DK348087A - 4-nitrogensubstituerede isoquinolinol-forbindelser samt fremgangsmaade til fremstilling deraf - Google Patents

4-nitrogensubstituerede isoquinolinol-forbindelser samt fremgangsmaade til fremstilling deraf

Info

Publication number
DK348087A
DK348087A DK348087A DK348087A DK348087A DK 348087 A DK348087 A DK 348087A DK 348087 A DK348087 A DK 348087A DK 348087 A DK348087 A DK 348087A DK 348087 A DK348087 A DK 348087A
Authority
DK
Denmark
Prior art keywords
procedures
preparing
compounds
nitrogen substituted
isoquinolinol
Prior art date
Application number
DK348087A
Other languages
English (en)
Other versions
DK348087D0 (da
Inventor
Ramesh M Kanojia
Robert Falotico
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of DK348087D0 publication Critical patent/DK348087D0/da
Publication of DK348087A publication Critical patent/DK348087A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lubricants (AREA)
  • Steroid Compounds (AREA)
DK348087A 1986-07-07 1987-07-06 4-nitrogensubstituerede isoquinolinol-forbindelser samt fremgangsmaade til fremstilling deraf DK348087A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/882,655 US4714705A (en) 1986-07-07 1986-07-07 4-nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties

Publications (2)

Publication Number Publication Date
DK348087D0 DK348087D0 (da) 1987-07-06
DK348087A true DK348087A (da) 1988-01-08

Family

ID=25381064

Family Applications (1)

Application Number Title Priority Date Filing Date
DK348087A DK348087A (da) 1986-07-07 1987-07-06 4-nitrogensubstituerede isoquinolinol-forbindelser samt fremgangsmaade til fremstilling deraf

Country Status (22)

Country Link
US (1) US4714705A (da)
EP (1) EP0252721B1 (da)
JP (1) JPS6322562A (da)
KR (1) KR880001603A (da)
CN (1) CN87105724A (da)
AT (1) ATE67992T1 (da)
AU (1) AU597083B2 (da)
DE (1) DE3773438D1 (da)
DK (1) DK348087A (da)
ES (1) ES2040750T3 (da)
FI (1) FI872980A7 (da)
GR (1) GR3002829T3 (da)
HK (1) HK107591A (da)
HU (1) HU196966B (da)
IL (1) IL83088A (da)
MY (1) MY101961A (da)
NO (1) NO872812L (da)
NZ (1) NZ220967A (da)
PH (1) PH22571A (da)
PT (1) PT85271B (da)
SG (1) SG95491G (da)
ZA (1) ZA874894B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880817A (en) * 1987-06-09 1989-11-14 Ortho Pharmaceutical Corporation O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
WO1998019672A1 (en) * 1996-11-01 1998-05-14 Nitromed Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1424348A (en) * 1972-11-30 1976-02-11 Wyeth John & Brother Ltd Isoquinoline derivatives
JPS625963A (ja) * 1985-07-02 1987-01-12 Mitsui Toatsu Chem Inc イソキノリン誘導体

Also Published As

Publication number Publication date
PT85271A (en) 1987-08-01
HK107591A (en) 1992-01-03
US4714705A (en) 1987-12-22
ATE67992T1 (de) 1991-10-15
HUT44515A (en) 1988-03-28
NO872812D0 (no) 1987-07-06
KR880001603A (ko) 1988-04-25
FI872980A7 (fi) 1988-01-08
NZ220967A (en) 1990-07-26
JPS6322562A (ja) 1988-01-30
DK348087D0 (da) 1987-07-06
SG95491G (en) 1991-12-13
PH22571A (en) 1988-10-17
FI872980A0 (fi) 1987-07-06
MY101961A (en) 1992-02-29
AU7527387A (en) 1988-01-14
DE3773438D1 (de) 1991-11-07
ES2040750T3 (es) 1993-11-01
NO872812L (no) 1988-01-08
IL83088A0 (en) 1987-12-31
GR3002829T3 (en) 1993-01-25
PT85271B (pt) 1990-03-30
CN87105724A (zh) 1988-03-09
AU597083B2 (en) 1990-05-24
HU196966B (en) 1989-02-28
IL83088A (en) 1991-08-16
ZA874894B (en) 1989-02-22
EP0252721A1 (en) 1988-01-13
EP0252721B1 (en) 1991-10-02

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Legal Events

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AHS Application shelved for other reasons than non-payment