DK346682A - Fremgangsmaade til fremstilling af polypeptidderivater - Google Patents

Fremgangsmaade til fremstilling af polypeptidderivater Download PDF

Info

Publication number: DK346682A
Authority: DK; Denmark
Prior art keywords: procedure; polypeptide derivatives; preparing polypeptide; water; threonine
Prior art date: 1981-08-10

Application number

DK346682A

Other languages

English (en)

Other versions

DK149314B (da

DK149314C (da

Inventor

Jan Markussen

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-10

Filing date

1982-08-03

Publication date

1983-02-11

1981-08-10 Priority claimed from DK353781A external-priority patent/DK353781A/da

1982-08-03 Application filed by Novo Industri As filed Critical Novo Industri As

1982-08-03 Priority to DK346682A priority Critical patent/DK149314C/da

1983-02-11 Publication of DK346682A publication Critical patent/DK346682A/da

1986-04-28 Publication of DK149314B publication Critical patent/DK149314B/da

1986-10-20 Application granted granted Critical

1986-10-20 Publication of DK149314C publication Critical patent/DK149314C/da

Links

238000000034 method Methods 0.000 title abstract 3
229920001184 polypeptide Polymers 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
125000000769 L-threonyl group Chemical class [H]N([H])[C@]([H])(C(=O)[*])[C@](O[H])(C([H])([H])[H])[H] 0.000 abstract 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
239000004473 Threonine Substances 0.000 abstract 1
102000004142 Trypsin Human genes 0.000 abstract 1
108090000631 Trypsin Proteins 0.000 abstract 1
230000009435 amidation Effects 0.000 abstract 1
238000007112 amidation reaction Methods 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
229960002898 threonine Drugs 0.000 abstract 1
239000012588 trypsin Substances 0.000 abstract 1

Landscapes

Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK346682A 1981-08-10 1982-08-03 Fremgangsmaade til fremstilling af humaninsulin eller threonin-b30-derivater af humaninsulin eller et salt eller kompleks deraf DK149314C (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK346682A DK149314C (da)	1981-08-10	1982-08-03	Fremgangsmaade til fremstilling af humaninsulin eller threonin-b30-derivater af humaninsulin eller et salt eller kompleks deraf

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK353781		1981-08-10
DK353781A DK353781A (da)	1981-08-10	1981-08-10	Fremgangsmaade til fremstilling af insulinderivater
DK346682		1982-08-03
DK346682A DK149314C (da)	1981-08-10	1982-08-03	Fremgangsmaade til fremstilling af humaninsulin eller threonin-b30-derivater af humaninsulin eller et salt eller kompleks deraf

Publications (3)

Publication Number	Publication Date
DK346682A true DK346682A (da)	1983-02-11
DK149314B DK149314B (da)	1986-04-28
DK149314C DK149314C (da)	1986-10-20

Family

ID=26067068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK346682A DK149314C (da)	1981-08-10	1982-08-03	Fremgangsmaade til fremstilling af humaninsulin eller threonin-b30-derivater af humaninsulin eller et salt eller kompleks deraf

Country Status (1)

Country	Link
DK (1)	DK149314C (da)

1982
- 1982-08-03 DK DK346682A patent/DK149314C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK149314B (da)	1986-04-28
DK149314C (da)	1986-10-20

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Legal Events

Date	Code	Title	Description
1986-05-05	AHB	Application shelved due to non-payment
2000-04-10	PBP	Patent lapsed