DK3468971T3 - Nye (hetero)aryl-substituterede piperidinyl-derivativer, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger indeholdende dem - Google Patents

Nye (hetero)aryl-substituterede piperidinyl-derivativer, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger indeholdende dem Download PDF

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Publication number
DK3468971T3
DK3468971T3 DK17728567.3T DK17728567T DK3468971T3 DK 3468971 T3 DK3468971 T3 DK 3468971T3 DK 17728567 T DK17728567 T DK 17728567T DK 3468971 T3 DK3468971 T3 DK 3468971T3
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DK
Denmark
Prior art keywords
hetero
aryl
procedure
preparation
new
Prior art date
Application number
DK17728567.3T
Other languages
English (en)
Inventor
Alba Macias
James Brooke Murray
Olivier Geneste
Didier Demarles
Elodie Lewkowicz
Lisa Ivanschitz
Maïa Chanrion
Árpád Kiss
András Kotschy
Balázs Molnár
Attila Vasas
Csaba Wéber
Original Assignee
Servier Lab
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR1655387A external-priority patent/FR3052451B1/fr
Priority claimed from FR1663463A external-priority patent/FR3061177B1/fr
Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab
Application granted granted Critical
Publication of DK3468971T3 publication Critical patent/DK3468971T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK17728567.3T 2016-06-10 2017-06-09 Nye (hetero)aryl-substituterede piperidinyl-derivativer, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger indeholdende dem DK3468971T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1655387A FR3052451B1 (fr) 2016-06-10 2016-06-10 Nouveaux derives de piperidinyle hetero(aryl)-substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR1663463A FR3061177B1 (fr) 2016-12-28 2016-12-28 Nouveaux derives piperidinyles hetero(aryle)-substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/EP2017/064062 WO2017212010A1 (en) 2016-06-10 2017-06-09 New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
DK3468971T3 true DK3468971T3 (da) 2020-05-18

Family

ID=59021522

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17728567.3T DK3468971T3 (da) 2016-06-10 2017-06-09 Nye (hetero)aryl-substituterede piperidinyl-derivativer, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger indeholdende dem

Country Status (42)

Country Link
US (1) US10654849B2 (da)
EP (1) EP3468971B1 (da)
JP (1) JP6985299B2 (da)
KR (1) KR102003532B1 (da)
CN (1) CN109563094B (da)
AU (1) AU2017277732B2 (da)
BR (1) BR112018075284A2 (da)
CA (1) CA3027008C (da)
CL (1) CL2018003473A1 (da)
CO (1) CO2018013141A2 (da)
CR (1) CR20180563A (da)
CU (1) CU20180146A7 (da)
CY (1) CY1123069T1 (da)
DK (1) DK3468971T3 (da)
DO (1) DOP2018000264A (da)
EC (1) ECSP18090046A (da)
ES (1) ES2778700T3 (da)
GE (2) GEAP202014982A (da)
HR (1) HRP20200556T1 (da)
HU (1) HUE048590T2 (da)
IL (1) IL263455B (da)
LT (1) LT3468971T (da)
MA (1) MA45223B1 (da)
MD (1) MD3468971T2 (da)
MX (1) MX374443B (da)
MY (1) MY196328A (da)
NI (1) NI201800133A (da)
PE (1) PE20220948A1 (da)
PH (1) PH12018502516B1 (da)
PL (1) PL3468971T3 (da)
PT (1) PT3468971T (da)
RS (1) RS60279B1 (da)
RU (1) RU2742271C2 (da)
SG (1) SG11201810576QA (da)
SI (1) SI3468971T1 (da)
SV (1) SV2018005792A (da)
TN (1) TN2018000395A1 (da)
TW (1) TWI647228B (da)
UA (1) UA123793C2 (da)
UY (1) UY37289A (da)
WO (1) WO2017212010A1 (da)
ZA (1) ZA201808286B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
FR3052452B1 (fr) * 2016-06-10 2018-06-22 Les Laboratoires Servier Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2018195450A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
SG11202001685TA (en) 2017-08-28 2020-03-30 Enanta Pharm Inc Hepatitis b antiviral agents
GB201801562D0 (en) 2018-01-31 2018-03-14 Almac Diagnostics Ltd Pharmaceutical compounds
UY38291A (es) * 2018-07-05 2020-06-30 Servier Lab Nuevos derivados de amino-pirimidonilo un proceso para su preparación y composiciones farmacéuticas
TW202024093A (zh) 2018-09-21 2020-07-01 美商安塔製藥公司 作為抗病毒劑之官能化雜環
UY38423A (es) * 2018-10-19 2021-02-26 Servier Lab Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen
EP3883570A4 (en) 2018-11-21 2022-07-13 Enanta Pharmaceuticals, Inc. FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS
US20220033397A1 (en) * 2018-12-06 2022-02-03 Almac Discovery Limited Pharmaceutical compounds and their use as inhibitors of ubiquitin specific protease 19 (usp19)
CA3134564A1 (en) * 2019-05-06 2020-11-12 Lawrence Marcin Inhibiting usp19
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
PT3994130T (pt) 2019-07-03 2024-10-07 Bayer Ag Tiofeno carboxamidas substituídas e derivados das mesmas como microbicidas
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
CN115103840B (zh) 2019-12-20 2025-07-22 拜耳公司 取代的噻吩甲酰胺、噻吩甲酸及其衍生物
CN113087718B (zh) * 2020-01-09 2024-02-09 四川科伦博泰生物医药股份有限公司 噻吩并嘧啶酮类化合物及其医药应用
GB202001980D0 (en) 2020-02-13 2020-04-01 Almac Discovery Ltd Therapeutic mentods
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
US20250214980A1 (en) 2022-03-14 2025-07-03 Slap Pharmaceuticals Llc Multicyclic compounds
CN116574084A (zh) * 2023-04-17 2023-08-11 华南理工大学 一种噻吩衍生物及其合成方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2679807A1 (en) * 2007-03-02 2008-09-12 Schering Corporation Piperidine derivatives and methods of use thereof
EP2565186A1 (en) * 2011-09-02 2013-03-06 Hybrigenics S.A. Selective and reversible inhibitors of ubiquitin specific protease 7
TWI698436B (zh) 2014-12-30 2020-07-11 美商佛瑪治療公司 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶
MA41291A (fr) * 2014-12-30 2017-11-07 Forma Therapeutics Inc Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer
HK1248221A1 (zh) 2015-02-05 2018-10-12 Forma Therapeutics, Inc. 异噻唑啉酮类，吡唑并嘧啶酮类和吡咯并嘧啶酮作为泛蛋白特异性蛋白酶7抑制剂
EP3253765A1 (en) 2015-02-05 2017-12-13 Forma Therapeutics, Inc. Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors
EP3253738A1 (en) 2015-02-05 2017-12-13 Forma Therapeutics, Inc. Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors

Also Published As

Publication number Publication date
GEP20207161B (en) 2020-10-12
US10654849B2 (en) 2020-05-19
US20190144449A1 (en) 2019-05-16
BR112018075284A2 (pt) 2019-03-19
RU2018147424A (ru) 2020-07-13
PT3468971T (pt) 2020-04-09
CL2018003473A1 (es) 2019-05-10
CN109563094B (zh) 2022-03-18
ES2778700T3 (es) 2020-08-11
PE20220948A1 (es) 2022-05-31
AU2017277732B2 (en) 2021-06-17
IL263455A (en) 2019-01-31
TN2018000395A1 (en) 2020-06-15
UA123793C2 (uk) 2021-06-02
MD3468971T2 (ro) 2020-06-30
CY1123069T1 (el) 2021-10-29
RU2742271C2 (ru) 2021-02-04
NI201800133A (es) 2019-04-08
RU2018147424A3 (da) 2020-07-13
KR102003532B1 (ko) 2019-07-24
MA45223A (fr) 2019-04-17
CO2018013141A2 (es) 2018-12-14
SI3468971T1 (sl) 2020-07-31
RS60279B1 (sr) 2020-06-30
CR20180563A (es) 2019-03-14
MA45223B1 (fr) 2020-04-30
UY37289A (es) 2018-01-02
TW201802094A (zh) 2018-01-16
ZA201808286B (en) 2021-07-28
AU2017277732A1 (en) 2018-12-20
PL3468971T3 (pl) 2020-08-10
EP3468971B1 (en) 2020-02-19
CN109563094A (zh) 2019-04-02
SG11201810576QA (en) 2018-12-28
CU20180146A7 (es) 2019-07-04
HUE048590T2 (hu) 2020-08-28
EP3468971A1 (en) 2019-04-17
TWI647228B (zh) 2019-01-11
MX374443B (es) 2025-03-06
WO2017212010A1 (en) 2017-12-14
GEAP202014982A (en) 2020-06-10
DOP2018000264A (es) 2019-05-15
ECSP18090046A (es) 2019-01-31
PH12018502516B1 (en) 2023-10-13
MX2018015212A (es) 2019-04-25
CA3027008C (en) 2021-02-09
PH12018502516A1 (en) 2019-10-28
LT3468971T (lt) 2020-04-10
JP2019521115A (ja) 2019-07-25
MY196328A (en) 2023-03-24
KR20190017032A (ko) 2019-02-19
SV2018005792A (es) 2019-05-20
HRP20200556T1 (hr) 2020-06-26
CA3027008A1 (en) 2017-12-14
IL263455B (en) 2021-01-31
JP6985299B2 (ja) 2021-12-22

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