PT3865484T - Inibidor da pde9 com esqueleto de imidazo pirazinona para tratamento de doenças periféricas - Google Patents

Inibidor da pde9 com esqueleto de imidazo pirazinona para tratamento de doenças periféricas

Info

Publication number
PT3865484T
PT3865484T PT202178331T PT20217833T PT3865484T PT 3865484 T PT3865484 T PT 3865484T PT 202178331 T PT202178331 T PT 202178331T PT 20217833 T PT20217833 T PT 20217833T PT 3865484 T PT3865484 T PT 3865484T
Authority
PT
Portugal
Prior art keywords
treatment
pde9 inhibitor
peripheral diseases
backbone
imidazo
Prior art date
Application number
PT202178331T
Other languages
English (en)
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of PT3865484T publication Critical patent/PT3865484T/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT202178331T 2015-07-07 2016-07-06 Inibidor da pde9 com esqueleto de imidazo pirazinona para tratamento de doenças periféricas PT3865484T (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201500393 2015-07-07
DKPA201500407 2015-07-10
DKPA201600209 2016-04-07

Publications (1)

Publication Number Publication Date
PT3865484T true PT3865484T (pt) 2024-01-30

Family

ID=56345156

Family Applications (1)

Application Number Title Priority Date Filing Date
PT202178331T PT3865484T (pt) 2015-07-07 2016-07-06 Inibidor da pde9 com esqueleto de imidazo pirazinona para tratamento de doenças periféricas

Country Status (20)

Country Link
US (5) US10513524B2 (pt)
EP (3) EP3865484B1 (pt)
CN (2) CN107810187B (pt)
AU (2) AU2016289856B2 (pt)
BR (1) BR112018000254A2 (pt)
CA (1) CA2990521C (pt)
DK (2) DK3865484T3 (pt)
ES (2) ES2971969T3 (pt)
FI (1) FI3865484T3 (pt)
HR (2) HRP20210543T1 (pt)
HU (2) HUE053968T2 (pt)
IL (2) IL280619B2 (pt)
LT (1) LT3865484T (pt)
MX (1) MX379456B (pt)
PL (1) PL3865484T3 (pt)
PT (1) PT3865484T (pt)
SI (2) SI3865484T1 (pt)
TN (1) TN2017000507A1 (pt)
WO (1) WO2017005786A1 (pt)
ZA (1) ZA201708341B (pt)

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PT3865484T (pt) * 2015-07-07 2024-01-30 H Lundbeck As Inibidor da pde9 com esqueleto de imidazo pirazinona para tratamento de doenças periféricas
MX2018016127A (es) * 2016-07-06 2019-05-30 Imara Inc Inhibidores de pde9 para el tratamiento de enfermedades perifericas.
CN115746003B (zh) * 2017-05-26 2024-08-09 卡都瑞恩医药公司 制备和使用pde9抑制剂的方法
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WO2018234488A1 (en) 2017-06-23 2018-12-27 Basf Se Substituted cyclopropyl derivatives
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CA3110680A1 (en) * 2018-08-31 2020-03-05 Imara Inc. Pde9 inhibitors for treating sickle cell disease
EP3946348A4 (en) * 2019-04-05 2023-08-02 Imara Inc. PDE9 INHIBITORS FOR THE TREATMENT OF SICKLE CELL DISEASE
EP3965768A1 (en) * 2019-05-07 2022-03-16 Imara Inc. Pde9 inhibitors for treating thalassemia
EP4077276A1 (en) 2019-12-19 2022-10-26 Curia Spain S.A.U. Process and intermediates for the preparation of upadacitinib
EP4143196A4 (en) 2020-04-29 2024-04-17 Relay Therapeutics, Inc. PI3K-A INHIBITORS AND METHODS OF USE THEREOF
WO2022036111A1 (en) * 2020-08-13 2022-02-17 Imara Inc. Methods and compositions for treating sickle cell disease
CN112552339A (zh) * 2020-12-10 2021-03-26 安徽昊帆生物有限公司 一种o-二苯基磷酰羟胺的制备方法
EP4370124A4 (en) * 2021-07-13 2025-05-07 Relay Therapeutics, Inc. PI3KA INHIBITORS AND METHODS OF USE THEREOF
CN115448864B (zh) * 2022-08-26 2023-12-22 上海方予健康医药科技有限公司 3-氟-3-(1-羟乙基)吡咯烷-1-羧酸叔丁酯的制备方法
WO2024151930A1 (en) * 2023-01-13 2024-07-18 Relay Therapeutics, Inc. Pi3k inhibitors and methods of making and using the same

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