DK3423076T3 - Topisk cyclosporinholdige formuleringer og anvendelser deraf - Google Patents
Topisk cyclosporinholdige formuleringer og anvendelser deraf Download PDFInfo
- Publication number
- DK3423076T3 DK3423076T3 DK17760643.1T DK17760643T DK3423076T3 DK 3423076 T3 DK3423076 T3 DK 3423076T3 DK 17760643 T DK17760643 T DK 17760643T DK 3423076 T3 DK3423076 T3 DK 3423076T3
- Authority
- DK
- Denmark
- Prior art keywords
- containing formulations
- topical cyclosporine
- cyclosporine
- topical
- formulations
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662301576P | 2016-02-29 | 2016-02-29 | |
| US201662302058P | 2016-03-01 | 2016-03-01 | |
| US201662302730P | 2016-03-02 | 2016-03-02 | |
| US201662311177P | 2016-03-21 | 2016-03-21 | |
| PCT/US2017/020008 WO2017151657A1 (en) | 2016-02-29 | 2017-02-28 | Topical cyclosporine-containing formulations and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3423076T3 true DK3423076T3 (da) | 2024-07-08 |
Family
ID=59744365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17760643.1T DK3423076T3 (da) | 2016-02-29 | 2017-02-28 | Topisk cyclosporinholdige formuleringer og anvendelser deraf |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US10918694B2 (da) |
| EP (2) | EP4410312A3 (da) |
| JP (3) | JP7072517B2 (da) |
| KR (1) | KR102766771B1 (da) |
| CN (2) | CN119185511A (da) |
| AU (2) | AU2017227585C1 (da) |
| BR (1) | BR112018067946A8 (da) |
| CA (1) | CA3015626A1 (da) |
| DK (1) | DK3423076T3 (da) |
| ES (1) | ES2981702T3 (da) |
| FI (1) | FI3423076T3 (da) |
| IL (1) | IL268056A (da) |
| MX (2) | MX2018010395A (da) |
| NZ (2) | NZ785158A (da) |
| PL (1) | PL3423076T3 (da) |
| PT (1) | PT3423076T (da) |
| RU (1) | RU2747455C2 (da) |
| SA (1) | SA519410114B1 (da) |
| SG (1) | SG11201906729RA (da) |
| WO (1) | WO2017151657A1 (da) |
| ZA (1) | ZA201904704B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2887923T3 (pl) | 2012-08-24 | 2023-08-14 | Sun Pharmaceutical Industries Limited | Preparat okulistyczny polioksylipidu lub polioksylowego kwasu tłuszczowego i leczenie chorób oczu |
| US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
| US20200237859A1 (en) | 2019-01-25 | 2020-07-30 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
| EP3373976B1 (en) | 2015-11-10 | 2024-01-03 | Sun Pharmaceutical Industries Limited | Topical formulations and uses thereof |
| US10918694B2 (en) | 2016-02-29 | 2021-02-16 | Sun Pharma Global Fze | Topical cyclosporine-containing formulations and uses thereof |
| CN112957450A (zh) * | 2019-12-20 | 2021-06-15 | 艾棣维欣(苏州)生物制药有限公司 | 一种难溶性药物的水溶液及其制备方法 |
| AU2022295164A1 (en) | 2021-06-14 | 2024-01-25 | Sun Pharmaceutical Industries Limited | Cyclosporine formulations for use in patients undergoing cataract surgery |
| WO2021224901A2 (en) * | 2021-08-20 | 2021-11-11 | Sun Pharmaceutical Industries Limited | Stable cyclosporine ophthalmic formulation and manufacturing process thereof |
| WO2024042550A1 (en) * | 2022-08-25 | 2024-02-29 | Sentiss Pharma Private Limited | Ophthalmic combination composition |
| JP2025538061A (ja) | 2022-11-04 | 2025-11-26 | クラリス バイオ インコーポレイテッド | クロマカリムの局所眼内送達 |
| EP4719350A1 (en) | 2023-05-29 | 2026-04-08 | Sun Pharmaceutical Industries Limited | Stable cyclosporine ophthalmic formulation and manufacturing process thereof |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69307505T2 (de) | 1992-05-13 | 1997-07-24 | Sandoz-Patent-Gmbh, 79539 Loerrach | Opthalmische zusammensetzungen enthaltend ein cyclosporin |
| NZ247516A (en) | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
| US5484597A (en) | 1993-07-30 | 1996-01-16 | Chesebrough-Pond's Usa Co. | Clear hydroalcholic cosmetic microemulsions |
| NZ280689A (en) | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
| MX9701946A (es) | 1997-03-14 | 1998-04-30 | Arturo Jimenez Bayardo | Solucion oftalmica transportadora. |
| US7678836B2 (en) | 1999-11-04 | 2010-03-16 | Fxs Ventures, Llc | Method for rendering a contact lens wettable |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| US20030176356A1 (en) | 2001-04-24 | 2003-09-18 | University Of North Texas Health Science Center | Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma |
| HRP20040354B1 (en) | 2001-10-19 | 2012-10-31 | Isotechnika Inc. | Novel cyclosporin analog microemulsion preconcentrates |
| WO2004069181A2 (en) | 2003-02-03 | 2004-08-19 | Pharmacia Corporation | Composition for the treatment of intraocular pressure |
| JP2004238346A (ja) | 2003-02-07 | 2004-08-26 | Shiono Chemical Co Ltd | トラニラストの安定な水溶液製剤 |
| WO2004096261A1 (es) | 2003-05-02 | 2004-11-11 | Arturo Jimenez Bayardo | Metodo para preparar una solucion acuosa de ciclosporina-a y solucion acuosa resultante |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| DE602004017477D1 (de) | 2004-11-09 | 2008-12-11 | Novagali Pharma Sa | Öl-in-Wasser-Emulsion mit niedriger Konzentration des kationischen Mittels und positivem Zetapotential |
| US20090209599A1 (en) | 2005-06-09 | 2009-08-20 | Yoko Endo | Eye drop containing roflumilast |
| EP1890677A4 (en) | 2005-06-16 | 2013-01-30 | Myriad Genetics Inc | PHARMACEUTICAL COMPOSITIONS AND THEIR USE |
| US20070015691A1 (en) * | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
| AU2006270041B2 (en) | 2005-07-18 | 2011-08-18 | Minu, Llc | Enhanced ocular neuroprotection/neurostimulation |
| US10137083B2 (en) | 2006-03-07 | 2018-11-27 | SGN Nanopharma Inc | Ophthalmic preparations |
| CA2650422A1 (en) | 2006-04-24 | 2007-11-08 | Nanocarrier Co., Ltd. | Process for producing polymer micelles encapsulating low molecular weight drugs |
| WO2007136134A1 (ja) | 2006-05-23 | 2007-11-29 | Nanocarrier Co., Ltd. | 疎水性薬物内包ポリマーミセルの製造方法 |
| CN101489574A (zh) | 2006-07-18 | 2009-07-22 | 那野伽利阿株式会社 | 内包生理活性多肽或蛋白质的高分子聚合物胶束及其制造方法 |
| US20100310462A1 (en) | 2007-04-18 | 2010-12-09 | Biochromix Ab | Binding of pathological forms of proteins using conjugated polyelectrolytes |
| US8512687B2 (en) | 2007-07-09 | 2013-08-20 | Novagali Pharma Sa | Oil in water emulsion comprising NSAIDs and quaternary ammonium halides |
| EP2193795B1 (en) | 2007-08-29 | 2014-10-01 | Wakamoto Pharmaceutical Co., Ltd. | Latanoprost-containing aqueous pharmaceutical composition |
| MX2007011165A (es) | 2007-09-12 | 2009-03-11 | Arturo Jimenez Bayardo | Composición farmacéutica estable de timolol, dorzolamida y brimonidina. |
| ES2667945T3 (es) | 2007-10-08 | 2018-05-16 | Aurinia Pharmaceuticals Inc. | Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR |
| JP2011508776A (ja) | 2008-01-04 | 2011-03-17 | アルコン ファーマシューティカルズ リミテッド | 安定な水性シクロスポリン組成物 |
| TWI544927B (zh) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
| EP2278953B1 (en) | 2008-05-28 | 2016-05-04 | Alcon Research, Ltd | Self-preserved emulsions |
| EP2127638A1 (en) | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Method and composition for treating ocular hypertension and glaucoma |
| AP2012006053A0 (en) | 2009-06-02 | 2012-02-29 | Brian Charles Keller | Pure peg-lipid conjugates. |
| EP2440185B1 (en) | 2009-06-09 | 2015-04-08 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
| EP2478906A4 (en) | 2009-09-17 | 2013-02-20 | Senju Pharma Co | AQUEOUS OPHTHALMIC DROPS THAT CONTAIN LATANOPROST, AND A METHOD OF INHIBITING ADSORPTION OF LATANOPROST ON A RESIN |
| US8637569B2 (en) | 2009-10-22 | 2014-01-28 | Api Genesis, Llc | Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds |
| EP2538965B1 (en) | 2010-02-25 | 2017-04-12 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
| WO2011138801A1 (en) | 2010-05-07 | 2011-11-10 | Sun Pharma Advanced Research Company Ltd. | Novel ophthalmic compositions |
| US20130065888A1 (en) | 2011-08-15 | 2013-03-14 | Biserka Cetina-Cizmek | Ophthalmic formulations and processes for their preparation |
| US9278132B2 (en) | 2012-02-13 | 2016-03-08 | Bausch & Lomb Incorporated | Ophthalmic pharmaceutical compositions and methods of making and using same |
| KR101211902B1 (ko) | 2012-04-30 | 2012-12-13 | 주식회사 휴온스 | 사이클로스포린 함유 무자극성 나노에멀젼 안약 조성물 |
| MX2014013714A (es) | 2012-05-11 | 2015-08-10 | Cipla Ltd | Composicion farmaceutica. |
| PL2887923T3 (pl) | 2012-08-24 | 2023-08-14 | Sun Pharmaceutical Industries Limited | Preparat okulistyczny polioksylipidu lub polioksylowego kwasu tłuszczowego i leczenie chorób oczu |
| WO2014126997A1 (en) | 2013-02-13 | 2014-08-21 | The Research Foundation For The State University Of New York | Glaucoma treatment |
| AU2015264181A1 (en) * | 2014-05-23 | 2016-12-01 | Ocular Technologies Sarl | Topical formulations and uses thereof |
| US20150352176A1 (en) | 2014-06-06 | 2015-12-10 | Newport Research, Inc. | Oil-free and fat-free aqueous suspensions of cyclosporin |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US20180133217A1 (en) | 2015-05-04 | 2018-05-17 | Ocular Technologies Sarl | Topical formulations and uses thereof |
| EP3373976B1 (en) | 2015-11-10 | 2024-01-03 | Sun Pharmaceutical Industries Limited | Topical formulations and uses thereof |
| EP3373924A4 (en) | 2015-11-12 | 2019-06-19 | Sun Pharma Global FZE | Topical formulations and uses thereof |
| US10918694B2 (en) | 2016-02-29 | 2021-02-16 | Sun Pharma Global Fze | Topical cyclosporine-containing formulations and uses thereof |
| WO2017152129A2 (en) | 2016-03-03 | 2017-09-08 | Ocular Technologies Sarl | Treatment of glaucoma and/or retinal diseases and formulations useful therefore |
| AU2022295164A1 (en) * | 2021-06-14 | 2024-01-25 | Sun Pharmaceutical Industries Limited | Cyclosporine formulations for use in patients undergoing cataract surgery |
-
2017
- 2017-02-28 US US16/079,928 patent/US10918694B2/en active Active
- 2017-02-28 SG SG11201906729RA patent/SG11201906729RA/en unknown
- 2017-02-28 EP EP24169238.3A patent/EP4410312A3/en active Pending
- 2017-02-28 NZ NZ785158A patent/NZ785158A/en unknown
- 2017-02-28 JP JP2018545269A patent/JP7072517B2/ja active Active
- 2017-02-28 WO PCT/US2017/020008 patent/WO2017151657A1/en not_active Ceased
- 2017-02-28 PT PT177606431T patent/PT3423076T/pt unknown
- 2017-02-28 CN CN202411358894.1A patent/CN119185511A/zh active Pending
- 2017-02-28 RU RU2019130403A patent/RU2747455C2/ru active
- 2017-02-28 AU AU2017227585A patent/AU2017227585C1/en active Active
- 2017-02-28 EP EP17760643.1A patent/EP3423076B1/en active Active
- 2017-02-28 FI FIEP17760643.1T patent/FI3423076T3/fi active
- 2017-02-28 CN CN201780026587.5A patent/CN109843316A/zh active Pending
- 2017-02-28 MX MX2018010395A patent/MX2018010395A/es unknown
- 2017-02-28 BR BR112018067946A patent/BR112018067946A8/pt active Search and Examination
- 2017-02-28 ES ES17760643T patent/ES2981702T3/es active Active
- 2017-02-28 DK DK17760643.1T patent/DK3423076T3/da active
- 2017-02-28 CA CA3015626A patent/CA3015626A1/en active Pending
- 2017-02-28 PL PL17760643.1T patent/PL3423076T3/pl unknown
- 2017-02-28 NZ NZ755442A patent/NZ755442A/en active IP Right Revival
- 2017-02-28 KR KR1020187027785A patent/KR102766771B1/ko active Active
-
2018
- 2018-08-29 MX MX2024010721A patent/MX2024010721A/es unknown
-
2019
- 2019-07-14 IL IL268056A patent/IL268056A/en unknown
- 2019-07-17 ZA ZA2019/04704A patent/ZA201904704B/en unknown
- 2019-09-12 SA SA519410114A patent/SA519410114B1/ar unknown
-
2021
- 2021-01-07 US US17/143,863 patent/US20210145924A1/en not_active Abandoned
-
2022
- 2022-05-10 JP JP2022077492A patent/JP7547411B2/ja active Active
- 2022-05-11 AU AU2022203135A patent/AU2022203135B2/en active Active
- 2022-09-26 US US17/935,177 patent/US11951153B2/en active Active
-
2024
- 2024-02-28 US US18/590,539 patent/US20240197818A1/en active Pending
- 2024-08-28 JP JP2024146154A patent/JP2024161602A/ja active Pending
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