DK3473296T3 - Minimalt invasiv dermal elektroporeringsenhed - Google Patents

Minimalt invasiv dermal elektroporeringsenhed Download PDF

Info

Publication number
DK3473296T3
DK3473296T3 DK18190065.5T DK18190065T DK3473296T3 DK 3473296 T3 DK3473296 T3 DK 3473296T3 DK 18190065 T DK18190065 T DK 18190065T DK 3473296 T3 DK3473296 T3 DK 3473296T3
Authority
DK
Denmark
Prior art keywords
minimally invasive
electroporation unit
invasive dermal
dermal electroporation
unit
Prior art date
Application number
DK18190065.5T
Other languages
English (en)
Inventor
Kate Broderick
Stephen Kemmerrer
Jay Mccoy
Original Assignee
Inovio Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inovio Pharmaceuticals Inc filed Critical Inovio Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3473296T3 publication Critical patent/DK3473296T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Electromagnetism (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Finger-Pressure Massage (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
DK18190065.5T 2011-06-28 2012-06-28 Minimalt invasiv dermal elektroporeringsenhed DK3473296T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161502198P 2011-06-28 2011-06-28
EP12846201.7A EP2726145B1 (en) 2011-06-28 2012-06-28 A miniminally invasive dermal electroporation device

Publications (1)

Publication Number Publication Date
DK3473296T3 true DK3473296T3 (da) 2020-11-09

Family

ID=48192559

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18190065.5T DK3473296T3 (da) 2011-06-28 2012-06-28 Minimalt invasiv dermal elektroporeringsenhed
DK12846201.7T DK2726145T3 (da) 2011-06-28 2012-06-28 Minimalt invasivt, dermalt elektroporationsapparat

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK12846201.7T DK2726145T3 (da) 2011-06-28 2012-06-28 Minimalt invasivt, dermalt elektroporationsapparat

Country Status (10)

Country Link
US (4) US9913978B2 (da)
EP (4) EP2726145B1 (da)
JP (7) JP2014524796A (da)
KR (6) KR102908569B1 (da)
CN (1) CN103687644B (da)
AU (1) AU2012333211A1 (da)
CA (1) CA2837214C (da)
DK (2) DK3473296T3 (da)
ES (1) ES2992120T3 (da)
WO (1) WO2013066427A1 (da)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
ES3005233T3 (en) 2010-10-01 2025-03-14 Modernatx Inc Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
AU2012333211A1 (en) 2011-06-28 2013-12-19 Inovio Pharmaceuticals, Inc. A miniminally invasive dermal electroporation device
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (en) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
JP2015501844A (ja) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
WO2013151663A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins
US20140132274A1 (en) * 2012-11-13 2014-05-15 Awareness Technology Inc. Method and apparatus for providing information in an electrolyte measurment system
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
CN103275874B (zh) * 2013-06-08 2014-09-10 苏州文曲生物微系统有限公司 一种高密度分布式立体电极装置
US12559741B2 (en) 2013-06-08 2026-02-24 Suzhou Etta Biotech Co., Ltd. High density distributed three-dimensional electrode device
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
JP6751351B2 (ja) * 2014-05-02 2020-09-02 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 細菌を不活化する装置
KR102350517B1 (ko) * 2014-09-30 2022-01-14 주식회사 엘지생활건강 피부침투장치 및 피부침투방법
KR20160038566A (ko) * 2014-09-30 2016-04-07 엘지전자 주식회사 피부침투장치 및 피부침투방법
KR101507493B1 (ko) * 2014-10-22 2015-03-30 (주)와이브레인 전기 자극 장치
CN104403943B (zh) * 2014-12-02 2016-06-15 陈剑 一种电击管和具有电击管的细胞电转仪
US11318305B2 (en) * 2015-03-31 2022-05-03 Oncosec Medical Incorporated Systems and methods for improved tissue-sensing based electroporation
US20180126183A1 (en) * 2015-05-29 2018-05-10 Koninklijke Philips N.V. A device for treating skin using non-thermal plasma
US11213671B2 (en) * 2015-06-25 2022-01-04 Newsouth Innovations Pty Limited Electroporation system for controlled localized therapeutics delivery
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
WO2017069085A1 (ja) * 2015-10-19 2017-04-27 株式会社ベックス 気泡噴出チップ、局所アブレーション装置及び局所アブレーション方法、並びにインジェクション装置及びインジェクション方法
CN116672600A (zh) * 2015-12-22 2023-09-01 因诺维奥制药公司 具有带电源开关的电池组的电穿孔装置
KR102723740B1 (ko) * 2015-12-28 2024-10-30 이노비오 파마수티컬즈, 인크. 진피내 제트 주입 전기천공 디바이스
ES2970438T3 (es) * 2015-12-30 2024-05-28 Inovio Pharmaceuticals Inc Dispositivo de electroporación con conjunto de agujas desmontable con sistema de bloqueo
WO2017180770A1 (en) 2016-04-13 2017-10-19 Synthetic Genomics, Inc. Recombinant arterivirus replicon systems and uses thereof
JP7382230B2 (ja) 2016-10-17 2023-11-16 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組み換えウイルスレプリコン系及びその使用
BR112019011661A2 (pt) 2016-12-05 2020-01-07 Synthetic Genomics, Inc. Composições e métodos para aumentar expressão de gene
US20200147361A1 (en) * 2017-05-03 2020-05-14 Mayo Foundation For Medical Education And Research Skin treatment devices and methods
KR20180123312A (ko) * 2017-05-08 2018-11-16 (주)오스힐 미세전류 조절 수단을 구비한 스킨 부스터
IT201700102644A1 (it) * 2017-09-13 2019-03-13 Univ Degli Studi Padova Applicatore ed apparecchiatura per elettroporazione
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
US11389531B2 (en) * 2017-12-19 2022-07-19 Janssen Sciences Ireland Unlimited Company Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines
KR20200111729A (ko) 2018-01-19 2020-09-29 얀센 파마슈티칼즈, 인코포레이티드 재조합 레플리콘 시스템을 이용한 면역 반응 유도 및 증진
US12331076B2 (en) 2018-10-08 2025-06-17 Janssen Pharmaceuticals, Inc. Alphavirus-based replicons for administration of biotherapeutics
US12508423B2 (en) 2019-02-04 2025-12-30 Rutgers, The State University Of New Jersey Device for tissue electrotransfer using a microelectrode
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
KR102279603B1 (ko) * 2019-06-11 2021-07-20 (주)비올 바늘 조립체, 이를 포함하는 피부 자극기 및 그 제조 방법
WO2021173105A1 (ru) * 2020-02-28 2021-09-02 Ирына Мыхайливна УДОВИЧЕНКО Устройство для электростимуляции
CN115361993A (zh) * 2020-03-20 2022-11-18 艾诺奥医药品有限公司 真空辅助电穿孔装置以及相关系统和方法
KR20220086094A (ko) 2020-12-16 2022-06-23 주식회사 은성글로벌 일렉트로포레이션 장치용 니들 주입 구성체
EP4363041A4 (en) * 2021-06-30 2025-05-14 Inovio Pharmaceuticals, Inc. Electrode arrays for electroporation and corresponding systems and methods
KR102832435B1 (ko) * 2022-04-11 2025-07-09 전우금 전극 교체형 전기 자극기
KR102812336B1 (ko) * 2022-09-30 2025-05-26 주식회사 밀알 니들의 종양 오염물을 밀폐할 수 있는 전기천공장치
KR102812334B1 (ko) * 2022-09-30 2025-05-26 주식회사 밀알 니들의 종양 오염물을 제거할 수 있는 올가미 형태의 와이어를 갖는 전기천공장치
KR102753355B1 (ko) * 2023-04-14 2025-01-13 (주)이지템 분할전극구조를 포함하는 에너지 기반 디바이스
US12485280B1 (en) 2024-07-15 2025-12-02 Tav-Tech Ltd Unitary enhanced jet spray dermal treatment handpiece

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648241A (en) 1989-09-15 1997-07-15 The General Hospital Corporation Conjugate vaccine against group B streptococcus
IL105503A (en) 1992-04-28 1999-05-09 Astra Ab Carbon peptide couplets capable of eliciting an immune response of T cells
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US6413935B1 (en) 1993-09-14 2002-07-02 Epimmune Inc. Induction of immune response against desired determinants
US6277116B1 (en) * 1994-05-06 2001-08-21 Vidaderm Systems and methods for shrinking collagen in the dermis
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
ES2200187T3 (es) * 1996-07-03 2004-03-01 Altea Therapeutics Corporation Microporacion mecanica multiple de la piel o de la mucosa.
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US7456012B2 (en) * 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
EP2428250A1 (en) * 1998-07-13 2012-03-14 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US7922709B2 (en) * 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
JP4499295B2 (ja) * 1999-01-28 2010-07-07 サイト パルス サイエンシズ、インコーポレイテッド 細胞内への巨大分子の送達
US6713291B2 (en) 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
AU2938100A (en) * 1999-03-08 2000-09-28 Yoram Palti Transdermal drug delivery system and method
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
EP1183068A4 (en) * 1999-05-10 2008-12-17 Gentronics Inc ENHANCED ACTIVE AGENT DELIVERY METHOD BY ELECTROPORATION
US6493402B1 (en) 1999-05-27 2002-12-10 Zenith Electronics Corporation Mode control for trellis decoder
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US7496401B2 (en) * 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7245963B2 (en) 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
CA2531493A1 (en) * 2003-07-16 2005-02-03 University Of South Florida Device and method to facilitate directed delivery and electroporation
JP2007509704A (ja) * 2003-10-31 2007-04-19 アルザ・コーポレーシヨン 経皮的ワクチン送達のための系および方法
US20060036210A1 (en) 2004-06-30 2006-02-16 Lei Zhang Modular electroporation device with disposable electrode and drug delivery components
US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US7657317B2 (en) 2005-04-26 2010-02-02 Boston Scientific Neuromodulation Corporation Evaluating stimulation therapies and patient satisfaction
US7713266B2 (en) * 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20070066934A1 (en) 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
EA200870252A1 (ru) * 2006-02-11 2009-02-27 Дженетроникс, Инк. Устройство и способ одноигольного электропорообразования in vivo
WO2008031141A1 (en) 2006-09-15 2008-03-20 Shoo Sticks Pty Limited Substrate to releasably adhere to a region of apparel
US8133216B2 (en) * 2006-10-16 2012-03-13 Syneron Medical Ltd. Methods and devices for treating tissue
PT3524316T (pt) * 2006-10-17 2024-11-29 Inovio Pharmaceuticals Inc Dispositivos de eletroporação para eletroporação de células em mamíferos
CN101563132A (zh) * 2006-10-17 2009-10-21 Vgx药品公司 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法
US20080132885A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Methods for treating tissue sites using electroporation
WO2008157485A1 (en) * 2007-06-15 2008-12-24 Transport Pharmaceuticals, Inc. Current concentration system and method for electrokinetic delivery of medicaments
CN101939047B (zh) * 2008-01-17 2014-04-16 基因特朗尼克斯公司 可变电流密度单针电穿孔系统和方法
US20100010484A1 (en) * 2008-07-14 2010-01-14 Primaeva Medical, Inc. Devices and methods for percutaneous energy delivery
DK2419169T3 (da) * 2009-04-16 2021-12-20 Inovio Pharmaceuticals Inc Kontaktløs elektrode til elektropermeabilisering samt fremgangsmåde
EP2432412A2 (en) * 2009-05-20 2012-03-28 Herlev Hospital Electroporation device with improved tip and electrode support
KR20120040727A (ko) * 2009-08-04 2012-04-27 폴로젠 리미티드 미용적 피부 재생
US8321012B2 (en) * 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
AU2011223753B2 (en) * 2010-03-01 2014-06-26 Inovio Pharmaceuticals, Inc. A tolerable and minimally invasive skin electroporation device
US11097099B2 (en) * 2010-03-01 2021-08-24 Inovio Pharmaceuticals, Inc. Multiple tissue layer electroporation applicator and device
US9289606B2 (en) * 2010-09-02 2016-03-22 St. Jude Medical, Atrial Fibrillation Division, Inc. System for electroporation therapy
AU2012333211A1 (en) 2011-06-28 2013-12-19 Inovio Pharmaceuticals, Inc. A miniminally invasive dermal electroporation device

Also Published As

Publication number Publication date
JP6423042B2 (ja) 2018-11-14
KR20230156804A (ko) 2023-11-14
US12251561B2 (en) 2025-03-18
KR102171142B1 (ko) 2020-10-28
CA2837214A1 (en) 2013-05-10
US20180236225A1 (en) 2018-08-23
KR102436439B1 (ko) 2022-08-25
EP3473296B1 (en) 2020-08-05
US20220212002A1 (en) 2022-07-07
AU2012333211A1 (en) 2013-12-19
US9913978B2 (en) 2018-03-13
KR102908569B1 (ko) 2026-01-07
EP3797824B1 (en) 2024-06-12
EP2726145A4 (en) 2015-02-25
DK2726145T3 (da) 2019-01-02
US20140222105A1 (en) 2014-08-07
JP2014524796A (ja) 2014-09-25
WO2013066427A1 (en) 2013-05-10
KR102081868B1 (ko) 2020-02-26
KR102325369B1 (ko) 2021-11-11
KR20220121912A (ko) 2022-09-01
EP2726145B1 (en) 2018-08-22
CN103687644B (zh) 2016-11-09
JP2024096416A (ja) 2024-07-12
JP2019058671A (ja) 2019-04-18
EP3473296A1 (en) 2019-04-24
KR20200123864A (ko) 2020-10-30
EP4438058A2 (en) 2024-10-02
JP2017170161A (ja) 2017-09-28
KR102599318B1 (ko) 2023-11-07
JP2021037322A (ja) 2021-03-11
CA2837214C (en) 2021-06-01
JP6955076B2 (ja) 2021-10-27
JP7519339B2 (ja) 2024-07-19
JP2020028759A (ja) 2020-02-27
US10668279B2 (en) 2020-06-02
EP3797824A1 (en) 2021-03-31
EP2726145A1 (en) 2014-05-07
CN103687644A (zh) 2014-03-26
KR20210135370A (ko) 2021-11-12
ES2992120T3 (es) 2024-12-09
US20200246613A1 (en) 2020-08-06
KR20200023494A (ko) 2020-03-04
JP2022002731A (ja) 2022-01-11
JP6626176B2 (ja) 2019-12-25
KR20140048213A (ko) 2014-04-23
US11291836B2 (en) 2022-04-05
JP6799128B2 (ja) 2020-12-09

Similar Documents

Publication Publication Date Title
DK2726145T3 (da) Minimalt invasivt, dermalt elektroporationsapparat
EP2819589A4 (en) MINIMALLY INVASIVE SURGICAL PROCEDURES
DK3061401T3 (da) Vævsbeholder
DK2539015T3 (da) Nethindeprotese
CO6930321A2 (es) Curación de tejidos
PT2663250T (pt) Instrumento eletrocirúrgico
EP2736612A4 (en) CARD MIXER
DK3501558T3 (da) Flydbare vævsprodukter
EP2744390A4 (en) ENDOSCOPE WITH MULTIVUE ELEMENT
PT2744519T (pt) Composições de rejuvenescimento dérmico
EP2833964A4 (en) MINIMALLY INVASIVE EPICARDIAL PACEMAKER
DE102011075781A8 (de) Elektrochirurgisches Instrument
EP2790769A4 (en) ANTISEPTIC APPLICATOR
GB2496735B (en) Electrosurgical instrument
GB2489925B (en) Electrosurgical generator
EP2612610A4 (en) MEDICAL KNIFE
PL2542300T3 (pl) Tolerowane i minimalnie inwazyjne urządzenie do elektroporacji skóry
EP2714975A4 (en) ELASTIC FABRIC
EP2790770A4 (en) ANTISEPTIC APPLICATOR
ZA201401944B (en) Hydrous adhesive skin patch
IL227732A0 (en) Cosmetic use
EP2851007A4 (en) TROKAR
EP2702954A4 (en) MEDICAL KNIFE
GB2492064B (en) Electrosurgical instrument
EP2657957A4 (en) EVAPORATOR