DK3341465T3 - Perfusionsfordeleranordning - Google Patents

Perfusionsfordeleranordning Download PDF

Info

Publication number
DK3341465T3
DK3341465T3 DK16840218.8T DK16840218T DK3341465T3 DK 3341465 T3 DK3341465 T3 DK 3341465T3 DK 16840218 T DK16840218 T DK 16840218T DK 3341465 T3 DK3341465 T3 DK 3341465T3
Authority
DK
Denmark
Prior art keywords
perfusion
distributor device
distributor
perfusion distributor
Prior art date
Application number
DK16840218.8T
Other languages
English (en)
Inventor
Daniel Levner
Josiah Daniel Sliz
Van Ruijven Petrus Martinus
Matthew Daniel Solomon
Christian Alexander Potzner
Patrick Sean Tuohy
Norman Wen
Jacob Freake
Doug Sabin
Ii Guy Robert Thompson
Joshua Gomes
Christopher David Hinojosa
Original Assignee
Emulate Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emulate Inc filed Critical Emulate Inc
Application granted granted Critical
Publication of DK3341465T3 publication Critical patent/DK3341465T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/567—Valves, taps or stop-cocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/12—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/04—Seals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/049—Valves integrated in closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Computer Hardware Design (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Mechanical Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
DK16840218.8T 2015-08-26 2016-08-26 Perfusionsfordeleranordning DK3341465T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562210122P 2015-08-26 2015-08-26
US201562250861P 2015-11-04 2015-11-04
US201662361244P 2016-07-12 2016-07-12
US201662366482P 2016-07-25 2016-07-25
PCT/US2016/049033 WO2017035484A1 (en) 2015-08-26 2016-08-26 Perfusion manifold assembly

Publications (1)

Publication Number Publication Date
DK3341465T3 true DK3341465T3 (da) 2023-11-20

Family

ID=57119971

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16840218.8T DK3341465T3 (da) 2015-08-26 2016-08-26 Perfusionsfordeleranordning

Country Status (12)

Country Link
US (14) US10184102B2 (da)
EP (3) EP4026616B1 (da)
JP (6) JP6608043B2 (da)
KR (6) KR102044109B1 (da)
CN (2) CN114540192A (da)
AU (3) AU2016312678B2 (da)
BR (1) BR112018003614A2 (da)
CA (3) CA3053745C (da)
DK (1) DK3341465T3 (da)
GB (4) GB2601649B (da)
SG (1) SG10201811548PA (da)
WO (1) WO2017035484A1 (da)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10184102B2 (en) 2015-08-26 2019-01-22 EMULATE, Inc. Controlling pressure
GB201614150D0 (en) 2016-08-18 2016-10-05 Univ Oxford Innovation Ltd Microfluidic arrangements
EP3362177A1 (en) 2015-10-16 2018-08-22 Oxford University Innovation Limited Microfluidic arrangements
US10908171B2 (en) 2016-07-12 2021-02-02 EMULATE, Inc. Additive channels
USD812766S1 (en) * 2016-07-12 2018-03-13 EMULATE, Inc. Microfluidic chip for use with a fluid perfusion module
USD860471S1 (en) * 2016-07-12 2019-09-17 EMULATE, Inc. Perfusion module lid
US10913063B2 (en) 2016-07-12 2021-02-09 EMULATE, Inc. Removing bubbles in a microfluidic device
USD838864S1 (en) * 2016-09-07 2019-01-22 EMULATE, Inc. Opaque microfluidic chip without pressure features for use with a fluid perfusion module
USD803173S1 (en) * 2016-09-07 2017-11-21 EMULATE, Inc. Perfusion module lid without pressure features
USD842493S1 (en) * 2016-09-07 2019-03-05 EMULATE, Inc. Microfluidic chip without pressure features for use with a fluid perfusion module
USD816861S1 (en) * 2016-09-07 2018-05-01 EMULATE, Inc. Transparent microfluidic chip without pressure features for use with a fluid perfusion module
US11001796B2 (en) 2016-11-23 2021-05-11 The Charles Stark Draper Laboratory, Inc. Bi-layer multi-well cell culture platform
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
US10508976B1 (en) * 2017-03-31 2019-12-17 Advanced Micro Instruments, Inc. Gas sampling device and method
AU2018262829A1 (en) 2017-05-04 2019-12-05 Ntnu - Norges Teknisk-Naturvitenskapelige Universitet Cell culture device
US20210400952A1 (en) 2017-06-07 2021-12-30 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
CA3067384C (en) 2017-06-14 2022-07-19 EMULATE, Inc. Microfluidic assemblies for studying the effects of space travel on human brain cells
CA3076664C (en) 2017-09-21 2023-10-10 EMULATE, Inc. Physiology and pathophysiology of human gut: intestine-on-chip
WO2019063840A1 (de) * 2017-09-29 2019-04-04 MEDUCOMP GmbH Vorrichtung und verfahren zur mikrobiologischen prüfung von waschmaschinen
WO2019157136A2 (en) * 2018-02-07 2019-08-15 EMULATE, Inc. Gas mixer and pressurizer apparatus
GB201802819D0 (en) 2018-02-21 2018-04-04 Univ Oxford Innovation Ltd Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
GB2586732B (en) 2018-04-03 2023-03-08 Emulate Inc Microfluidic control
US20200123484A1 (en) * 2018-10-22 2020-04-23 National Tsing Hua University Integrated chip and method for sperm sorting, oocyte incubation, and in vitro fertilization
JP7246041B2 (ja) * 2018-11-07 2023-03-27 ウシオ電機株式会社 細胞培養チップ及びその製造方法
US11725190B2 (en) 2019-02-22 2023-08-15 EMULATE, Inc. Microfluidic proximal tubule kidney-on-chip
US11841361B2 (en) 2019-02-22 2023-12-12 EMULATE, Inc. Microfluidic proximal tubule kidney-on-chip
WO2020216791A1 (en) * 2019-04-26 2020-10-29 Stilla Technologies Assembly for pressure controlled fluid release and its method therefore
WO2020236850A1 (en) * 2019-05-20 2020-11-26 Immunovalent Therapeutics Inc. Solid phase devices and methods of use for purifying and quantifying tissue-specific leukocytes
CN110205242B (zh) * 2019-06-18 2024-04-26 苏州锐讯生物科技有限公司 一种快速实现数字pcr反应的微流控芯片组件及其应用
FR3100033B1 (fr) * 2019-08-23 2021-11-05 Commissariat Energie Atomique Appareil pour mise en œuvre d'un procédé de traitement de fluide dans des conditions stériles
CN110523448B (zh) * 2019-09-03 2022-03-18 广东顺德工业设计研究院(广东顺德创新设计研究院) 微滴制备系统及制备方法
USD959017S1 (en) * 2019-09-30 2022-07-26 Tokyo Ohka Kogyo Co., Ltd. Container for cell observation
AU2020388676B2 (en) * 2019-11-21 2024-07-18 Emulate Inc. Antibody producing microfluidic devices
JP7469795B2 (ja) * 2020-03-27 2024-04-17 学校法人東海大学 細胞培養装置
EP4141094A4 (en) * 2020-04-20 2024-01-24 MGI Tech Co., Ltd. Liquid spreading device, liquid spreading method, liquid spreading system, combination device, and liquid passage device
TWI762948B (zh) * 2020-06-11 2022-05-01 豐康微流體晶片股份有限公司 應用於微流控晶片之快速拆接之密封匹配接頭模組
US20230272327A1 (en) * 2020-07-02 2023-08-31 University Of Florida Research Foundation, Inc. Perfusion-enabled bioreactor
CN111826273B (zh) * 2020-07-22 2023-03-21 上海逢伙泰企业管理有限公司 一种用于核酸检测的自动化全封闭微流控芯片
KR102451521B1 (ko) * 2020-08-25 2022-10-05 인제대학교 산학협력단 내장 장기칩 및 이의 제조방법
EP3964291A1 (en) * 2020-09-08 2022-03-09 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk Onderzoek TNO Conditioning chamber for dual-interface fluidic system
US12613187B2 (en) * 2020-09-18 2026-04-28 Salvus, Llc Interferometric detection and quantification system and methods of use in chemical processing
WO2022122489A1 (de) * 2020-12-09 2022-06-16 Robert Bosch Gmbh INJEKTIONSSTÖßELPAKET FÜR EIN MIKROFLUIDIK-ANALYSESYSTEM SOWIE VERFAHREN UND MEHRKAVITÄTEN-SPRITZGIEßWERKZEUG ZU SEINER HERSTELLUNG
EP4263794A1 (en) * 2020-12-15 2023-10-25 Global Life Sciences Solutions USA LLC Culture vessel for a bioprocessing system
WO2022140342A1 (en) * 2020-12-23 2022-06-30 Parallel Fluidics Inc. Modular microfluidics platform
CN112280678B (zh) * 2020-12-25 2021-04-06 苏州大学 一种可拆卸、可重复使用的疏水或超疏水微流控器官芯片
CN112522081B (zh) * 2020-12-28 2022-09-27 上海揽微赛尔生物科技有限公司 一种细胞培养皿灌流装置
CN117677439A (zh) * 2021-06-18 2024-03-08 莱卡生物系统努斯洛赫有限责任公司 盒和使用该盒的组织包埋方法
KR102293717B1 (ko) * 2021-06-29 2021-08-26 에스디바이오센서 주식회사 플로우 커버를 포함하는 유전체 추출 장치
IL311623A (en) * 2021-09-24 2024-05-01 3D Systems Inc Manifolds, systems and methods for performing biological studies under flow
EP4194542A1 (en) * 2021-12-07 2023-06-14 Fluigent Apparatus for feeding a liquid medium to a fluidic system
CN116331644B (zh) * 2021-12-23 2025-07-29 财团法人工业技术研究院 细胞与组织层片成型包装与细胞灌注设备
KR20230143375A (ko) * 2022-04-05 2023-10-12 한림대학교 산학협력단 장기 모사 칩 구조체 제조방법
KR20230143372A (ko) * 2022-04-05 2023-10-12 한림대학교 산학협력단 장기 모사 칩
CA3154534A1 (en) * 2022-04-07 2023-10-07 Wasim Kapadia Microfluidic viscometer for measuring the viscosity of microliter-volume liquid samples
GB202205709D0 (en) * 2022-04-19 2022-06-01 Keratify Ltd Biological culture unit
KR20250024979A (ko) * 2022-06-15 2025-02-20 글로벌 라이프 사이언시즈 솔루션즈 유에스에이 엘엘씨 바이오 처리 시스템용 일회용 키트 및 배양 용기
CN115921222B (zh) * 2022-09-07 2023-11-28 常州铭赛机器人科技股份有限公司 螺杆阀的出胶控制方法
CN115541817B (zh) * 2022-09-19 2025-03-25 中铁十九局集团矿业投资有限公司 一种基岩面预爆裂检测装置及使用方法
US12565045B2 (en) 2023-03-15 2026-03-03 Brady Worldwide, Inc. Hydrophilic foam having improved fluid retention
KR102640929B1 (ko) 2023-06-02 2024-02-27 (주) 멥스젠 미세생체조직시스템 형성 장치
EP4731744A1 (en) * 2023-06-23 2026-04-29 ETH Zürich Ex vivo tissue sampling system
TWI889052B (zh) * 2023-08-16 2025-07-01 新加坡商克雷多生醫股份有限公司 卡匣及其定量方法
EP4541459A1 (en) * 2023-10-18 2025-04-23 Livedrop A device for a microfluidic chip
EP4556119A1 (en) 2023-11-20 2025-05-21 Fluigent Liquid distribution system for a fluidic chip
CN120158364B (zh) * 2023-12-15 2026-01-16 广州国家实验室 细胞培养监测设备
US12410408B2 (en) * 2024-02-02 2025-09-09 Paragonix Technologies, Inc. Method for hypothermic transport of biological samples
CN118086053B (zh) * 2024-04-29 2024-07-09 四川迪亚生物科技集团有限公司 一种自灌流培养板及使用方法
WO2025235411A1 (en) * 2024-05-06 2025-11-13 Mango, Inc. Extended depth of field for high resolution images based on sub-pixel shifted images
WO2026028112A1 (en) * 2024-08-02 2026-02-05 Universita' Degli Studi Del Piemonte Orientale "Amedeo Avogadro" Chip device for an organ-on-a chip (ooc)
WO2026055235A1 (en) * 2024-09-06 2026-03-12 Siemens Healthcare Diagnostics Inc. Sensor cartridge assembly having manufacturing-tolerance compensation for use in biological sample analyzers
WO2026085456A1 (en) * 2024-10-18 2026-04-23 Massachusetts Institute Of Technology Scaffold system for microfluidic applications and methods of using thereof
WO2026131702A1 (en) * 2024-12-16 2026-06-25 Universität Basel Handling module, perfusion system and operation platform

Family Cites Families (206)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207394A (en) * 1976-01-28 1980-06-10 Mcdonnell Douglas Corporation Process and apparatus for analyzing specimens for the presence of microorganisms therein
US4301414A (en) * 1979-10-29 1981-11-17 United States Surgical Corporation Disposable sample card and method of making same
US4397725A (en) * 1980-12-15 1983-08-09 Transidyne General Corp. Apparatus for measuring electrochemical activity
US4507707A (en) * 1981-12-30 1985-03-26 Willis John G Electro-pneumatic assembly device
US4682891A (en) * 1985-05-31 1987-07-28 Health Research, Incorporated Microcircle system
US4682890A (en) * 1985-05-31 1987-07-28 Health Research, Incorporated Microsample holder and carrier therefor
US4871439A (en) * 1987-02-05 1989-10-03 Steven Enzer Disposable self-calibratable electrode package
US4940527A (en) * 1987-06-01 1990-07-10 Abbott Laboratories Two-part test cartridge for centrifuge
US5236668A (en) * 1991-12-23 1993-08-17 Higdon William R Detachable column cartridge gas chromatograph
US5279797A (en) * 1992-10-05 1994-01-18 Avl Scientific Corporation Disposable liquid reagent cartridge and receptacle therefor
JP2948069B2 (ja) * 1993-09-20 1999-09-13 株式会社日立製作所 化学分析装置
FR2723735B1 (fr) * 1994-08-18 1996-10-31 Abx Sa Boitier a branchement automatique pour distribution de reactifs dans un appareil notamment un analyseur hematologique.
DE19546952C2 (de) * 1994-12-17 1999-06-17 Horiba Ltd Gasanalysator-Einschubanordnung
US5731212A (en) * 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
MX9705850A (es) * 1995-02-03 1997-11-29 Nvb Int Conector de valvula.
US5609828A (en) * 1995-05-31 1997-03-11 bio M erieux Vitek, Inc. Sample card
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5885533A (en) * 1996-05-20 1999-03-23 Sendx Medical, Inc. Integral fluid and waste container for blood analyzer
US6016712A (en) * 1997-09-18 2000-01-25 Accumetrics Device for receiving and processing a sample
US6893877B2 (en) * 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6095697A (en) * 1998-03-31 2000-08-01 Honeywell International Inc. Chip-to-interface alignment
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
DE19854096A1 (de) * 1998-11-24 2000-05-25 Merck Patent Gmbh Anschlußträger für plattenförmige Mikrokomponenten
US6319476B1 (en) * 1999-03-02 2001-11-20 Perseptive Biosystems, Inc. Microfluidic connector
US6428053B1 (en) * 1999-03-12 2002-08-06 California Institute Of Technology Micromachined fluidic coupler and method of making the same
US6673620B1 (en) * 1999-04-20 2004-01-06 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
WO2000066036A2 (en) 1999-04-30 2000-11-09 Massachusetts General Hospital Fabrication of vascularized tissue using microfabricated two-dimensional molds
US20020182749A1 (en) * 1999-05-11 2002-12-05 Aclara Biosciences, Inc. Sample evaporative control
US6555389B1 (en) * 1999-05-11 2003-04-29 Aclara Biosciences, Inc. Sample evaporative control
US7396444B2 (en) * 1999-06-22 2008-07-08 Agilent Technologies Inc. Device to operate a laboratory microchip
DE19928412C2 (de) * 1999-06-22 2002-03-21 Agilent Technologies Inc Versorgungselement für einen Labor-Mikrochip
US6692697B1 (en) * 1999-07-30 2004-02-17 Texas Instruments Incorporated Versatile flow cell front-end for optically-based integrated sensors
US20060128006A1 (en) 1999-11-10 2006-06-15 Gerhardt Antimony L Hydrodynamic capture and release mechanisms for particle manipulation
US20030091477A1 (en) * 1999-12-22 2003-05-15 Paul Eric A. Flow-thru chip cartridge, chip holder, system & method thereof
MXPA02008290A (es) * 2000-02-23 2004-09-10 Caliper Technologies Inc Sistema de control de presion de multi-reserva-.
US20050118073A1 (en) * 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
US6698798B2 (en) * 2000-04-13 2004-03-02 California Institute Of Technology Micromachined rubber O-ring microfluidic couplers
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
US7630063B2 (en) 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US7641856B2 (en) * 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US7125540B1 (en) 2000-06-06 2006-10-24 Battelle Memorial Institute Microsystem process networks
US6864097B1 (en) * 2000-09-27 2005-03-08 Agilent Technologies, Inc. Arrays and their reading
WO2002026114A2 (en) 2000-09-27 2002-04-04 Bitensky Mark W Cellular diagnostic arrays, methods of using and processes for producing same
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
US6934836B2 (en) * 2000-10-06 2005-08-23 Protasis Corporation Fluid separation conduit cartridge with encryption capability
JP4361271B2 (ja) * 2000-10-10 2009-11-11 バイオトローブ・インコーポレイテツド アッセイ、合成、および保存用の器具、ならびに、その作製、使用、および操作の方法
SE0004352D0 (sv) * 2000-11-27 2000-11-27 Helen Andersson System och metod för anslutning av vätskor i ett mikrofluidiskt flödescellsystem
WO2002053193A2 (en) 2001-01-02 2002-07-11 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology
AU2002306486A1 (en) * 2001-02-09 2002-08-28 Microchem Solutions Method and apparatus for sample injection in microfabricated devices
DE10106558C1 (de) * 2001-02-13 2002-11-07 Siemens Ag System zur automatisierten Behandlung von Fluiden, mit aneinanderreihbaren, austauschbaren Prozessmodulen
DE10111457B4 (de) * 2001-03-09 2006-12-14 Siemens Ag Diagnoseeinrichtung
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
KR100425536B1 (ko) * 2001-07-16 2004-03-30 학교법인 포항공과대학교 유체 마이크로칩용 브레드보드
US6749292B2 (en) * 2001-10-18 2004-06-15 Hewlett-Packard Development Company, L.P. Replaceable ink container for an inkjet printing system
US7189580B2 (en) 2001-10-19 2007-03-13 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
AU2002366697A1 (en) * 2001-12-19 2003-07-09 Sau Lan Tang Staats Interface members and holders for microfluidic array devices
US7048893B2 (en) * 2002-02-06 2006-05-23 Sebia Mask for depositing and distributing reagents on an analytical support
US7189370B2 (en) * 2002-02-11 2007-03-13 Microchem Solutions Apparatus and methods for high throughput and high-resolution assays
US7189581B2 (en) * 2002-04-30 2007-03-13 Wisconsin Alumni Research Foundation Method of obtaining a sample concentration of a solution in a microfluidic device
JP2005529327A (ja) * 2002-06-11 2005-09-29 ケムパック エイ／エス 液体中に懸濁された粒子を特徴付けるための使い捨てカートリッジ
US7244961B2 (en) * 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
AU2003264734A1 (en) * 2002-09-06 2004-03-29 Epigem Limited Modular microfluidic system
EP1569510B1 (en) 2002-09-27 2011-11-02 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
AU2003284055A1 (en) * 2002-10-09 2004-05-04 The Board Of Trustees Of The University Of Illinois Microfluidic systems and components
US7932098B2 (en) * 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
US7118708B2 (en) * 2002-11-12 2006-10-10 Automated Biotechnology, Inc. System of sample medium carriers with built-in memory elements and information input/output station for the carriers
AU2003293399A1 (en) * 2002-12-04 2004-06-23 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
US20050266582A1 (en) * 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
ATE439039T1 (de) 2003-01-16 2009-08-15 Gen Hospital Corp Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
US7435601B2 (en) * 2003-02-19 2008-10-14 Fitzco Incorporated Biological specimen handling method
EP1473084B1 (en) * 2003-03-31 2015-07-29 Canon Kabushiki Kaisha Biochemical reaction cartridge
WO2004094275A1 (en) 2003-04-17 2004-11-04 Cambridge International, Inc. Plastic woven spiral conveyor belt
US7960166B2 (en) 2003-05-21 2011-06-14 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
US7220244B2 (en) * 2003-08-04 2007-05-22 Bioquiddity, Inc. Infusion apparatus with constant force spring energy source
GB0320337D0 (en) * 2003-08-29 2003-10-01 Syrris Ltd A microfluidic system
US6972955B2 (en) * 2003-09-25 2005-12-06 Harris Corporation Electro-fluidic device and interconnect and related methods
JP4407271B2 (ja) * 2003-12-19 2010-02-03 株式会社日立製作所 チップ、反応分析装置、反応分析方法
US7666285B1 (en) * 2004-02-06 2010-02-23 University Of Central Florida Research Foundation, Inc. Portable water quality monitoring system
US7569127B1 (en) * 2004-02-06 2009-08-04 University Of Central Florida Research Foundation, Inc. Interconnecting microfluidic package and fabrication method
JP4464158B2 (ja) * 2004-02-13 2010-05-19 キヤノン株式会社 生化学反応カートリッジ
JP5148267B2 (ja) * 2004-04-02 2013-02-20 エービー サイエックス エルエルシー 微小溶液の接続
US7465558B2 (en) * 2004-05-12 2008-12-16 Wyeth Perfusion system and apparatus for automated multi-channel patch-clamp recordings utilizing inside-out whole-cell configuration
US20060024702A1 (en) * 2004-05-12 2006-02-02 Connolly Dennis M Device, system, and method for detecting a target molecule in a sample
PT1773978E (pt) * 2004-05-19 2014-05-29 Massachusetts Inst Technology Modelo de doença com células/tecidos tri-dimensionais perfundidos
US7648792B2 (en) * 2004-06-25 2010-01-19 Ultracell Corporation Disposable component on a fuel cartridge and for use with a portable fuel cell system
US8329437B1 (en) * 2004-07-29 2012-12-11 E.I. Spectra, Llc Disposable particle counter cartridge
WO2006029387A1 (en) * 2004-09-09 2006-03-16 Microfluidic Systems Inc. A handheld and portable microfluidic device to automatically prepare nucleic acids for analysis
US7159848B2 (en) * 2004-09-10 2007-01-09 Agilent Technologies, Inc. Clamping systems
JP4455306B2 (ja) * 2004-12-13 2010-04-21 キヤノン株式会社 生化学処理方法
GB2421202B (en) * 2004-12-15 2009-12-09 Syrris Ltd Modular microfluidic system
US7582263B2 (en) * 2005-01-27 2009-09-01 Octrolix Bv Universal interface for a micro-fluidic chip
US7918980B2 (en) 2005-04-05 2011-04-05 George Mason Intellectual Properties, Inc. Electrocapturing flow cell
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
EP1874424A2 (en) * 2005-04-14 2008-01-09 California Institute of Technology Integrated chromatography devices and systems for monitoring analytes in real time and methods for manufacturing the same
EP1882189A2 (en) * 2005-04-20 2008-01-30 Fluidigm Corporation Analysis engine and database for manipulating parameters for fluidic systems on a chip
US9388374B2 (en) * 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
EP3029135B1 (en) 2005-07-07 2021-03-17 The Regents of the University of California Apparatus for cell culture array
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9637715B2 (en) * 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
AU2006294199B2 (en) * 2005-09-22 2011-11-10 Koninklijke Philips Electronics N.V. Detection and subsequent removal of an aperture blockage
US7790028B1 (en) 2005-09-28 2010-09-07 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a cellularized nephron unit
US7727371B2 (en) * 2005-10-07 2010-06-01 Caliper Life Sciences, Inc. Electrode apparatus for use with a microfluidic device
US9248421B2 (en) 2005-10-07 2016-02-02 Massachusetts Institute Of Technology Parallel integrated bioreactor device and method
US20070084706A1 (en) * 2005-10-18 2007-04-19 Shuichi Takayama Microfluidic cell culture device and method for using same
JP2007147456A (ja) * 2005-11-28 2007-06-14 Seiko Epson Corp マイクロ流体システム、試料分析装置、及び標的物質の検出または測定方法
WO2007078833A2 (en) * 2005-12-16 2007-07-12 The Curators Of The University Of Missouri Reusable pcr amplification system and method
WO2007075919A2 (en) * 2005-12-22 2007-07-05 Honeywell International Inc. Portable sample analyzer system
US7976795B2 (en) 2006-01-19 2011-07-12 Rheonix, Inc. Microfluidic systems
US8501497B2 (en) * 2006-02-07 2013-08-06 Stokes Bio Limited Forming sample combinations using liquid bridge systems
US7560071B2 (en) * 2006-03-29 2009-07-14 Nichols Michael J Instrument docking station for an automated testing system
US8795593B2 (en) * 2006-03-29 2014-08-05 Michael J. Nichols Instrument docking station for an automated testing system
JP2007292714A (ja) * 2006-03-29 2007-11-08 Seiko Epson Corp マイクロ流体システムおよび試料分析装置
US8293524B2 (en) 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
US7678338B2 (en) * 2006-04-07 2010-03-16 General Dynamics Armament And Technical Products Fluid retaining assembly and method of using the same
US7641860B2 (en) * 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
DE102006030068A1 (de) 2006-06-28 2008-01-03 M2P-Labs Gmbh Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays
EP1895308A1 (en) 2006-09-01 2008-03-05 Agilent Technologies, Inc. Droplet-based fluidic coupling
NL1032425C2 (nl) * 2006-09-04 2008-03-05 Micronit Microfluidics Bv Samenstel van ten minste één microfluïdische inrichting en een opzetstuk, opzetstuk en werkwijzen voor het vervaardigen en gebruik van zo een samenstel.
WO2008030433A2 (en) * 2006-09-06 2008-03-13 Canon U.S. Life Sciences, Inc. Chip and cartridge design configuration for performing micro-fluidic assays
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
CN103495439B (zh) * 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
US8465706B2 (en) 2007-06-20 2013-06-18 Trustees Of Columbia University In The City Of New York On-demand microfluidic droplet or bubble generation
WO2008156837A1 (en) 2007-06-20 2008-12-24 The Trustees Of Columbia University In The City Of New York On-demand microfluidic droplet or bubble generation
WO2009002152A1 (en) * 2007-06-26 2008-12-31 Micronit Microfluidics B.V. Device and method for fluidic coupling of fluidic conduits to a microfluidic chip, and uncoupling thereof
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
WO2009045050A2 (en) * 2007-10-05 2009-04-09 Seoul National University Industry Foundation Fluidic channel system and method for fabricating fine structure
US20090121476A1 (en) * 2007-11-08 2009-05-14 The Government Of The Us, As Represented By The Secretary Of The Navy Microfluidic Bus for Interconnecting Multiple Fluid Conduits
US7919062B2 (en) * 2008-03-20 2011-04-05 Corning Incorporated Modular microfluidic system and method for building a modular microfludic system
US8961902B2 (en) * 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
US20090301592A1 (en) * 2008-06-06 2009-12-10 Jochen Mueller Fluidic module connection
US8389294B2 (en) * 2008-06-09 2013-03-05 Wisconsin Alumni Research Foundation Microfluidic device and method for coupling discrete microchannels and for co-culture
KR102667365B1 (ko) 2008-07-16 2024-05-21 칠드런'즈 메디컬 센터 코포레이션 마이크로채널을 갖는 기관 모방 장치 및 그 사용 및 제조 방법
WO2010025302A2 (en) * 2008-08-27 2010-03-04 Life Technologies Corporation Apparatus for and method of processing biological samples
US8133451B2 (en) * 2008-08-28 2012-03-13 Microfluidic Systems, Inc. Sample preparation apparatus
US9089844B2 (en) * 2010-11-01 2015-07-28 Bio-Rad Laboratories, Inc. System for forming emulsions
US20110229961A1 (en) * 2008-11-05 2011-09-22 Nanopoint, Inc. Active microfluidic system for in vitro culture
US9040285B2 (en) * 2008-12-18 2015-05-26 Koninklijkle Philips N.V. Sensing device for sensing a fluid
JP5715068B2 (ja) * 2009-01-30 2015-05-07 マイクロニクス， インコーポレイテッド 携帯型高利得蛍光検出システム
US9095791B2 (en) * 2009-03-06 2015-08-04 Waters Technologies Corporation Electrospray interface to a microfluidic substrate
AU2010229490B2 (en) * 2009-03-24 2015-02-12 University Of Chicago Slip chip device and methods
US8573259B2 (en) * 2009-03-25 2013-11-05 The Regents Of The University Of Michigan Modular microfluidic assembly block and system including the same
US8354080B2 (en) * 2009-04-10 2013-01-15 Canon U.S. Life Sciences, Inc. Fluid interface cartridge for a microfluidic chip
EP2251079A1 (en) * 2009-05-11 2010-11-17 Chemtrix B.V. A micro-fluidic system and the use thereof
GB2473868A (en) * 2009-09-28 2011-03-30 Invitrogen Dynal As Apparatus and method of automated processing of biological samples
RU2559541C2 (ru) 2009-06-05 2015-08-10 Интедженкс Инк. Универсальная система подготовки образцов и применение в интегрированной системе анализа
US9919311B2 (en) * 2009-07-20 2018-03-20 Siloam Biosciences, Inc. Microfluidic assay platforms
US8492165B2 (en) * 2009-09-01 2013-07-23 Corsolutions, Llc Microfluidic interface
US8372657B2 (en) 2009-10-20 2013-02-12 Agency For Science, Technology, And Research Microfluidic system for detecting a biological entity in a sample
KR101141248B1 (ko) * 2009-10-22 2012-05-04 전남대학교산학협력단 공기방울 제거 및 유체 주입/제거를 위한 미세 유체칩용 소자
FI4060325T3 (fi) * 2009-12-07 2024-09-25 Meso Scale Technologies Llc Määrityskasetin lukija
US9353342B2 (en) * 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
US9188243B2 (en) 2010-01-29 2015-11-17 The Trustees Of Columbia University In The City Of New York Microfluidic flow devices, methods and systems
WO2011094577A2 (en) * 2010-01-29 2011-08-04 Micronics, Inc. Sample-to-answer microfluidic cartridge
EP2933629B1 (en) * 2010-02-19 2019-04-10 Pacific Biosciences Of California, Inc. System for measuring analytical reactions comprising a socket for an optode array chip
US8994946B2 (en) * 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
JP6104793B2 (ja) * 2010-04-16 2017-03-29 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーＯｐｋｏ Ｄｉａｇｎｏｓｔｉｃｓ，Ｌｌｃ マイクロ流体システム内でのフィードバック制御
WO2011149853A1 (en) * 2010-05-27 2011-12-01 3M Innovative Properties Company Methods and articles for sample processing
JP2013527458A (ja) * 2010-05-27 2013-06-27 スリーエム イノベイティブ プロパティズ カンパニー 試料処理用の一体化されたシステム及び組立品
WO2011147421A1 (en) * 2010-05-27 2011-12-01 Danmarks Tekniske Universitet Chip connector
WO2011151804A1 (en) * 2010-06-03 2011-12-08 Spinomix S.A. A fluidic interfacing system and assembly
US8651642B2 (en) * 2010-10-22 2014-02-18 Hewlett-Packard Development Company, L.P. Fluid cartridge
US8657420B2 (en) * 2010-12-28 2014-02-25 Fujifilm Corporation Fluid recirculation in droplet ejection devices
EP2681306B1 (en) * 2011-02-28 2019-01-09 President and Fellows of Harvard College Cell culture system
CN102114275B (zh) 2011-03-17 2012-10-17 浙江大学 类肝小叶生物反应器
US10526572B2 (en) * 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
FR2973720B1 (fr) * 2011-04-08 2016-02-26 Commissariat Energie Atomique Dispositif de connexion d'une carte microfluidique
US20140038225A1 (en) * 2011-04-12 2014-02-06 Nils Goedecke Cell culture device
US9011801B2 (en) * 2011-06-06 2015-04-21 Corsolutions Llc Fluidic interface
WO2013028765A1 (en) 2011-08-22 2013-02-28 Waters Technologies Corporation Microfluidic device with dried blood spots (dbs) card interface
WO2013130910A1 (en) * 2012-02-29 2013-09-06 Integenx Inc. Sample preparation, processing and analysis systems
US8894946B2 (en) 2011-10-21 2014-11-25 Integenx Inc. Sample preparation, processing and analysis systems
US9121824B2 (en) * 2011-11-14 2015-09-01 Mettler-Toledo Thornton, Inc. Fluidic and electrical interface for microfluidic chips
SG11201402558QA (en) * 2011-12-03 2014-06-27 Emd Millipore Corp Micro-incubation systems for microfluidic cell culture and methods
US9725687B2 (en) * 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
WO2013134383A1 (en) 2012-03-06 2013-09-12 The Uab Research Foundation Three-dimesional, prevascularized, engineered tissue constructs, methods of making and methods of using the tissue constructs
US9533302B2 (en) * 2012-03-09 2017-01-03 Lexmark International, Inc. Fluid cartridge and system for dispensing fluid
US20130299003A1 (en) * 2012-05-09 2013-11-14 David J. Beebe Method And Device For Actuating Fluid Flow In A Microchannel
US9180449B2 (en) * 2012-06-12 2015-11-10 Hach Company Mobile water analysis
US9255245B2 (en) 2012-07-03 2016-02-09 Agilent Technologies, Inc. Sample probes and methods for sampling intracellular material
JP6302187B2 (ja) * 2012-08-13 2018-03-28 キヤノン株式会社 マイクロ流路チップおよびその製造方法
US20140161686A1 (en) * 2012-12-10 2014-06-12 Advanced Liquid Logic, Inc. System and method of dispensing liquids in a microfluidic device
KR101653701B1 (ko) 2013-03-15 2016-09-02 지멘스 헬쓰케어 다이아그노스틱스 인크. 미세유체 분배 장치
WO2014145555A1 (en) * 2013-03-15 2014-09-18 Lariat Biosciences, Inc. Microfluidic methods for manipulating dna
EP2777499B1 (en) * 2013-03-15 2015-09-16 Ortho-Clinical Diagnostics Inc Rotatable fluid sample collection device
US9416776B2 (en) 2013-03-15 2016-08-16 Siemens Healthcare Diagnostics Inc. Microfluidic distributing device
WO2014149277A2 (en) * 2013-03-16 2014-09-25 Roberts Leslie Don Self-contained modular analytical cartridge and programmable reagent delivery system
DE102013006542B4 (de) * 2013-04-16 2017-03-23 Dräger Safety AG & Co. KGaA Messvorrichtung, Reaktionsträger und Messverfahren
US20160136646A1 (en) 2013-06-26 2016-05-19 President And Fellows Of Harvard College Interconnect Adaptor
CN113789372B (zh) 2013-08-08 2025-02-25 伊鲁米那股份有限公司 用于向流动池的试剂输送的流体系统
JP6230103B2 (ja) * 2013-10-08 2017-11-15 国立研究開発法人産業技術総合研究所 細胞培養装置および細胞培養方法
WO2015059799A1 (ja) * 2013-10-24 2015-04-30 株式会社日立製作所 自動培養装置
WO2015086531A1 (en) * 2013-12-13 2015-06-18 Ventana Medical Systems, Inc. Automated processing systems and methods of thermally processing microscope slides
EP3142790B8 (en) * 2014-05-14 2019-04-24 Hooke Bio Limited Method for handling fluid in a microfluidic device with channel plates
EP3169626A4 (en) 2014-07-14 2018-04-04 President and Fellows of Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
US9593997B2 (en) * 2014-08-08 2017-03-14 Fluke Corporation Self-locking modular pressure controller/calibrator
CA2964422C (en) * 2014-10-27 2018-06-12 The Governing Council Of The University Of Toronto Microfluidic device for cell-based assays
US9861982B2 (en) * 2015-03-09 2018-01-09 Emd Millipore Corporation Connectors for pneumatic devices in microfluidic systems
US10479972B2 (en) * 2015-04-20 2019-11-19 Rush University Medical Center Chamber for imaging cells and method of use thereof
US10184102B2 (en) * 2015-08-26 2019-01-22 EMULATE, Inc. Controlling pressure
US10913063B2 (en) * 2016-07-12 2021-02-09 EMULATE, Inc. Removing bubbles in a microfluidic device
CN206868242U (zh) * 2017-04-01 2018-01-12 南京岚煜生物科技有限公司 基于主动控制液体流动的微流控芯片
CN111289762B (zh) * 2020-04-02 2024-11-15 厦门大学附属翔安医院 一种微流控芯片加样装置及测试方法

Also Published As

Publication number Publication date
US11820966B2 (en) 2023-11-21
KR102044109B1 (ko) 2019-12-02
JP6741826B2 (ja) 2020-08-19
US20170058248A1 (en) 2017-03-02
CA3053745A1 (en) 2017-03-02
AU2016312678A1 (en) 2018-03-29
EP4026616A1 (en) 2022-07-13
JP6931434B2 (ja) 2021-09-01
US20220403312A9 (en) 2022-12-22
US10689608B2 (en) 2020-06-23
GB2595786A (en) 2021-12-08
KR102398531B1 (ko) 2022-05-17
US20170055522A1 (en) 2017-03-02
GB201614577D0 (en) 2016-10-12
AU2019272039B2 (en) 2020-12-03
US10184102B2 (en) 2019-01-22
US20190169557A1 (en) 2019-06-06
AU2016312678B2 (en) 2019-12-12
EP3341465A1 (en) 2018-07-04
US10233416B2 (en) 2019-03-19
KR102257981B1 (ko) 2021-05-31
EP3656844A1 (en) 2020-05-27
JP2021101746A (ja) 2021-07-15
EP3341465A4 (en) 2018-11-07
WO2017035484A1 (en) 2017-03-02
US20190040348A1 (en) 2019-02-07
US20170058243A1 (en) 2017-03-02
JP2019136046A (ja) 2019-08-22
KR102499711B1 (ko) 2023-02-13
WO2017035484A8 (en) 2018-05-03
CA3053745C (en) 2023-01-24
GB2595786B (en) 2022-06-15
JP6871972B2 (ja) 2021-05-19
AU2019272039C1 (en) 2021-03-25
SG10201811548PA (en) 2019-02-27
CN114540192A (zh) 2022-05-27
EP3341465B1 (en) 2023-10-04
GB2601649B (en) 2022-09-28
JP2024003181A (ja) 2024-01-11
AU2020286174B2 (en) 2021-10-07
EP4026616B1 (en) 2024-12-11
US20200190455A1 (en) 2020-06-18
KR102605693B1 (ko) 2023-11-24
US20170058257A1 (en) 2017-03-02
GB2544152A (en) 2017-05-10
JP2019136047A (ja) 2019-08-22
US10913924B2 (en) 2021-02-09
US10519410B2 (en) 2019-12-31
KR20210064399A (ko) 2021-06-02
KR20180042366A (ko) 2018-04-25
US20170056880A1 (en) 2017-03-02
CA3176776A1 (en) 2017-03-02
CA2996000A1 (en) 2017-03-02
AU2020286174A1 (en) 2021-01-07
JP6608043B2 (ja) 2019-11-20
JP2021175416A (ja) 2021-11-04
KR102709830B1 (ko) 2024-09-24
US20190112566A1 (en) 2019-04-18
US20190002811A1 (en) 2019-01-03
US20210179992A1 (en) 2021-06-17
AU2019272039A1 (en) 2019-12-19
GB2601650A (en) 2022-06-08
KR20230164753A (ko) 2023-12-04
JP2018525022A (ja) 2018-09-06
KR20230026525A (ko) 2023-02-24
GB202110792D0 (en) 2021-09-08
US10988721B2 (en) 2021-04-27
GB2601649A (en) 2022-06-08
US10988722B2 (en) 2021-04-27
US10125342B2 (en) 2018-11-13
CN108699504B (zh) 2022-04-26
US11834641B2 (en) 2023-12-05
CA2996000C (en) 2019-12-10
KR20190090093A (ko) 2019-07-31
BR112018003614A2 (pt) 2018-09-25
US20240093136A1 (en) 2024-03-21
GB2601650B (en) 2022-09-28
US11920114B2 (en) 2024-03-05
US10273441B2 (en) 2019-04-30
HK1250739A1 (en) 2019-01-11
US20190040349A1 (en) 2019-02-07
JP7387681B2 (ja) 2023-11-28
US20230022203A1 (en) 2023-01-26
CN108699504A (zh) 2018-10-23
KR20220066205A (ko) 2022-05-23

Similar Documents

Publication Publication Date Title
DK3697887T3 (da) Perfusionsfremgangsmåder
DK3346961T3 (da) Anordning til stomi
DK3395192T3 (da) Fastgørelsesanordning
EP3754089C0 (de) Dosiereinrichtung
DK3250263T3 (da) Medikamenttilførselsanordning
EP3566455A4 (en) CLOTHING DEVICE
DE112016005396A5 (de) Anschlusseinrichtung
DK3294373T3 (da) Justerbart injektionsapparat
BR112017022533A2 (pt) dispositivo de preensão.
DK3310414T3 (da) Lægemiddeladministrationsanordning
EP3069836C0 (de) Überlappungsvorrichtung
DK3285830T3 (da) Medikamenttilførselsanordning
DK3297802T3 (da) Forskallingsanordning
DK3303854T3 (da) Fastgørelsesanordning
EP3288133C0 (en) STOP DEVICE
DK3517268T3 (da) Læggeenhed
DK3363428T3 (da) Perfusionsdoseringsform
UA33635S (uk) Обчислювальний пристрій
DK3380168T3 (da) Injektionsanordning
EP3250086C0 (en) SHELF MANAGEMENT DEVICE
EP3315974A4 (en) Dispensing device
DK3355967T3 (da) Injektionsapparat
DK3380152T3 (da) Medikamentinjektionsanordning
BR112017017581A2 (pt) dispositivo de aperto
ITUB20152114A1 (it) Dispositivo insetticida