DK3341485T3 - Forøget produktion af immunglobuliner - Google Patents

Forøget produktion af immunglobuliner

Info

Publication number
DK3341485T3
DK3341485T3 DK16840048.9T DK16840048T DK3341485T3 DK 3341485 T3 DK3341485 T3 DK 3341485T3 DK 16840048 T DK16840048 T DK 16840048T DK 3341485 T3 DK3341485 T3 DK 3341485T3
Authority
DK
Denmark
Prior art keywords
immunoglobulins
increased production
production
increased
Prior art date
Application number
DK16840048.9T
Other languages
English (en)
Inventor
Matthias Wabl
Bao Duong
Original Assignee
Trianni Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trianni Inc filed Critical Trianni Inc
Application granted granted Critical
Publication of DK3341485T3 publication Critical patent/DK3341485T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK16840048.9T 2015-08-24 2016-08-24 Forøget produktion af immunglobuliner DK3341485T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562209267P 2015-08-24 2015-08-24
PCT/US2016/048436 WO2017035252A1 (en) 2015-08-24 2016-08-24 Enhanced production of immunoglobulins

Publications (1)

Publication Number Publication Date
DK3341485T3 true DK3341485T3 (da) 2026-02-02

Family

ID=58097538

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16840048.9T DK3341485T3 (da) 2015-08-24 2016-08-24 Forøget produktion af immunglobuliner

Country Status (11)

Country Link
US (3) US20170058052A1 (da)
EP (2) EP3341485B1 (da)
JP (2) JP2018525007A (da)
KR (1) KR102974390B1 (da)
CN (1) CN108138200A (da)
AU (1) AU2016311268B2 (da)
CA (1) CA2995717A1 (da)
DK (1) DK3341485T3 (da)
IL (1) IL257411B2 (da)
RU (1) RU2018110364A (da)
WO (2) WO2017035252A1 (da)

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US10662256B2 (en) 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
CN103025884B (zh) 2010-07-26 2015-11-25 特里安尼公司 转基因动物和使用方法
EP3384030A4 (en) 2015-12-03 2019-07-03 Trianni, Inc. IMPROVED IMMUNOGLULINIVITY
EP4414484A3 (en) 2016-02-04 2025-01-15 Trianni, Inc. Enhanced production of immunoglobulins
CN109280674B (zh) * 2017-07-21 2020-12-01 北京百奥赛图基因生物技术有限公司 一种筛选抗体的非人模式动物的构建方法及其应用
AU2018302343B2 (en) 2017-07-21 2020-11-26 Trianni, Inc. Single chain vh and heavy chain antibodies
EP3476942B1 (en) 2017-10-27 2022-01-26 Trianni, Inc. Long germline dh genes and long hcdr3 antibodies
US10735066B2 (en) 2017-12-22 2020-08-04 Samsung Electronics Co., Ltd. Methods of beam codebook generation for the 5G terminals
EP3785536B2 (en) 2019-08-28 2025-09-17 Trianni, Inc. Adam6 knockin mice
CA3164996A1 (en) 2019-12-20 2021-06-14 Novarock Biotherapeutics, Ltd. Anti-interleukin-23 p19 antibodies and methods of use thereof
KR20230060509A (ko) 2020-09-04 2023-05-04 노바록 바이오테라퓨틱스 리미티드 넥틴-4 항체 및 이의 용도
JP7822400B2 (ja) 2020-12-09 2026-03-02 トリアンニ，インコーポレーテッド 重鎖のみ抗体
AU2022268937A1 (en) 2021-05-05 2023-10-26 Trianni, Inc. Transgenic rodents expressing chimeric equine-rodent antibodies and methods of use thereof
CN118056006A (zh) 2021-10-01 2024-05-17 雅伯希勒拉生物公司 用于细胞系鉴定和富集的转基因啮齿动物
JP2024543248A (ja) 2021-11-10 2024-11-20 トリアニ・インコーポレイテッド トランスジェニック哺乳動物およびその使用方法
KR20250049568A (ko) 2022-07-15 2025-04-11 페온 테라퓨틱스 리미티드 Cdcp1에 결합하는 항체 약물 접합체 및 이의 용도
CN120958025A (zh) 2022-12-16 2025-11-14 费恩治疗有限公司 针对含cub结构域的蛋白1(cdcp1)的抗体及其用途
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
WO2025262641A1 (en) 2024-06-19 2025-12-26 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof
US20260078179A1 (en) 2024-07-18 2026-03-19 Novarock Biotherapeutics, Ltd. Cdh17 antibodies and uses thereof
WO2026078443A1 (en) 2024-10-11 2026-04-16 Pheon Therapeutics Ltd. Antibody drug conjugates that bind cdcp1 and uses thereof
WO2026105061A1 (en) 2024-11-15 2026-05-21 Pheon Therapeutics Ltd Antibody-drug conjugates that bind cdcp1 and uses thereof

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US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
CA2090473A1 (en) 1990-08-29 1992-03-01 Robert M. Kay Homologous recombinatin in mammalian cells
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
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WO2011072204A1 (en) * 2009-12-10 2011-06-16 Regeneron Pharmaceuticals, Inc. Mice that make heavy chain antibodies
PL3248462T3 (pl) * 2010-03-31 2024-07-08 Ablexis, Llc Modyfikacja myszy metodami inżynierii genetycznej w celu wytworzenia przeciwciał chimerycznych
CN103025884B (zh) * 2010-07-26 2015-11-25 特里安尼公司 转基因动物和使用方法
CN103619876A (zh) * 2011-03-10 2014-03-05 Hco抗体股份有限公司 双特异性三链抗体样分子
WO2012122512A1 (en) * 2011-03-10 2012-09-13 Hco Antibody, Inc. Recombinant production of mixtures of single chain antibodies
EP2686348B1 (en) 2011-03-17 2015-12-30 Ramot at Tel-Aviv University Ltd. Bi- and monospecific, asymmetric antibodies and methods of generating the same
ES2872081T3 (es) * 2011-08-05 2021-11-02 Regeneron Pharma Ratones con cadena ligera universal humanizada
WO2013063391A2 (en) * 2011-10-28 2013-05-02 Trianni, Inc. Transgenic animals and methods of use
SMT201900296T1 (it) * 2011-12-20 2019-07-11 Regeneron Pharma Topi di catena leggera umanizzata
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FR3007763A1 (fr) * 2013-06-28 2015-01-02 Galderma Res & Dev Anticorps diriges contre le canal sodique nav1.9 humain et leurs utilisations en diagnostic

Also Published As

Publication number Publication date
KR20180038055A (ko) 2018-04-13
EP3340786A4 (en) 2019-03-13
JP2018525007A (ja) 2018-09-06
AU2016311268B2 (en) 2023-02-02
WO2017035241A1 (en) 2017-03-02
US20200190218A1 (en) 2020-06-18
IL257411B1 (en) 2024-01-01
IL257411A (en) 2018-04-30
CA2995717A1 (en) 2017-03-02
US20180230238A1 (en) 2018-08-16
AU2016311268A1 (en) 2018-03-08
EP3341485A4 (en) 2019-03-27
EP3341485B1 (en) 2025-11-26
US20170058052A1 (en) 2017-03-02
CN108138200A (zh) 2018-06-08
EP3341485A1 (en) 2018-07-04
JP2021168662A (ja) 2021-10-28
WO2017035252A1 (en) 2017-03-02
KR102974390B1 (ko) 2026-06-05
EP3340786A1 (en) 2018-07-04
IL257411B2 (en) 2024-05-01
RU2018110364A (ru) 2019-09-26

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