DK3341485T3 - Forøget produktion af immunglobuliner - Google Patents

Forøget produktion af immunglobuliner

Info

Publication number
DK3341485T3
DK3341485T3 DK16840048.9T DK16840048T DK3341485T3 DK 3341485 T3 DK3341485 T3 DK 3341485T3 DK 16840048 T DK16840048 T DK 16840048T DK 3341485 T3 DK3341485 T3 DK 3341485T3
Authority
DK
Denmark
Prior art keywords
immunoglobulins
increased production
production
increased
Prior art date
Application number
DK16840048.9T
Other languages
English (en)
Inventor
Matthias Wabl
Bao Duong
Original Assignee
Trianni Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trianni Inc filed Critical Trianni Inc
Application granted granted Critical
Publication of DK3341485T3 publication Critical patent/DK3341485T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK16840048.9T 2015-08-24 2016-08-24 Forøget produktion af immunglobuliner DK3341485T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562209267P 2015-08-24 2015-08-24
PCT/US2016/048436 WO2017035252A1 (en) 2015-08-24 2016-08-24 Enhanced production of immunoglobulins

Publications (1)

Publication Number Publication Date
DK3341485T3 true DK3341485T3 (da) 2026-02-02

Family

ID=58097538

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16840048.9T DK3341485T3 (da) 2015-08-24 2016-08-24 Forøget produktion af immunglobuliner

Country Status (11)

Country Link
US (3) US20170058052A1 (da)
EP (2) EP3340786A4 (da)
JP (2) JP2018525007A (da)
KR (1) KR20180038055A (da)
CN (1) CN108138200A (da)
AU (1) AU2016311268B2 (da)
CA (1) CA2995717A1 (da)
DK (1) DK3341485T3 (da)
IL (1) IL257411B2 (da)
RU (1) RU2018110364A (da)
WO (2) WO2017035241A1 (da)

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US10793829B2 (en) 2010-07-26 2020-10-06 Trianni, Inc. Transgenic mammals and methods of use thereof
JP6482757B2 (ja) 2010-07-26 2019-03-13 トリアンニ インコーポレイテッドＴｒｉａｎｎｉ，Ｉｎｃ． トランスジェニック動物および使用方法
US10662256B2 (en) 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
EP3384030A4 (en) * 2015-12-03 2019-07-03 Trianni, Inc. IMPROVED IMMUNOGLULINIVITY
AU2017213633B2 (en) 2016-02-04 2023-08-03 Trianni, Inc. Enhanced production of immunoglobulins
CN111065650A (zh) 2017-07-21 2020-04-24 特里安尼公司 单链VH-L1-Cκ-L2-CH1-抗体
CN109280674B (zh) * 2017-07-21 2020-12-01 北京百奥赛图基因生物技术有限公司 一种筛选抗体的非人模式动物的构建方法及其应用
EP3476942B1 (en) 2017-10-27 2022-01-26 Trianni, Inc. Long germline dh genes and long hcdr3 antibodies
US10735066B2 (en) 2017-12-22 2020-08-04 Samsung Electronics Co., Ltd. Methods of beam codebook generation for the 5G terminals
DK3785536T4 (da) 2019-08-28 2025-10-27 Trianni Inc Adam6-knockin-mus
CA3164996A1 (en) 2019-12-20 2021-06-14 Novarock Biotherapeutics, Ltd. Anti-interleukin-23 p19 antibodies and methods of use thereof
US20230331867A1 (en) 2020-09-04 2023-10-19 Novarock Biotherapeutics, Ltd. Nectin-4 antibodies and uses thereof
CA3204101A1 (en) 2020-12-09 2022-06-16 Trianni, Inc. Heavy chain-only antibodies
AU2022268937A1 (en) 2021-05-05 2023-10-26 Trianni, Inc. Transgenic rodents expressing chimeric equine-rodent antibodies and methods of use thereof
EP4408981A1 (en) 2021-10-01 2024-08-07 AbCellera Biologics Inc. Transgenic rodents for cell line identification and enrichment
IL312359A (en) 2021-11-10 2024-06-01 Trianni Inc Transgenic mammals and methods of use thereof
JP2025524728A (ja) 2022-07-15 2025-07-30 フィアン セラピューティクス エルティーディー 抗体－薬物複合体
KR20250134734A (ko) 2022-12-16 2025-09-11 페온 테라퓨틱스 리미티드 Cub 도메인-함유 단백질 1(cdcp1)에 대한 항체 및 이의 용도
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
WO2025262641A1 (en) 2024-06-19 2025-12-26 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof
WO2026020031A2 (en) 2024-07-18 2026-01-22 Novarock Biotherapeutics, Ltd. Cdh17 antibodies and uses thereof
WO2026078443A1 (en) 2024-10-11 2026-04-16 Pheon Therapeutics Ltd. Antibody drug conjugates that bind cdcp1 and uses thereof

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US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ATE352612T1 (de) 1990-08-29 2007-02-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE4228162C1 (de) 1992-08-25 1994-01-13 Rajewsky Klaus Dr Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
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DE60037896D1 (de) * 1999-07-29 2008-03-13 Medarex Inc Menschliche antikörper gegen her2/neu
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JP6482757B2 (ja) * 2010-07-26 2019-03-13 トリアンニ インコーポレイテッドＴｒｉａｎｎｉ，Ｉｎｃ． トランスジェニック動物および使用方法
JP2014515598A (ja) * 2011-03-10 2014-07-03 エイチシーオー アンティボディ， インク． 二重特異性三鎖抗体様分子
WO2012122512A1 (en) * 2011-03-10 2012-09-13 Hco Antibody, Inc. Recombinant production of mixtures of single chain antibodies
IN2013MN01438A (da) * 2011-03-17 2015-06-12 Univ Ramot
RS59728B1 (sr) * 2011-08-05 2020-02-28 Regeneron Pharma Humanizovani miševi univerzalnog lakog lanca
US20140283153A1 (en) * 2011-10-28 2014-09-18 Trianni, Inc. Transgenic animals and methods of use
RU2664181C2 (ru) * 2011-12-20 2018-08-15 Регенерон Фармасьютикалз, Инк. Мыши с гуманизированной легкой цепью
MX2014011047A (es) 2012-03-16 2015-04-08 Regeneron Pharma Ratones que producen proteinas de union a un antigeno con caracteristicas de union dependientes del ph.
GB2502127A (en) * 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
EP3878964A1 (en) * 2012-11-27 2021-09-15 Ajou University Industry-Academic Cooperation Foundation Ch3 domain variant pair inducing formation of heterodimer of heavy chain constant region of antibody at high efficiency, method for preparing same, and use thereof
FR3007763A1 (fr) * 2013-06-28 2015-01-02 Galderma Res & Dev Anticorps diriges contre le canal sodique nav1.9 humain et leurs utilisations en diagnostic

Also Published As

Publication number Publication date
US20200190218A1 (en) 2020-06-18
US20170058052A1 (en) 2017-03-02
EP3340786A1 (en) 2018-07-04
CN108138200A (zh) 2018-06-08
US20180230238A1 (en) 2018-08-16
JP2018525007A (ja) 2018-09-06
IL257411B1 (en) 2024-01-01
EP3341485A4 (en) 2019-03-27
CA2995717A1 (en) 2017-03-02
IL257411A (en) 2018-04-30
EP3341485A1 (en) 2018-07-04
WO2017035241A1 (en) 2017-03-02
EP3341485B1 (en) 2025-11-26
AU2016311268A1 (en) 2018-03-08
IL257411B2 (en) 2024-05-01
KR20180038055A (ko) 2018-04-13
JP2021168662A (ja) 2021-10-28
EP3340786A4 (en) 2019-03-13
WO2017035252A1 (en) 2017-03-02
AU2016311268B2 (en) 2023-02-02
RU2018110364A (ru) 2019-09-26

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