DK3464628T5 - Target reporter constructs and uses thereof - Google Patents

Target reporter constructs and uses thereof Download PDF

Info

Publication number
DK3464628T5
DK3464628T5 DK17731374.9T DK17731374T DK3464628T5 DK 3464628 T5 DK3464628 T5 DK 3464628T5 DK 17731374 T DK17731374 T DK 17731374T DK 3464628 T5 DK3464628 T5 DK 3464628T5
Authority
DK
Denmark
Prior art keywords
reporter constructs
target reporter
target
constructs
reporter
Prior art date
Application number
DK17731374.9T
Other languages
English (en)
Other versions
DK3464628T3 (en
Inventor
Michael L Metzker
Christopher August Weier
Original Assignee
Redvault Biosciences Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Redvault Biosciences Lp filed Critical Redvault Biosciences Lp
Publication of DK3464628T3 publication Critical patent/DK3464628T3/da
Application granted granted Critical
Publication of DK3464628T5 publication Critical patent/DK3464628T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
DK17731374.9T 2016-06-06 2017-06-06 Target reporter constructs and uses thereof DK3464628T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662346334P 2016-06-06 2016-06-06
PCT/US2017/036129 WO2017214127A1 (en) 2016-06-06 2017-06-06 Target reporter constructs and uses thereof

Publications (2)

Publication Number Publication Date
DK3464628T3 DK3464628T3 (en) 2024-06-03
DK3464628T5 true DK3464628T5 (da) 2024-10-14

Family

ID=59078201

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17731374.9T DK3464628T5 (da) 2016-06-06 2017-06-06 Target reporter constructs and uses thereof

Country Status (9)

Country Link
US (2) US11299769B2 (da)
EP (2) EP4372102A3 (da)
AU (1) AU2017278350B2 (da)
CA (1) CA3026193A1 (da)
DK (1) DK3464628T5 (da)
FI (1) FI3464628T3 (da)
PT (1) PT3464628T (da)
SG (1) SG11201810907UA (da)
WO (1) WO2017214127A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103328654B (zh) 2010-10-27 2017-07-11 哈佛学院院长等 立足点引物双链体的组合物及其使用方法
ES2891085T3 (es) 2015-01-30 2022-01-26 Harvard College Obtención de imágenes sin microscopio
PT3464628T (pt) * 2016-06-06 2024-06-03 Redvault Biosciences Lp Construções repórter de alvo e suas utilizações
US11492661B2 (en) * 2017-01-10 2022-11-08 President And Fellows Of Harvard College Multiplexed signal amplification
WO2019147945A1 (en) 2018-01-26 2019-08-01 President And Fellows Of Harvard College Proximity detection methods and compositions
CN108273056A (zh) * 2018-02-01 2018-07-13 中国科学院长春应用化学研究所 一种改性金纳米材料/核酸探针纳米体系及其制备方法、应用
US11125743B2 (en) * 2018-02-20 2021-09-21 Arizona Board Of Regents On Behalf Of Arizona State University Detection of norovirus using norovirus-specific toehold switches
CN108665451B (zh) * 2018-05-04 2022-02-25 江西理工大学 基于三元高斯差分演化算法的圆检测方法
SG11202101405RA (en) 2018-08-14 2021-03-30 Harvard College In vitro detection of nucleic acid
JP7528067B2 (ja) * 2018-10-25 2024-08-05 イルミナ インコーポレイテッド インデックス及びバーコードを使用してアレイ上のリガンドを識別するための方法及び組成物
CN109371136B (zh) * 2018-12-28 2021-07-02 青岛泱深生物医药有限公司 一种与肺腺癌相关的lncRNA及其应用
CA3129868A1 (en) * 2019-03-01 2020-09-10 Mercy Bioanalytics, Inc. Systems, compositions, and methods for target entity detection
CN110004213B (zh) * 2019-03-04 2023-01-03 山东师范大学 基于Toehold介导链置换反应引发滚环扩增和FRET检测miRNA的方法
US11900595B2 (en) * 2020-05-08 2024-02-13 Singular Genomics Systems, Inc. Imaging systems and methods useful for patterned structures
CN112501304A (zh) * 2020-12-17 2021-03-16 浙江清华长三角研究院 miRNA-424作为脑垂体瘤诊断标志物的应用
CN115896254A (zh) * 2021-09-23 2023-04-04 海南大学 一种miRNA的定性检测方法
PL447879A1 (pl) * 2024-02-28 2025-09-01 Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polska Akademia Nauk Struktury microRNA do predykcji, monitorowania i diagnozowania epileptogenezy i padaczki

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0224126A3 (en) 1985-11-25 1989-02-01 The University of Calgary Covalently linked complementary oligodeoxynucleotides as universal nucleic acid sequencing primer linkers
US6107023A (en) 1988-06-17 2000-08-22 Genelabs Technologies, Inc. DNA amplification and subtraction techniques
NZ231641A (en) 1988-12-07 1991-09-25 Gen Hospital Corp A method of enriching a gene sequence involving hybridisation of two populations of nucleic acid molecules
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
DE19826758C1 (de) 1998-06-15 1999-10-21 Soft Gene Gmbh Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
EP1238105A2 (en) 1999-12-02 2002-09-11 Molecular Staging Inc. Generation of single-strand circular dna from linear self-annealing segments
EP3034627B1 (en) 2000-10-06 2019-01-30 The Trustees of Columbia University in the City of New York Massive parallel method for decoding dna and rna
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US20030228611A1 (en) 2002-05-01 2003-12-11 President And Fellows Of Harvard College Nucleic acid memory device
AU2003259350A1 (en) 2002-08-23 2004-03-11 Solexa Limited Modified nucleotides for polynucleotide sequencing
AU2003272438B2 (en) 2002-09-20 2009-04-02 New England Biolabs, Inc. Helicase dependent amplification of nucleic acids
US7662594B2 (en) 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
GB0304371D0 (en) 2003-02-26 2003-04-02 Solexa Ltd DNA Sequence analysis
US7622279B2 (en) 2004-03-03 2009-11-24 The Trustees Of Columbia University In The City Of New York Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry
US20100075384A1 (en) 2004-03-25 2010-03-25 New England Biolabs, Inc. Helicase-dependent amplification of circular nucleic acids
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
WO2007120208A2 (en) 2005-11-14 2007-10-25 President And Fellows Of Harvard College Nanogrid rolling circle dna sequencing
US7368265B2 (en) 2006-01-23 2008-05-06 Compass Genetics, Llc Selective genome amplification
WO2007102006A2 (en) 2006-03-09 2007-09-13 Solexa Limited Non-cloning vector method for generating genomic templates for cluster formation and sbs sequencing
WO2008109176A2 (en) 2007-03-07 2008-09-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
AU2009257369B2 (en) 2008-06-11 2015-03-26 Agilent Technologies, Inc. Nucleotides and nucleosides and methods for their use in DNA sequencing
EP2310524A4 (en) 2008-07-10 2013-07-24 Versitech Ltd METHODS OF CARTOGRAPHY OF NUCLEIC ACIDS AND IDENTIFICATION OF FINE STRUCTURAL VARIATIONS IN NUCLEIC ACIDS
EP2393940B1 (en) 2009-02-03 2014-12-17 New England Biolabs, Inc. Generation of random double-strand breaks in dna using enzymes
US20120156728A1 (en) 2010-12-17 2012-06-21 Life Technologies Corporation Clonal amplification of nucleic acid on solid surface with template walking
US9309566B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
CA2874716A1 (en) 2012-05-31 2013-12-05 Takeda Pharmaceutical Company Limited Method for assessing endometriosis
US9650676B2 (en) 2014-03-19 2017-05-16 University Of South Carolina Leukocyte MicroRNAS for use in diagnosis and treatment of endometriosis
US11993816B2 (en) 2014-03-27 2024-05-28 Yale University Circulating microRNA as biomarkers for endometriosis
WO2016019455A1 (en) * 2014-07-28 2016-02-11 Simply Diagnostics Inc. Site-specific endonuclease guided rolling circle amplification
KR101764585B1 (ko) * 2014-10-30 2017-08-10 이화여자대학교 산학협력단 표적 유전자 검출용 미세 유동 장치, 이의 제조방법 및 이를 이용한 검출 방법
CN105349683B (zh) * 2015-12-09 2018-12-18 山东大学 目标物保护的哑铃分子探针介导的级联滚环扩增策略用于dna甲基转移酶活性的灵敏检测
WO2017175190A1 (en) 2016-04-07 2017-10-12 Uhnder, Inc. Adaptive transmission and interference cancellation for mimo radar
PT3464628T (pt) * 2016-06-06 2024-06-03 Redvault Biosciences Lp Construções repórter de alvo e suas utilizações

Also Published As

Publication number Publication date
FI3464628T3 (fi) 2024-05-03
SG11201810907UA (en) 2019-01-30
CA3026193A1 (en) 2017-12-14
DK3464628T3 (en) 2024-06-03
AU2017278350A1 (en) 2019-01-03
EP4372102A3 (en) 2024-08-14
AU2017278350B2 (en) 2023-10-19
US11299769B2 (en) 2022-04-12
EP3464628C0 (en) 2024-01-31
EP3464628B1 (en) 2024-01-31
WO2017214127A1 (en) 2017-12-14
US20220307076A1 (en) 2022-09-29
US12435356B2 (en) 2025-10-07
US20170349939A1 (en) 2017-12-07
EP4372102A2 (en) 2024-05-22
PT3464628T (pt) 2024-06-03
EP3464628A1 (en) 2019-04-10

Similar Documents

Publication Publication Date Title
IL285286A (en) Transposase polypeptides and uses thereof
DK3464628T3 (en) Target reporter constructs and uses thereof
HUE058874T2 (hu) Hõmérséklet-meghatározás
MA46458A (fr) Compositions debacillus thuringiensis
IL280863A (en) Autotaxin inhibitors and uses thereof
PT3443009T (pt) Anticorpos anti-tim-3 e composições
PT3368534T (pt) Ditosilato de valbenazina e polimorfos do mesmo
IL248979B (en) Syntac polypeptides and uses thereof
LT3280441T (lt) Anti-sortilino antikūnai ir jų naudojimo būdai
IL263273A (en) Anti-gitr antibodies and uses thereof
EP3585901A4 (en) NUCLEIC ACID CONSTRUCTIONS INCLUDING MULTIPLE GENE EDITING SITES AND THEIR USES
PL3293188T3 (pl) Silany i utwardzalne kompozycje obejmujące wskazane silany
IL282201B (en) Anti-tenascin c antibodies and uses thereof
EP3604821A4 (en) HELICOIDAL FAN
EP3490365A4 (en) WHEAT
PL3703518T3 (pl) Formulacja ulegająca aerozolowaniu
IL250796B (en) Binding proteins specific for lox1 and uses thereof
EP3723248A4 (en) COOLING FAN
PT3337506T (pt) Combinações e suas utilizações
EP3312578A4 (en) THERMOMETER
EP3556666A4 (en) DEFINABLE RADIATOR
EP3677506A4 (en) Flying body
EP3535492A4 (en) ENVIRONMENTAL THERMAL ENERGY CONVERSION
EP3530711A4 (en) GEL COMPOSITION
IL258744B (en) An improved herbicidal formulation