DK3380496T3 - Forbedret proteinproduktion og fremgangsmåder hertil - Google Patents
Forbedret proteinproduktion og fremgangsmåder hertil Download PDFInfo
- Publication number
- DK3380496T3 DK3380496T3 DK16831675.0T DK16831675T DK3380496T3 DK 3380496 T3 DK3380496 T3 DK 3380496T3 DK 16831675 T DK16831675 T DK 16831675T DK 3380496 T3 DK3380496 T3 DK 3380496T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- protein production
- improved protein
- improved
- production
- Prior art date
Links
- 230000014616 translation Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562387578P | 2015-12-23 | 2015-12-23 | |
| US201662308440P | 2016-03-15 | 2016-03-15 | |
| PCT/US2016/067936 WO2017112733A1 (en) | 2015-12-23 | 2016-12-21 | Enhanced protein production and methods thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3380496T3 true DK3380496T3 (da) | 2020-08-24 |
Family
ID=57910120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16831675.0T DK3380496T3 (da) | 2015-12-23 | 2016-12-21 | Forbedret proteinproduktion og fremgangsmåder hertil |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20180371445A1 (da) |
| EP (1) | EP3380496B1 (da) |
| JP (1) | JP6993339B2 (da) |
| KR (1) | KR102826031B1 (da) |
| CN (1) | CN108779154B (da) |
| DK (1) | DK3380496T3 (da) |
| WO (1) | WO2017112733A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| CN111670244B (zh) * | 2018-01-03 | 2023-08-01 | 丹尼斯科美国公司 | 突变的和遗传修饰的芽孢杆菌属细胞及其用于增加蛋白质产生的方法 |
| US11781147B2 (en) | 2018-11-28 | 2023-10-10 | Danisco Us Inc. | Promoter sequences and methods thereof for enhanced protein production in Bacillus cells |
| CN109456929A (zh) * | 2018-12-13 | 2019-03-12 | 江南大学 | 一种产磷脂酶d的重组枯草芽孢杆菌及其应用 |
| WO2020156903A1 (en) | 2019-01-30 | 2020-08-06 | Novozymes A/S | Cognate foldase co-expression |
| WO2021086606A1 (en) * | 2019-10-28 | 2021-05-06 | Danisco Us Inc | Microbial host cells for the production of heterologous cyanuric acid hydrolases and biuret hydrolases |
| US20250034535A1 (en) * | 2021-12-10 | 2025-01-30 | Novozymes A/S | Improved protein production in recombinant bacteria |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264366A (en) | 1984-05-29 | 1993-11-23 | Genencor, Inc. | Protease deficient bacillus |
| US6762039B2 (en) * | 1997-07-15 | 2004-07-13 | Genencor International, Inc. | Bacillus subtillis with an inactivated cysteine protease-1 |
| US6509185B1 (en) | 2000-01-07 | 2003-01-21 | Genencor International, Inc. | Mutant aprE promotor |
| KR100483934B1 (ko) * | 2004-07-23 | 2005-04-19 | 주식회사 비피도 | 비피도박테리움 롱검 mg1 유래 신규 플라스미드를 함유하는 셔틀벡터 |
| JP4096009B2 (ja) * | 2005-10-12 | 2008-06-04 | アサヒビール株式会社 | 組換えタンパクの製造方法 |
| JP5629584B2 (ja) * | 2007-12-21 | 2014-11-19 | ダニスコ・ユーエス・インク | バチルス内での促進されたタンパク質生成 |
| AR076941A1 (es) * | 2009-06-11 | 2011-07-20 | Danisco Us Inc | Cepa de bacillus para una mayor produccion de proteina |
| CN102220366B (zh) * | 2011-04-27 | 2013-12-04 | 南京农业大学 | 通过超量表达comA基因提高枯草芽孢杆菌抗菌肽产量的方法 |
| US20140329309A1 (en) | 2011-12-09 | 2014-11-06 | Danisco Us Inc. | Ribosomal Promoters for Production in Microorganisms |
| KR101724614B1 (ko) * | 2014-05-27 | 2017-04-19 | 주식회사 제노포커스 | 신규 카탈라아제 신호서열 및 이를 이용한 카탈라아제 발현방법 |
| KR101681669B1 (ko) * | 2014-05-27 | 2016-12-02 | 주식회사 제노포커스 | 유전자 침묵에 의한 목적 단백질의 과발현 방법 |
-
2016
- 2016-12-21 US US16/064,710 patent/US20180371445A1/en not_active Abandoned
- 2016-12-21 WO PCT/US2016/067936 patent/WO2017112733A1/en not_active Ceased
- 2016-12-21 JP JP2018533603A patent/JP6993339B2/ja active Active
- 2016-12-21 DK DK16831675.0T patent/DK3380496T3/da active
- 2016-12-21 CN CN201680082390.9A patent/CN108779154B/zh active Active
- 2016-12-21 KR KR1020187021108A patent/KR102826031B1/ko active Active
- 2016-12-21 EP EP16831675.0A patent/EP3380496B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6993339B2 (ja) | 2022-02-21 |
| KR20180088915A (ko) | 2018-08-07 |
| EP3380496B1 (en) | 2020-05-20 |
| EP3380496A1 (en) | 2018-10-03 |
| CN108779154B (zh) | 2022-12-27 |
| KR102826031B1 (ko) | 2025-06-26 |
| WO2017112733A1 (en) | 2017-06-29 |
| JP2019505196A (ja) | 2019-02-28 |
| CN108779154A (zh) | 2018-11-09 |
| US20180371445A1 (en) | 2018-12-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3390444T3 (da) | Anti-tl1a-antigenbindende proteiner og anvendelser deraf | |
| DK3368655T3 (da) | Forbedret proteinekspression og fremgangsmåder dertil | |
| IL252126A0 (en) | Methods for transduction and cell processing | |
| IL254516A0 (en) | Proteins specific for cd137 | |
| DK3283106T3 (da) | Terapeutiske antistoffer og anvendelser deraf | |
| DK3134149T3 (da) | Mikrokanyler og fremgangsmåder til fremstilling deraf | |
| DK3268470T3 (da) | Transposasepolypeptider og anvendelser deraf | |
| DK3229838T3 (da) | Anti-C10orf54-antistoffer og anvendelser deraf | |
| DK3126388T3 (da) | Anti-EGFRvIII-antistoffer og anvendelser deraf | |
| DK3215147T3 (da) | Neurodæmpende norketamin-forbindelser og fremgangsmåder | |
| DK3653221T3 (da) | Anti-pvrig-antistoffer og anvendelsesfremgangsmåder | |
| DK3235830T3 (da) | Interleukin-15-proteinkompleks og anvendelse deraf | |
| DK3218358T3 (da) | Ifluorometyl-aminopyridiner og difluorometyl-aminopyrimidiner | |
| DK3316909T3 (da) | Anti-ntb-a-antistoffer og relaterede sammensætninger og fremgangsmåder | |
| IL257170B (en) | Stable proteins and methods for designing same | |
| DK3113797T3 (da) | Antistoffer, anvendelser og fremgangsmåder | |
| PL3371206T3 (pl) | Sposoby wytwarzania postaci fukozylowanej i niefukozylowanej białka | |
| DK3498292T3 (da) | Uspa2-proteinkonstruktioner og anvendelser deraf | |
| DK3161139T3 (da) | Tlr-4-specifikke aptamerer og anvendelser heraf | |
| DK3322734T3 (da) | Multivalente og multispecifikke DR5-bindende fusionsproteiner | |
| DK3237432T3 (da) | Proteinfremstilling | |
| DK3478830T3 (da) | Optimerede binucleasefusioner og metoder | |
| DK3265123T3 (da) | Antistoffer, anvendelser og fremgangsmåder | |
| DK3368578T3 (da) | Anti-HtrA1-antistoffer og fremgangsmåder til anvendelse deraf | |
| DK3265641T3 (da) | Stigørenhed og fremgangsmåde |