DK330488A - (substitueret aralkyl)-heterocykliske forbindelser, fremgangsmaader til fremstilling heraf samt farmaceutiske og veterinaere midler indeholdende disse - Google Patents

(substitueret aralkyl)-heterocykliske forbindelser, fremgangsmaader til fremstilling heraf samt farmaceutiske og veterinaere midler indeholdende disse

Info

Publication number: DK330488A
Authority: DK; Denmark
Prior art keywords: radical; cyano; hydroxy; alkyl; alkoxy
Prior art date: 1987-06-16

Application number

DK330488A

Other languages

English (en)

Other versions

DK330488D0 (da

DK174573B1 (da

Inventor

Philips Neil Edwards

Michael Stewart Large

Original Assignee

Ici Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-16

Filing date

1988-06-16

Publication date

1988-12-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10618970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK330488(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-06-16 Application filed by Ici Plc filed Critical Ici Plc

1988-06-16 Publication of DK330488D0 publication Critical patent/DK330488D0/da

1988-12-17 Publication of DK330488A publication Critical patent/DK330488A/da

2003-06-23 Application granted granted Critical

2003-06-23 Publication of DK174573B1 publication Critical patent/DK174573B1/da

Links

238000000034 method Methods 0.000 title 1
-1 azido, carbamoyl Chemical group 0.000 abstract 25
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 3
HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000001589 carboacyl group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 abstract 1
125000001401 1,2,4-triazol-4-yl group Chemical group N=1N=C([H])N([*])C=1[H] 0.000 abstract 1
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical compound [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
229910052805 deuterium Inorganic materials 0.000 abstract 1
125000005117 dialkylcarbamoyl group Chemical group 0.000 abstract 1
150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
125000006518 morpholino carbonyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])N(C(*)=O)C1([H])[H] 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
WEMXRTXQKRXSIO-UHFFFAOYSA-N propanenitrile Chemical compound [CH2]CC#N WEMXRTXQKRXSIO-UHFFFAOYSA-N 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK198803304A 1987-06-16 1988-06-16 (Substitueret aralkyl)-triazolyl-,imidazolyl-, -pyridinyl- eller -pyrimidinyl- forbindelser, fremgangsmåder til fremstilling heraf samt farmaceutiske og veterinære midler indeholdende disse DK174573B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8714013		1987-06-16
GB878714013A GB8714013D0 (en)	1987-06-16	1987-06-16	(substituted-aralkyl)heterocyclic compounds

Publications (3)

Publication Number	Publication Date
DK330488D0 DK330488D0 (da)	1988-06-16
DK330488A true DK330488A (da)	1988-12-17
DK174573B1 DK174573B1 (da)	2003-06-23

Family

ID=10618970

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198803304A DK174573B1 (da)	1987-06-16	1988-06-16	(Substitueret aralkyl)-triazolyl-,imidazolyl-, -pyridinyl- eller -pyrimidinyl- forbindelser, fremgangsmåder til fremstilling heraf samt farmaceutiske og veterinære midler indeholdende disse

Country Status (21)

Country	Link
US (2)	US4935437A (da)
EP (1)	EP0296749B1 (da)
JP (1)	JP2609290B2 (da)
AT (1)	ATE113277T1 (da)
AU (1)	AU605872B2 (da)
CA (1)	CA1337420C (da)
DE (1)	DE3851914T2 (da)
DK (1)	DK174573B1 (da)
ES (1)	ES2063036T3 (da)
FI (1)	FI97804C (da)
GB (1)	GB8714013D0 (da)
HU (1)	HU211142A9 (da)
IE (1)	IE65570B1 (da)
IL (1)	IL86499A (da)
LU (1)	LU88778I2 (da)
MX (1)	MX9202876A (da)
NL (1)	NL970012I2 (da)
NO (2)	NO170080C (da)
NZ (1)	NZ225037A (da)
PT (1)	PT87720B (da)
ZA (1)	ZA883691B (da)

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WO2007039919A1 (en) *	2005-10-06	2007-04-12	Natco Pharma Limited	Crystalline forms of anastrozole
US20070100148A1 (en) *	2005-10-31	2007-05-03	Veerender Murki	Process for preparing anastrozole
EP1994014A4 (en) *	2006-03-10	2010-01-20	Shilpa Medicare Ltd	IMPROVED PROCESS FOR HIGH-PURITY ANASTROZOL
EP2024343B1 (en) *	2006-05-19	2015-09-09	Synthon B.V.	Process for purification of anastrozole
EP2029557A1 (en) *	2006-06-05	2009-03-04	Cadila Healthcare Ltd.	A process for preparing pure anastrozole
WO2008034644A2 (en) *	2006-09-22	2008-03-27	Synthon B.V.	Process for making anastrozole
WO2008044041A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
EP2073807A1 (en)	2006-10-12	2009-07-01	Astex Therapeutics Limited	Pharmaceutical combinations
WO2008047104A1 (en) *	2006-10-17	2008-04-24	Cipla Limited	Process for the preparation of pure anastrozole
US20080177081A1 (en) *	2007-01-19	2008-07-24	Formosa Laboratories, Inc.	Process for Preparation of Anastrozole
CN101307027B (zh) *	2007-05-17	2011-09-07	杜焕达	一种阿那曲唑的新的制备方法
WO2009018811A1 (de) *	2007-08-06	2009-02-12	Schebo Biotech Ag	Neue pharmazeutika, verfahren zu ihrer herstellung und ihre verwendung in der medizinischen therapie
BRPI0818637A2 (pt)	2007-10-16	2015-04-07	Repros Therapeutics Inc	Métodos de tratamento de sintoma da síndrome metabólica, de glicose em jejum prejudicada, da síndrome metabólica e de redução de níveis de glicose em, jejum em sujeito com hipogonadismo hipogonadotrófico secundário ou idiopático
WO2009128919A1 (en) *	2008-04-15	2009-10-22	Concert Pharmaceuticals, Inc.	Deuterium bearing analogs of anastrozole as aromatase inhibitors for the treatment of breast cancer
US20100111901A1 (en) *	2008-11-03	2010-05-06	Auspex Pharmaceuticals, Inc.	Triazole inhibitors of aromatase
DE102010046464A1 (de)	2009-03-19	2011-04-21	Amw Gmbh	Transdermales System mit Aromatasehemmer
EP2343278A1 (en)	2010-01-07	2011-07-13	Hexal AG	A process for preparing trisubstituted phenyl derivatives comprising a (1H-1,2,4-triazol-1-yl)alkyl group
DE102010026883A1 (de)	2010-03-11	2011-12-15	Amw Gmbh	Transdermales System mit Aromatasehemmer
JP2015508825A (ja)	2012-02-29	2015-03-23	レプロスセラピューティクスインコーポレイティド	アンドロゲン欠乏症を治療するための併用療法
CN103172580B (zh) *	2013-03-29	2015-04-22	凯莱英医药集团（天津）股份有限公司	一种阿那曲唑的制备方法
ITRM20130285A1 (it)	2013-05-14	2014-11-15	Corden Pharma Latina S P A Con Uni Co Socio	Metodo per la preparazione di anastrozolo di grado farmaceutico
CN103342663B (zh) *	2013-07-15	2015-07-29	凯莱英医药集团（天津）股份有限公司	一种阿那曲唑关键中间体的制备方法
CN104387332B (zh) *	2014-11-27	2016-04-13	江苏正大清江制药有限公司	一种合成芳香化酶抑制剂的方法
EP3373967B9 (en)	2015-11-10	2023-10-04	Paracrine Therapeutics AB	Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen
CN106083748B (zh) *	2016-06-21	2019-08-16	扬子江药业集团江苏海慈生物药业有限公司	一种阿那曲唑的制备方法
CN115611731A (zh) *	2021-04-26	2023-01-17	成都伊诺达博医药科技有限公司	一种依洛昔巴特中间体的合成方法

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1987
- 1987-06-16 GB GB878714013A patent/GB8714013D0/en active Pending
1988
- 1988-05-19 IE IE150588A patent/IE65570B1/en active Protection Beyond IP Right Term
- 1988-05-24 ZA ZA883691A patent/ZA883691B/xx unknown
- 1988-05-25 IL IL86499A patent/IL86499A/xx not_active IP Right Cessation
- 1988-05-31 AU AU16911/88A patent/AU605872B2/en not_active Expired
- 1988-06-10 US US07/204,743 patent/US4935437A/en not_active Ceased
- 1988-06-14 DE DE3851914T patent/DE3851914T2/de not_active Expired - Lifetime
- 1988-06-14 LU LU88778C patent/LU88778I2/fr unknown
- 1988-06-14 EP EP88305429A patent/EP0296749B1/en not_active Expired - Lifetime
- 1988-06-14 ES ES88305429T patent/ES2063036T3/es not_active Expired - Lifetime
- 1988-06-14 AT AT88305429T patent/ATE113277T1/de active
- 1988-06-14 PT PT87720A patent/PT87720B/pt not_active IP Right Cessation
- 1988-06-15 NZ NZ225037A patent/NZ225037A/xx unknown
- 1988-06-15 CA CA000569512A patent/CA1337420C/en not_active Expired - Lifetime
- 1988-06-15 NO NO882628A patent/NO170080C/no not_active IP Right Cessation
- 1988-06-16 FI FI882882A patent/FI97804C/fi active Protection Beyond IP Right Term
- 1988-06-16 JP JP63147068A patent/JP2609290B2/ja not_active Expired - Lifetime
- 1988-06-16 DK DK198803304A patent/DK174573B1/da not_active IP Right Cessation
1992
- 1992-06-15 MX MX9202876A patent/MX9202876A/es unknown
1995
- 1995-05-31 HU HU95P/P00144P patent/HU211142A9/hu unknown
1996
- 1996-04-03 US US08/627,311 patent/USRE36617E/en not_active Expired - Lifetime
1997
- 1997-03-04 NL NL970012C patent/NL970012I2/nl unknown
- 1997-05-16 NO NO1997006C patent/NO1997006I1/no unknown

Also Published As

Publication number	Publication date
EP0296749A1 (en)	1988-12-28
ES2063036T3 (es)	1995-01-01
NZ225037A (en)	1991-10-25
DK330488D0 (da)	1988-06-16
NO882628D0 (no)	1988-06-15
FI882882A0 (fi)	1988-06-16
NL970012I2 (nl)	1997-07-01
DE3851914T2 (de)	1995-03-23
PT87720A (pt)	1988-07-01
HK1000206A1 (en)	1998-02-06
ZA883691B (en)	1989-02-22
NO882628L (no)	1988-12-19
FI97804B (fi)	1996-11-15
NO170080B (no)	1992-06-01
DE3851914D1 (de)	1994-12-01
ATE113277T1 (de)	1994-11-15
FI882882A7 (fi)	1988-12-17
CA1337420C (en)	1995-10-24
IE65570B1 (en)	1995-11-01
US4935437A (en)	1990-06-19
LU88778I2 (fr)	1996-11-05
HU211142A9 (en)	1995-10-30
JPS6419067A (en)	1989-01-23
AU1691188A (en)	1988-12-22
DK174573B1 (da)	2003-06-23
USRE36617E (en)	2000-03-14
NO1997006I1 (no)	1997-05-16
AU605872B2 (en)	1991-01-24
PT87720B (pt)	1992-10-30
NL970012I1 (nl)	1997-05-01
IE881505L (en)	1988-12-16
EP0296749B1 (en)	1994-10-26
NO170080C (no)	1992-09-09
IL86499A0 (en)	1988-11-15
JP2609290B2 (ja)	1997-05-14
IL86499A (en)	1997-09-30
FI97804C (fi)	1997-02-25
GB8714013D0 (en)	1987-07-22
MX9202876A (es)	1992-06-30

Legal Events

Date

Code

Title

Description

2004-10-11

CTFF

Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 2003 00028

Filing date: 20031219

Expiry date: 20100811

2006-10-09

CTFG

Supplementary protection certificate (spc) issued

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