DK3383436T3 - Forbedret fremgangsmåde til fremstilling af indocyaningrønt - Google Patents
Forbedret fremgangsmåde til fremstilling af indocyaningrønt Download PDFInfo
- Publication number
- DK3383436T3 DK3383436T3 DK16870081.3T DK16870081T DK3383436T3 DK 3383436 T3 DK3383436 T3 DK 3383436T3 DK 16870081 T DK16870081 T DK 16870081T DK 3383436 T3 DK3383436 T3 DK 3383436T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- improved process
- indocyanine green
- indocyanine
- green
- Prior art date
Links
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 title 1
- 229960004657 indocyanine green Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
- A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0071—Process features in the making of dyestuff preparations; Dehydrating agents; Dispersing agents; Dustfree compositions
- C09B67/0092—Dyes in solid form
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0096—Purification; Precipitation; Filtration
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4536MU2015 | 2015-12-01 | ||
| PCT/IB2016/057178 WO2017093889A1 (en) | 2015-12-01 | 2016-11-29 | An improved process for the preparation of indocyanine green |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3383436T3 true DK3383436T3 (da) | 2023-11-20 |
Family
ID=58796411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16870081.3T DK3383436T3 (da) | 2015-12-01 | 2016-11-29 | Forbedret fremgangsmåde til fremstilling af indocyaningrønt |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10287436B2 (da) |
| EP (1) | EP3383436B1 (da) |
| JP (1) | JP2018538428A (da) |
| KR (1) | KR102786409B1 (da) |
| AU (1) | AU2016362673A1 (da) |
| CA (1) | CA3007062A1 (da) |
| DK (1) | DK3383436T3 (da) |
| WO (1) | WO2017093889A1 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017093866A2 (en) * | 2015-12-01 | 2017-06-08 | Dishman Pharmaceuticals And Chemicals Limited | An improved process for the preparation of indigo carmine |
| US20190337896A1 (en) * | 2018-05-02 | 2019-11-07 | Biophore India Pharmaceuticals Pvt. Ltd. | PROCESS FOR THE PREPARATION OF SODIUM 4-(2-((1E,3E,5E,7Z)-7-(1,1-DIMETHYL-3-(4-SULFONATOBUTYL)-1H-BENZO[e]INDOL-2(3H)-YLIDENE) HEPTA-1,3,5-TRIENYL)-1,1-DIMETHYL-1H-BENZO[e]INDOLIUM-3-YL) BUTANE-1-SULFONATE (INDOCYANINE GREEN) |
| CN110885570B (zh) * | 2019-12-16 | 2021-05-25 | 常州工程职业技术学院 | 一种近红外染料的制备方法 |
| WO2022021072A1 (zh) * | 2020-07-28 | 2022-02-03 | 北京数字精准医疗科技有限公司 | 吲哚菁绿酸三乙胺盐的制备方法 |
| CN112638873B (zh) * | 2020-12-01 | 2023-07-14 | 珠海市迪谱医疗科技有限公司 | 吲哚菁绿的精制方法 |
| US20240165275A1 (en) | 2021-03-17 | 2024-05-23 | Provepharm Life Solutions | Stable formulations of indocyanine green |
| EP4308082A1 (en) | 2021-03-17 | 2024-01-24 | Provepharm Life Solutions | Stable formulations of indocyanine green |
| JP2024510501A (ja) | 2021-03-17 | 2024-03-07 | プルーヴファーム・ライフ・ソリューションズ | インドシアニングリーンの安定な処方物 |
| IT202100006794A1 (it) * | 2021-03-22 | 2022-09-22 | Icrom Srl | Processo per preparare il verde indocianina |
| EP4314168A1 (en) * | 2021-03-22 | 2024-02-07 | Icrom Srl | Solid composition of indocyanine green and sodium fluorescein |
| CN113332428B (zh) * | 2021-05-31 | 2022-08-30 | 南京诺源医疗器械有限公司 | 一种基于吲哚三碳菁结构的小分子在制备肿瘤光热治疗药物中的应用 |
| KR102635160B1 (ko) | 2021-06-14 | 2024-02-13 | 농심태경 주식회사 | 아몬드 단백질 발효물 및 콩 단백의 효소 반응물을 주 단백질원으로 함유하는 식물성 치즈 및 그의 제조방법 |
| CN119677818A (zh) | 2022-05-06 | 2025-03-21 | 普如制药生命解决方案公司 | 结晶态吲哚菁绿及其制备方法 |
| EP4543990A1 (en) * | 2022-06-23 | 2025-04-30 | The Children's Medical Center Corporation | Indocyanine green (icg) modification for treatment of liver cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE580869A (da) | 1957-06-05 | |||
| FR2710060B1 (fr) * | 1993-09-17 | 1995-11-17 | Rech Biolog Et | Procédé de préparation de benz[e]indoles substitués de pureté élevée et leurs sels alcalins. |
| JP2000095758A (ja) * | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
| ATE284433T1 (de) * | 1999-07-02 | 2004-12-15 | Visen Medical Inc | Fluorescierende cyaninlabels mit einem sulphamidobrückenglied |
| DE102005025560A1 (de) | 2005-06-01 | 2006-12-07 | Pulsion Medical Systems Ag | Verfahren zur Aufreinigung von Betainen |
| FR2889700B1 (fr) * | 2005-08-11 | 2012-11-23 | Synthinnove Lab | Marqueurs, leur procede de fabrication et leurs applications |
| US20080181965A1 (en) | 2006-04-10 | 2008-07-31 | Leon Jeffrey W | Loaded latex optical molecular imaging probes |
| WO2014165216A1 (en) | 2013-03-12 | 2014-10-09 | The Trustees Of The University Of Pennsylvania | Diagnosing and treating cancer |
| US9329185B2 (en) * | 2013-03-15 | 2016-05-03 | University Of Massachusetts | Sulfonate compounds |
| EP2943584B1 (en) | 2013-05-30 | 2019-08-14 | Canon Kabushiki Kaisha | Macrophage identification agent, and identification method, sorting method, evaluation method, screening method and kit using the macrophage identifier agent |
| CN104130178A (zh) * | 2014-06-30 | 2014-11-05 | 辽宁天医生物制药股份有限公司 | 一种药用吲哚菁绿的工业化合成方法 |
-
2016
- 2016-11-29 DK DK16870081.3T patent/DK3383436T3/da active
- 2016-11-29 KR KR1020187018918A patent/KR102786409B1/ko active Active
- 2016-11-29 US US15/780,555 patent/US10287436B2/en active Active
- 2016-11-29 AU AU2016362673A patent/AU2016362673A1/en not_active Abandoned
- 2016-11-29 CA CA3007062A patent/CA3007062A1/en not_active Abandoned
- 2016-11-29 WO PCT/IB2016/057178 patent/WO2017093889A1/en not_active Ceased
- 2016-11-29 JP JP2018548295A patent/JP2018538428A/ja active Pending
- 2016-11-29 EP EP16870081.3A patent/EP3383436B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180087413A (ko) | 2018-08-01 |
| WO2017093889A1 (en) | 2017-06-08 |
| US20180346728A1 (en) | 2018-12-06 |
| JP2018538428A (ja) | 2018-12-27 |
| EP3383436B1 (en) | 2023-08-30 |
| KR102786409B1 (ko) | 2025-03-24 |
| CA3007062A1 (en) | 2017-06-08 |
| EP3383436A4 (en) | 2019-07-03 |
| AU2016362673A1 (en) | 2018-06-28 |
| US10287436B2 (en) | 2019-05-14 |
| EP3383436A1 (en) | 2018-10-10 |
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