DK3409765T3 - Ketoreduktase-medieret stereoselektiv rute til alpha-chloralkoholer - Google Patents
Ketoreduktase-medieret stereoselektiv rute til alpha-chloralkoholer Download PDFInfo
- Publication number
- DK3409765T3 DK3409765T3 DK18185054.6T DK18185054T DK3409765T3 DK 3409765 T3 DK3409765 T3 DK 3409765T3 DK 18185054 T DK18185054 T DK 18185054T DK 3409765 T3 DK3409765 T3 DK 3409765T3
- Authority
- DK
- Denmark
- Prior art keywords
- ketoreductase
- chloral
- alcohols
- alpha
- stereoselective route
- Prior art date
Links
- -1 CHLORAL ALCOHOLS Chemical class 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21916209P | 2009-06-22 | 2009-06-22 | |
| US30305710P | 2010-02-10 | 2010-02-10 | |
| EP10797576.5A EP2446025B1 (en) | 2009-06-22 | 2010-06-22 | Ketoreductase-mediated stereoselective route to alpha chloroalcohols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3409765T3 true DK3409765T3 (da) | 2021-09-27 |
Family
ID=43429767
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10797576.5T DK2446025T3 (da) | 2009-06-22 | 2010-06-22 | : ketoreduktase-medieret stereoselektiv vej til alfa-chloralkoholer |
| DK18185054.6T DK3409765T3 (da) | 2009-06-22 | 2010-06-22 | Ketoreduktase-medieret stereoselektiv rute til alpha-chloralkoholer |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10797576.5T DK2446025T3 (da) | 2009-06-22 | 2010-06-22 | : ketoreduktase-medieret stereoselektiv vej til alfa-chloralkoholer |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US8796002B2 (da) |
| EP (2) | EP2446025B1 (da) |
| CN (1) | CN102482648B (da) |
| DK (2) | DK2446025T3 (da) |
| HU (1) | HUE055413T2 (da) |
| SG (1) | SG177331A1 (da) |
| WO (1) | WO2011005527A2 (da) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011100265A2 (en) | 2010-02-10 | 2011-08-18 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
| CN103044361B (zh) * | 2012-12-30 | 2014-08-06 | 江苏八巨药业有限公司 | 一种（2r,3s）-环氧化氨基苯丁烷的制备方法 |
| CN103435525B (zh) * | 2013-07-25 | 2015-11-18 | 凯莱英医药集团（天津）股份有限公司 | 一种制备依折麦布的方法 |
| CN103468757A (zh) * | 2013-09-18 | 2013-12-25 | 苏州汉酶生物技术有限公司 | 一种阿扎那韦中间体的生物制备方法 |
| ES2653559T3 (es) | 2013-12-11 | 2018-02-07 | F. Hoffmann-La Roche Ag | Procedimiento para la preparación de una 2-(4-aminofenil)morfolina quiral |
| CN107354179B (zh) * | 2016-05-09 | 2021-02-19 | 上海医药工业研究院 | 一种制备含有羟基的手性化合物的方法 |
| CN106011095B (zh) * | 2016-07-27 | 2021-02-26 | 苏州汉酶生物技术有限公司 | 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法 |
| CN107674046B (zh) * | 2016-08-01 | 2022-09-13 | 上海朴颐化学科技有限公司 | 一种阿扎那韦环氧化物中间体的纯化方法 |
| CN106755152B (zh) * | 2017-01-23 | 2020-06-16 | 苏州引航生物科技有限公司 | 一种制备奥格列汀中间体的方法 |
| CN106947791B (zh) * | 2017-03-14 | 2021-05-04 | 四川奇格曼药业有限公司 | 一种利用生物酶催化合成阿扎那韦中间体氯醇的方法 |
| CN109439696A (zh) * | 2017-09-04 | 2019-03-08 | 尚科生物医药（上海）有限公司 | 一种制备（r）-2-氯-1-（3,4-二氟苯基）乙醇的方法 |
| CN109897872B (zh) * | 2017-12-11 | 2023-12-22 | 湖州颐盛生物科技有限公司 | 酶法制备(2s,3s)-n-叔丁氧羰基-3-氨基-1-氯-2-羟基-4-苯基丁烷 |
| CN109957584A (zh) * | 2017-12-25 | 2019-07-02 | 尚科生物医药（上海）有限公司 | 一种用于制备（r）-(4-氯苯基)-2-吡啶甲醇的生物催化方法 |
| WO2019140682A1 (zh) * | 2018-01-22 | 2019-07-25 | 吉林凯莱英医药化学有限公司 | 酮还原酶突变体及其应用 |
| CN108300743B (zh) * | 2018-02-06 | 2021-05-14 | 江苏八巨药业有限公司 | 一种(r)-2-氯-1-(6-氟-苯并二氢吡喃-2-基)-1-乙醇的生物催化方法 |
| CN108484361B (zh) * | 2018-05-11 | 2022-09-30 | 弈柯莱生物科技(上海)股份有限公司 | (s)-4-氯-1-(2,5)-二氟苯基丁-1-醇及其制备方法和应用 |
| CN109097344B (zh) * | 2018-08-07 | 2021-10-22 | 浙江海洋大学 | 一种海洋新鞘脂菌短链醇脱氢酶突变体及其应用 |
| CN109022473B (zh) * | 2018-08-13 | 2021-09-17 | 浙江海洋大学 | 一种酶法制备奥利司他中间体的方法 |
| CN109182410B (zh) * | 2018-09-29 | 2020-10-02 | 台州学院 | 一种(S)-N-Boc-3-羟基哌啶的酶催化制备方法 |
| CN110079564A (zh) * | 2019-04-29 | 2019-08-02 | 上海健康医学院 | 一种催化合成阿扎那韦中间体的方法及其应用 |
| CN112708641A (zh) * | 2019-10-24 | 2021-04-27 | 上海医药工业研究院 | 托莫西汀的化学-酶合成方法 |
| CN110791483B (zh) * | 2019-12-05 | 2022-11-29 | 西南交通大学 | 一种短链还原酶及其制备方法和应用 |
| CN111235123B (zh) * | 2020-03-27 | 2020-10-27 | 长兴制药股份有限公司 | 一种醇溶液高浓度耐受的羰基还原酶及其应用 |
| CN111378703B (zh) * | 2020-03-27 | 2021-05-18 | 长兴制药股份有限公司 | 一种(2s,3s)-2-羟基-4-苯基丁烷衍生物的制备方法 |
| CN111378695B (zh) * | 2020-04-07 | 2023-07-28 | 宁波酶赛生物工程有限公司 | 合成r-3-(2-氯-1-羟基乙基)苯酚的方法、去氧肾上腺素、滴眼剂 |
| CN112322676B (zh) * | 2020-11-10 | 2022-06-07 | 江苏八巨药业有限公司 | 一种酶催化制备氟伐二醇的方法 |
| CN113430240B (zh) * | 2021-06-29 | 2023-07-04 | 华东理工大学 | 一种连续流生物催化合成阿扎那韦中间体氯醇的方法 |
| CN115537405B (zh) * | 2021-06-30 | 2024-04-12 | 尚科生物医药（上海）有限公司 | 一种酮还原酶及其在制备(s)-1-(3-氯苯基)-1,3-丙二醇中的应用 |
| CN113717996B (zh) * | 2021-09-28 | 2023-05-02 | 江苏八巨药业有限公司 | 一种2-脱氧-2,2-二氟-3,5-二苯甲酰基-d-呋喃核糖的生物合成方法 |
| CN113816836B (zh) * | 2021-09-29 | 2024-05-03 | 山东睿鹰制药集团有限公司 | 一种(s)-1-(4-氯苯基)-1,3-丙二醇的酶法生产方法 |
| CN113981013B (zh) * | 2021-12-02 | 2024-02-20 | 上海升华医药科技有限公司 | 一种手性四氢萘-2-醇化合物的生物催化制备方法 |
| CN116515780A (zh) * | 2022-06-30 | 2023-08-01 | 上海合全药业股份有限公司 | 一种羰基还原酶突变体及其应用 |
| CN116200353A (zh) * | 2023-02-01 | 2023-06-02 | 格林生物科技股份有限公司 | 一种羰基还原酶突变体、重组菌及其应用 |
| CN117126823B (zh) * | 2023-09-01 | 2024-03-29 | 华南理工大学 | 一种酮还原酶突变体及其应用 |
| WO2025096445A1 (en) | 2023-10-30 | 2025-05-08 | Alkermes, Inc. | Synthesis of intermediates for the preparation of macrocyclic compounds |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538867A (en) | 1988-09-13 | 1996-07-23 | Elf Aquitaine | Process for the electrochemical regeneration of pyridine cofactors |
| US5570670A (en) | 1991-09-23 | 1996-11-05 | Powell; Brian L. | Two stroke internal combustion engine |
| JP3155107B2 (ja) | 1993-01-12 | 2001-04-09 | ダイセル化学工業株式会社 | 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法 |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| DK0765394T3 (da) | 1994-06-03 | 2001-12-10 | Novozymes As | Oprensede Myceliopthora-laccaser og nukleinsyrer der koder for disse |
| EP1559776A3 (en) | 1994-06-30 | 2006-01-11 | Novozymes Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system and promoters and terminators for use therein |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
| FI104465B (fi) | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
| US5891685A (en) * | 1996-06-03 | 1999-04-06 | Mitsubishi Chemical Corporation | Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid |
| DK1036198T3 (da) | 1997-12-08 | 2013-01-02 | California Inst Of Techn | Fremgangsmåde til fremstilling af polynukleotid- og polypeptidsekvenser |
| US6495023B1 (en) | 1998-07-09 | 2002-12-17 | Michigan State University | Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration |
| DE19857302C2 (de) | 1998-12-14 | 2000-10-26 | Forschungszentrum Juelich Gmbh | Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester |
| JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
| EP1181356B1 (en) | 1999-03-11 | 2005-12-07 | Eastman Chemical Company | Phosphine stabilizers for oxidoreductase enzymes |
| EP1947172B1 (en) | 1999-07-27 | 2012-12-19 | Food Industry Research and Development Institute | Engineering of metabolic control |
| AU1551701A (en) | 1999-12-03 | 2001-06-12 | Kaneka Corporation | Novel carbonyl reductase, gene thereof and method of using the same |
| EP1272967A2 (en) | 2000-03-30 | 2003-01-08 | Maxygen, Inc. | In silico cross-over site selection |
| PL366098A1 (en) * | 2000-08-16 | 2005-01-24 | Bristol-Myers Squibb Company | Stereoselective reduction of substituted oxo-butanes |
| US7202070B2 (en) * | 2000-10-31 | 2007-04-10 | Biocatalytics, Inc. | Method for reductive amination of a ketone using a mutated enzyme |
| US6800477B2 (en) * | 2001-03-22 | 2004-10-05 | Bristol-Myers Squibb Co. | Stereoselective reduction of substituted acetophenone |
| CA2493941A1 (en) | 2002-08-09 | 2004-02-19 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
| EP1654356A1 (en) | 2003-08-11 | 2006-05-10 | Codexis, Inc. | Improved halohydrin dehalogenases and related polynucleotides |
| JP2007502114A (ja) | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド |
| EP1660669A4 (en) | 2003-08-11 | 2008-10-01 | Codexis Inc | ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS |
| EP1654354A1 (en) | 2003-08-11 | 2006-05-10 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
| EP1712633A1 (en) | 2003-12-02 | 2006-10-18 | Mercian Corporation | Process for producing optically active tetrahydrothiophene derivative and method of crystallizing optically active tetrahydrothiophen-3-ol |
| KR20070050461A (ko) | 2004-08-06 | 2007-05-15 | 가부시키가이샤 가네카 | 신규 카르보닐 환원 효소, 그의 유전자 및 그의 이용 방법 |
| US7582468B2 (en) | 2005-05-25 | 2009-09-01 | Bristol-Myers Squibb Company | Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof |
| WO2006130657A2 (en) * | 2005-05-31 | 2006-12-07 | Bristol-Myers Squibb Company | Stereoselective reduction process for the preparation of pyrrolotriazine compounds |
| DE102005028312B4 (de) | 2005-06-18 | 2008-05-08 | Archimica Gmbh | Verfahren zur Herstellung von enantiomerenreinen Epoxiden durch ADH-Reduktion von α-Abgangsgruppen-substituierten Ketonen und Cyclisierung |
| GB0619240D0 (en) | 2006-09-29 | 2006-11-08 | Almac Sciences Ltd | Reduction of alpha-halo ketones |
| US7879585B2 (en) * | 2006-10-02 | 2011-02-01 | Codexis, Inc. | Ketoreductase enzymes and uses thereof |
| TWI601825B (zh) | 2007-09-27 | 2017-10-11 | Ｉｅｐ有限公司 | 對映異構選擇性酶催化還原中間產物之方法 |
| WO2009042984A1 (en) * | 2007-09-28 | 2009-04-02 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| WO2011100265A2 (en) | 2010-02-10 | 2011-08-18 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
-
2010
- 2010-06-22 EP EP10797576.5A patent/EP2446025B1/en active Active
- 2010-06-22 EP EP18185054.6A patent/EP3409765B1/en active Active
- 2010-06-22 SG SG2011095387A patent/SG177331A1/en unknown
- 2010-06-22 HU HUE18185054A patent/HUE055413T2/hu unknown
- 2010-06-22 US US13/378,618 patent/US8796002B2/en active Active
- 2010-06-22 CN CN201080027481.5A patent/CN102482648B/zh active Active
- 2010-06-22 DK DK10797576.5T patent/DK2446025T3/da active
- 2010-06-22 DK DK18185054.6T patent/DK3409765T3/da active
- 2010-06-22 WO PCT/US2010/039511 patent/WO2011005527A2/en not_active Ceased
-
2014
- 2014-06-24 US US14/313,465 patent/US9029112B2/en active Active
-
2015
- 2015-04-27 US US14/697,262 patent/US9296992B2/en active Active
-
2016
- 2016-02-17 US US15/046,011 patent/US9404092B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SG177331A1 (en) | 2012-02-28 |
| EP2446025B1 (en) | 2018-08-08 |
| US8796002B2 (en) | 2014-08-05 |
| US20160160187A1 (en) | 2016-06-09 |
| EP3409765A2 (en) | 2018-12-05 |
| WO2011005527A3 (en) | 2011-05-12 |
| US9296992B2 (en) | 2016-03-29 |
| EP2446025A4 (en) | 2016-04-06 |
| WO2011005527A2 (en) | 2011-01-13 |
| CN102482648A (zh) | 2012-05-30 |
| US20150240217A1 (en) | 2015-08-27 |
| EP3409765B1 (en) | 2021-08-04 |
| US20120190086A1 (en) | 2012-07-26 |
| HUE055413T2 (hu) | 2021-11-29 |
| US20140308732A1 (en) | 2014-10-16 |
| EP3409765A3 (en) | 2019-02-27 |
| US9029112B2 (en) | 2015-05-12 |
| US9404092B2 (en) | 2016-08-02 |
| EP2446025A2 (en) | 2012-05-02 |
| CN102482648B (zh) | 2014-12-10 |
| DK2446025T3 (da) | 2018-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3409765T3 (da) | Ketoreduktase-medieret stereoselektiv rute til alpha-chloralkoholer | |
| IT1395790B1 (it) | Struttura di sella ventilata. | |
| PL2414015T4 (pl) | System laryngoskopowy | |
| EP2430979A4 (en) | Biopsy support system | |
| EP2499580A4 (en) | SOCIAL BROWSING | |
| EP2509515A4 (en) | WITHERS | |
| BR112012000204A2 (pt) | apomorfina sublingual. | |
| DK2401438T3 (da) | Anti-erosionssystem | |
| DK2482768T3 (da) | Intrauterint system | |
| DK2406243T3 (da) | Benzofuranderivat | |
| DK2430196T3 (da) | Fremgangsmåde til fremstilling af alkoholer | |
| HUE042614T2 (hu) | Felnyílómozgató-rendszer | |
| FI20095098A0 (fi) | Putkenkatkaisulaite | |
| EP2417016A4 (en) | SPILL SYSTEM | |
| DK2488872T3 (da) | Fremgangsmåde til prrsv detektering | |
| FR2952847B3 (fr) | > | |
| BRPI1011222A2 (pt) | membrana de camada metálica | |
| DK2491292T3 (da) | Dobbeltrørsystem | |
| AT508315A3 (de) | Solaranlage | |
| DK2494125T3 (da) | Pudsesystem | |
| BR112012000785A2 (pt) | sistema flutuante | |
| IT1394347B1 (it) | Impianto termico | |
| EP2431805A4 (en) | OPTICAL DEMODULATOR | |
| IT1402521B1 (it) | Smussatore | |
| IT1396530B1 (it) | Piscina termale isolata |