DK3458074T3 - COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH - Google Patents

COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH Download PDF

Info

Publication number
DK3458074T3
DK3458074T3 DK17800042.8T DK17800042T DK3458074T3 DK 3458074 T3 DK3458074 T3 DK 3458074T3 DK 17800042 T DK17800042 T DK 17800042T DK 3458074 T3 DK3458074 T3 DK 3458074T3
Authority
DK
Denmark
Prior art keywords
trna
nanoparticles
delivery
compositions
methods
Prior art date
Application number
DK17800042.8T
Other languages
English (en)
Inventor
Philip J Thomas
Daniel J Siegwart
Arthur E Johnson
Michael J Torres
Jason B Miller
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of DK3458074T3 publication Critical patent/DK3458074T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK17800042.8T 2016-05-16 2017-05-16 COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH DK3458074T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662337096P 2016-05-16 2016-05-16
PCT/US2017/032967 WO2017201091A1 (en) 2016-05-16 2017-05-16 COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH

Publications (1)

Publication Number Publication Date
DK3458074T3 true DK3458074T3 (da) 2024-07-29

Family

ID=60326616

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17800042.8T DK3458074T3 (da) 2016-05-16 2017-05-16 COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH

Country Status (11)

Country Link
US (2) US20170354672A1 (da)
EP (2) EP4393549A3 (da)
JP (3) JP7312552B2 (da)
CN (1) CN109414451B (da)
AU (3) AU2017268272C1 (da)
CA (1) CA3024135C (da)
DK (1) DK3458074T3 (da)
ES (1) ES2985317T3 (da)
PL (1) PL3458074T3 (da)
PT (1) PT3458074T (da)
WO (1) WO2017201091A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3349802B1 (en) 2015-09-14 2021-08-04 The Board of Regents of the University of Texas System Lipocationic dendrimers and uses thereof
GB2574769A (en) 2017-03-03 2019-12-18 Univ California RNA Targeting of mutations via suppressor tRNAs and deaminases
CN111712248B (zh) 2017-11-02 2024-07-26 衣阿华大学研究基金会 使用ACE-tRNA经由遗传重分配拯救终止密码子的方法
US12357580B2 (en) 2018-06-19 2025-07-15 The Board Of Regents Of The University Of Texas System Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids
WO2020051220A1 (en) 2018-09-04 2020-03-12 The Board of the Regents of the University of Texas System Compositions and methods for organ specific delivery of nucleic acids
CN112996519B (zh) 2018-09-04 2025-02-28 德克萨斯大学系统董事会 用于核酸的器官特异性递送的组合物和方法
CN109266734A (zh) * 2018-09-25 2019-01-25 深圳市人民医院 自身免疫性疾病诊断试剂盒和应用
US10905778B2 (en) * 2018-09-26 2021-02-02 Case Western Reserve University Methods and compositions for treating a premature stop codon-mediated disorder
EP3856253A4 (en) * 2018-09-26 2022-07-06 Case Western Reserve University METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATED BY PREMATURE STOPCODON
US12281314B2 (en) * 2018-09-26 2025-04-22 Case Western Reserve University Methods and compositions for increasing protein expression and/or treating a haploinsufficiency disorder
CN114269921A (zh) * 2019-05-31 2022-04-01 旗舰创业股份有限公司 TREM组合物用以调节tRNA池的用途
WO2021113270A1 (en) 2019-12-02 2021-06-10 Shape Therapeutics Inc. Therapeutic editing
EP4165183A1 (en) * 2020-06-12 2023-04-19 University of Rochester Encoding and expression of ace-trnas
JP2024511463A (ja) 2021-03-22 2024-03-13 リコード セラピューティクス，インク． 細胞への標的送達のための組成物および方法
JP2024511437A (ja) 2021-03-23 2024-03-13 リコード セラピューティクス，インク． ポリヌクレオチド組成物、関連製剤、およびその使用方法
JP2024520834A (ja) * 2021-06-09 2024-05-24 レコード・セラピューティクス・インコーポレイテッド ポリヌクレオチド組成物、関連する製剤及びその使用方法
CN113416784A (zh) * 2021-07-18 2021-09-21 南京中医药大学 一种与乳腺癌诊断相关的血清外泌体tsRNA标志物及其应用
US20250295687A1 (en) * 2022-05-09 2025-09-25 Flagship Pioneering Innovations Vi, Llc Trem compositions and methods of use for treating proliferative disorders
WO2023218420A1 (en) 2022-05-13 2023-11-16 Janssen Pharmaceuticals, Inc. Mrna compositions for inducing latent hiv-1 reversal
CN115851911B (zh) * 2022-11-25 2025-10-24 南京鼓楼医院 一种用于鉴别狼疮性肾炎的尿液外泌体tsRNA标志物和探针及其应用
EP4630057A1 (en) 2022-12-08 2025-10-15 Recode Therapeutics, Inc. Lipid nanoparticle compositions and uses thereof
CN116515827B (zh) * 2023-03-20 2024-12-10 复旦大学附属眼耳鼻喉科医院 用于治疗年龄相关性黄斑变性的活性成分、药物组合物和应用
US12364773B2 (en) 2023-12-01 2025-07-22 Recode Therapeutics, Inc. Lipid nanoparticle compositions and uses thereof
WO2025137646A1 (en) 2023-12-22 2025-06-26 Recode Therapeutics, Inc. Gene editing methods and compositions for treating cystic fibrosis
CN117965718B (zh) * 2024-02-02 2024-09-06 江苏省中医院 一种与脓毒症相关的生物标志物及其应用
CN118178452A (zh) * 2024-02-23 2024-06-14 山东大学 小分子RNA tRF-1:29-Gly-CCC-1-M4在制备抗间充质干细胞衰老药物中的应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824311A (en) 1987-11-30 1998-10-20 Trustees Of The University Of Pennsylvania Treatment of tumors with monoclonal antibodies against oncogene antigens
US5846945A (en) 1993-02-16 1998-12-08 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US5801005A (en) 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
GB9506466D0 (en) 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US5739169A (en) 1996-05-31 1998-04-14 Procept, Incorporated Aromatic compounds for inhibiting immune response
ES2346645T3 (es) * 2002-03-14 2010-10-19 Commonwealth Scientific And Industrial Research Organisation Procedimientos y medios de supervision y modulacion del silenciamiento genico.
US7404969B2 (en) * 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
CN101283106A (zh) * 2005-07-27 2008-10-08 肿瘤疗法科学股份有限公司 小细胞肺癌的诊断方法
KR20080113226A (ko) * 2006-03-16 2008-12-29 더 스크립스 리서치 인스티튜트 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현
CA2658768C (en) * 2006-07-21 2016-05-17 Massachusetts Institute Of Technology End-modified poly(beta-amino esters) and uses thereof
US20100196277A1 (en) * 2006-10-09 2010-08-05 The University Of North Carolina At Chapel Hill Nanoparticle compositions for controlled delivery of nucleic acids
CN101595215A (zh) * 2006-10-30 2009-12-02 普罗梅加公司 具有增强的动力学和功能性表达的突变水解酶蛋白
WO2009061413A2 (en) * 2007-11-05 2009-05-14 Promega Corporation Hybrid fusion reporter and uses thereof
MX2010005080A (es) * 2007-11-07 2010-07-28 Genentech Inc Metodos y composiciones para determinar la sensibilidad de linfoma de celula b al tratamiento con anticuerpos anti-cd40.
CN104119242B (zh) * 2008-10-09 2017-07-07 泰米拉制药公司 改善的氨基脂质和递送核酸的方法
ES2646630T3 (es) 2008-11-07 2017-12-14 Massachusetts Institute Of Technology Lipidoides aminoalcohólicos y usos de los mismos
KR100909786B1 (ko) * 2008-11-10 2009-07-29 고려대학교 산학협력단 올리고 펩티드를 수식한 신규한 양이온성 지질, 그의 제조 방법 및 그를 포함하는 전달체
AP2012006053A0 (en) 2009-06-02 2012-02-29 Brian Charles Keller Pure peg-lipid conjugates.
CN101591428B (zh) * 2009-06-29 2011-05-25 浙江大学 一种聚酯树枝状大分子的制备方法
DK2823810T3 (da) * 2009-07-09 2019-05-27 Novosom Verwaltungs Gmbh Amfotere liposomer, der omfatter iminolipider
CA2816925C (en) * 2009-11-04 2023-01-10 The University Of British Columbia Nucleic acid-containing lipid particles and related methods
KR101183989B1 (ko) * 2010-02-04 2012-09-19 전남대학교산학협력단 세포내 유전자 전달용 복합체, 이의 제조 방법 및 이를 이용한 세포내로의 유전자 전달 방법
AU2011281121A1 (en) * 2010-07-22 2013-02-21 Anima Cell Metrology, Inc. Systems and methods for detection of cellular stress
KR102035187B1 (ko) * 2011-04-06 2019-11-08 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 지질-기반 나노입자들
EP2532649B1 (en) * 2011-06-07 2015-04-08 Incella GmbH Amino lipids, their synthesis and uses thereof
CN107043334B (zh) * 2011-06-08 2020-06-16 日东电工株式会社 用于定向药物输送和增强siRNA活性的化合物
HK1205747A1 (en) * 2012-02-29 2015-12-24 Ambrx, Inc. Modified adiponectin polypeptides and their uses
EP2885318A4 (en) * 2012-08-14 2016-03-30 Angiochem Inc PEPTIDE DENDRIMER CONJUGATES AND ITS USES
KR20140048404A (ko) 2012-10-11 2014-04-24 포항공과대학교 산학협력단 저밀도 지단백질 유사 나노입자 및 이를 포함하는 간 표적 진단 및 치료용 조성물
WO2015011633A1 (en) * 2013-07-23 2015-01-29 Protiva Biotherapeutics, Inc. Compositions and methods for delivering messenger rna
CN103999853B (zh) * 2014-06-11 2015-07-22 中国农业大学 荧光树枝状纳米大分子在制备药物载体中的应用
EP2966068A1 (en) * 2014-07-08 2016-01-13 Incella GmbH Synthesis and use of amino lipids
CN104383596A (zh) * 2014-10-24 2015-03-04 东华大学 一种tpgs载药脂质体-天然材料复合纳米纤维支架的制备方法
AU2015360794B2 (en) 2014-12-08 2021-07-08 The Board Of Regents Of The University Of Texas System Lipocationic polymers and uses thereof
EP3349802B1 (en) 2015-09-14 2021-08-04 The Board of Regents of the University of Texas System Lipocationic dendrimers and uses thereof
CA3024129A1 (en) * 2016-05-16 2017-11-23 The Board Of Regents Of The University Of Texas System Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids

Also Published As

Publication number Publication date
EP4393549A2 (en) 2024-07-03
BR112018073671A2 (pt) 2019-02-26
AU2021225244B2 (en) 2023-09-28
AU2017268272C1 (en) 2022-05-05
CN115919769A (zh) 2023-04-07
EP3458074A4 (en) 2020-01-22
CN109414451B (zh) 2022-08-12
US20170354672A1 (en) 2017-12-14
JP7789725B2 (ja) 2025-12-22
WO2017201091A1 (en) 2017-11-23
EP4393549A3 (en) 2024-10-09
AU2021225244A1 (en) 2021-09-30
AU2017268272B2 (en) 2021-09-23
JP2026034537A (ja) 2026-02-27
EP3458074A1 (en) 2019-03-27
PL3458074T3 (pl) 2024-11-12
AU2023226641A1 (en) 2023-09-21
AU2017268272A1 (en) 2018-11-29
ES2985317T3 (es) 2024-11-05
JP2023123863A (ja) 2023-09-05
JP7312552B2 (ja) 2023-07-21
EP3458074B1 (en) 2024-04-17
PT3458074T (pt) 2024-08-21
CN109414451A (zh) 2019-03-01
JP2019515016A (ja) 2019-06-06
US20210023120A1 (en) 2021-01-28
CA3024135C (en) 2024-09-24
CA3024135A1 (en) 2017-11-23
AU2023226641B2 (en) 2025-06-26

Similar Documents

Publication Publication Date Title
DK3458074T3 (da) COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH
IL285553A (en) Use of prg4 as an anti-inflammatory agent
BR112016015706A2 (pt) composto, uso do mesmo e composição farmacêutica
EP3478308A4 (en) CANNABIS-BASED COMPOSITION AND PROCESSES
IL248519A0 (en) Bioceramic compositions and biomodulatory uses thereof
IL249061B (en) Combination, composition, and method of administering the combination or composition to animals
HUE052095T2 (hu) Keratin kezelési készítmények és eljárások
IL255307B (en) Tpp1 formulations and uses thereon in cln2 disease
DK3182962T3 (da) Compositions and uses of amidine derivatives
MA54716A (fr) Réduction de la viscosité de formulations pharmaceutiques
EP3194564A4 (en) Trichoderma compositions and methods of use
IL280690A (en) Pharmaceutical preparations that include DGLA and their use
EP3283580C0 (en) ANTI-CORROSION NANOPARTICLE COMPOSITIONS
EP3190886A4 (en) Compositions and methods of use thereof
IL246823B (en) History of benzimidazole and their pharmaceutical preparations for the treatment of inflammatory disorders
EP3110422A4 (en) Compositions and methods for the delivery of therapeutics
IL264445A (en) Compounds and compositions and uses thereof
PL3209828T3 (pl) Kompozycje włókniste zawierające n-halamine i ich zastosowanie
PL3145508T3 (pl) Nanocząstki klewidypiny i ich kompozycje farmaceutyczne
PL3373922T3 (pl) Kompozycje i sposoby do stosowania do leczenia homocystynurii
IL246587A0 (en) Preparations for use in the treatment of allergic conditions
BR112017012240A2 (pt) métodos de preparação de composições contendo alcaloides e suas utilizações
EP3305309A4 (en) ANTICARIOGENIC AGENT AND ANTICARIAC COMPOSITION
DK3233104T3 (da) Immunterapi-behandlinger og -sammensætninger
PT3191080T (pt) Composições parentéricas e suas utilizações