DK3697887T3 - Perfusionsfremgangsmåder - Google Patents

Perfusionsfremgangsmåder Download PDF

Info

Publication number: DK3697887T3
Authority: DK; Denmark
Prior art keywords: perfusion procedures; perfusion; procedures
Prior art date: 2017-10-16

Application number

DK18797333.4T

Other languages

English (en)

Inventor

Matthew Angelini

Ashley Witmer

Anthony Debiase

Original Assignee

Regeneron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-10-16

Filing date

2018-10-15

Publication date

2022-05-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=64110133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3697887(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2018-10-15 Application filed by Regeneron Pharma filed Critical Regeneron Pharma

2022-05-02 Application granted granted Critical

2022-05-02 Publication of DK3697887T3 publication Critical patent/DK3697887T3/da

Links

238000000034 method Methods 0.000 title 1
230000010412 perfusion Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M43/00—Combinations of bioreactors or fermenters with other apparatus
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/14—Incubators; Climatic chambers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/38—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of metabolites or enzymes in the cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Sustainable Development (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Cell Biology (AREA)
Physics & Mathematics (AREA)
Thermal Sciences (AREA)
Molecular Biology (AREA)
General Physics & Mathematics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Computer Hardware Design (AREA)
Immunology (AREA)
Pathology (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK18797333.4T 2017-10-16 2018-10-15 Perfusionsfremgangsmåder DK3697887T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201762572918P	2017-10-16	2017-10-16
PCT/US2018/055891 WO2019079188A1 (en)	2017-10-16	2018-10-15	PERFUSION BIOREACTOR AND METHODS OF USE THEREOF

Publications (1)

Publication Number	Publication Date
DK3697887T3 true DK3697887T3 (da)	2022-05-02

Family

ID=64110133

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK18797333.4T DK3697887T3 (da)	2017-10-16	2018-10-15	Perfusionsfremgangsmåder

Country Status (18)

Country	Link
US (3)	US11193103B2 (da)
EP (2)	EP3697887B1 (da)
JP (3)	JP7337784B2 (da)
KR (2)	KR20240125704A (da)
CN (6)	CN118580925A (da)
AR (1)	AR113772A1 (da)
AU (2)	AU2018350898B9 (da)
CA (1)	CA3075679A1 (da)
DK (1)	DK3697887T3 (da)
EA (1)	EA202090740A1 (da)
ES (1)	ES2919850T3 (da)
HU (1)	HUE058924T2 (da)
IL (2)	IL315801A (da)
MX (1)	MX2020002851A (da)
PL (1)	PL3697887T3 (da)
SG (1)	SG11202002339XA (da)
TW (3)	TW202538049A (da)
WO (1)	WO2019079188A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2019071076A1 (en)	2017-10-06	2019-04-11	Lonza Ltd.	AUTOMATED CONTROL OF CELL CULTURE BY SPECTROSCOPY RAMAN
IL315801A (en) *	2017-10-16	2024-11-01	Regeneron Pharma	Perfusion bioreactor and methods of using it
MY204234A (en)	2018-08-27	2024-08-16	Regeneron Pharma	Use of raman spectroscopy in downstream purification
CN113924355B (zh) *	2019-05-28	2024-04-02	上海药明生物技术有限公司	用于监测和自动控制灌流细胞培养的拉曼光谱集成灌流细胞培养系统
MX2021014644A (es) *	2019-06-13	2022-04-06	Amgen Inc	Control de perfusion basado en biomasa automatizado en la fabricacion de productos biologicos.
CN114599775B (zh) *	2019-11-07	2025-07-22	默克专利股份公司	用于进行灌注细胞培养的方法和系统
US12529024B2 (en)	2019-11-15	2026-01-20	Lonza Ltd	Process and system for producing an inoculum
IL294268A (en)	2020-01-02	2022-08-01	Hoffmann La Roche	A disposable cell culture container with one or more on-site in-line sensors
WO2021140002A1 (en) *	2020-01-07	2021-07-15	Cytiva Sweden Ab	Systems and method for controlling fluid flow in bioreactors
KR20220129006A (ko) *	2020-01-15	2022-09-22	우시 바이올로직스 아일랜드 리미티드	배양 세포로부터 생산된 생체 물질을 연속적으로 수확하기 위한 장치 및 방법
CA3190611A1 (en) *	2020-08-21	2022-02-24	Merck Patent Gmbh	Process system for bioreactor-based clean meat production
KR102656244B1 (ko)	2020-10-26	2024-04-09	성균관대학교산학협력단	바이오리액터
WO2022119910A1 (en) *	2020-12-01	2022-06-09	The Brigham And Women's Hospital, Inc.	Spectrometry systems, methods, and applications
KR102590857B1 (ko) *	2021-08-25	2023-10-19	재단법인 아산사회복지재단	세포 배양 장치
WO2023196391A1 (en) *	2022-04-07	2023-10-12	Mirror Biologics, Inc.	Artificial lymph node bioreator
US20230383241A1 (en) *	2022-05-25	2023-11-30	Repligen Corporation	Recovery of perfusion bleed product via alternating tangential flow filtration in a sedimentation reactor
JP2024030410A (ja)	2022-08-24	2024-03-07	横河電機株式会社	細胞培養システム、及び細胞培養方法
NL2033094B1 (en) *	2022-09-21	2024-03-26	Simabs Nv	Method for controlling a perfusion process in a bioreactor
JP2025064520A (ja)	2023-10-06	2025-04-17	横河電機株式会社	装置、方法、コントローラ、細胞培養システム、およびプログラム
WO2025122785A1 (en) *	2023-12-05	2025-06-12	Massachusetts Institute Of Technology	Magnetic resonance relaxometry bioreactor monitoring

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0211241A3 (de)	1985-07-06	1989-06-28	Forschungszentrum Jülich Gmbh	Verfahren zur Exoenzymgewinnung durch Bakterienkultur
EP0567738A3 (en) *	1992-05-01	1995-09-06	American Cyanamid Co	Controlling perfusion rates in continuous bioreactor culture of animal cells
WO1997021824A2 (en)	1995-12-15	1997-06-19	Systemix, Inc.	Method for obtaining retroviral vector supernatant having high transduction efficiency
US6544424B1 (en)	1999-12-03	2003-04-08	Refined Technology Company	Fluid filtration system
ITPD20030142A1 (it)	2003-06-27	2004-12-28	Livia Barenghi	Bioreattore, in particolare per spettroscopia nmr
AU2004260106C1 (en)	2003-07-17	2010-12-09	Global Cell Solutions, Llc.	Automated cell culture system and process
CA2557046A1 (en)	2004-03-05	2005-10-13	John Crowley	Process for cell culturing by continuous perfusion and alternating tangential flow
WO2005084696A1 (en)	2004-03-08	2005-09-15	Universita'degli Studi Di Milano	Methods and agents for controlling intestinal inflammation and mucosal immunity using agents interacting with tir8/sigirr
CN101443444A (zh) *	2004-12-29	2009-05-27	比奥根艾迪克Ma公司	生物反应器过程控制系统及方法
EP2267024B1 (en)	2005-06-03	2012-05-09	Ares Trading S.A.	Production of recombinant Il-18 binding protein
US8003408B2 (en) *	2005-12-29	2011-08-23	Intel Corporation	Modification of metal nanoparticles for improved analyte detection by surface enhanced Raman spectroscopy (SERS)
WO2007089551A2 (en) *	2006-01-27	2007-08-09	Prescient Medical, Inc.	Raman spectroscopic test strip systems
SI2041259T1 (sl)	2006-07-14	2016-04-29	Dpx Holdings B.V.	Izboljšan postopek kultiviranja celic
US9109193B2 (en)	2007-07-30	2015-08-18	Ge Healthcare Bio-Sciences Corp.	Continuous perfusion bioreactor system
WO2009023562A2 (en)	2007-08-09	2009-02-19	Wyeth	Use of perfusion to enhance production of fed-batch cell culture in bioreactors
WO2010016943A2 (en)	2008-08-08	2010-02-11	Biogen Idec Ma Inc.	Nutrient monitoring and feedback control for increased bioproduct production
CA2766902C (en)	2009-07-06	2021-07-06	Genentech, Inc.	Method of culturing eukaryotic cells
ES2642629T3 (es)	2009-11-17	2017-11-17	E. R. Squibb & Sons, L.L.C.	Métodos para la producción mejorada de proteínas
WO2012095176A1 (en)	2011-01-13	2012-07-19	Dsm Ip Assets B.V.	Oscillating flow minireactor
DK2726600T3 (da)	2011-07-01	2017-05-15	Amgen Inc	Pattedyrcellekultur
EP2758510A4 (en) *	2011-09-25	2015-05-06	Theranos Inc	SYSTEMS AND METHOD FOR MULTILAYER ANALYSIS
EP2800966B1 (en) *	2012-01-06	2021-09-29	Bend Research, Inc.	Dielectric spectroscopy methods and apparatus
WO2014059035A1 (en)	2012-10-10	2014-04-17	Bayer Healthcare Llc	Methods and systems for optimizing perfusion cell culture system
SG10201709131UA (en) *	2013-03-08	2017-12-28	Genzyme Corp	Continuous purification of therapeutic proteins
US11249026B2 (en) *	2013-03-15	2022-02-15	Biogen Ma Inc.	Use of raman spectroscopy to monitor culture medium
US10214718B2 (en) *	2013-07-01	2019-02-26	University Of Massachusetts	Distributed perfusion bioreactor system for continuous culture of biological cells
BR122021001466B1 (pt) *	2013-09-16	2021-10-13	Genzyme Corporation	Sistema de filtração de circuito aberto
US20160244725A1 (en)	2013-10-11	2016-08-25	Regeneron Pharmaceuticals, Inc.	Metabolically optimized cell culture
DK3083933T3 (da)	2013-12-20	2026-03-16	Biogen Ma Inc	Anvendelse af perfusionssåningskulturer til forbedring af biofarmaceutisk fed-batch-produktionskapacitet og -produktkvalitet
WO2016004322A2 (en) *	2014-07-02	2016-01-07	Biogen Ma Inc.	Cross-scale modeling of bioreactor cultures using raman spectroscopy
CN107922919A (zh) *	2015-05-29	2018-04-17	勃林格殷格翰国际公司	连续培养中的细胞控制的灌注
EP3303561A2 (en) *	2015-05-29	2018-04-11	Biogen MA Inc.	Cell culture methods and systems
CN106834117B (zh) *	2015-10-27	2018-11-23	苏州迪欧益生物科技有限公司	用于解除动物细胞贴附的酶反应器及智能酶反应工作站
US20180312802A1 (en)	2015-11-02	2018-11-01	Ares Trading S.A.	Methods for modulating production profiles of recombinant proteins in perfusion mode
CN116083344A (zh) *	2016-01-26	2023-05-09	勃林格殷格翰国际公司	对连续流动搅拌釜反应器细胞培养系统的连接灌注
CN205528832U (zh) *	2016-02-26	2016-08-31	南京农业大学	一种体外灌流系统
WO2019071076A1 (en)	2017-10-06	2019-04-11	Lonza Ltd.	AUTOMATED CONTROL OF CELL CULTURE BY SPECTROSCOPY RAMAN
IL315801A (en) *	2017-10-16	2024-11-01	Regeneron Pharma	Perfusion bioreactor and methods of using it

2018
- 2018-10-15 IL IL315801A patent/IL315801A/en unknown
- 2018-10-15 KR KR1020247026774A patent/KR20240125704A/ko active Pending
- 2018-10-15 WO PCT/US2018/055891 patent/WO2019079188A1/en not_active Ceased
- 2018-10-15 PL PL18797333.4T patent/PL3697887T3/pl unknown
- 2018-10-15 CN CN202410761962.2A patent/CN118580925A/zh active Pending
- 2018-10-15 CA CA3075679A patent/CA3075679A1/en active Pending
- 2018-10-15 EP EP18797333.4A patent/EP3697887B1/en not_active Revoked
- 2018-10-15 ES ES18797333T patent/ES2919850T3/es active Active
- 2018-10-15 CN CN202410768488.6A patent/CN118580927A/zh active Pending
- 2018-10-15 CN CN202410768516.4A patent/CN118580928A/zh active Pending
- 2018-10-15 KR KR1020207010709A patent/KR102694992B1/ko active Active
- 2018-10-15 CN CN202410768485.2A patent/CN118580926A/zh active Pending
- 2018-10-15 SG SG11202002339XA patent/SG11202002339XA/en unknown
- 2018-10-15 EP EP22160280.8A patent/EP4039786A1/en active Pending
- 2018-10-15 MX MX2020002851A patent/MX2020002851A/es unknown
- 2018-10-15 DK DK18797333.4T patent/DK3697887T3/da active
- 2018-10-15 AU AU2018350898A patent/AU2018350898B9/en active Active
- 2018-10-15 US US16/160,465 patent/US11193103B2/en active Active
- 2018-10-15 TW TW114121002A patent/TW202538049A/zh unknown
- 2018-10-15 TW TW107136209A patent/TWI827555B/zh active
- 2018-10-15 JP JP2020517855A patent/JP7337784B2/ja active Active
- 2018-10-15 EA EA202090740A patent/EA202090740A1/ru unknown
- 2018-10-15 CN CN201880066815.6A patent/CN111212899B/zh active Active
- 2018-10-15 TW TW112146996A patent/TWI889045B/zh active
- 2018-10-15 CN CN202410761960.3A patent/CN118580924A/zh active Pending
- 2018-10-15 HU HUE18797333A patent/HUE058924T2/hu unknown
- 2018-10-15 IL IL273150A patent/IL273150B2/en unknown
- 2018-10-16 AR ARP180103002A patent/AR113772A1/es unknown
2021
- 2021-11-02 US US17/517,422 patent/US11965153B2/en active Active
2023
- 2023-08-23 JP JP2023135344A patent/JP7700184B2/ja active Active
2024
- 2024-03-19 US US18/609,573 patent/US20240218313A1/en active Pending
- 2024-10-04 AU AU2024227125A patent/AU2024227125A1/en active Pending
2025
- 2025-06-18 JP JP2025101877A patent/JP2025128361A/ja active Pending

Also Published As

Publication number	Publication date
JP2023156504A (ja)	2023-10-24
HUE058924T2 (hu)	2022-09-28
IL273150A (en)	2020-04-30
WO2019079188A1 (en)	2019-04-25
TWI889045B (zh)	2025-07-01
US11965153B2 (en)	2024-04-23
CN118580927A (zh)	2024-09-03
AU2018350898A1 (en)	2020-04-16
EP3697887B1 (en)	2022-04-06
KR102694992B1 (ko)	2024-08-14
PL3697887T3 (pl)	2022-08-01
CN118580926A (zh)	2024-09-03
CN118580924A (zh)	2024-09-03
MX2020002851A (es)	2020-07-24
TW202538049A (zh)	2025-10-01
JP7337784B2 (ja)	2023-09-04
US20240218313A1 (en)	2024-07-04
CA3075679A1 (en)	2019-04-25
IL273150B2 (en)	2025-02-01
EP3697887A1 (en)	2020-08-26
JP7700184B2 (ja)	2025-06-30
US20220056398A1 (en)	2022-02-24
JP2025128361A (ja)	2025-09-02
ES2919850T3 (es)	2022-07-28
CN118580928A (zh)	2024-09-03
SG11202002339XA (en)	2020-04-29
TW202426623A (zh)	2024-07-01
IL315801A (en)	2024-11-01
KR20200062236A (ko)	2020-06-03
TWI827555B (zh)	2024-01-01
EP4039786A1 (en)	2022-08-10
AU2024227125A1 (en)	2024-10-24
US20190153381A1 (en)	2019-05-23
BR112020005209A2 (pt)	2020-09-15
TW201934744A (zh)	2019-09-01
EA202090740A1 (ru)	2020-07-07
AU2018350898B9 (en)	2024-07-25
AU2018350898B2 (en)	2024-07-04
JP2020536521A (ja)	2020-12-17
CN111212899B (zh)	2024-07-02
US11193103B2 (en)	2021-12-07
CN118580925A (zh)	2024-09-03
IL273150B1 (en)	2024-10-01
KR20240125704A (ko)	2024-08-19
AR113772A1 (es)	2020-06-10
CN111212899A (zh)	2020-05-29

Publication	Publication Date	Title
DK3697887T3 (da)	2022-05-02	Perfusionsfremgangsmåder
DK3731771T3 (da)	2023-08-28	V462033dk00
CL2018000524S1 (es)	2018-10-05	Golilla
DK3474804T3 (da)	2020-11-02	Medicinsk forbinding
DK3341465T3 (da)	2023-11-20	Perfusionsfordeleranordning
EP3589248A4 (en)	2021-01-06	CRYOTHERAPIES
EP3333966A4 (en)	2019-03-27	COOLER
DE202018003363U8 (de)	2019-01-24	Handgelenkssphygmomanometer
EP3634404C0 (en)	2024-11-20	PYRAZOLE-BASED MAGL INHIBITORS
EP3697802A4 (en)	2021-11-24	TRITERPENIC SAPONIN ANALOGUES
EP3588580A4 (en)	2020-12-02	SCHOTTKY MOS TRENCH DIODE
DK3351526T3 (da)	2021-02-08	Diisopentylterephthalat
EP3654852A4 (en)	2020-06-17	TOURNIQUET
EP3634397A4 (en)	2021-03-17	HETEROCYCLYL POLYMETHINE-BASED IR CHROMOPHORES
DK3568655T3 (da)	2023-04-17	Rekuperator
DK3571580T5 (da)	2021-11-08	Load-logical-and-shift-guarded-instruktion
DK3612237T3 (da)	2021-12-06	Genterapi
EP3611402A4 (en)	2020-04-15	SERVO CYLINDER
EP3615471A4 (en)	2021-01-06	PLASMA PHOTOELECTRONIC IMMUNE SENSOR
EP3669219C0 (en)	2024-08-14	NETWORK SCALE
EP3714787A4 (en)	2021-03-17	BIOSENSOR
IT201700085305A1 (it)	2019-01-26	Cannula di perfusione bidirezionale
DK3474803T3 (da)	2020-11-02	Medicinsk forbinding
EP3305185A4 (en)	2019-01-23	SPHYGMOMANOMETER
DK3576686T3 (da)	2022-01-03	Brokbind