DK341181A - Fremgangsmaade til fremstilling af benzodiazepin-derivater eller farmaceutisk acceptable syreadditionssalte deraf samt ved fremgangsmaaden som mellemprodukter anvendelige forbindelser - Google Patents

Fremgangsmaade til fremstilling af benzodiazepin-derivater eller farmaceutisk acceptable syreadditionssalte deraf samt ved fremgangsmaaden som mellemprodukter anvendelige forbindelser

Info

Publication number
DK341181A
DK341181A DK341181A DK341181A DK341181A DK 341181 A DK341181 A DK 341181A DK 341181 A DK341181 A DK 341181A DK 341181 A DK341181 A DK 341181A DK 341181 A DK341181 A DK 341181A
Authority
DK
Denmark
Prior art keywords
procedure
intermediates
preparation
acid addition
addition salts
Prior art date
Application number
DK341181A
Other languages
English (en)
Inventor
Q Branca
A E Fischli
A Szente
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK341181A publication Critical patent/DK341181A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK341181A 1980-07-31 1981-07-30 Fremgangsmaade til fremstilling af benzodiazepin-derivater eller farmaceutisk acceptable syreadditionssalte deraf samt ved fremgangsmaaden som mellemprodukter anvendelige forbindelser DK341181A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH584180 1980-07-31

Publications (1)

Publication Number Publication Date
DK341181A true DK341181A (da) 1982-02-01

Family

ID=4300189

Family Applications (1)

Application Number Title Priority Date Filing Date
DK341181A DK341181A (da) 1980-07-31 1981-07-30 Fremgangsmaade til fremstilling af benzodiazepin-derivater eller farmaceutisk acceptable syreadditionssalte deraf samt ved fremgangsmaaden som mellemprodukter anvendelige forbindelser

Country Status (9)

Country Link
US (1) US4327026A (da)
EP (1) EP0045452A3 (da)
JP (1) JPS5758674A (da)
AU (1) AU7339781A (da)
CA (1) CA1157855A (da)
DK (1) DK341181A (da)
IL (1) IL63406A0 (da)
PH (1) PH17045A (da)
ZA (1) ZA815115B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3431195A1 (de) * 1984-08-24 1986-03-06 Troponwerke GmbH & Co KG, 5000 Köln Neue benzodiazepine, verfahren zu ihrer herstellung sowie ihre verwendung
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
AU666318B2 (en) * 1991-06-28 1996-02-08 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US6403578B1 (en) 1993-12-21 2002-06-11 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US6100254A (en) * 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012151512A2 (en) 2011-05-04 2012-11-08 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2721031B1 (en) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
EP2864336B1 (en) 2012-06-06 2016-11-23 Constellation Pharmaceuticals, Inc. Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof
CA2952830C (en) 2014-06-20 2022-11-01 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL23270A (en) * 1964-04-10 1969-02-27 Hoffmann La Roche Quinazoline derivatives and process for the manufacture and conversion thereof
DE2163622A1 (de) * 1971-12-21 1973-06-28 Standard Elektrik Lorenz Ag Steuerung von wechselspannungsgeraeten
CA1114373A (en) * 1978-08-11 1981-12-15 Albert E. Fischli Benzodiazepine derivatives

Also Published As

Publication number Publication date
US4327026A (en) 1982-04-27
EP0045452A2 (de) 1982-02-10
JPS5758674A (en) 1982-04-08
ZA815115B (en) 1982-08-25
IL63406A0 (en) 1981-10-30
CA1157855A (en) 1983-11-29
AU7339781A (en) 1982-02-04
PH17045A (en) 1984-05-17
EP0045452A3 (de) 1982-03-31

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