DK3481826T3 - Tyrosinkinaseinhibitorer - Google Patents

Tyrosinkinaseinhibitorer Download PDF

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Publication number
DK3481826T3
DK3481826T3 DK17742601.2T DK17742601T DK3481826T3 DK 3481826 T3 DK3481826 T3 DK 3481826T3 DK 17742601 T DK17742601 T DK 17742601T DK 3481826 T3 DK3481826 T3 DK 3481826T3
Authority
DK
Denmark
Prior art keywords
tyrosinkinase
inhibitors
tyrosinkinase inhibitors
Prior art date
Application number
DK17742601.2T
Other languages
English (en)
Inventor
Sacha Holland
Rajinder Singh
Somasekhar Bhamidipati
Pingyu Ding
Rao Kolluri
Ihab Darwish
Esteban Masuda
Jiaxin Yu
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3481826T3 publication Critical patent/DK3481826T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK17742601.2T 2016-07-08 2017-07-10 Tyrosinkinaseinhibitorer DK3481826T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662360297P 2016-07-08 2016-07-08
PCT/US2017/041396 WO2018009938A1 (en) 2016-07-08 2017-07-10 Tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
DK3481826T3 true DK3481826T3 (da) 2022-01-10

Family

ID=59383641

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17742601.2T DK3481826T3 (da) 2016-07-08 2017-07-10 Tyrosinkinaseinhibitorer

Country Status (7)

Country Link
US (4) US10130623B2 (da)
EP (1) EP3481826B1 (da)
JP (2) JP7061993B2 (da)
CA (1) CA3030283A1 (da)
DK (1) DK3481826T3 (da)
ES (1) ES2903526T3 (da)
WO (1) WO2018009938A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3481826T3 (da) 2016-07-08 2022-01-10 Rigel Pharmaceuticals Inc Tyrosinkinaseinhibitorer
EP4178955A1 (en) 2020-07-11 2023-05-17 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
WO2022143864A1 (zh) * 2020-12-31 2022-07-07 江苏先声药业有限公司 三环类化合物及用途
CN113698345B (zh) * 2021-10-27 2022-02-01 上海挚盟医药科技有限公司 作为钾通道调节剂的化合物及其制备和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003137866A (ja) 2001-11-01 2003-05-14 Sankyo Co Ltd フェニレンジアミン誘導体
CN102127078A (zh) 2005-07-14 2011-07-20 安斯泰来制药株式会社 Janus激酶3的杂环类抑制剂
CN101595094B (zh) 2006-12-27 2013-02-20 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹诺酮衍生物
EP3628665B1 (en) * 2011-04-01 2022-11-02 University of Utah Research Foundation Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase
TW201522337A (zh) 2013-03-12 2015-06-16 Arqule Inc 經取代之三環吡唑並-嘧啶化合物類
BR112017003651A2 (pt) 2014-09-02 2017-12-05 Pf Medicament derivados de isoquinolinona úteis no tratamento de câncer
US9840503B2 (en) * 2015-05-11 2017-12-12 Incyte Corporation Heterocyclic compounds and uses thereof
DK3481826T3 (da) * 2016-07-08 2022-01-10 Rigel Pharmaceuticals Inc Tyrosinkinaseinhibitorer

Also Published As

Publication number Publication date
WO2018009938A1 (en) 2018-01-11
US20190099411A1 (en) 2019-04-04
US11672791B2 (en) 2023-06-13
JP2021185203A (ja) 2021-12-09
JP2019520397A (ja) 2019-07-18
US20200078348A1 (en) 2020-03-12
US20230012676A1 (en) 2023-01-19
US11110082B2 (en) 2021-09-07
US10130623B2 (en) 2018-11-20
CA3030283A1 (en) 2018-01-11
EP3481826A1 (en) 2019-05-15
ES2903526T3 (es) 2022-04-04
EP3481826B1 (en) 2021-11-03
JP7061993B2 (ja) 2022-05-02
US10434096B2 (en) 2019-10-08
US20180008589A1 (en) 2018-01-11

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