DK3481826T3 - Tyrosinkinaseinhibitorer - Google Patents

Tyrosinkinaseinhibitorer Download PDF

Info

Publication number
DK3481826T3
DK3481826T3 DK17742601.2T DK17742601T DK3481826T3 DK 3481826 T3 DK3481826 T3 DK 3481826T3 DK 17742601 T DK17742601 T DK 17742601T DK 3481826 T3 DK3481826 T3 DK 3481826T3
Authority
DK
Denmark
Prior art keywords
tyrosinkinase
inhibitors
tyrosinkinase inhibitors
Prior art date
Application number
DK17742601.2T
Other languages
English (en)
Inventor
Sacha Holland
Rajinder Singh
Somasekhar Bhamidipati
Pingyu Ding
Rao Kolluri
Ihab Darwish
Esteban Masuda
Jiaxin Yu
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3481826T3 publication Critical patent/DK3481826T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK17742601.2T 2016-07-08 2017-07-10 Tyrosinkinaseinhibitorer DK3481826T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662360297P 2016-07-08 2016-07-08
PCT/US2017/041396 WO2018009938A1 (en) 2016-07-08 2017-07-10 Tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
DK3481826T3 true DK3481826T3 (da) 2022-01-10

Family

ID=59383641

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17742601.2T DK3481826T3 (da) 2016-07-08 2017-07-10 Tyrosinkinaseinhibitorer

Country Status (7)

Country Link
US (4) US10130623B2 (da)
EP (1) EP3481826B1 (da)
JP (2) JP7061993B2 (da)
CA (1) CA3030283A1 (da)
DK (1) DK3481826T3 (da)
ES (1) ES2903526T3 (da)
WO (1) WO2018009938A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3481826B1 (en) 2016-07-08 2021-11-03 Rigel Pharmaceuticals, Inc. Tyrosine kinase inhibitors
WO2022013684A1 (en) 2020-07-11 2022-01-20 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
WO2022143864A1 (zh) * 2020-12-31 2022-07-07 江苏先声药业有限公司 三环类化合物及用途
KR102694996B1 (ko) * 2021-10-27 2024-08-13 상하이 지멍 바이오파마 아이엔씨 칼륨 채널 조절제로 사용되는 화합물 및 이의 제조 및 응용

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003137866A (ja) 2001-11-01 2003-05-14 Sankyo Co Ltd フェニレンジアミン誘導体
CN102127078A (zh) 2005-07-14 2011-07-20 安斯泰来制药株式会社 Janus激酶3的杂环类抑制剂
RU2457203C2 (ru) 2006-12-27 2012-07-27 Санофи-Авентис Замещенные циклоалкиламином производные изохинолона
EP3628665B1 (en) 2011-04-01 2022-11-02 University of Utah Research Foundation Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase
WO2014164729A1 (en) * 2013-03-12 2014-10-09 Arqule, Inc. Substituted tricyclic pyrazolo-pyrimidine compounds
CN106795154B (zh) 2014-09-02 2019-07-05 皮埃尔法布雷医药公司 用于治疗癌症的异喹啉酮衍生物
US9840503B2 (en) * 2015-05-11 2017-12-12 Incyte Corporation Heterocyclic compounds and uses thereof
EP3481826B1 (en) 2016-07-08 2021-11-03 Rigel Pharmaceuticals, Inc. Tyrosine kinase inhibitors

Also Published As

Publication number Publication date
JP2021185203A (ja) 2021-12-09
US20200078348A1 (en) 2020-03-12
WO2018009938A1 (en) 2018-01-11
US20230012676A1 (en) 2023-01-19
US20180008589A1 (en) 2018-01-11
US11110082B2 (en) 2021-09-07
CA3030283A1 (en) 2018-01-11
US10434096B2 (en) 2019-10-08
US20190099411A1 (en) 2019-04-04
EP3481826A1 (en) 2019-05-15
US10130623B2 (en) 2018-11-20
JP2019520397A (ja) 2019-07-18
US11672791B2 (en) 2023-06-13
EP3481826B1 (en) 2021-11-03
JP7061993B2 (ja) 2022-05-02
ES2903526T3 (es) 2022-04-04

Similar Documents

Publication Publication Date Title
IL269196A (en) Novel inhibitors
CY1125826T1 (el) Ενωσεις αναστολεις της βητα-λακταμασης
IL263586A (en) Inhibitors of the menin-mll interaction
EP3541932A4 (en) INHIBITORS OF CRISPR-CAS9
DK3442972T3 (da) Bromdomænehæmmere
LT3303334T (lt) Tirozinkinazės inhibitoriai
DK3497103T3 (da) Pyridopyrimdinon-cdk2/4/6-inhibitorer
DK3571192T3 (da) Jak1-selektive inhibitorer
HUE042335T2 (hu) ROR-gamma dihidropirrolopiridin inhibitorai
LT3137169T (lt) Lizinui specifinės demetilazės-1 inhibitoriai
LT3160956T (lt) Lizinui specifinės demetilazės-1 inhibitoriai
EP3313828A4 (en) METALLO-BETA-Lactamase INHIBITORS
CU20160125A7 (es) Inhibidores de diacilglicerol aciltransferasa 2
LT3511319T (lt) Lizinui specifinės demetilazės-1 inhibitoriai
EP3541821A4 (en) Magl inhibitors
DK3341379T3 (da) EZH2-hæmmere
DK3186242T3 (da) Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere
DK3630744T3 (da) Pyrazol-magl-inhibitorer
DK3114120T3 (da) Tetrazolon-substituerede dihydropyridinon-mgat2-hæmmere
MA43367A (fr) Inhibiteurs de métallo-bêta-lactamases
MA46889A (fr) Inhibiteurs de gsk-3
EP3600301A4 (en) KDM4 INHIBITORS
MA46280A (fr) Inhibiteurs de la dopamine-b-hydroxylase
EP3519429A4 (en) BACTERIAL INHIBITORS
EP3454852A4 (en) PHOSPHOTIDYLINOSITOL 3-KINASES INHIBITORS