DK3750893T3 - Dioxazolinforbindelse, fremgangsmåde til fremstilling deraf og anvendelser deraf - Google Patents
Dioxazolinforbindelse, fremgangsmåde til fremstilling deraf og anvendelser deraf Download PDFInfo
- Publication number
- DK3750893T3 DK3750893T3 DK19751025.8T DK19751025T DK3750893T3 DK 3750893 T3 DK3750893 T3 DK 3750893T3 DK 19751025 T DK19751025 T DK 19751025T DK 3750893 T3 DK3750893 T3 DK 3750893T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- dioxazoline compound
- dioxazoline
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710107756 | 2017-02-27 | ||
| PCT/CN2018/076233 WO2018153293A1 (zh) | 2017-02-27 | 2018-02-11 | 二噁烷并喹唑啉与二噁烷并喹啉类化合物及其制备方法与应用 |
| CN201810983341.3A CN110156803A (zh) | 2017-02-27 | 2018-08-27 | 二噁烷并喹啉类化合物及其制备方法与应用 |
| PCT/CN2019/073260 WO2019154133A1 (zh) | 2018-02-11 | 2019-01-25 | 二噁烷并喹啉类化合物及其制备方法与应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3750893T3 true DK3750893T3 (da) | 2023-05-08 |
Family
ID=63374400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19751025.8T DK3750893T3 (da) | 2017-02-27 | 2019-01-25 | Dioxazolinforbindelse, fremgangsmåde til fremstilling deraf og anvendelser deraf |
Country Status (5)
| Country | Link |
|---|---|
| CN (3) | CN108503650B (da) |
| AU (1) | AU2019218187B2 (da) |
| DK (1) | DK3750893T3 (da) |
| ES (1) | ES2945573T3 (da) |
| SG (1) | SG11202007554TA (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11731946B2 (en) | 2017-10-19 | 2023-08-22 | The General Hospital Corporation | Broad spectrum antivirulence, anti-persistence compounds |
| CN110156804B (zh) * | 2018-02-11 | 2021-01-12 | 北京赛特明强医药科技有限公司 | 一种二噁烷并喹啉类化合物及其制备方法 |
| CN111196814B (zh) * | 2018-11-19 | 2022-12-06 | 北京赛特明强医药科技有限公司 | 芳环连二噁烷并喹唑啉或喹啉类化合物、组合物及其应用 |
| CN111004257B (zh) * | 2019-12-24 | 2021-06-29 | 武汉九州钰民医药科技有限公司 | 制备RET抑制剂Selpercatinib的方法 |
| CN112939995A (zh) * | 2021-02-02 | 2021-06-11 | 北京工业大学 | 二噁烷并喹唑啉衍生物制备方法 |
| CN114957136A (zh) * | 2021-02-24 | 2022-08-30 | 南京科默生物医药有限公司 | 一种用作vegfr抑制剂的抗肿瘤化合物及其用途 |
| KR20250090348A (ko) * | 2022-11-01 | 2025-06-19 | 베이징 사이텍-엠큐 파마슈티컬즈 리미티드 | 디옥산 퀴놀린 화합물의 염, 이의 결정 형태, 이의 제조 방법 및 이의 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2210607B1 (en) * | 2003-09-26 | 2011-08-17 | Exelixis Inc. | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer |
| US8664244B2 (en) * | 2010-09-12 | 2014-03-04 | Advenchen Pharmaceuticals, LLC | Compounds as c-Met kinase inhibitors |
| HUE045810T2 (hu) * | 2010-09-27 | 2020-01-28 | Exelixis Inc | MET és VEGF kettõs inhibitorai kasztrációrezisztens prosztatarák és oszteoblasztos csontáttétek kezelésére |
| CN104530063B (zh) * | 2015-01-13 | 2017-01-18 | 北京赛特明强医药科技有限公司 | 喹唑啉并杂环类化合物及其制备方法和作为用于治疗癌症的表皮生长因子受体抑制剂的应用 |
| CN106279147A (zh) * | 2015-05-21 | 2017-01-04 | 中国科学院上海药物研究所 | 一种吡啶并氮杂环化合物及其制备方法和用途 |
| CN105837586B (zh) * | 2015-12-14 | 2018-02-13 | 北京赛特明强医药科技有限公司 | 二噁烷并喹唑啉胺类化合物及其制备方法和作为表皮生长因子受体抑制剂的应用 |
| CN105541798B (zh) * | 2016-02-03 | 2018-01-23 | 中国人民解放军第二军医大学 | 具有抗肿瘤活性的喹啉类多靶点激酶抑制剂及其制备方法 |
| WO2018153293A1 (zh) * | 2017-02-27 | 2018-08-30 | 北京赛特明强医药科技有限公司 | 二噁烷并喹唑啉与二噁烷并喹啉类化合物及其制备方法与应用 |
-
2017
- 2017-03-17 CN CN201710161873.4A patent/CN108503650B/zh active Active
-
2018
- 2018-08-27 CN CN201810983341.3A patent/CN110156803A/zh active Pending
-
2019
- 2019-01-25 SG SG11202007554TA patent/SG11202007554TA/en unknown
- 2019-01-25 DK DK19751025.8T patent/DK3750893T3/da active
- 2019-01-25 AU AU2019218187A patent/AU2019218187B2/en active Active
- 2019-01-25 ES ES19751025T patent/ES2945573T3/es active Active
- 2019-01-25 CN CN201980012397.7A patent/CN111788207B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN111788207A (zh) | 2020-10-16 |
| AU2019218187A1 (en) | 2020-09-10 |
| CN108503650B (zh) | 2021-02-12 |
| CN110156803A (zh) | 2019-08-23 |
| CN111788207B (zh) | 2021-03-23 |
| CN108503650A (zh) | 2018-09-07 |
| SG11202007554TA (en) | 2020-09-29 |
| AU2019218187B2 (en) | 2021-10-14 |
| ES2945573T3 (es) | 2023-07-04 |
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