PL3458074T3 - KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA - Google Patents
KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIAInfo
- Publication number
- PL3458074T3 PL3458074T3 PL17800042.8T PL17800042T PL3458074T3 PL 3458074 T3 PL3458074 T3 PL 3458074T3 PL 17800042 T PL17800042 T PL 17800042T PL 3458074 T3 PL3458074 T3 PL 3458074T3
- Authority
- PL
- Poland
- Prior art keywords
- trna
- nanoparticles
- delivery
- compositions
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662337096P | 2016-05-16 | 2016-05-16 | |
| PCT/US2017/032967 WO2017201091A1 (en) | 2016-05-16 | 2017-05-16 | COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3458074T3 true PL3458074T3 (pl) | 2024-11-12 |
Family
ID=60326616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17800042.8T PL3458074T3 (pl) | 2016-05-16 | 2017-05-16 | KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20170354672A1 (pl) |
| EP (2) | EP4393549A3 (pl) |
| JP (3) | JP7312552B2 (pl) |
| CN (2) | CN109414451B (pl) |
| AU (3) | AU2017268272C1 (pl) |
| CA (1) | CA3024135C (pl) |
| DK (1) | DK3458074T3 (pl) |
| ES (1) | ES2985317T3 (pl) |
| PL (1) | PL3458074T3 (pl) |
| PT (1) | PT3458074T (pl) |
| WO (1) | WO2017201091A1 (pl) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11247968B2 (en) * | 2015-09-14 | 2022-02-15 | The Board Of Regents Of The University Of Texas System | Lipocationic dendrimers and uses thereof |
| EP3589751A4 (en) | 2017-03-03 | 2021-11-17 | The Regents of The University of California | RNA TARGETING OF MUTATIONS VIA SUPPRESSOR RNA AND DEAMINASES |
| KR102857378B1 (ko) | 2017-11-02 | 2025-09-11 | 유니버시티 오브 아이오와 리써치 파운데이션 | ACE-tRNA에 의한 유전자 재지정을 통해 정지 코돈을 구조하는 방법 |
| US12357580B2 (en) | 2018-06-19 | 2025-07-15 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids |
| GB2592505B (en) | 2018-09-04 | 2023-05-03 | Univ Texas | Compositions and methods for organ specific delivery of nucleic acids |
| WO2020051220A1 (en) | 2018-09-04 | 2020-03-12 | The Board of the Regents of the University of Texas System | Compositions and methods for organ specific delivery of nucleic acids |
| CN109266734A (zh) * | 2018-09-25 | 2019-01-25 | 深圳市人民医院 | 自身免疫性疾病诊断试剂盒和应用 |
| US10905778B2 (en) | 2018-09-26 | 2021-02-02 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| CA3114108A1 (en) * | 2018-09-26 | 2020-04-02 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| WO2020069199A1 (en) * | 2018-09-26 | 2020-04-02 | Case Western Reserve University | Methods and compositions for increasing protein expression and/or treating a haploinsufficiency disorder |
| WO2020243560A1 (en) * | 2019-05-31 | 2020-12-03 | Flagship Pioneering, Inc. | Uses of trem compositions to modulate trna pools |
| CN115038789A (zh) | 2019-12-02 | 2022-09-09 | 塑造治疗公司 | 治疗性编辑 |
| WO2021252354A1 (en) * | 2020-06-12 | 2021-12-16 | University Of Rochester | ENCODING AND EXPRESSION OF ACE-tRNAs |
| WO2022204219A1 (en) | 2021-03-22 | 2022-09-29 | Recode Therapeutics, Inc. | Compositions and methods for targeted delivery to cells |
| JP2024511437A (ja) | 2021-03-23 | 2024-03-13 | リコード セラピューティクス,インク. | ポリヌクレオチド組成物、関連製剤、およびその使用方法 |
| CN117881789A (zh) * | 2021-06-09 | 2024-04-12 | 瑞科德治疗公司 | 多核苷酸组合物、相关制剂、及其使用方法 |
| CN113416784A (zh) * | 2021-07-18 | 2021-09-21 | 南京中医药大学 | 一种与乳腺癌诊断相关的血清外泌体tsRNA标志物及其应用 |
| CA3257006A1 (en) * | 2022-05-09 | 2023-11-16 | Flagship Pioneering Innovations Vi, Llc | TREM COMPOSITIONS AND METHODS OF USE FOR TREATING PROLIFERATIVE DISORDERS |
| WO2023218420A1 (en) | 2022-05-13 | 2023-11-16 | Janssen Pharmaceuticals, Inc. | Mrna compositions for inducing latent hiv-1 reversal |
| CN115851911B (zh) * | 2022-11-25 | 2025-10-24 | 南京鼓楼医院 | 一种用于鉴别狼疮性肾炎的尿液外泌体tsRNA标志物和探针及其应用 |
| CN120693181A (zh) | 2022-12-08 | 2025-09-23 | 瑞科德治疗公司 | 脂质纳米颗粒组合物及其用途 |
| CN116515827B (zh) * | 2023-03-20 | 2024-12-10 | 复旦大学附属眼耳鼻喉科医院 | 用于治疗年龄相关性黄斑变性的活性成分、药物组合物和应用 |
| US12364773B2 (en) | 2023-12-01 | 2025-07-22 | Recode Therapeutics, Inc. | Lipid nanoparticle compositions and uses thereof |
| WO2025137646A1 (en) | 2023-12-22 | 2025-06-26 | Recode Therapeutics, Inc. | Gene editing methods and compositions for treating cystic fibrosis |
| CN117965718B (zh) * | 2024-02-02 | 2024-09-06 | 江苏省中医院 | 一种与脓毒症相关的生物标志物及其应用 |
| CN117771265B (zh) * | 2024-02-23 | 2024-06-11 | 山东大学 | 一种用于延缓间充质干细胞衰老的小分子rna及其应用 |
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| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US5801029A (en) | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
| EP1490489B1 (en) * | 2002-03-14 | 2010-06-02 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for monitoring and modulating gene silencing |
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| WO2008045486A2 (en) * | 2006-10-09 | 2008-04-17 | The University Of North Carolina At Chapel Hill | Nanoparticle compositions for controlled delivery of nucleic acids |
| CN101595215A (zh) * | 2006-10-30 | 2009-12-02 | 普罗梅加公司 | 具有增强的动力学和功能性表达的突变水解酶蛋白 |
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| JP5777519B2 (ja) * | 2008-10-09 | 2015-09-09 | テクミラ ファーマシューティカルズ コーポレイション | 改良されたアミノ脂質および核酸の送達方法 |
| WO2010053572A2 (en) | 2008-11-07 | 2010-05-14 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| KR100909786B1 (ko) * | 2008-11-10 | 2009-07-29 | 고려대학교 산학협력단 | 올리고 펩티드를 수식한 신규한 양이온성 지질, 그의 제조 방법 및 그를 포함하는 전달체 |
| EP2437756A2 (en) | 2009-06-02 | 2012-04-11 | Wu, Nian | Pure peg-lipid conjugates |
| CN101591428B (zh) | 2009-06-29 | 2011-05-25 | 浙江大学 | 一种聚酯树枝状大分子的制备方法 |
| CA2765694C (en) * | 2009-07-09 | 2021-05-18 | Marina Biotech, Inc. | Amphoteric liposomes comprising imino lipids |
| EP2496700B1 (en) * | 2009-11-04 | 2017-03-01 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
| KR101183989B1 (ko) * | 2010-02-04 | 2012-09-19 | 전남대학교산학협력단 | 세포내 유전자 전달용 복합체, 이의 제조 방법 및 이를 이용한 세포내로의 유전자 전달 방법 |
| AU2011281121A1 (en) * | 2010-07-22 | 2013-02-21 | Anima Cell Metrology, Inc. | Systems and methods for detection of cellular stress |
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| CN103999853B (zh) | 2014-06-11 | 2015-07-22 | 中国农业大学 | 荧光树枝状纳米大分子在制备药物载体中的应用 |
| EP2966068A1 (en) | 2014-07-08 | 2016-01-13 | Incella GmbH | Synthesis and use of amino lipids |
| CN104383596A (zh) * | 2014-10-24 | 2015-03-04 | 东华大学 | 一种tpgs载药脂质体-天然材料复合纳米纤维支架的制备方法 |
| AU2015360794B2 (en) | 2014-12-08 | 2021-07-08 | The Board Of Regents Of The University Of Texas System | Lipocationic polymers and uses thereof |
| US11247968B2 (en) | 2015-09-14 | 2022-02-15 | The Board Of Regents Of The University Of Texas System | Lipocationic dendrimers and uses thereof |
| EP3458032A4 (en) * | 2016-05-16 | 2019-12-25 | The Board of Regents of The University of Texas System | CATIONIC SULFONAMIDE AMINOLIPIDS AND AMPHIPHILE ZWITTERIONIC AMINOLIPIDS |
-
2017
- 2017-05-16 WO PCT/US2017/032967 patent/WO2017201091A1/en not_active Ceased
- 2017-05-16 JP JP2018560153A patent/JP7312552B2/ja active Active
- 2017-05-16 PL PL17800042.8T patent/PL3458074T3/pl unknown
- 2017-05-16 PT PT178000428T patent/PT3458074T/pt unknown
- 2017-05-16 AU AU2017268272A patent/AU2017268272C1/en active Active
- 2017-05-16 ES ES17800042T patent/ES2985317T3/es active Active
- 2017-05-16 CN CN201780038893.0A patent/CN109414451B/zh active Active
- 2017-05-16 EP EP24161024.5A patent/EP4393549A3/en active Pending
- 2017-05-16 US US15/597,063 patent/US20170354672A1/en not_active Abandoned
- 2017-05-16 DK DK17800042.8T patent/DK3458074T3/da active
- 2017-05-16 CN CN202210856722.1A patent/CN115919769A/zh active Pending
- 2017-05-16 CA CA3024135A patent/CA3024135C/en active Active
- 2017-05-16 EP EP17800042.8A patent/EP3458074B1/en active Active
-
2020
- 2020-10-06 US US17/064,505 patent/US20210023120A1/en not_active Abandoned
-
2021
- 2021-09-03 AU AU2021225244A patent/AU2021225244B2/en active Active
-
2023
- 2023-07-10 JP JP2023112723A patent/JP7789725B2/ja active Active
- 2023-09-05 AU AU2023226641A patent/AU2023226641B2/en active Active
-
2025
- 2025-12-10 JP JP2025244172A patent/JP2026034537A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3024135A1 (en) | 2017-11-23 |
| JP7789725B2 (ja) | 2025-12-22 |
| DK3458074T3 (da) | 2024-07-29 |
| JP7312552B2 (ja) | 2023-07-21 |
| CN109414451A (zh) | 2019-03-01 |
| EP4393549A3 (en) | 2024-10-09 |
| JP2023123863A (ja) | 2023-09-05 |
| CN115919769A (zh) | 2023-04-07 |
| US20210023120A1 (en) | 2021-01-28 |
| EP4393549A2 (en) | 2024-07-03 |
| WO2017201091A1 (en) | 2017-11-23 |
| AU2023226641B2 (en) | 2025-06-26 |
| AU2021225244B2 (en) | 2023-09-28 |
| EP3458074B1 (en) | 2024-04-17 |
| AU2023226641A1 (en) | 2023-09-21 |
| AU2021225244A1 (en) | 2021-09-30 |
| US20170354672A1 (en) | 2017-12-14 |
| AU2017268272C1 (en) | 2022-05-05 |
| BR112018073671A2 (pt) | 2019-02-26 |
| EP3458074A1 (en) | 2019-03-27 |
| CA3024135C (en) | 2024-09-24 |
| AU2017268272A1 (en) | 2018-11-29 |
| JP2026034537A (ja) | 2026-02-27 |
| PT3458074T (pt) | 2024-08-21 |
| JP2019515016A (ja) | 2019-06-06 |
| EP3458074A4 (en) | 2020-01-22 |
| CN109414451B (zh) | 2022-08-12 |
| ES2985317T3 (es) | 2024-11-05 |
| AU2017268272B2 (en) | 2021-09-23 |
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