DK3383845T3 - Fremstilling af latanoprostenbunod af ønsket, foruddefineret kvalitet ved hjælp af gravitationskromatografi - Google Patents

Fremstilling af latanoprostenbunod af ønsket, foruddefineret kvalitet ved hjælp af gravitationskromatografi Download PDF

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Publication number
DK3383845T3
DK3383845T3 DK16822513.4T DK16822513T DK3383845T3 DK 3383845 T3 DK3383845 T3 DK 3383845T3 DK 16822513 T DK16822513 T DK 16822513T DK 3383845 T3 DK3383845 T3 DK 3383845T3
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DK
Denmark
Prior art keywords
latanoprosten
bunod
preparation
predefined quality
gravity chromatography
Prior art date
Application number
DK16822513.4T
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English (en)
Inventor
Péter Buzder-Lantos
Ibolya Fekete
Gábor Havasi
Irén Hortobágyi
Zsuzsanna Kardos
István Lászlófi
László Takács
Original Assignee
Euroapi Hungary Llc
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Publication date
Application filed by Euroapi Hungary Llc filed Critical Euroapi Hungary Llc
Application granted granted Critical
Publication of DK3383845T3 publication Critical patent/DK3383845T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK16822513.4T 2015-12-04 2016-11-11 Fremstilling af latanoprostenbunod af ønsket, foruddefineret kvalitet ved hjælp af gravitationskromatografi DK3383845T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1500594A HU231175B1 (hu) 2015-12-04 2015-12-04 Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával
PCT/HU2016/000071 WO2017093771A1 (en) 2015-12-04 2016-11-11 Preparation of latanoprostene bunod of desired, pre-defined quality by gravity chromatography

Publications (1)

Publication Number Publication Date
DK3383845T3 true DK3383845T3 (da) 2023-10-16

Family

ID=89984412

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16822513.4T DK3383845T3 (da) 2015-12-04 2016-11-11 Fremstilling af latanoprostenbunod af ønsket, foruddefineret kvalitet ved hjælp af gravitationskromatografi

Country Status (18)

Country Link
US (1) US10487051B2 (da)
EP (1) EP3383845B1 (da)
JP (1) JP7050673B2 (da)
KR (1) KR102688945B1 (da)
CN (1) CN108779069B (da)
AU (1) AU2016364014B2 (da)
BR (1) BR112018011212B1 (da)
DK (1) DK3383845T3 (da)
ES (1) ES2959590T3 (da)
FI (1) FI3383845T3 (da)
HR (1) HRP20231317T1 (da)
HU (2) HU231175B1 (da)
LT (1) LT3383845T (da)
PL (1) PL3383845T3 (da)
PT (1) PT3383845T (da)
RU (1) RU2726408C2 (da)
TW (1) TWI724072B (da)
WO (1) WO2017093771A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102069205B1 (ko) * 2017-08-09 2020-01-22 연성정밀화학(주) 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체
US11332433B2 (en) 2020-07-24 2022-05-17 Chirogate International Inc. Process for the preparation of latanoprostene bunod and intermediate thereof and compositions comprising the same
CN115322094B (zh) * 2021-01-27 2026-04-17 Agc株式会社 他氟前列素的纯化方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU461731A1 (ru) * 1974-04-12 1975-02-28 1-Й Московский Ордена Ленина И Ордена Трудового Красного Знамени Медицинский Институт Им. И.М. Сеченова Способ получени простагландинов
US4118584A (en) * 1977-04-11 1978-10-03 The Upjohn Company 9-Deoxy-9-methylene-16-phenyl-PGF compounds
JPS59122463A (ja) * 1982-12-28 1984-07-14 Teijin Ltd 7―置換プロスタグランジン類
US7166730B2 (en) * 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
GB0112699D0 (en) 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
ES2767136T3 (es) * 2004-01-05 2020-06-16 Nicox Sa Derivados de prostaglandinas
US7705040B2 (en) * 2005-10-07 2010-04-27 The University Of Hong Kong Reagents for highly specific detection of peroxynitrite
KR101045935B1 (ko) * 2009-03-11 2011-07-01 연성정밀화학(주) 프로스타글란딘 유도체의 제조방법
HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására

Also Published As

Publication number Publication date
HUE063228T2 (hu) 2024-01-28
KR102688945B1 (ko) 2024-07-25
HUP1500594A2 (en) 2017-06-28
TWI724072B (zh) 2021-04-11
WO2017093771A1 (en) 2017-06-08
JP2019501146A (ja) 2019-01-17
CN108779069B (zh) 2021-07-27
PT3383845T (pt) 2023-11-13
RU2018124293A (ru) 2020-01-14
CN108779069A (zh) 2018-11-09
US20190002405A1 (en) 2019-01-03
JP7050673B2 (ja) 2022-04-08
EP3383845B1 (en) 2023-07-12
CA3007160A1 (en) 2017-06-08
RU2726408C2 (ru) 2020-07-14
BR112018011212B1 (pt) 2024-02-27
AU2016364014A1 (en) 2018-07-19
HU231175B1 (hu) 2021-06-28
HK1255130A1 (en) 2019-08-09
BR112018011212A2 (pt) 2018-11-21
AU2016364014B2 (en) 2021-04-01
TW201731814A (zh) 2017-09-16
FI3383845T3 (fi) 2023-10-09
PL3383845T3 (pl) 2024-02-05
ES2959590T3 (es) 2024-02-27
HRP20231317T1 (hr) 2024-02-02
LT3383845T (lt) 2023-11-27
RU2018124293A3 (da) 2020-02-28
US10487051B2 (en) 2019-11-26
EP3383845A1 (en) 2018-10-10
KR20180101360A (ko) 2018-09-12

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