DK3465207T3 - Ligand-identificering via co-fraktionering - Google Patents

Ligand-identificering via co-fraktionering Download PDF

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Publication number
DK3465207T3
DK3465207T3 DK17725620.3T DK17725620T DK3465207T3 DK 3465207 T3 DK3465207 T3 DK 3465207T3 DK 17725620 T DK17725620 T DK 17725620T DK 3465207 T3 DK3465207 T3 DK 3465207T3
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DK
Denmark
Prior art keywords
fractioning
identification via
ligand identification
ligand
identification
Prior art date
Application number
DK17725620.3T
Other languages
English (en)
Inventor
Sylwia Kierszniowska
Lothar Willmitzer
Aleksandra Skirycz
Monika Chodasiewicz
Daniel Veyel
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK3465207T3 publication Critical patent/DK3465207T3/da

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34Purifying; Cleaning
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/087Structure determination of a chemical compound, e.g. of a biomolecule such as a protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
DK17725620.3T 2016-05-30 2017-05-29 Ligand-identificering via co-fraktionering DK3465207T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16172000 2016-05-30
PCT/EP2017/062841 WO2017207460A1 (en) 2016-05-30 2017-05-29 Ligand identification by co-fractionation

Publications (1)

Publication Number Publication Date
DK3465207T3 true DK3465207T3 (da) 2021-11-15

Family

ID=56119308

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17725620.3T DK3465207T3 (da) 2016-05-30 2017-05-29 Ligand-identificering via co-fraktionering

Country Status (15)

Country Link
US (1) US10976310B2 (da)
EP (1) EP3465207B1 (da)
KR (1) KR102346785B1 (da)
CN (1) CN109219750B (da)
AU (1) AU2017272493B2 (da)
BR (1) BR112018074856A2 (da)
DK (1) DK3465207T3 (da)
ES (1) ES2899110T3 (da)
HU (1) HUE056359T2 (da)
LT (1) LT3465207T (da)
PL (1) PL3465207T3 (da)
PT (1) PT3465207T (da)
SG (1) SG11201810531TA (da)
SI (1) SI3465207T1 (da)
WO (1) WO2017207460A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3115315A1 (en) 2018-10-15 2020-04-23 Anthony A. HYMAN Compounds for treatment of diseases and methods of screening therefor
US11493519B2 (en) 2019-02-08 2022-11-08 Dewpoint Therapeutics, Inc. Methods of characterizing condensate-associated characteristics of compounds and uses thereof
JP2022548695A (ja) 2019-09-18 2022-11-21 デューポイント セラピューティクス, インコーポレイテッド 凝縮体関連特異性のスクリーニング方法及びその使用
JP7327096B2 (ja) * 2019-11-13 2023-08-16 株式会社島津製作所 分子の分離方法
KR20220137672A (ko) * 2020-02-13 2022-10-12 에프. 호프만-라 로슈 아게 핵 자기 공명 이완법으로 aav 입자의 부하 상태를 결정하는 방법
CN113528497B (zh) * 2021-07-22 2022-06-24 中国林业科学研究院林业研究所 Fba8基因或fba8蛋白在制备具有磷酸转移活性和/或蛋白水解活性的试剂中的应用
WO2024112940A1 (en) * 2022-11-26 2024-05-30 Enveda Therapeutics, Inc. Methods and systems for identifying compounds for forming, stabilizing or disrupting molecular complexes
CN118685492A (zh) * 2024-03-08 2024-09-24 西湖实验室(生命科学和生物医学浙江省实验室) 微量新鲜样本六组学连续提取方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4459359A (en) 1981-11-19 1984-07-10 New York Blood Center, Inc. Sensitive immunoassays of antigens or antibodies sequestered within immune complexes
CA2369868A1 (en) * 1999-04-15 2000-10-26 The University Of Virginia Patent Foundation Proteome mining
JP2005535727A (ja) * 2002-08-14 2005-11-24 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート タンパク質−タンパク質相互作用に関与するタンパク質亜集団の単離方法
WO2006015796A1 (en) * 2004-08-09 2006-02-16 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for high-throughput screening of test molecules binding to target molecules
US20150105280A1 (en) 2010-03-10 2015-04-16 Perfinity Biosciences, Inc. Selector based recognition and quantification system and method for multiple analytes in a single analysis
AU2013347838A1 (en) 2012-11-26 2015-06-11 Caris Life Sciences Switzerland Holdings Gmbh Biomarker compositions and methods

Also Published As

Publication number Publication date
CA3025711A1 (en) 2017-12-07
BR112018074856A2 (pt) 2019-03-06
KR20190013999A (ko) 2019-02-11
EP3465207B1 (en) 2021-09-01
SG11201810531TA (en) 2018-12-28
SI3465207T1 (sl) 2022-01-31
PT3465207T (pt) 2021-11-30
US10976310B2 (en) 2021-04-13
LT3465207T (lt) 2021-12-10
AU2017272493B2 (en) 2021-07-22
EP3465207A1 (en) 2019-04-10
AU2017272493A1 (en) 2018-12-20
HUE056359T2 (hu) 2022-02-28
WO2017207460A1 (en) 2017-12-07
KR102346785B1 (ko) 2022-01-04
PL3465207T3 (pl) 2022-01-17
CN109219750B (zh) 2022-05-31
CN109219750A (zh) 2019-01-15
US20190361012A1 (en) 2019-11-28
ES2899110T3 (es) 2022-03-10

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