PL3116891T3 - Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczania - Google Patents
Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczaniaInfo
- Publication number
- PL3116891T3 PL3116891T3 PL15708522T PL15708522T PL3116891T3 PL 3116891 T3 PL3116891 T3 PL 3116891T3 PL 15708522 T PL15708522 T PL 15708522T PL 15708522 T PL15708522 T PL 15708522T PL 3116891 T3 PL3116891 T3 PL 3116891T3
- Authority
- PL
- Poland
- Prior art keywords
- purification
- immunoglobulin
- steps
- purification steps
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1400131A HUP1400131A1 (hu) | 2014-03-10 | 2014-03-10 | Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával |
| HU1500053A HUP1500053A1 (hu) | 2015-02-09 | 2015-02-09 | Immunglobulin tisztítása elõtisztítási lépések alkalmazásával |
| EP15708522.6A EP3116891B1 (en) | 2014-03-10 | 2015-03-09 | Immunoglobulin purification using pre-cleaning steps |
| PCT/EP2015/054862 WO2015135884A1 (en) | 2014-03-10 | 2015-03-09 | Immunoglobulin purification using pre-cleaning steps |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3116891T3 true PL3116891T3 (pl) | 2020-07-27 |
Family
ID=89991731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15708522T PL3116891T3 (pl) | 2014-03-10 | 2015-03-09 | Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczania |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10487138B2 (pl) |
| EP (2) | EP3116891B1 (pl) |
| JP (1) | JP6293907B2 (pl) |
| KR (1) | KR101921552B1 (pl) |
| CN (1) | CN106103465B (pl) |
| CA (1) | CA2930350C (pl) |
| DK (1) | DK3116891T3 (pl) |
| ES (1) | ES2784749T3 (pl) |
| HR (1) | HRP20200711T1 (pl) |
| HU (1) | HUE048782T2 (pl) |
| LT (1) | LT3116891T (pl) |
| PL (1) | PL3116891T3 (pl) |
| PT (1) | PT3116891T (pl) |
| SI (1) | SI3116891T1 (pl) |
| WO (1) | WO2015135884A1 (pl) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3116891T1 (sl) | 2014-03-10 | 2020-07-31 | Richter Gedeon Nyrt. | Čiščenje imunoglobulina z uporabo predčistilnih stopenj |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
| JP6851109B2 (ja) * | 2016-06-16 | 2021-03-31 | Jsr株式会社 | 抗体を精製する方法及び担体を洗浄する方法 |
| TWI798179B (zh) * | 2016-06-17 | 2023-04-11 | 美商建南德克公司 | 多特異性抗體之純化 |
| EP3512884A4 (en) * | 2016-09-14 | 2020-09-16 | Kinbio Ltd. | METHODS FOR CLEANING UP AND QUALIFYING ANTIBODIES |
| MX2019011343A (es) * | 2017-03-24 | 2019-11-18 | Council Scient Ind Res | Un procedimiento para la purificacion de fragmentos de anticuerpos recombinantes. |
| MA49962A (fr) * | 2017-08-22 | 2020-07-01 | Biogen Ma Inc | Procédés de purification d'anticorps présentant des agrégats réduits à poids moléculaire élevé |
| KR20190047376A (ko) | 2017-10-27 | 2019-05-08 | 주식회사 녹십자 | 개선된 면역글로불린의 정제방법 |
| CN111818980B (zh) * | 2018-03-08 | 2022-10-11 | 生物辐射实验室股份有限公司 | 阴离子交换-疏水混合模式色谱树脂 |
| WO2019183334A1 (en) | 2018-03-21 | 2019-09-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbents, devices and methods |
| GB201805142D0 (en) * | 2018-03-29 | 2018-05-16 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| EP3823594B1 (en) * | 2018-07-19 | 2025-02-05 | Ichnos Sciences S.A. | Liquid antibody formulation |
| KR102262012B1 (ko) | 2018-10-15 | 2021-06-09 | 연세대학교 산학협력단 | 생산성이 향상된 항체 및 이의 제조방법 |
| KR102209790B1 (ko) * | 2018-12-20 | 2021-02-01 | 에이치케이이노엔 주식회사 | 친화성 크로마토그래피를 이용한 백신용 바이러스 정제방법 |
| CN119716045A (zh) | 2018-12-30 | 2025-03-28 | 豪夫迈·罗氏有限公司 | 基于pH梯度SPR的结合测定 |
| SG11202107870RA (en) * | 2019-03-21 | 2021-08-30 | Agency Science Tech & Res | A method of capturing and/or purifying a target |
| US12233356B2 (en) * | 2019-03-21 | 2025-02-25 | Lonza Sales Ag | Process for preparing extracellular vesicles |
| HU231498B1 (hu) | 2019-04-04 | 2024-05-28 | Richter Gedeon Nyrt | Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelőző flokkulálás alkalmazásával |
| MX2021015302A (es) * | 2019-06-10 | 2022-01-18 | Takeda Pharmaceuticals Co | Metodos de purificacion de anticuerpos y composiciones de estos. |
| US20220267449A1 (en) * | 2019-06-10 | 2022-08-25 | Takeda Pharmaceutical Company Limited | METHODS OF PRODUCING AN ANTI-a4B7 ANTIBODY |
| US11896969B2 (en) | 2019-09-05 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Anionic exchange-hydrophobic mixed mode chromatography resins |
| US11732004B2 (en) | 2020-04-10 | 2023-08-22 | Plasma Technologies, Llc | Compositions and methods for simplified high efficiency isolation of proteins |
| CN113563469A (zh) * | 2020-04-28 | 2021-10-29 | 江苏中新医药有限公司 | 高回收率纯化阿达木单抗的方法 |
| EP4142905A4 (en) * | 2020-05-01 | 2024-11-13 | Kashiv Biosciences, LLC | IMPROVED PROCESS FOR PURIFICATION OF PROTEIN |
| AU2021262609A1 (en) | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| ES3040791T3 (en) * | 2020-12-18 | 2025-11-05 | Richter Gedeon Nyrt | Methods for the purification of refolded fc-peptide fusion protein |
| AU2022361768A1 (en) * | 2021-10-08 | 2024-05-02 | Kashiv Biosciences, Llc | Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| WO2023057994A1 (en) * | 2021-10-08 | 2023-04-13 | Kashiv Biosciences, Llc | Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| CN114133446A (zh) * | 2021-12-31 | 2022-03-04 | 方坦思(上海)生物医药有限公司 | 单克隆抗体的纯化方法 |
| CN115304673B (zh) * | 2022-06-24 | 2024-10-01 | 上海赛伦生物技术股份有限公司 | 一种马抗破伤风特异性免疫球蛋白F(ab’)2的纯化方法及其应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989000579A1 (en) * | 1987-07-16 | 1989-01-26 | Schering Corporation | Purification of gm-csf |
| CA1341235C (en) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4983722A (en) | 1988-06-08 | 1991-01-08 | Miles Inc. | Removal of protein A from antibody preparations |
| AU8001291A (en) * | 1990-05-31 | 1991-12-31 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Method for purifying hiv reverse transcriptase |
| CA2736076A1 (en) | 1991-03-18 | 1992-09-19 | New York University | Monoclonal and chimeric antibodies specific for human tumor necrosis factor |
| ATE255131T1 (de) | 1991-06-14 | 2003-12-15 | Genentech Inc | Humanisierter heregulin antikörper |
| DE69303494T2 (de) | 1992-11-13 | 1997-01-16 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma |
| US5429746A (en) * | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| HU230048B1 (hu) | 1996-02-09 | 2015-06-29 | Abbvie Biotechnology Ltd | Humán TNFalfa-kötő antitestek alkalmazása |
| IL132240A0 (en) | 1997-04-07 | 2001-03-19 | Genentech Inc | Anti-vegf antibodies |
| WO2001015011A2 (en) | 1999-08-26 | 2001-03-01 | Symtec Limited | Methods and devices for selecting data files |
| CA2451955C (en) | 2001-06-26 | 2015-09-29 | Abgenix, Inc. | Antibodies to opgl |
| WO2003016909A1 (en) * | 2001-08-16 | 2003-02-27 | Ludwig Institute For Cancer Research | Method for determining protein component in a biological sample |
| DE10155984A1 (de) | 2001-11-15 | 2003-05-28 | Boehringer Ingelheim Pharma | Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices |
| DK1501369T3 (en) | 2002-04-26 | 2015-09-28 | Genentech Inc | Non-affinity purification of proteins |
| CA2516518A1 (en) | 2003-02-28 | 2004-09-10 | Lonza Biologics Plc. | Antibody purification by protein a and ion exchange chromatography |
| JPWO2004087761A1 (ja) | 2003-03-31 | 2006-07-27 | 麒麟麦酒株式会社 | ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製 |
| HUE029951T2 (en) | 2003-07-28 | 2017-04-28 | Genentech Inc | Reduction of Protein A Dissolution in Protein A Affinity Chromatography |
| ES2285543T3 (es) * | 2003-11-05 | 2007-11-16 | Ares Trading S.A. | Procedimiento para la purificacion de la proteina de union a il-18. |
| CA2552639C (en) * | 2004-02-27 | 2012-05-01 | Ge Healthcare Bio-Sciences Ab | A process for the purification of antibodies |
| AU2005279347A1 (en) | 2004-08-30 | 2006-03-09 | Lonza Biologics Plc. | Affinity- plus ion exchange- chromatography for purifying antibodies |
| CN105315323A (zh) | 2007-10-30 | 2016-02-10 | 健泰科生物技术公司 | 通过阳离子交换层析进行的抗体纯化 |
| EP2281000A2 (en) | 2008-05-15 | 2011-02-09 | Novo Nordisk A/S | Antibody purification process |
| TW201024318A (en) | 2008-10-20 | 2010-07-01 | Abbott Lab | Isolation and purification of antibodies using protein A affinity chromatography |
| EP2360183B1 (en) | 2008-12-19 | 2016-07-27 | Takeda Pharmaceutical Company Limited | Antibody purification method by mixed mode chromatography utilizing an arginine-containing loading solution |
| CN102471377B (zh) * | 2009-07-24 | 2015-04-22 | 霍夫曼-拉罗奇有限公司 | 优化抗体的生产 |
| ES2817802T3 (es) | 2009-08-07 | 2021-04-08 | Emd Millipore Corp | Métodos para purificar una proteína objetivo de una o más impurezas en una muestra |
| EP3736338A1 (en) * | 2009-09-01 | 2020-11-11 | F. Hoffmann-La Roche AG | Enhanced protein purification through a modified protein a elution |
| EP2490780A4 (en) | 2009-10-20 | 2014-04-09 | Merck Sharp & Dohme | USE OF A MIXED MODE CHROMATOGRAPHY FOR THE DETECTION AND PURIFICATION OF BASIC ANTIBODY PRODUCTS |
| EP2519537A4 (en) | 2009-12-29 | 2013-07-10 | Reddys Lab Ltd Dr | CLEANING PROTEINS |
| EP4492053A3 (en) | 2010-05-25 | 2025-03-19 | F. Hoffmann-La Roche AG | Methods of purifying polypeptides |
| SG10201508401TA (en) * | 2010-10-11 | 2015-11-27 | Abbvie Bahamas Ltd | Processes for purification of proteins |
| HRP20180858T1 (hr) * | 2011-07-11 | 2018-09-21 | Glenmark Pharmaceuticals S.A. | Protutijela koja se vežu na ox40 i njihove uporabe |
| WO2013066707A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Chromatography process for resolving heterogeneous antibody aggregates |
| EP3527274B1 (en) | 2011-11-02 | 2025-12-24 | F. Hoffmann-La Roche AG | Overload and elute chromatography |
| WO2013180647A1 (en) * | 2012-05-31 | 2013-12-05 | Agency For Science, Technology And Research | Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities |
| CN104487448B (zh) * | 2012-06-21 | 2020-04-24 | 斯索恩生物制药有限公司 | 纯化抗体的方法 |
| SI3116891T1 (sl) | 2014-03-10 | 2020-07-31 | Richter Gedeon Nyrt. | Čiščenje imunoglobulina z uporabo predčistilnih stopenj |
-
2015
- 2015-03-09 SI SI201531188T patent/SI3116891T1/sl unknown
- 2015-03-09 KR KR1020167022454A patent/KR101921552B1/ko active Active
- 2015-03-09 EP EP15708522.6A patent/EP3116891B1/en active Active
- 2015-03-09 HU HUE15708522A patent/HUE048782T2/hu unknown
- 2015-03-09 CA CA2930350A patent/CA2930350C/en active Active
- 2015-03-09 ES ES15708522T patent/ES2784749T3/es active Active
- 2015-03-09 LT LTEP15708522.6T patent/LT3116891T/lt unknown
- 2015-03-09 PT PT157085226T patent/PT3116891T/pt unknown
- 2015-03-09 PL PL15708522T patent/PL3116891T3/pl unknown
- 2015-03-09 HR HRP20200711TT patent/HRP20200711T1/hr unknown
- 2015-03-09 DK DK15708522.6T patent/DK3116891T3/da active
- 2015-03-09 EP EP20155836.8A patent/EP3674310B1/en active Active
- 2015-03-09 WO PCT/EP2015/054862 patent/WO2015135884A1/en not_active Ceased
- 2015-03-09 US US15/120,359 patent/US10487138B2/en active Active
- 2015-03-09 JP JP2016544089A patent/JP6293907B2/ja active Active
- 2015-03-09 CN CN201580012972.5A patent/CN106103465B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106103465A (zh) | 2016-11-09 |
| EP3674310B1 (en) | 2026-05-06 |
| JP6293907B2 (ja) | 2018-03-14 |
| CN106103465B (zh) | 2021-01-08 |
| DK3116891T3 (da) | 2020-05-04 |
| ES2784749T3 (es) | 2020-09-30 |
| HUE048782T2 (hu) | 2020-08-28 |
| SI3116891T1 (sl) | 2020-07-31 |
| HRP20200711T1 (hr) | 2020-07-24 |
| CA2930350A1 (en) | 2015-09-17 |
| KR101921552B1 (ko) | 2018-11-23 |
| WO2015135884A1 (en) | 2015-09-17 |
| JP2017507907A (ja) | 2017-03-23 |
| EP3674310A1 (en) | 2020-07-01 |
| US20170058019A1 (en) | 2017-03-02 |
| US10487138B2 (en) | 2019-11-26 |
| LT3116891T (lt) | 2020-03-25 |
| KR20160124107A (ko) | 2016-10-26 |
| CA2930350C (en) | 2021-04-06 |
| EP3116891B1 (en) | 2020-02-12 |
| PT3116891T (pt) | 2020-05-18 |
| EP3116891A1 (en) | 2017-01-18 |
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