DK3303339T3 - Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme - Google Patents

Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme Download PDF

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Publication number
DK3303339T3
DK3303339T3 DK16734707.9T DK16734707T DK3303339T3 DK 3303339 T3 DK3303339 T3 DK 3303339T3 DK 16734707 T DK16734707 T DK 16734707T DK 3303339 T3 DK3303339 T3 DK 3303339T3
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Prior art keywords
skeleline
imidazotriazinon
imidazopyrazinon
treatment
pde9 inhibitors
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DK16734707.9T
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English (en)
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Kate Wen
Niels Svenstrup
Yazhou Wang
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H Lundbeck As
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK16734707.9T 2015-07-07 2016-07-06 Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme DK3303339T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA201500393 2015-07-07
DKPA201500407 2015-07-10
DKPA201600209 2016-04-07
PCT/EP2016/065964 WO2017005786A1 (en) 2015-07-07 2016-07-06 Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases

Publications (1)

Publication Number Publication Date
DK3303339T3 true DK3303339T3 (da) 2021-04-12

Family

ID=56345156

Family Applications (2)

Application Number Title Priority Date Filing Date
DK20217833.1T DK3865484T3 (da) 2015-07-07 2016-07-06 Pde9-hæmmer med imidazopyrazinon-rygrad til behandling af perifere sygdomme
DK16734707.9T DK3303339T3 (da) 2015-07-07 2016-07-06 Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme

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DK20217833.1T DK3865484T3 (da) 2015-07-07 2016-07-06 Pde9-hæmmer med imidazopyrazinon-rygrad til behandling af perifere sygdomme

Country Status (20)

Country Link
US (5) US10513524B2 (da)
EP (3) EP3303339B1 (da)
CN (2) CN107810187B (da)
AU (2) AU2016289856B2 (da)
BR (1) BR112018000254A2 (da)
CA (1) CA2990521C (da)
DK (2) DK3865484T3 (da)
ES (2) ES2971969T3 (da)
FI (1) FI3865484T3 (da)
HR (2) HRP20240082T1 (da)
HU (2) HUE053968T2 (da)
IL (2) IL280619B2 (da)
LT (1) LT3865484T (da)
MX (1) MX379456B (da)
PL (1) PL3865484T3 (da)
PT (1) PT3865484T (da)
SI (2) SI3865484T1 (da)
TN (1) TN2017000507A1 (da)
WO (1) WO2017005786A1 (da)
ZA (1) ZA201708341B (da)

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CA2990521C (en) 2015-07-07 2023-10-10 H. Lundbeck A/S Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
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KR20250108770A (ko) 2018-08-31 2025-07-15 카듀리온 파마슈티칼스, 인크. 겸상 세포 질환의 치료를 위한 pde9 억제제
WO2020206336A1 (en) * 2019-04-05 2020-10-08 Imara Inc. Pde9 inhibitors for treating sickle cell disease
CN114072151A (zh) * 2019-05-07 2022-02-18 伊马拉公司 用于治疗地中海贫血的pde9抑制剂
BR112022012153A2 (pt) 2019-12-19 2022-08-30 Curia Spain S A U Processo para preparar um composto e composto
AU2021263914B2 (en) 2020-04-29 2026-07-23 D.E. Shaw Research, Llc PI3K-α inhibitors and methods of use thereof
WO2022036111A1 (en) * 2020-08-13 2022-02-17 Imara Inc. Methods and compositions for treating sickle cell disease
CN112552339A (zh) * 2020-12-10 2021-03-26 安徽昊帆生物有限公司 一种o-二苯基磷酰羟胺的制备方法
AR126447A1 (es) * 2021-07-13 2023-10-11 Relay Therapeutics Inc INHIBIDORES DE PI3Ka Y MÉTODOS DE USO DE LOS MISMOS
CN115448864B (zh) * 2022-08-26 2023-12-22 上海方予健康医药科技有限公司 3-氟-3-(1-羟乙基)吡咯烷-1-羧酸叔丁酯的制备方法
CN120676939A (zh) * 2023-01-13 2025-09-19 传达治疗有限公司 Pi3k抑制剂及其制备和使用方法

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