DK3559227T3 - Proteasevarianter og anvendelser deraf - Google Patents

Proteasevarianter og anvendelser deraf Download PDF

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Publication number
DK3559227T3
DK3559227T3 DK17832644.3T DK17832644T DK3559227T3 DK 3559227 T3 DK3559227 T3 DK 3559227T3 DK 17832644 T DK17832644 T DK 17832644T DK 3559227 T3 DK3559227 T3 DK 3559227T3
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Denmark
Prior art keywords
protease variants
protease
variants
Prior art date
Application number
DK17832644.3T
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English (en)
Inventor
Lilia Maria Babe
Lydia Dankmeyer
David A Estell
Frits Goedegebuur
Thijs Kaper
Harm Mulder
Sina Pricelius
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Danisco Us Inc
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Application filed by Danisco Us Inc filed Critical Danisco Us Inc
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Publication of DK3559227T3 publication Critical patent/DK3559227T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21062—Subtilisin (3.4.21.62)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK17832644.3T 2016-12-21 2017-12-19 Proteasevarianter og anvendelser deraf DK3559227T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662437171P 2016-12-21 2016-12-21
PCT/US2017/067312 WO2018118917A1 (en) 2016-12-21 2017-12-19 Protease variants and uses thereof

Publications (1)

Publication Number Publication Date
DK3559227T3 true DK3559227T3 (da) 2025-05-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK17832644.3T DK3559227T3 (da) 2016-12-21 2017-12-19 Proteasevarianter og anvendelser deraf

Country Status (5)

Country Link
US (3) US20200392477A1 (da)
EP (2) EP3559227B1 (da)
CN (1) CN110312795B (da)
DK (1) DK3559227T3 (da)
WO (1) WO2018118917A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110312794B (zh) * 2016-12-21 2024-04-12 丹尼斯科美国公司 吉氏芽孢杆菌进化枝丝氨酸蛋白酶
US20200354708A1 (en) 2017-11-29 2020-11-12 Danisco Us Inc. Subtilisin variants having improved stability
JP2021527413A (ja) * 2018-06-19 2021-10-14 ザ プロクター アンド ギャンブル カンパニーＴｈｅ Ｐｒｏｃｔｅｒ ＆ Ｇａｍｂｌｅ Ｃｏｍｐａｎｙ 自動食器洗浄洗剤組成物
EP3810769A1 (en) * 2018-06-19 2021-04-28 The Procter & Gamble Company Automatic dishwashing detergent composition
EP3799601A1 (en) * 2018-06-19 2021-04-07 Danisco US Inc. Subtilisin variants
CA3102261C (en) 2018-06-20 2023-10-03 The Procter & Gamble Company A fabric care or home care product comprising polysaccharide derivatives
US12509672B2 (en) 2018-11-28 2025-12-30 Danisco Us Inc. Subtilisin variants having improved stability
CA3136356A1 (en) 2019-04-12 2020-10-15 Ecolab Usa Inc. Antimicrobial multi-purpose cleaner and methods of making and using the same
CN114174504B (zh) * 2019-05-24 2026-04-17 丹尼斯科美国公司 枯草杆菌蛋白酶变体和使用方法
EP3976775A1 (en) * 2019-05-24 2022-04-06 The Procter & Gamble Company Automatic dishwashing detergent composition
BR112022007697A2 (pt) 2019-10-24 2022-07-12 Danisco Us Inc Alfa-amilase variante que forma maltopentaose/maltohexaose
CN110846299B (zh) * 2019-11-22 2021-09-24 江南大学 一种前导肽突变体及其在角蛋白酶生产中的应用
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
CN118647716A (zh) 2021-12-16 2024-09-13 丹尼斯科美国公司 成麦芽五糖/麦芽六糖变体α-淀粉酶
CN119855892A (zh) 2022-09-02 2025-04-18 丹尼斯科美国公司 洗涤剂组合物及其相关方法
CN120112635A (zh) 2022-09-02 2025-06-06 丹尼斯科美国公司 枯草杆菌蛋白酶变体及其相关方法
JP2026503673A (ja) 2023-02-01 2026-01-29 ザ プロクター アンド ギャンブル カンパニー 酵素を含有する洗剤組成物
EP4658776A1 (en) 2023-02-01 2025-12-10 Danisco US Inc. Subtilisin variants and methods of use
CN116732818B (zh) * 2023-06-09 2025-06-13 陕西科技大学 一种短碳纤维增强木质-环氧树脂型纸基摩擦片及其制备方法
WO2026024922A1 (en) 2024-07-25 2026-01-29 Danisco Us Inc. Subtilisin variants and methods of use
WO2026093440A1 (en) * 2024-11-04 2026-05-07 Novozymes A/S Protease variants and compositions comprising same

Family Cites Families (199)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1296839A (da) 1969-05-29 1972-11-22
GB1372034A (en) 1970-12-31 1974-10-30 Unilever Ltd Detergent compositions
GB2048606B (en) 1979-02-28 1983-03-16 Barr & Stroud Ltd Optical scanning system
US4302544A (en) 1979-10-15 1981-11-24 University Of Rochester Asporogenous mutant of B. subtilis for use as host component of HV1 system
DK187280A (da) 1980-04-30 1981-10-31 Novo Industri As Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode
GR76237B (da) 1981-08-08 1984-08-04 Procter & Gamble
US4450235A (en) 1982-04-21 1984-05-22 Cpc International Inc. Asporogenic mutant of bacillus subtilis useful as a host in a host-vector system
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
DE3480411D1 (en) 1983-07-06 1989-12-14 Gist Brocades Nv Molecular cloning and expression in industrial microorganism species
JPS60165486A (ja) 1984-02-08 1985-08-28 三洋電機株式会社 断熱箱体
US5972682A (en) 1984-05-29 1999-10-26 Genencor International, Inc. Enzymatically active modified subtilisins
US5763257A (en) 1984-05-29 1998-06-09 Genencor International, Inc. Modified subtilisins having amino acid alterations
DK154572C (da) 1985-08-07 1989-04-24 Novo Industri As Enzymatisk detergentadditiv, detergent og fremgangsmaade til vask af tekstiler
EP0218272B1 (en) 1985-08-09 1992-03-18 Gist-Brocades N.V. Novel lipolytic enzymes and their use in detergent compositions
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
EP0258068B1 (en) 1986-08-29 1994-08-31 Novo Nordisk A/S Enzymatic detergent additive
GB8629837D0 (en) 1986-12-13 1987-01-21 Interox Chemicals Ltd Bleach activation
US4765916A (en) 1987-03-24 1988-08-23 The Clorox Company Polymer film composition for rinse release of wash additives
US4972017A (en) 1987-03-24 1990-11-20 The Clorox Company Rinse soluble polymer film composition for wash additives
US4853871A (en) * 1987-04-06 1989-08-01 Genex Corporation Computer-based method for designing stablized proteins
DE3851875T2 (de) 1987-05-29 1995-04-13 Genencor Int Cutinase haltige reinigungsmittelzusammensetzungen.
EP0305216B1 (en) 1987-08-28 1995-08-02 Novo Nordisk A/S Recombinant Humicola lipase and process for the production of recombinant humicola lipases
JPS6474992A (en) 1987-09-16 1989-03-20 Fuji Oil Co Ltd Dna sequence, plasmid and production of lipase
JP2624859B2 (ja) 1988-01-07 1997-06-25 ノボ‐ノルディスク アクティーゼルスカブ 酵素洗剤
JP3079276B2 (ja) 1988-02-28 2000-08-21 天野製薬株式会社 組換え体ｄｎａ、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法
US4977252A (en) 1988-03-11 1990-12-11 National Starch And Chemical Investment Holding Corporation Modified starch emulsifier characterized by shelf stability
WO1990009446A1 (en) 1989-02-17 1990-08-23 Plant Genetic Systems N.V. Cutinase
ATE166922T1 (de) 1989-06-29 1998-06-15 Genencor Int Mutierte mikrobielle alpha-amylasen mit erhöhter thermischer, saurer und/oder alkylischer stabilität
EP0528828B2 (de) 1990-04-14 1997-12-03 Genencor International GmbH Alkalische bacillus-lipasen, hierfür codierende dna-sequenzen sowie bacilli, die diese lipasen produzieren
US5354559A (en) 1990-05-29 1994-10-11 Grain Processing Corporation Encapsulation with starch hydrolyzate acid esters
DE69133035T2 (de) 1991-01-16 2003-02-13 The Procter & Gamble Company, Cincinnati Kompakte Waschmittelzusammensetzungen mit hochaktiven Cellulasen
GB9108136D0 (en) 1991-04-17 1991-06-05 Unilever Plc Concentrated detergent powder compositions
US5340735A (en) 1991-05-29 1994-08-23 Cognis, Inc. Bacillus lentus alkaline protease variants with increased stability
KR950702633A (ko) * 1992-07-17 1995-07-29 한스 발터 라벤 고알칼리성 세린 프로테아제(high alkaline serine proteases)
EP0651794B1 (en) 1992-07-23 2009-09-30 Novozymes A/S MUTANT $g(a)-AMYLASE, DETERGENT AND DISH WASHING AGENT
BR9307576A (pt) 1992-12-01 1999-06-15 Novo Nordisk As Processo para oxidar um substrato com uma enzima peroxidase ou um composto atuando como peroxidase na presença de uma fonte de peróxido de hidrogênio aditivo detergente e composição detergente
CA2155831C (en) 1993-02-11 2009-11-10 Richard L. Antrim Oxidatively stable alpha-amylase
CA2162459A1 (en) 1993-05-08 1994-11-24 Juergen Haerer Corrosion inhibitors for silver (ii)
CZ286401B6 (en) 1993-05-08 2000-04-12 Henkel Kgaa Use of inorganic redox-active substances
DK77393D0 (da) 1993-06-29 1993-06-29 Novo Nordisk As Aktivering af enzymer
JPH09503916A (ja) 1993-10-08 1997-04-22 ノボ ノルディスク アクティーゼルスカブ アミラーゼ変異体
DE4342680A1 (de) 1993-12-15 1995-06-22 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
US5861271A (en) 1993-12-17 1999-01-19 Fowler; Timothy Cellulase enzymes and systems for their expressions
EP1921147B1 (en) 1994-02-24 2011-06-08 Henkel AG & Co. KGaA Improved enzymes and detergents containing them
ES2364776T3 (es) 1994-02-24 2011-09-14 HENKEL AG & CO. KGAA Enzimas mejoradas y detergentes que las contienen.
US5691295A (en) 1995-01-17 1997-11-25 Cognis Gesellschaft Fuer Biotechnologie Mbh Detergent compositions
ES2250969T3 (es) 1994-03-29 2006-04-16 Novozymes A/S Amilasa alcalina de bacilo.
AU685638B2 (en) 1994-06-17 1998-01-22 Genencor International, Inc. Novel amylolytic enzymes derived from the b. licheniformis alpha-amylase, having improved characteristics
NZ289115A (en) 1994-06-17 1999-02-25 Genencor Int Laundry compositions with cellulase and pectinase enzymes suitable for degrading cell walls of vegetable origin
NZ291984A (en) 1994-08-11 1998-04-27 Genencor Int Bleach-containing cleaning composition comprising a mutant alpha-amylase and optionally a mutant protease
MX9705906A (es) 1995-02-03 1997-10-31 Novo Nordisk As Un metodo para diseñar mutantes de alfa-amilasa con propiedades predeterminadas.
US5534179A (en) 1995-02-03 1996-07-09 Procter & Gamble Detergent compositions comprising multiperacid-forming bleach activators
AR000862A1 (es) 1995-02-03 1997-08-06 Novozymes As Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del
KR19980702783A (ko) 1995-03-24 1998-08-05 혼 마가렛 에이 아밀라제를 포함하는 개선된 세탁 세제 조성물
JP3895377B2 (ja) 1995-06-13 2007-03-22 ノボザイムス アクティーゼルスカブ 酵素安定剤としての４−置換フェニルボロン酸
US5597936A (en) 1995-06-16 1997-01-28 The Procter & Gamble Company Method for manufacturing cobalt catalysts
AU6513096A (en) 1995-07-19 1997-02-18 Novo Nordisk A/S Treatment of fabrics
US5576282A (en) 1995-09-11 1996-11-19 The Procter & Gamble Company Color-safe bleach boosters, compositions and laundry methods employing same
ATE309373T1 (de) 1995-09-13 2005-11-15 Genencor Int Alkalophile und thermophile mikroorganismen und damit erhaltene enzymen
AU2692897A (en) 1996-04-30 1997-11-19 Novo Nordisk A/S Alpha-amylase mutants
US6211134B1 (en) 1996-05-14 2001-04-03 Genecor International, Inc. Mutant α-amylase
US5763385A (en) 1996-05-14 1998-06-09 Genencor International, Inc. Modified α-amylases having altered calcium binding properties
BR9713470A (pt) 1996-09-24 2000-04-11 Procter & Gamble Detergentes lìquidos contendo enzima proteolìtica e inibidores da protease
CN1231693A (zh) 1996-09-26 1999-10-13 诺沃挪第克公司 一种具有淀粉酶活性的酶
AU1461497A (en) 1996-12-09 1998-07-03 Genencor International, Inc. Proteins Having Increased Stability
BR9808657A (pt) 1997-03-07 2000-05-23 Procter & Gamble Métodos aperfeiçoados de produção de macropoliciclos ligados com ponte cruzada
DE19882201T1 (de) 1997-03-18 2000-01-27 Seagate Technology Verbesserter Magnetowiderstandslesesensor und Verfahren zur Herstellung eines Magnetowiderstandslesesensors
US6008026A (en) 1997-07-11 1999-12-28 Genencor International, Inc. Mutant α-amylase having introduced therein a disulfide bond
GB2327947A (en) 1997-08-02 1999-02-10 Procter & Gamble Detergent tablet
US6080568A (en) 1997-08-19 2000-06-27 Genencor International, Inc. Mutant α-amylase comprising modification at residues corresponding to A210, H405 and/or T412 in Bacillus licheniformis
GB9719637D0 (en) 1997-09-15 1997-11-19 Genencor Int Bv Proteases from gram-positive organisms
GB9719636D0 (en) 1997-09-15 1997-11-19 Genencor Int Bv Proteases from gram-positive organisms
WO1999019467A1 (en) 1997-10-13 1999-04-22 Novo Nordisk A/S α-AMYLASE MUTANTS
AR016969A1 (es) * 1997-10-23 2001-08-01 Procter & Gamble VARIANTE DE PROTEASA, ADN, VECTOR DE EXPRESIoN, MICROORGANISMO HUESPED, COMPOSICIoN DE LIMPIEZA, ALIMENTO PARA ANIMALES Y COMPOSICIoN PARA TRATAR UN TEXTIL
EP2386568B1 (en) 1997-10-30 2014-08-06 Novozymes A/S Alpha-amylase mutants
US5935826A (en) 1997-10-31 1999-08-10 National Starch And Chemical Investment Holding Corporation Glucoamylase converted starch derivatives and their use as emulsifying and encapsulating agents
AU1225099A (en) 1997-11-21 1999-06-15 Novo Nordisk A/S Protease variants and compositions
AU2207099A (en) 1997-12-24 1999-07-19 Genencor International, Inc. An improved method of assaying for a preferred enzyme and/or preferred detergentcomposition
GB9727464D0 (en) 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
GB9727471D0 (en) 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
AU2411699A (en) 1998-02-18 1999-09-06 Novo Nordisk A/S Alkaline bacillus amylase
AU757935B2 (en) 1998-02-27 2003-03-13 Novozymes A/S Maltogenic alpha-amylase variants
CA2320813A1 (en) 1998-02-27 1999-09-02 Novo Nordisk A/S Amylolytic enzyme variants
KR20010041617A (ko) 1998-03-09 2001-05-25 피아 스타르 전분으로부터 글루코스 시럽의 효소성 제조
EP2284272B1 (en) 1998-06-10 2014-08-13 Novozymes A/S Mannanases
US6376450B1 (en) 1998-10-23 2002-04-23 Chanchal Kumar Ghosh Cleaning compositions containing multiply-substituted protease variants
US6197565B1 (en) 1998-11-16 2001-03-06 Novo-Nordisk A/S α-Amylase variants
JP2002531457A (ja) 1998-11-30 2002-09-24 ザ、プロクター、エンド、ギャンブル、カンパニー 架橋テトラアザマクロサイクル類の製造方法
CA2355574C (en) * 1998-12-18 2011-06-07 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having an additional amino acid residue in an active site loop region
AU3419300A (en) 1999-03-30 2000-10-23 Novozymes A/S Alpha-amylase variants
EP2011864B1 (en) 1999-03-31 2014-12-31 Novozymes A/S Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
DE60041536D1 (de) 1999-03-31 2009-03-26 Novozymes As Polypeptide mit alkaliner alpha-amylase-aktivität und für diese kodierende nukleinsäuren
DE60033945T2 (de) 1999-08-20 2007-12-06 Novozymes A/S Alkalische amylase aus bacillus
WO2001034784A1 (en) 1999-11-10 2001-05-17 Novozymes A/S Fungamyl-like alpha-amylase variants
WO2001064852A1 (en) 2000-03-03 2001-09-07 Novozymes A/S Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
EP2302048B1 (en) 2000-03-08 2014-07-09 Novozymes A/S Variants with altered properties
WO2001088107A2 (en) 2000-05-12 2001-11-22 Novozymes A/S Alpha-amylase variants with altered 1,6-activity
AU2001273880A1 (en) 2000-06-14 2001-12-24 Novozymes A/S Pre-oxidized alpha-amylase
CA2702204C (en) 2000-08-01 2011-09-06 Novozymes A/S Alpha-amylase mutants with altered properties
US6440991B1 (en) 2000-10-02 2002-08-27 Wyeth Ethers of 7-desmethlrapamycin
WO2002031124A2 (en) 2000-10-13 2002-04-18 Novozymes A/S Alpha-amylase variant with altered properties
EP3000881A3 (en) 2001-05-15 2016-07-20 Novozymes A/S Alpha-amylase variant with altered properties
GB0114847D0 (en) 2001-06-18 2001-08-08 Unilever Plc Water soluble package and liquid contents thereof
DK200101090A (da) * 2001-07-12 2001-08-16 Novozymes As Subtilase variants
DE60310264T2 (de) 2002-12-17 2007-07-05 Novozymes A/S Thermostabile alpha-amylase
CN1768137A (zh) * 2003-01-30 2006-05-03 诺和酶股份有限公司 枯草杆菌酶
JP4757191B2 (ja) 2003-04-30 2011-08-24 ジェネンコー・インターナショナル・インク 新規なバチルスｍＨＫｃｅｌセルラーゼ
ATE387487T1 (de) 2003-05-23 2008-03-15 Procter & Gamble Waschmittelzusammensetzung zum gebrauch in einer textilwasch- oder geschirrspülmaschine
AU2004252572B2 (en) 2003-06-25 2011-09-08 Novozymes A/S Polypeptides having alpha-amylase activity and polypeptides encoding same
MXPA06000212A (es) 2003-06-25 2006-03-21 Novozymes As Enzimas para procesar almidon.
ATE510925T1 (de) 2003-06-25 2011-06-15 Novozymes As Stärkehydrolyseverfahren
EP1657981A1 (en) 2003-08-22 2006-05-24 Novozymes A/S Process for preparing a dough comprising a starch-degrading glucogenic exo-amylase of family 13
AU2004267142B2 (en) 2003-08-22 2010-07-22 Novozymes A/S Fungal alpha-amylase variants
CA2544820C (en) 2003-11-06 2014-02-18 Genencor International, Inc. Bacterial expression of protease inhibitors and variants thereof
US7754460B2 (en) 2003-12-03 2010-07-13 Danisco Us Inc. Enzyme for the production of long chain peracid
CN102766614A (zh) 2003-12-03 2012-11-07 明治制果药业株式会社 内切葡聚糖酶stce和含有内切葡聚糖酶的纤维素酶配制品
ATE500322T1 (de) 2003-12-03 2011-03-15 Genencor Int Perhydrolase
ES2539955T3 (es) 2003-12-08 2015-07-07 Meiji Seika Pharma Co., Ltd. Celulasa tolerante a los tensioactivos y procedimiento de modificación de la misma
EP1709167B1 (en) 2004-01-08 2010-04-21 Novozymes A/S Amylase
CA2571864C (en) 2004-07-05 2014-09-23 Novozymes A/S Alpha-amylase variants with altered properties
CA2575875A1 (en) 2004-08-02 2006-02-09 Novozymes A/S Maltogenic alpha-amylase variants
WO2006012902A2 (en) 2004-08-02 2006-02-09 Novozymes A/S Creation of diversity in polypeptides
CN103181400B (zh) 2004-09-10 2016-08-10 诺维信北美公司 防止、去除、减少或破坏生物膜的方法
US7659101B2 (en) 2004-12-15 2010-02-09 Novozymes A/S Alkaline Bacillus amylase
DK1926753T3 (da) 2004-12-22 2011-03-14 Novozymes As Hybridenzymer, der består af en endoamylase som første aminosyresekvens og et kulhydratbindingsmodul som anden aminosyresekvens
WO2006066594A2 (en) 2004-12-23 2006-06-29 Novozymes A/S Alpha-amylase variants
EP1896057A2 (en) 2005-06-24 2008-03-12 Novozymes A/S Amylases for pharmaceutical use
CN101243182B (zh) * 2005-08-16 2014-08-06 诺维信公司 枯草蛋白酶
WO2007044993A2 (en) 2005-10-12 2007-04-19 Genencor International, Inc. Use and production of storage-stable neutral metalloprotease
JP4627086B2 (ja) * 2005-10-21 2011-02-09 株式会社島津製作所 タンパク質又はペプチドのｃ末端修飾法、ｃ末端固定化法、及び解析法
BRPI0708504A8 (pt) 2006-03-02 2017-03-01 Danisco Us Inc Genecor Div alvejante ativo na superfície e ph dinâmico
CA2652678A1 (en) 2006-06-05 2007-12-21 The Procter & Gamble Company Detergent compositions comprising polysaccharides as enzyme stabilizers
US20090226564A1 (en) 2006-06-30 2009-09-10 Novozymes A/S Bacterial alpha-amylase variants
CN104232365A (zh) 2006-07-18 2014-12-24 丹尼斯科美国公司 在宽温度范围内具有活性的蛋白酶变体
WO2008088493A2 (en) 2006-12-21 2008-07-24 Danisco Us, Inc., Genencor Division Compositions and uses for an alpha-amylase polypeptide of bacillus species 195
EP2121910A1 (en) 2007-02-01 2009-11-25 Novozymes A/S Alpha-amylase and its use
US8021863B2 (en) 2007-02-19 2011-09-20 Novozymes A/S Polypeptides with starch debranching activity
EP2121909A1 (en) 2007-02-27 2009-11-25 Danisco US Inc. Cleaning enzymes and fragrance production
CA2678760A1 (en) 2007-02-27 2008-09-04 Danisco Us Inc. Cleaning enzymes and malodor prevention
DE102007011236A1 (de) 2007-03-06 2008-09-11 Henkel Ag & Co. Kgaa Carboxylgruppen tragende Benzophenon-oderBenzoesäureanilid-Derivate als Enzymstabilisatoren
BRPI0808513A2 (pt) 2007-03-09 2014-08-19 Danisco Us Inc Genencor Div Variantes de alfa-amilase de espécies de bacillus alcalifílico, composições compreendendo variantes de alfa-amilase e métodos de uso
MX2010004372A (es) 2007-10-31 2010-05-20 Danisco Us Inc Uso y elaboracion de metaloproteasas neutras estables en citrato.
EP2205732A2 (en) 2007-11-01 2010-07-14 Danisco US Inc. Production of thermolysin and variants thereof and use in liquid detergents
WO2009061380A2 (en) 2007-11-05 2009-05-14 Danisco Us Inc., Genencor Division VARIANTS OF BACILLUS sp. TS-23 ALPHA-AMYLASE WITH ALTERED PROPERTIES
AU2008325249B2 (en) 2007-11-05 2013-10-10 Danisco Us Inc. Alpha-amylase variants with altered properties
MX2010008359A (es) 2008-02-04 2010-08-30 Danisco Us Inc Variantes de alfa-amilasa ts23 con propiedades alteradas.
US20090209447A1 (en) * 2008-02-15 2009-08-20 Michelle Meek Cleaning compositions
EP2100947A1 (en) 2008-03-14 2009-09-16 The Procter and Gamble Company Automatic dishwashing detergent composition
JP5973166B2 (ja) 2008-03-26 2016-08-23 ノボザイムス アクティーゼルスカブ 安定化された液体酵素組成物
EP2280992A1 (en) 2008-05-16 2011-02-09 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
BRPI0915681A2 (pt) 2008-06-06 2015-08-04 Danisco Us Inc Composições e métodos compreendendo proteases microbianas variantes
MX350760B (es) 2008-06-06 2017-09-18 Danisco Us Inc Alfa-amilasas variantes de bacillus subtilis y metodos de uso de las mismas.
CN103396904B (zh) 2008-11-11 2015-12-23 宝洁公司 包含丝氨酸蛋白酶变体的组合物和方法
BRPI0922083A2 (pt) 2008-11-11 2017-05-30 Danisco Us Inc proteases compreendendo uma ou mais mutações combináveis
BRPI0920925A2 (pt) 2008-11-11 2015-08-18 Danisco Us Inc Composições e métodos compreendendo uma variante de subtilisina
CN103589529A (zh) 2008-11-13 2014-02-19 诺维信公司 洗涤剂组合物
US20100122864A1 (en) 2008-11-17 2010-05-20 Allan Rosman Hybrid hydraulic drive system for all terrestrial vehicles, with the hydraulic accumulator as the vehicle chassis
WO2010059413A2 (en) 2008-11-20 2010-05-27 Novozymes, Inc. Polypeptides having amylolytic enhancing activity and polynucleotides encoding same
WO2010088447A1 (en) 2009-01-30 2010-08-05 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
WO2010091221A1 (en) 2009-02-06 2010-08-12 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
US20120172275A1 (en) 2009-03-10 2012-07-05 Danisco Us Inc. Bacillus Megaterium Strain DSM90-Related Alpha-Amylases, and Methods of Use, Thereof
RU2011144134A (ru) 2009-04-01 2013-05-10 ДАНИСКО ЮЭс ИНК. Композиции и способы, включающие варианты альфа-амилазы с измененными свойствами
CN102388131B (zh) 2009-04-08 2014-04-30 丹尼斯科美国公司 盐单胞菌属菌株WDG195相关α-淀粉酶及其使用方法
EP2279804A1 (en) 2009-07-28 2011-02-02 Koninklijke Philips Electronics N.V. Washing and sterilizing unit
CA2775037A1 (en) 2009-09-25 2011-03-31 Novozymes A/S Detergent composition
EP3434764B1 (en) * 2009-12-09 2026-04-08 The Procter & Gamble Company Fabric and home care products
CN102762222B (zh) 2009-12-09 2015-11-25 丹尼斯科美国公司 包含蛋白酶变体的组合物和方法
WO2011076897A1 (en) 2009-12-22 2011-06-30 Novozymes A/S Use of amylase variants at low temperature
CN102933227A (zh) 2009-12-22 2013-02-13 诺维信公司 包含增强性多肽和淀粉降解酶的组合物及其用途
CN102884183B (zh) 2010-01-04 2015-09-16 诺维信公司 趋于钙耗竭和酸性pH的α-淀粉酶的稳定化
EP3892709A3 (en) 2010-02-10 2022-01-19 Novozymes A/S Variants and compositions comprising variants with high stability in presence of a chelating agent
WO2011140316A1 (en) 2010-05-06 2011-11-10 The Procter & Gamble Company Consumer products with protease variants
CA3194062A1 (en) 2011-05-05 2012-11-08 Danisco Us Inc. Compositions and methods comprising serine protease variants
BR112013028440A2 (pt) * 2011-05-05 2016-11-29 Procter & Gamble composições e métodos que compreendem variantes de serina protease
BR112013033811A2 (pt) 2011-07-01 2017-02-14 Novozymes A / S composição, método de preparação da composição, e, composto
BR112013033816A2 (pt) 2011-07-01 2017-02-14 Novozymes A / S composição de detergente líquido sem boro
EP3845641A1 (en) 2011-10-28 2021-07-07 Danisco US Inc. Variant maltohexaose-forming alpha-amylase variants
JP6378089B2 (ja) 2011-12-09 2018-08-22 ダニスコ・ユーエス・インク 微生物におけるタンパク質産生のための、Ｂ．ズブチリス（Ｂ．ｓｕｂｔｉｌｉｓ）からのリボソームプロモーター
MX350713B (es) * 2012-02-17 2017-09-14 Novozymes As Variantes de subtilisina y polinucleotidos que las codifican.
ES2909509T3 (es) 2012-06-08 2022-05-06 Danisco Us Inc Variante de alfa-amilasas con mayor actividad en polímeros de almidón
CN110093330B (zh) 2012-10-12 2023-11-28 丹尼斯科美国公司 包含脂解酶变体的组合物和方法
EP2914720B1 (en) 2012-11-05 2022-08-31 Danisco US Inc. Compositions and methods comprising thermolysin protease variants
US20160053243A1 (en) 2012-12-21 2016-02-25 Danisco Us Inc. Alpha-amylase variants
ES2676895T5 (es) 2013-03-11 2022-04-27 Danisco Us Inc Variantes combinatorias de alfa-amilasa
EP3004314B1 (en) 2013-05-29 2018-06-20 Danisco US Inc. Novel metalloproteases
EP3004342B1 (en) 2013-05-29 2023-01-11 Danisco US Inc. Novel metalloproteases
JP2016526880A (ja) 2013-05-29 2016-09-08 ダニスコ・ユーエス・インク 新規メタロプロテアーゼ
EP3260538B1 (en) 2013-05-29 2021-04-14 Danisco US Inc. Novel metalloproteases
ES2956266T3 (es) 2013-07-19 2023-12-18 Danisco Us Inc Composiciones y procedimientos que comprenden una variante de enzima lipolítica
BR112016005286A2 (pt) 2013-09-12 2017-09-12 Danisco Us Inc composições e métodos compreendendo variantes de protease do clado lg12
JP6560214B2 (ja) 2013-11-20 2019-08-14 ダニスコ・ユーエス・インク プロテアーゼ開裂に対する感受性を低減した変異体α−アミラーゼ、及びその使用方法
EP3514230B1 (en) 2013-12-13 2021-09-22 Danisco US Inc. Serine proteases of bacillus species
EP3910057A1 (en) 2013-12-13 2021-11-17 Danisco US Inc. Serine proteases of the bacillus gibsonii-clade
EP3739029A1 (en) * 2014-07-04 2020-11-18 Novozymes A/S Subtilase variants and polynucleotides encoding same
EP3327122B1 (en) * 2014-07-04 2021-02-17 Novozymes A/S Subtilase variants and polynucleotides encoding same
WO2016007929A2 (en) 2014-07-11 2016-01-14 Danisco Us Inc. Paenibacillus and bacillus spp. mannanases
DK3212780T3 (da) * 2014-10-27 2020-03-23 Danisco Us Inc Serinprotease
EP4234693A3 (en) * 2015-06-17 2023-11-01 Danisco US Inc Bacillus gibsonii-clade serine proteases
CA2989667A1 (en) 2015-06-17 2016-12-22 Danisco Us Inc. Proteases with modified propeptide regions

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