 2015-04-08 2016-04-08 Inhibitorer og anvendelser deraf
DK16717193.3T DK3280404T3 (da) 2015-04-08 2016-04-08 Fremgangsmåder til valg af phosphatase-selektive og ikke-selektive phosphatasehæmmere

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK16717193.3T DK3280404T3 (da) 2015-04-08 2016-04-08 Fremgangsmåder til valg af phosphatase-selektive og ikke-selektive phosphatasehæmmere

Country Status (14)

Country Link
US (5) US11364211B2 (da)
EP (2) EP3280404B1 (da)
JP (2) JP6868568B2 (da)
KR (2) KR102572217B1 (da)
CN (2) CN107820518B (da)
AU (2) AU2016246099B2 (da)
BR (2) BR112017021507B1 (da)
CA (2) CA2982040C (da)
DK (2) DK3280405T3 (da)
ES (2) ES2886571T3 (da)
IL (2) IL254928B (da)
MX (2) MX379437B (da)
SG (2) SG11201708246TA (da)
WO (2) WO2016162689A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX379437B (es) * 2015-04-08 2025-03-10 Res & Innovation Uk Derivados de hidrazina-bencilo sustituidos, como inhibidores de ppp1r15a y ppp1r15b, y el uso de los mismos para el tratamiento de trastorno de proteostasis.
US20180230105A1 (en) 2017-01-13 2018-08-16 Regents Of The University Of Minnesota Therapeutic compounds
GB201709927D0 (en) * 2017-06-21 2017-08-02 Medical Res Council Biochemically defined functional and selective activity and methods for selecting selective inhibitors of holophosphatases targeting their regulatory subunits
WO2024009280A1 (en) * 2022-07-08 2024-01-11 Baylor College Of Medicine Integrated stress response inhibitors and methods of using the same
US20240293343A1 (en) * 2023-02-13 2024-09-05 Inflectis Bioscience Benzylideneaminoguanidine derivatives as NR2B-selective NMDA receptor antagonists and their therapeutic applications
EP4680216A1 (en) * 2023-03-16 2026-01-21 Kyoto Prefectural Public University Corporation Sephin1 and related compounds for the treatment of diseases and disorders amenable to treatment by ampk activation and/or chop inhibition
CN116735892B (zh) * 2023-05-24 2026-04-17 中南大学湘雅医院 一种阿尔茨海默病早期诊断标志物及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1223492A (en) 1967-10-13 1971-02-24 American Home Prod Guanidines
US3592935A (en) * 1969-12-11 1971-07-13 Sandoz Ag Substituted benzylidene hydrazines as anti-inflammatory agents
US3982020A (en) * 1970-03-17 1976-09-21 Sandoz, Inc. Substituted benzylidene hydrazines for treating hyperglycemia, obesity and inflammation
GB1550401A (en) 1976-01-07 1979-08-15 Hexachimie Hydrazine derivatives their preparation and their use
WO2001025192A1 (en) * 1999-10-06 2001-04-12 Melacure Therapeutics Ab Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase
GB0019357D0 (en) * 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
KR20060088885A (ko) * 2003-09-25 2006-08-07 아카디아 파마슈티칼스 인코포레이티드 뉴로펩티드 ff 리셉터 2의 작용제를 이용한 신경병증성통증 치료 방법
FR2893844B1 (fr) 2005-11-28 2008-02-01 Centre Nat Rech Scient Utilisation du guanabenz et de ses derives pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules
EP1908464A1 (en) * 2006-10-04 2008-04-09 Centre National De La Recherche Scientifique (Cnrs) Use of chlorine guanabenz derivatives for treating polyglutamine expansion associated diseases
EP1908465B1 (en) 2006-10-04 2009-04-29 Centre National De La Recherche Scientifique (Cnrs) Use of chlorine guanabenz derivatives for treating prion-based diseases
GB201300435D0 (en) 2013-01-10 2013-02-27 Medical Res Council Benzylideneguanidine Derivatives and Therapeutic Use for the Treatment of Protein Misfolding Diseases
WO2014138298A1 (en) 2013-03-05 2014-09-12 University Of Chicago Treatment of demyelinating disorders
US20150246140A1 (en) 2014-02-10 2015-09-03 California Institute Of Technology Compositions and methods for modulating sleep and wakefulness
RU2712452C2 (ru) 2014-07-02 2020-01-29 Инфлектис Байосайенс Новое терапевтическое применение производных бензилиденгуанидина для лечения протеинопатий
KR20170027737A (ko) 2014-07-02 2017-03-10 인플렉티스 바이오사이언스 O-알킬-벤질리덴구아니딘 유도체 및 미스폴딩된 단백질의 축적 관련 장애의 치료를 위한 치료 용도
MX379437B (es) * 2015-04-08 2025-03-10 Res & Innovation Uk Derivados de hidrazina-bencilo sustituidos, como inhibidores de ppp1r15a y ppp1r15b, y el uso de los mismos para el tratamiento de trastorno de proteostasis.
US20180230105A1 (en) * 2017-01-13 2018-08-16 Regents Of The University Of Minnesota Therapeutic compounds

Also Published As

Publication number Publication date
KR20180018491A (ko) 2018-02-21
JP6868568B2 (ja) 2021-05-12
MX2017012926A (es) 2017-12-20
BR112017021522A2 (pt) 2018-07-03
MX2017012924A (es) 2018-08-01
AU2016246099B2 (en) 2020-09-10
EP3280405A1 (en) 2018-02-14
KR20180009740A (ko) 2018-01-29
US20180125801A1 (en) 2018-05-10
AU2016246099A1 (en) 2017-10-26
KR102602998B1 (ko) 2023-11-15
US11154519B2 (en) 2021-10-26
AU2016246098B2 (en) 2020-09-17
BR112017021522B1 (pt) 2024-02-06
SG11201708246TA (en) 2017-11-29
US11331286B2 (en) 2022-05-17
EP3280404A1 (en) 2018-02-14
US20200197337A1 (en) 2020-06-25
IL254916B (en) 2021-10-31
CA2982040C (en) 2023-10-31
MX382385B (es) 2025-03-12
WO2016162689A1 (en) 2016-10-13
DK3280404T3 (da) 2021-11-08
ES2897712T3 (es) 2022-03-02
JP2018517668A (ja) 2018-07-05
US20180111896A1 (en) 2018-04-26
CN107820518A (zh) 2018-03-20
US11337941B2 (en) 2022-05-24
CA2982040A1 (en) 2016-10-13
WO2016162688A1 (en) 2016-10-13
ES2886571T3 (es) 2021-12-20
IL254928A0 (en) 2017-12-31
HK1250929A1 (zh) 2019-01-18
IL254928B (en) 2022-01-01
CA2982033C (en) 2024-01-02
EP3280405B1 (en) 2021-07-07
CA2982033A1 (en) 2016-10-13
JP6882189B2 (ja) 2021-06-02
CN107709291A (zh) 2018-02-16
EP3280404B1 (en) 2021-10-06
BR112017021507B1 (pt) 2023-10-31
CN107709291B (zh) 2021-03-12
JP2018517402A (ja) 2018-07-05
AU2016246098A1 (en) 2017-10-26
US11364211B2 (en) 2022-06-21
US20220313628A1 (en) 2022-10-06
KR102572217B1 (ko) 2023-08-28
US20200297668A1 (en) 2020-09-24
CN107820518B (zh) 2023-04-21
HK1250926A1 (zh) 2019-01-18
IL254916A0 (en) 2017-12-31
MX379437B (es) 2025-03-10
SG11201708249SA (en) 2017-11-29
BR112017021507A2 (pt) 2018-07-03

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