DK338379A - Pyrazinderivater og fremgangsmaade til deres fremstilling - Google Patents

Pyrazinderivater og fremgangsmaade til deres fremstilling

Info

Publication number
DK338379A
DK338379A DK338379A DK338379A DK338379A DK 338379 A DK338379 A DK 338379A DK 338379 A DK338379 A DK 338379A DK 338379 A DK338379 A DK 338379A DK 338379 A DK338379 A DK 338379A
Authority
DK
Denmark
Prior art keywords
procedures
preparation
pyrazine derivatives
pyrazine
derivatives
Prior art date
Application number
DK338379A
Other languages
English (en)
Inventor
R A Appleton
D Johnston
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of DK338379A publication Critical patent/DK338379A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK338379A 1978-08-15 1979-08-13 Pyrazinderivater og fremgangsmaade til deres fremstilling DK338379A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7833431 1978-08-15
GB7848348 1978-12-13

Publications (1)

Publication Number Publication Date
DK338379A true DK338379A (da) 1980-02-16

Family

ID=26268543

Family Applications (1)

Application Number Title Priority Date Filing Date
DK338379A DK338379A (da) 1978-08-15 1979-08-13 Pyrazinderivater og fremgangsmaade til deres fremstilling

Country Status (9)

Country Link
US (1) US4296114A (da)
EP (1) EP0008864A1 (da)
AU (1) AU4985379A (da)
DK (1) DK338379A (da)
FI (1) FI792507A7 (da)
GR (1) GR69706B (da)
IL (1) IL58038A0 (da)
NO (1) NO792653L (da)
PT (1) PT70064A (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030795A3 (en) * 1979-12-06 1981-09-09 Imperial Chemical Industries Plc Quinoxaline derivatives, processes therefor, pharmaceutical compositions, and benzene derivatives
DE3032994A1 (de) * 1980-09-02 1982-04-22 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyrazino-azepine, deren herstellung und diese sie enthaltende arzneimittel
JPS62198671A (ja) * 1986-02-25 1987-09-02 Toyo Jozo Co Ltd １−置換アルキル１，２−ジヒドロ−２−ピラジノン誘導体
JPS62281878A (ja) * 1986-02-26 1987-12-07 Taisho Pharmaceut Co Ltd アザアントラセン化合物
JPH0678319B2 (ja) * 1986-03-11 1994-10-05 東ソー株式会社 キノキサリノン誘導体
JPS6450868A (en) * 1987-08-21 1989-02-27 Toyo Jozo Kk 1-substituted alkyl-2-oxo-1,2-dihydroquinoxaline derivative
JPH0276860A (ja) * 1987-10-05 1990-03-16 Toyo Jozo Co Ltd ６−置換アルコキシ−２−オキソ−１，２−ジヒドロキノキサリン誘導体
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
GB9413975D0 (en) * 1994-07-11 1994-08-31 Fujisawa Pharmaceutical Co New heterobicyclic derivatives
AU9049391A (en) * 1990-12-20 1992-07-22 Warner-Lambert Company 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
FR2696456B1 (fr) * 1992-10-07 1995-01-06 Pf Medicament Dérivés de dihydro-1,2 oxo amino-3 quinoxalines, leur préparation et leur application en thérapeutique.
DE4340045A1 (de) * 1993-11-24 1995-06-01 Basf Ag Neue Chinoxaline und Arzneimittel daraus
IL112235A (en) * 1994-01-03 2000-06-29 Acea Pharm Inc 1,4-dihydro-pyrido¬2,3-b¾pyrazine-2,3-dione (5 or 8) oxide derivatives and pharmaceutical compositions containing them
GB2291422A (en) * 1994-07-18 1996-01-24 Fujisawa Pharmaceutical Co 4-phenyl-pyrido[2,3-b]pyrazin-4-ones
FR2731221B1 (fr) * 1995-03-01 1997-05-30 Pf Medicament Nouveaux derives de l'ethyl-1 dihydro-1, 2 oxo-2 methylamino-3 quinoxaline, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant
GB9526558D0 (en) * 1995-12-27 1996-02-28 Fujisawa Pharmaceutical Co Heterobicyclic derivatives
ZA973884B (en) * 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
EP1380298A3 (en) * 1996-05-23 2004-04-07 Bristol-Myers Squibb Pharma Company Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders, anorexia, inflammation
US5869487A (en) * 1996-10-24 1999-02-09 Merck & Co., Inc. Pyrido 3,4-B!pyrazines for use as thrombin inhibitors
US6087373A (en) * 1997-09-23 2000-07-11 Merck & Co., Inc. Thrombin inhibitors
AU5758199A (en) * 1998-09-29 2000-04-17 Fujisawa Pharmaceutical Co., Ltd. Novel salts of pyridopyrazine compound and crystals thereof
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
CA2374654A1 (en) 1999-06-04 2000-12-14 Merck & Co., Inc. Thrombin inhibitors
WO2002092090A1 (en) * 2001-05-14 2002-11-21 Bristol-Myers Squibb Pharma Company Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands
SE0302324D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302323D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
EP1670774A1 (en) * 2003-09-30 2006-06-21 Janssen Pharmaceutica N.V. Quinoxaline compounds
CA2543710A1 (en) * 2003-11-03 2005-05-12 Warner-Lambert Company Llc Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders
WO2005067932A1 (en) * 2004-01-06 2005-07-28 Janssen Pharmaceutica, N.V. (3-oxo-3, 4-dihydro-quinoxalin-2-yl-amino) -benzamide derivatives and related compound as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity
JP2008509212A (ja) * 2004-08-09 2008-03-27 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 中枢神経系障害の治療のための新規なキノキサリノンノルエピネフリン再吸収阻害剤
US7601716B2 (en) 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
TW200808771A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
DE102007050673A1 (de) 2007-10-19 2009-04-23 Friedrich-Schiller-Universität Jena Neue Hexaaza-acene und Verfahren zu ihrer Herstellung
WO2009061271A1 (en) 2007-11-06 2009-05-14 Astrazeneca Ab Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
AU2009221213B2 (en) 2008-03-05 2014-02-27 Merck Patent Gmbh Pyridopyrazinones derivatives insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes
WO2009109259A1 (en) 2008-03-05 2009-09-11 Merck Patent Gmbh Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
JP5548685B2 (ja) 2009-06-26 2014-07-16 イハラケミカル工業株式会社 ケトマロン酸化合物又はその抱水体の製造法
AU2010302420B2 (en) 2009-10-02 2013-07-04 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase
JP5921500B2 (ja) 2013-07-19 2016-05-24 イハラケミカル工業株式会社 ケトマロン酸化合物の製造方法
EP3109227B1 (en) 2014-02-17 2020-04-08 Kumiai Chemical Industry Co., Ltd. Method for continuously producing ketomalonic acid compound using flow reactor
ES2909316T3 (es) 2015-12-24 2022-05-06 Univ California Reguladores de CFTR y métodos de uso de los mismos
RU2730855C2 (ru) * 2015-12-24 2020-08-26 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа Кфтр регуляторы и способы их применения
KR20200044873A (ko) 2017-08-24 2020-04-29 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 안구 제약학적 조성물
WO2026088070A1 (en) * 2024-10-24 2026-04-30 Pfizer Inc. Compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1189552B (de) * 1959-07-03 1965-03-25 Donau Pharmazie Ges M B H Verfahren zur Herstellung von 2-Oxo-1, 2-dihydrochinoxalinen und von deren Salzen und quaternaeren Ammoniumverbindungen
US4077955A (en) * 1977-02-17 1978-03-07 E. R. Squibb & Sons, Inc. Amino derivatives of 1,2,3,4-tetrahydro-2-oxopyrido[2,2-b]-pyrazine carboxylic acids and esters

Also Published As

Publication number Publication date
NO792653L (no) 1980-02-18
PT70064A (en) 1979-09-01
AU4985379A (en) 1980-02-21
FI792507A7 (fi) 1981-01-01
US4296114A (en) 1981-10-20
GR69706B (da) 1982-07-09
EP0008864A1 (en) 1980-03-19
IL58038A0 (en) 1979-12-30

Similar Documents

Publication Publication Date Title
NO781130L (no) Cephemderivater og fremgangsmaate til deres fremstilling
DK297076A (da) Phenyleddikesyrederivater og fremgangsmade til deres fremstilling
NO150634C (no) Sementholdige blandinger og fremgangsmaate for deres fremstilling
DK148576A (da) Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling
NO790626L (no) Nye antigenderivater og fremgangsmaate til deres fremstilling
DK83679A (da) Eddikesyrederivater og fremgangsmaade til deres fremstilling
DK170679A (da) Isoquinolinderivater deres fremstilling og anvendelser
NO790934L (no) 2,6-dialkoksybenzamider og fremgangsmaate til deres fremstilling
DK401882A (da) Cyclopentadienderivater og fremgangsmaader til deres fremstilling
DK582578A (da) 2,4-thiazolidindion-derivater og fremgangsmaade til deres fremstilling
DK308878A (da) Aminoglyosidderivater og fremgangsmaader til deres fremstilling
DK270077A (da) 6,7-benzomorphanderivater og fremgangsmade til deres fremstillling
DK21579A (da) 5-phenethyl-2-oxazolidon-derivater og fremgangsmaade til deres fremstilling
NO790047L (no) Kompoundmaterialer og fremgangsmaate til deres fremstilling
DK334079A (da) Anthraquinon-derivater og fremgangsmaade til deres fremstilling
DK161377A (da) Naphtyridinderivater og fremgangsmade til deres fremstilling
DK341576A (da) Homophthalimider og fremgangsmade til deres fremstilling
DK118879A (da) 2-hydroxymethyl-pyrazin-derivater og fremgangsmaade til deres fremstilling
DK416278A (da) 2-oxazolidon-derivater og fremgangsmaade til deres fremstilling
NO821206L (no) Imidazolderivater og fremgangsmaate for deres fremstilling
DK24280A (da) Spiro-quinolylhydantoiner fremgangsmaade til deres fremstilling og deres anvendelse
DK131379A (da) Steroid-spiro-oxazolderivater deres fremstilling og anvendelse
DK566978A (da) Phosphoramidothioat-derivater deres fremstilling og anvendelse
DK329078A (da) Oleandomycinderivater og fremgangsmaade til deres fremstilling
DK73579A (da) Nitrosourinstofderivater isaer n1-glucofurasosid 6-yl-n3nitrosourinsoffer og fremgangsmaade til fremstilling deraf