DK3383385T4 - Melflufen-doseringsregimer for cancer - Google Patents

Melflufen-doseringsregimer for cancer Download PDF

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Publication number
DK3383385T4
DK3383385T4 DK16805792.5T DK16805792T DK3383385T4 DK 3383385 T4 DK3383385 T4 DK 3383385T4 DK 16805792 T DK16805792 T DK 16805792T DK 3383385 T4 DK3383385 T4 DK 3383385T4
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DK
Denmark
Prior art keywords
melflufen
cancer
dosing regimens
regimens
dosing
Prior art date
Application number
DK16805792.5T
Other languages
English (en)
Other versions
DK3383385T3 (da
Inventor
Jakob Lindberg
Original Assignee
Oncopeptides Ab
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55177548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3383385(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Oncopeptides Ab filed Critical Oncopeptides Ab
Application granted granted Critical
Publication of DK3383385T3 publication Critical patent/DK3383385T3/da
Publication of DK3383385T4 publication Critical patent/DK3383385T4/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK16805792.5T 2015-12-01 2016-12-01 Melflufen-doseringsregimer for cancer DK3383385T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1521217.8A GB201521217D0 (en) 2015-12-01 2015-12-01 Dosage regimens
PCT/EP2016/079511 WO2017093443A1 (en) 2015-12-01 2016-12-01 Melflufen dosage regimens for cancer

Publications (2)

Publication Number Publication Date
DK3383385T3 DK3383385T3 (da) 2020-10-12
DK3383385T4 true DK3383385T4 (da) 2023-11-06

Family

ID=55177548

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16805792.5T DK3383385T4 (da) 2015-12-01 2016-12-01 Melflufen-doseringsregimer for cancer

Country Status (27)

Country Link
US (3) US20180369141A1 (da)
EP (3) EP3383385B2 (da)
JP (2) JP6878431B2 (da)
KR (2) KR102279629B1 (da)
CN (1) CN108289876A (da)
AU (2) AU2016363591B2 (da)
BR (1) BR112018010012A8 (da)
CA (1) CA3003102C (da)
CY (1) CY1123469T1 (da)
DK (1) DK3383385T4 (da)
ES (1) ES2828033T5 (da)
FI (1) FI3383385T4 (da)
GB (1) GB201521217D0 (da)
HR (1) HRP20201632T4 (da)
HU (1) HUE051525T2 (da)
IL (2) IL301019B2 (da)
LT (1) LT3383385T (da)
MX (2) MX384724B (da)
PL (1) PL3383385T5 (da)
PT (1) PT3383385T (da)
RS (1) RS60986B2 (da)
RU (2) RU2020134307A (da)
SG (1) SG11201803551YA (da)
SI (1) SI3383385T2 (da)
SM (1) SMT202000567T1 (da)
WO (1) WO2017093443A1 (da)
ZA (2) ZA201802816B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7603199B2 (ja) * 2018-10-18 2024-12-20 オンコペプティデス・イノベーション・エービー 重水素を含有する化合物
IL321343A (en) * 2019-01-28 2025-08-01 Sanofi Sa Methods of treating multiple myeloma
WO2020201542A1 (en) * 2019-04-03 2020-10-08 Oncopeptides Ab Treatment of al amyloidosis with melflufen
GB201905477D0 (en) * 2019-04-17 2019-05-29 Oncopeptides Ab Novel formulations
WO2021053185A1 (en) * 2019-09-20 2021-03-25 Oncopeptides Ab Melflufen formulations and their use in the treatment or prophylaxis of osteosarcoma
SE544998C2 (en) * 2021-01-13 2023-02-21 Bkmdcl Ab Peptide conjugates of melphalan for the treatment of cancer
WO2023281007A1 (en) * 2021-07-08 2023-01-12 Oncopeptides Ab Melflufen for use in the treatment of multiple myeloma

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0002202D0 (sv) * 2000-06-13 2000-06-13 Karolinska Innovations Ab New peptides
SI2701720T1 (sl) 2011-04-28 2017-11-30 Oncopeptides Ab Liofilizirani pripravek citotoksičnih dipeptidov
US10042382B2 (en) 2012-10-22 2018-08-07 Parker Hannifin Manufacturing Sweden Ab Joystick
WO2014065751A1 (en) 2012-10-26 2014-05-01 Oncopeptides Ab Lyophilized preparations of melphalan flufenamide
EP2983654B1 (en) * 2013-04-08 2025-11-12 BPGbio, Inc. Treatment of cancer using coenzyme q10 combination therapies

Also Published As

Publication number Publication date
MX2021008738A (es) 2021-08-24
RS60986B1 (sr) 2020-11-30
RS60986B2 (sr) 2023-12-29
KR102279629B1 (ko) 2021-07-20
JP2019501881A (ja) 2019-01-24
ES2828033T5 (es) 2024-04-04
SI3383385T1 (sl) 2020-11-30
HRP20201632T1 (hr) 2021-01-08
US20220047507A1 (en) 2022-02-17
RU2018123718A (ru) 2020-01-09
GB201521217D0 (en) 2016-01-13
US20250144023A1 (en) 2025-05-08
AU2021200436A1 (en) 2021-02-25
HRP20201632T4 (hr) 2023-11-10
CN108289876A (zh) 2018-07-17
IL301019B1 (en) 2025-08-01
AU2016363591A1 (en) 2018-06-28
CY1123469T1 (el) 2022-03-24
RU2020134307A (ru) 2020-11-27
BR112018010012A2 (pt) 2018-11-21
ZA201802816B (en) 2021-07-28
MX384724B (es) 2025-03-14
KR20210092327A (ko) 2021-07-23
SG11201803551YA (en) 2018-05-30
US20180369141A1 (en) 2018-12-27
BR112018010012A8 (pt) 2019-02-26
JP6878431B2 (ja) 2021-05-26
ES2828033T3 (es) 2021-05-25
AU2016363591B2 (en) 2020-12-10
EP3750534A1 (en) 2020-12-16
LT3383385T (lt) 2020-12-28
FI3383385T4 (fi) 2023-11-01
ZA202102438B (en) 2025-08-27
JP2021088560A (ja) 2021-06-10
MX2018006706A (es) 2018-08-01
SI3383385T2 (sl) 2024-01-31
EP3903777A1 (en) 2021-11-03
CA3003102C (en) 2022-09-13
IL259101A (en) 2018-06-28
KR20180087254A (ko) 2018-08-01
IL301019B2 (en) 2025-12-01
EP3383385B1 (en) 2020-07-29
CA3003102A1 (en) 2017-06-08
EP3383385B2 (en) 2023-09-06
RU2734930C2 (ru) 2020-10-26
PT3383385T (pt) 2020-10-26
PL3383385T3 (pl) 2021-05-04
WO2017093443A1 (en) 2017-06-08
NZ742548A (en) 2023-10-27
DK3383385T3 (da) 2020-10-12
PL3383385T5 (pl) 2023-12-18
HUE051525T2 (hu) 2021-03-01
RU2018123718A3 (da) 2020-04-02
IL301019A (en) 2023-05-01
SMT202000567T1 (it) 2020-11-10
EP3383385A1 (en) 2018-10-10

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