PL3116891T3 - Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczania - Google Patents
Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczaniaInfo
- Publication number
- PL3116891T3 PL3116891T3 PL15708522T PL15708522T PL3116891T3 PL 3116891 T3 PL3116891 T3 PL 3116891T3 PL 15708522 T PL15708522 T PL 15708522T PL 15708522 T PL15708522 T PL 15708522T PL 3116891 T3 PL3116891 T3 PL 3116891T3
- Authority
- PL
- Poland
- Prior art keywords
- purification
- immunoglobulin
- steps
- purification steps
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1400131A HUP1400131A1 (hu) | 2014-03-10 | 2014-03-10 | Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával |
| HU1500053A HUP1500053A1 (hu) | 2015-02-09 | 2015-02-09 | Immunglobulin tisztítása elõtisztítási lépések alkalmazásával |
| EP15708522.6A EP3116891B1 (en) | 2014-03-10 | 2015-03-09 | Immunoglobulin purification using pre-cleaning steps |
| PCT/EP2015/054862 WO2015135884A1 (en) | 2014-03-10 | 2015-03-09 | Immunoglobulin purification using pre-cleaning steps |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3116891T3 true PL3116891T3 (pl) | 2020-07-27 |
Family
ID=89991731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15708522T PL3116891T3 (pl) | 2014-03-10 | 2015-03-09 | Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczania |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10487138B2 (pl) |
| EP (2) | EP3116891B1 (pl) |
| JP (1) | JP6293907B2 (pl) |
| KR (1) | KR101921552B1 (pl) |
| CN (1) | CN106103465B (pl) |
| CA (1) | CA2930350C (pl) |
| DK (2) | DK3116891T3 (pl) |
| ES (1) | ES2784749T3 (pl) |
| FI (1) | FI3674310T3 (pl) |
| HR (2) | HRP20200711T1 (pl) |
| HU (1) | HUE048782T2 (pl) |
| LT (2) | LT3116891T (pl) |
| PL (1) | PL3116891T3 (pl) |
| PT (2) | PT3674310T (pl) |
| SI (1) | SI3116891T1 (pl) |
| WO (1) | WO2015135884A1 (pl) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3116891B1 (en) | 2014-03-10 | 2020-02-12 | Richter Gedeon Nyrt. | Immunoglobulin purification using pre-cleaning steps |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
| JP6851109B2 (ja) * | 2016-06-16 | 2021-03-31 | Jsr株式会社 | 抗体を精製する方法及び担体を洗浄する方法 |
| CA3026518A1 (en) * | 2016-06-17 | 2017-12-21 | Genentech, Inc. | Purification of multispecific antibodies |
| WO2018051348A1 (en) * | 2016-09-14 | 2018-03-22 | Insight Biopharmaceutical Ltd. | Methods of purifying and qualifying antibodies |
| MX2019011343A (es) * | 2017-03-24 | 2019-11-18 | Council Scient Ind Res | Un procedimiento para la purificacion de fragmentos de anticuerpos recombinantes. |
| MA49962A (fr) | 2017-08-22 | 2020-07-01 | Biogen Ma Inc | Procédés de purification d'anticorps présentant des agrégats réduits à poids moléculaire élevé |
| KR20190047376A (ko) | 2017-10-27 | 2019-05-08 | 주식회사 녹십자 | 개선된 면역글로불린의 정제방법 |
| CN111818980B (zh) * | 2018-03-08 | 2022-10-11 | 生物辐射实验室股份有限公司 | 阴离子交换-疏水混合模式色谱树脂 |
| US11155575B2 (en) | 2018-03-21 | 2021-10-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbent, devices and methods |
| GB201805142D0 (en) * | 2018-03-29 | 2018-05-16 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| ES3014697T3 (en) * | 2018-07-19 | 2025-04-24 | Ichnos Sciences S A | Liquid antibody formulation |
| US12590164B2 (en) | 2018-10-15 | 2026-03-31 | Yonsei University Biohealth Technology Holdings, Inc. | Productivity-enhanced antibody and method for producing same |
| KR102209790B1 (ko) * | 2018-12-20 | 2021-02-01 | 에이치케이이노엔 주식회사 | 친화성 크로마토그래피를 이용한 백신용 바이러스 정제방법 |
| WO2020141117A1 (en) * | 2018-12-30 | 2020-07-09 | F. Hoffmann-La Roche Ag | Ph-gradient spr-based binding assay |
| CN113518654B (zh) * | 2019-03-21 | 2023-12-15 | 新加坡科技研究局 | 捕获和/或纯化靶标的方法 |
| EP3941607A1 (en) * | 2019-03-21 | 2022-01-26 | Codiak BioSciences, Inc. | Process for preparing extracellular vesicles |
| HU231498B1 (hu) | 2019-04-04 | 2024-05-28 | Richter Gedeon Nyrt | Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelőző flokkulálás alkalmazásával |
| CA3143167A1 (en) * | 2019-06-10 | 2020-12-17 | Takeda Pharmaceutical Company Limited | Methods of producing an anti-.alpha.4.beta.7 antibody |
| AR119268A1 (es) * | 2019-06-10 | 2021-12-09 | Millennium Pharm Inc | Métodos de purificación de anticuerpos y composiciones de estos |
| CN114040815B (zh) | 2019-09-05 | 2024-06-28 | 生物辐射实验室股份有限公司 | 阴离子交换-疏水混合模式色谱树脂 |
| EP4118108A4 (en) | 2020-04-10 | 2024-05-15 | Plasma Technologies, LLC | COMPOSITIONS AND METHODS FOR HIGHLY EFFICIENT SIMPLIFIED PROTEIN ISOLATION |
| CN113563469A (zh) * | 2020-04-28 | 2021-10-29 | 江苏中新医药有限公司 | 高回收率纯化阿达木单抗的方法 |
| AU2021262609A1 (en) | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| CA3182314A1 (en) * | 2020-05-01 | 2021-11-04 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| CN112979806A (zh) * | 2020-12-15 | 2021-06-18 | 北京双鹭生物技术有限公司 | 一种抗Her2抗体的制备方法 |
| SMT202500333T1 (it) * | 2020-12-18 | 2025-11-10 | Richter Gedeon Nyrt | Metodi per la purificazione di proteina di fusione fc-peptide |
| AU2022361768A1 (en) * | 2021-10-08 | 2024-05-02 | Kashiv Biosciences, Llc | Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| WO2023057994A1 (en) * | 2021-10-08 | 2023-04-13 | Kashiv Biosciences, Llc | Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| CN114133446A (zh) * | 2021-12-31 | 2022-03-04 | 方坦思(上海)生物医药有限公司 | 单克隆抗体的纯化方法 |
| CN115304673B (zh) * | 2022-06-24 | 2024-10-01 | 上海赛伦生物技术股份有限公司 | 一种马抗破伤风特异性免疫球蛋白F(ab’)2的纯化方法及其应用 |
Family Cites Families (38)
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| AU632460B2 (en) * | 1987-07-16 | 1993-01-07 | Schering Corporation | Purification of gm-csf |
| CA1341235C (en) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4983722A (en) | 1988-06-08 | 1991-01-08 | Miles Inc. | Removal of protein A from antibody preparations |
| WO1991018975A1 (en) * | 1990-05-31 | 1991-12-12 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Method for purifying hiv reverse transcriptase |
| DE07012626T1 (de) | 1991-03-18 | 2010-01-21 | New York University | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| ATE139900T1 (de) | 1992-11-13 | 1996-07-15 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma |
| US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| ATE239041T1 (de) | 1996-02-09 | 2003-05-15 | Basf Ag | Humane antikörper welche an humanen tnfalpha binden |
| DE69829891T2 (de) | 1997-04-07 | 2005-10-06 | Genentech, Inc., South San Francisco | Anti-VEGF Antikörper |
| EP1222572A2 (en) | 1999-08-26 | 2002-07-17 | Symtec Limited | Methods and devices for selecting data files |
| TR201809678T4 (tr) | 2001-06-26 | 2018-07-23 | Amgen Fremont Inc | Opgl ye karşi antikorlar. |
| US20030040027A1 (en) * | 2001-08-16 | 2003-02-27 | Gerd Ritter | Method for determining protein component in a biological sample |
| DE10155984A1 (de) | 2001-11-15 | 2003-05-28 | Boehringer Ingelheim Pharma | Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices |
| SI1501369T1 (sl) | 2002-04-26 | 2015-10-30 | Genentech, Inc. | Neafinitetno čiščenje proteinov |
| WO2004076485A1 (en) | 2003-02-28 | 2004-09-10 | Lonza Biologics Plc. | Antibody purification by protein a and ion exchange chromatography |
| US20060257972A1 (en) | 2003-03-31 | 2006-11-16 | Takashi Ishihara | Purification of human monoclonal antibody and human polyclonal antibody |
| JP4599355B2 (ja) * | 2003-07-28 | 2010-12-15 | ジェネンテック， インコーポレイテッド | プロテインａアフィニティークロマトグラフィーの間のプロテインａの浸出の低減 |
| ES2285543T3 (es) * | 2003-11-05 | 2007-11-16 | Ares Trading S.A. | Procedimiento para la purificacion de la proteina de union a il-18. |
| KR101150050B1 (ko) * | 2004-02-27 | 2012-07-05 | 지이 헬스케어 바이오-사이언시스 에이비 | 항체 정제 방법 |
| US20080312425A1 (en) * | 2004-08-30 | 2008-12-18 | Lonza Biologics Plc. | Ion Exchange Chromatography and Purification of Antibodies |
| HUE024877T2 (en) | 2007-10-30 | 2016-02-29 | Genentech Inc | Antibody purification by cation exchange chromatography |
| CN103396480A (zh) | 2008-05-15 | 2013-11-20 | 诺沃—诺迪斯克有限公司 | 抗体纯化方法 |
| CA2932207A1 (en) | 2008-10-20 | 2010-12-09 | Abbvie Inc. | Isolation and purification of antibodies using protein a affinity chromatography |
| WO2010071208A1 (ja) * | 2008-12-19 | 2010-06-24 | 武田薬品工業株式会社 | 抗体の精製方法 |
| JP5540095B2 (ja) * | 2009-07-24 | 2014-07-02 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 抗体製造の最適化 |
| US8536316B2 (en) * | 2009-08-07 | 2013-09-17 | Emd Millipore Corporation | Methods for purifying a target protein from one or more impurities in a sample |
| BR112012004697B8 (pt) * | 2009-09-01 | 2021-05-25 | Genentech Inc | método para purificar um polipeptídeo compreendendo uma região ch2/ch3 |
| WO2011049798A1 (en) | 2009-10-20 | 2011-04-28 | Merck Sharp & Dohme Corp. | Use of mixed mode chromatography for the capture and purification of basic antibody products |
| US20130116413A1 (en) | 2009-12-29 | 2013-05-09 | Dr. Reddy's Laboratories, Inc. | Purification of proteins |
| HRP20171095T4 (hr) | 2010-05-25 | 2022-07-22 | F. Hoffmann - La Roche Ag | Postupci pročišćavanja polipeptida |
| BR112013008738B1 (pt) * | 2010-10-11 | 2017-12-19 | Abbvie Bahamas Ltd. | Method for purification of a protein |
| KR102119840B1 (ko) * | 2011-07-11 | 2020-06-09 | 아이크노스 사이언스 에스. 아. | Ox40에 결합하는 항체 및 이들의 용도 |
| US20140288278A1 (en) | 2011-10-31 | 2014-09-25 | Joseph Nti-Gyabaah | Chromatography process for resolving heterogeneous antibody aggregates |
| KR20140091721A (ko) | 2011-11-02 | 2014-07-22 | 제넨테크, 인크. | 오버로드 및 용리 크로마토그래피 |
| SG11201407809QA (en) * | 2012-05-31 | 2014-12-30 | Agency Science Tech & Res | Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities |
| DK2864346T3 (en) * | 2012-06-21 | 2019-02-04 | Synthon Biopharmaceuticals Bv | Method of purifying an antibody. |
| EP3116891B1 (en) | 2014-03-10 | 2020-02-12 | Richter Gedeon Nyrt. | Immunoglobulin purification using pre-cleaning steps |
-
2015
- 2015-03-09 EP EP15708522.6A patent/EP3116891B1/en active Active
- 2015-03-09 WO PCT/EP2015/054862 patent/WO2015135884A1/en not_active Ceased
- 2015-03-09 CN CN201580012972.5A patent/CN106103465B/zh active Active
- 2015-03-09 JP JP2016544089A patent/JP6293907B2/ja active Active
- 2015-03-09 HU HUE15708522A patent/HUE048782T2/hu unknown
- 2015-03-09 PT PT201558368T patent/PT3674310T/pt unknown
- 2015-03-09 FI FIEP20155836.8T patent/FI3674310T3/fi active
- 2015-03-09 CA CA2930350A patent/CA2930350C/en active Active
- 2015-03-09 HR HRP20200711TT patent/HRP20200711T1/hr unknown
- 2015-03-09 DK DK15708522.6T patent/DK3116891T3/da active
- 2015-03-09 ES ES15708522T patent/ES2784749T3/es active Active
- 2015-03-09 KR KR1020167022454A patent/KR101921552B1/ko active Active
- 2015-03-09 DK DK20155836.8T patent/DK3674310T3/da active
- 2015-03-09 LT LTEP15708522.6T patent/LT3116891T/lt unknown
- 2015-03-09 PL PL15708522T patent/PL3116891T3/pl unknown
- 2015-03-09 PT PT157085226T patent/PT3116891T/pt unknown
- 2015-03-09 SI SI201531188T patent/SI3116891T1/sl unknown
- 2015-03-09 US US15/120,359 patent/US10487138B2/en active Active
- 2015-03-09 EP EP20155836.8A patent/EP3674310B1/en active Active
- 2015-03-09 HR HRP20260699TT patent/HRP20260699T1/hr unknown
- 2015-03-09 LT LTEP20155836.8T patent/LT3674310T/lt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10487138B2 (en) | 2019-11-26 |
| LT3674310T (lt) | 2026-07-10 |
| US20170058019A1 (en) | 2017-03-02 |
| HRP20260699T1 (hr) | 2026-07-17 |
| EP3674310B1 (en) | 2026-05-06 |
| DK3674310T3 (da) | 2026-07-20 |
| FI3674310T3 (fi) | 2026-07-13 |
| HUE048782T2 (hu) | 2020-08-28 |
| JP6293907B2 (ja) | 2018-03-14 |
| KR101921552B1 (ko) | 2018-11-23 |
| ES2784749T3 (es) | 2020-09-30 |
| EP3116891B1 (en) | 2020-02-12 |
| CN106103465A (zh) | 2016-11-09 |
| EP3674310A1 (en) | 2020-07-01 |
| LT3116891T (lt) | 2020-03-25 |
| CA2930350C (en) | 2021-04-06 |
| HRP20200711T1 (hr) | 2020-07-24 |
| PT3116891T (pt) | 2020-05-18 |
| SI3116891T1 (sl) | 2020-07-31 |
| KR20160124107A (ko) | 2016-10-26 |
| WO2015135884A1 (en) | 2015-09-17 |
| CA2930350A1 (en) | 2015-09-17 |
| DK3116891T3 (da) | 2020-05-04 |
| JP2017507907A (ja) | 2017-03-23 |
| PT3674310T (pt) | 2026-06-17 |
| EP3116891A1 (en) | 2017-01-18 |
| CN106103465B (zh) | 2021-01-08 |
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| EP3160502B1 (en) | BI-SPECIFIC ANTIBODIES ANTI-IL4-IL13 | |
| HUE054148T2 (hu) | Anti-ORAI1 antitest |