DK3402821T5 - Psma-bindende antistof og anvendelser deraf - Google Patents

Psma-bindende antistof og anvendelser deraf Download PDF

Info

Publication number: DK3402821T5
Authority: DK; Denmark
Prior art keywords: psma; binding antibodies; antibodies; binding
Prior art date: 2016-01-14

Application number

DK17701290.3T

Other languages

English (en)

Other versions

DK3402821T3 (da

Inventor

Helmut Salih

Fabian Vogt

Gundram Jung

Latifa Zekri-Metref

Original Assignee

Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts

Univ Eberhard Karls Tuebingen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-01-14

Filing date

2017-01-16

Publication date

2024-09-23

2017-01-16 Application filed by Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, Univ Eberhard Karls Tuebingen filed Critical Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts

2023-11-06 Publication of DK3402821T3 publication Critical patent/DK3402821T3/da

2024-09-23 Application granted granted Critical

2024-09-23 Publication of DK3402821T5 publication Critical patent/DK3402821T5/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001194—Prostate specific antigen [PSA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001195—Prostate specific membrane antigen [PSMA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/884—Vaccine for a specifically defined cancer prostate
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Cell Biology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Microbiology (AREA)
Developmental Biology & Embryology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Reproductive Health (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK17701290.3T 2016-01-14 2017-01-16 Psma-bindende antistof og anvendelser deraf DK3402821T5 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP16151281.9A EP3192810A1 (en)	2016-01-14	2016-01-14	Psma binding antibody and uses thereof
PCT/EP2017/050834 WO2017121905A1 (en)	2016-01-14	2017-01-16	Psma binding antibody and uses thereof

Publications (2)

Publication Number	Publication Date
DK3402821T3 DK3402821T3 (da)	2023-11-06
DK3402821T5 true DK3402821T5 (da)	2024-09-23

Family

ID=55349634

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK17701290.3T DK3402821T5 (da)	2016-01-14	2017-01-16	Psma-bindende antistof og anvendelser deraf

Country Status (16)

Country	Link
US (3)	US11612646B2 (da)
EP (3)	EP3192810A1 (da)
JP (1)	JP6893939B2 (da)
CN (1)	CN108699157B (da)
AU (2)	AU2017207947B9 (da)
CA (2)	CA3011098A1 (da)
DK (1)	DK3402821T5 (da)
ES (1)	ES2963561T3 (da)
FI (1)	FI3402821T3 (da)
HU (1)	HUE064205T2 (da)
IL (1)	IL260402B2 (da)
PL (1)	PL3402821T3 (da)
PT (1)	PT3402821T (da)
RU (1)	RU2762704C2 (da)
WO (1)	WO2017121905A1 (da)
ZA (1)	ZA201804601B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104203981A (zh) *	2011-12-19	2014-12-10	合成免疫股份有限公司	双特异性抗体分子
EP3192810A1 (en)	2016-01-14	2017-07-19	Deutsches Krebsforschungszentrum	Psma binding antibody and uses thereof
CN119143875A (zh)	2018-06-21	2024-12-17	瑞泽恩制药公司	双特异性抗psma x抗cd28抗体及其用途
JP7137696B2 (ja)	2019-05-14	2022-09-14	プロヴェンション・バイオ・インコーポレイテッド	１型糖尿病を予防するための方法および組成物
KR20230092863A (ko)	2020-06-11	2023-06-26	프로벤션 바이오, 인코포레이티드	제1형 당뇨병을 예방하기 위한 방법 및 조성물
CN116323667A (zh)	2020-07-08	2023-06-23	拉法医疗股份有限公司	结合PSMA和γ-δT细胞受体的抗体
AU2021345124A1 (en)	2020-09-16	2023-03-30	Amgen Inc.	Methods for administering therapeutic doses of bispecific T-cell engaging molecules for the treatment of cancer
CN114349867B (zh) *	2020-10-14	2024-05-28	广东菲鹏制药股份有限公司	融合蛋白及其应用
CN116867519A (zh) *	2020-12-01	2023-10-10	约翰斯霍普金斯大学	治疗t细胞癌症的方法和材料
AU2021390501A1 (en) *	2020-12-01	2023-06-29	Aptevo Research And Development Llc	Heterodimeric psma and cd3-binding bispecific antibodies
CN112480260B (zh) *	2020-12-09	2022-03-08	福州迈新生物技术开发有限公司	抗psma蛋白单克隆抗体、细胞系及其制备方法和应用
CN117580867A (zh) *	2021-01-28	2024-02-20	詹森生物科技公司	Psma结合蛋白及其用途
MX2023008909A (es) *	2021-01-28	2023-10-23	Janssen Biotech Inc	Proteínas de unión a psma y usos de estas.
US20240209115A1 (en)	2021-04-29	2024-06-27	Amgen Inc.	Methods for reducing low molecular weight species of recombinantly-produced proteins
MX2023013851A (es)	2021-05-24	2023-12-08	Provention Bio Inc	Metodos para el tratamiento de diabetes tipo 1.
WO2023183231A1 (en)	2022-03-21	2023-09-28	Amgen Inc.	Combination therapy methods with t-cell engaging molecules for treatment of prostate cancer
CN118922449A (zh) *	2022-04-11	2024-11-08	江苏恒瑞医药股份有限公司	特异性结合psma和cd28的抗原结合分子及其医药用途
TW202442689A (zh)	2023-03-03	2024-11-01	美商亞森諾生物科學公司	靶向ｐｓｍａ及ｃａ９之系統
TW202515907A (zh) *	2023-08-23	2025-04-16	日商明治制果藥業股份有限公司	新穎抗切斷型突變calr-cd3雙特異性抗體及醫藥組合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL85035A0 (en)	1987-01-08	1988-06-30	Int Genetic Eng	Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0590058B1 (en)	1991-06-14	2003-11-26	Genentech, Inc.	HUMANIZED Heregulin ANTIBODy
US6107090A (en) *	1996-05-06	2000-08-22	Cornell Research Foundation, Inc.	Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
US8188231B2 (en)	2002-09-27	2012-05-29	Xencor, Inc.	Optimized FC variants
US20040132101A1 (en)	2002-09-27	2004-07-08	Xencor	Optimized Fc variants and methods for their generation
AU2003210060B2 (en)	2002-03-22	2010-02-25	Aprogen, Inc.	Humanized antibody and process for preparing same
WO2008119567A2 (en)	2007-04-03	2008-10-09	Micromet Ag	Cross-species-specific cd3-epsilon binding domain
PL2155788T3 (pl)	2007-04-03	2013-02-28	Amgen Res Munich Gmbh	Swoiste międzygatunkowe bispecyficzne czynniki wiążące
EP2352763B2 (en) *	2008-10-01	2022-09-21	Amgen Research (Munich) GmbH	Bispecific single chain antibodies with specificity for high molecular weight target antigens
AU2009322167B2 (en) *	2008-12-05	2014-11-20	Molecular Insight Pharmaceuticals, Inc.	Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting PSMA
CN104203981A (zh)	2011-12-19	2014-12-10	合成免疫股份有限公司	双特异性抗体分子
BR112016000666A2 (pt) *	2013-07-12	2017-10-03	Zymeworks Inc	Constructos de ligação de antígeno cd3 e cd19 biespecíficos
JP6693872B2 (ja) *	2013-07-25	2020-05-13	シトムクスセラピューティクス，インコーポレイティド	多重特異性抗体、多重特異性活性化可能抗体、及びそれらの使用方法
WO2015143033A1 (en) *	2014-03-18	2015-09-24	Emergent Product Development Seattle, Llc	Cell line-based redirected t-cell cytotoxicity assay
RS62471B1 (sr)	2014-04-16	2021-11-30	Juno Therapeutics Gmbh	Metode, kompleti i uređaji za proširenje populacije ćelija
EP2985294A1 (en) *	2014-08-14	2016-02-17	Deutsches Krebsforschungszentrum	Recombinant antibody molecule and its use for target cell restricted T cell activation
EP3192810A1 (en)	2016-01-14	2017-07-19	Deutsches Krebsforschungszentrum	Psma binding antibody and uses thereof

2016
- 2016-01-14 EP EP16151281.9A patent/EP3192810A1/en not_active Withdrawn
2017
- 2017-01-16 IL IL260402A patent/IL260402B2/en unknown
- 2017-01-16 AU AU2017207947A patent/AU2017207947B9/en active Active
- 2017-01-16 US US16/069,656 patent/US11612646B2/en active Active
- 2017-01-16 CA CA3011098A patent/CA3011098A1/en active Pending
- 2017-01-16 ES ES17701290T patent/ES2963561T3/es active Active
- 2017-01-16 PT PT177012903T patent/PT3402821T/pt unknown
- 2017-01-16 CN CN201780014034.8A patent/CN108699157B/zh active Active
- 2017-01-16 RU RU2018128414A patent/RU2762704C2/ru active
- 2017-01-16 HU HUE17701290A patent/HUE064205T2/hu unknown
- 2017-01-16 EP EP17701290.3A patent/EP3402821B1/en not_active Revoked
- 2017-01-16 FI FIEP17701290.3T patent/FI3402821T3/fi active
- 2017-01-16 EP EP20162696.7A patent/EP3693396A3/en active Pending
- 2017-01-16 JP JP2018556006A patent/JP6893939B2/ja active Active
- 2017-01-16 DK DK17701290.3T patent/DK3402821T5/da active
- 2017-01-16 WO PCT/EP2017/050834 patent/WO2017121905A1/en not_active Ceased
- 2017-01-16 CA CA3199697A patent/CA3199697A1/en active Pending
- 2017-01-16 PL PL17701290.3T patent/PL3402821T3/pl unknown
2018
- 2018-07-10 ZA ZA2018/04601A patent/ZA201804601B/en unknown
2022
- 2022-09-22 US US17/934,232 patent/US12398208B2/en active Active
2023
- 2023-05-16 AU AU2023203041A patent/AU2023203041A1/en not_active Abandoned
2025
- 2025-07-22 US US19/276,687 patent/US20250346669A1/en active Pending

Also Published As

Publication number	Publication date
US11612646B2 (en)	2023-03-28
AU2017207947B9 (en)	2023-09-21
RU2018128414A3 (da)	2020-10-20
DK3402821T3 (da)	2023-11-06
US20230132249A1 (en)	2023-04-27
FI3402821T3 (fi)	2023-10-26
IL260402B1 (en)	2023-08-01
JP2019505589A (ja)	2019-02-28
CA3199697A1 (en)	2017-07-20
EP3402821B1 (en)	2023-08-23
AU2017207947B2 (en)	2023-09-07
RU2762704C2 (ru)	2021-12-22
EP3402821A1 (en)	2018-11-21
US20250346669A1 (en)	2025-11-13
BR112018014215A2 (pt)	2018-12-26
EP3192810A1 (en)	2017-07-19
PL3402821T3 (pl)	2024-03-04
US12398208B2 (en)	2025-08-26
WO2017121905A1 (en)	2017-07-20
IL260402A (da)	2018-08-30
CA3011098A1 (en)	2017-07-20
NZ744221A (en)	2025-07-25
CN108699157A (zh)	2018-10-23
EP3693396A2 (en)	2020-08-12
RU2018128414A (ru)	2020-02-14
ZA201804601B (en)	2019-04-24
IL260402B2 (en)	2023-12-01
ES2963561T3 (es)	2024-03-27
US20190022205A1 (en)	2019-01-24
AU2023203041A1 (en)	2023-06-08
HUE064205T2 (hu)	2024-02-28
AU2017207947A1 (en)	2018-07-26
PT3402821T (pt)	2023-09-26
EP3693396A3 (en)	2020-10-14
JP6893939B2 (ja)	2021-06-23
CN108699157B (zh)	2022-02-01

Publication	Publication Date	Title
DK3625263T3 (da)	2025-06-30	Anti-galectin- 9-antistoffer og anvendelser deraf
DK3383916T3 (da)	2022-03-28	Anti-CD73-antistoffer og anvendelser deraf
IL262095A (en)	2018-11-29	Anti-pacap antibodies and uses thereof
DK3468990T3 (da)	2024-06-24	Anti-C5-antistoffer og anvendelser deraf
DK3402821T3 (da)	2023-11-06	Psma-bindende antistof og anvendelser deraf
DK3532499T3 (da)	2021-06-28	ANTI-IL-33-antistoffer og anvendelser deraf
DK3443009T3 (da)	2021-12-13	Anti-tim-3-antistoffer og sammensætninger
DK3350220T3 (da)	2021-07-12	Anti-pro/latente-myostatin-antistoffer og anvendelser deraf
DK3458479T3 (da)	2021-02-08	Anti-b7-h3-antistoffer og antistof-lægemiddelkonjugater
DK3596125T3 (da)	2025-12-22	Anti-PAR2-antistoffer og anvendelser deraf
DK3504242T3 (da)	2020-08-17	Anti-ox40-antistoffer og anvendelse deraf
DK3333191T3 (da)	2020-10-26	Anti-C10ORF54-antistoffer og anvendelser deraf
DK3390444T3 (da)	2026-02-23	Anti-tl1a-antigenbindende proteiner og anvendelser deraf
DK3126388T3 (da)	2019-07-29	Anti-EGFRvIII-antistoffer og anvendelser deraf
DK3347379T3 (da)	2020-02-17	Anti-tigit-antistoffer, anti-pvrig-antistoffer og kombinationer deraf
DK3283106T3 (da)	2022-01-10	Terapeutiske antistoffer og anvendelser deraf
DK3365368T3 (da)	2023-06-26	Tgfbeta1-bindende immunoglobuliner og anvendelse deraf
DK3448386T3 (da)	2021-04-26	Isoquinolin-3-ylcarboxamider og fremstilling og anvendelse deraf
DK3149042T3 (da)	2019-11-04	PD-L1-antistoffer og anvendelser deraf
DK3274370T3 (da)	2020-02-17	Anti-ceacam6-antistoffer og anvendelser deraf
DK3316909T3 (da)	2023-11-13	Anti-ntb-a-antistoffer og relaterede sammensætninger og fremgangsmåder
IL263273A (en)	2018-12-31	Anti-gitr antibodies and uses thereof
DK3463435T3 (da)	2021-11-22	Alpha-synuklein-antistoffer og anvendelser deraf
IL271398A (en)	2020-01-30	Anti-l1-cam antibodies and uses thereof
DK3359563T3 (da)	2019-09-30	Antigenreceptorer og anvendelser deraf