MA46889A - Inhibiteurs de gsk-3 - Google Patents
Inhibiteurs de gsk-3Info
- Publication number
- MA46889A MA46889A MA046889A MA46889A MA46889A MA 46889 A MA46889 A MA 46889A MA 046889 A MA046889 A MA 046889A MA 46889 A MA46889 A MA 46889A MA 46889 A MA46889 A MA 46889A
- Authority
- MA
- Morocco
- Prior art keywords
- gsk
- inhibitors
- Prior art date
Links
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 title 1
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662426631P | 2016-11-28 | 2016-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA46889A true MA46889A (fr) | 2019-10-02 |
Family
ID=60655130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA046889A MA46889A (fr) | 2016-11-28 | 2017-11-27 | Inhibiteurs de gsk-3 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10752609B2 (fr) |
| EP (1) | EP3544613B1 (fr) |
| JP (1) | JP7114591B2 (fr) |
| KR (1) | KR102575990B1 (fr) |
| CN (1) | CN110545817B (fr) |
| ES (1) | ES2878078T3 (fr) |
| MA (1) | MA46889A (fr) |
| WO (1) | WO2018098412A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110198934B (zh) * | 2016-11-28 | 2022-07-22 | 百时美施贵宝公司 | 作为gsk-3抑制剂的嘧啶甲酰胺 |
| MA54550A (fr) | 2018-12-20 | 2022-03-30 | Amgen Inc | Inhibiteurs de kif18a |
| AU2019401495B2 (en) | 2018-12-20 | 2025-06-26 | Amgen Inc. | Heteroaryl amides useful as KIF18A inhibitors |
| AU2019404576B2 (en) * | 2018-12-20 | 2025-07-17 | Amgen Inc. | Heteroaryl amides useful as KIF18A inhibitors |
| AU2020325115B2 (en) | 2019-08-02 | 2026-03-12 | Amgen Inc. | Pyridine derivatives as KIF18A inhibitors |
| JP7699100B2 (ja) | 2019-08-02 | 2025-06-26 | アムジエン・インコーポレーテツド | Ｋｉｆ１８ａ阻害剤 |
| CN116178281B (zh) * | 2023-04-27 | 2023-07-21 | 中国药科大学 | 一种双功能免疫抑制剂及其制备方法和应用 |
| CN121666382A (zh) * | 2023-05-10 | 2026-03-13 | 缆图药品公司 | GSK3α抑制剂和其使用方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102438D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| BRPI0814441A2 (pt) * | 2007-07-19 | 2015-07-14 | Schering Corp | Compostos de amida heterocíclica como inibidores de proteína cinase |
| WO2012024179A1 (fr) * | 2010-08-18 | 2012-02-23 | Merck Sharp & Dohme Corp. | Dérivés d'amide substitués en tant qu'inhibiteurs de dgat-1 |
| JP2017500287A (ja) * | 2013-11-06 | 2017-01-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｇｓｋ−３阻害剤として有用な置換ピリジン誘導体 |
| AU2014347027A1 (en) | 2013-11-06 | 2016-06-23 | Bristol-Myers Squibb Company | GSK -3 inhibitors |
| WO2016144792A1 (fr) * | 2015-03-06 | 2016-09-15 | Alpharmagen, Llc | Modulateurs allostériques des récepteurs nicotiniques de l'acétylcholine de type alpha 7, leurs dérivés et leurs utilisations |
| CN110198934B (zh) * | 2016-11-28 | 2022-07-22 | 百时美施贵宝公司 | 作为gsk-3抑制剂的嘧啶甲酰胺 |
-
2017
- 2017-11-27 MA MA046889A patent/MA46889A/fr unknown
- 2017-11-27 JP JP2019528512A patent/JP7114591B2/ja active Active
- 2017-11-27 CN CN201780084344.7A patent/CN110545817B/zh active Active
- 2017-11-27 EP EP17812188.5A patent/EP3544613B1/fr active Active
- 2017-11-27 KR KR1020197018285A patent/KR102575990B1/ko active Active
- 2017-11-27 ES ES17812188T patent/ES2878078T3/es active Active
- 2017-11-27 WO PCT/US2017/063231 patent/WO2018098412A1/fr not_active Ceased
- 2017-11-27 US US16/463,467 patent/US10752609B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20190315714A1 (en) | 2019-10-17 |
| US10752609B2 (en) | 2020-08-25 |
| ES2878078T3 (es) | 2021-11-18 |
| KR20190085114A (ko) | 2019-07-17 |
| JP7114591B2 (ja) | 2022-08-08 |
| JP2019535788A (ja) | 2019-12-12 |
| KR102575990B1 (ko) | 2023-09-08 |
| EP3544613A1 (fr) | 2019-10-02 |
| CN110545817A (zh) | 2019-12-06 |
| EP3544613B1 (fr) | 2021-06-09 |
| CN110545817B (zh) | 2022-11-15 |
| WO2018098412A1 (fr) | 2018-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL263586A (en) | Inhibitors of the menin-mll interaction | |
| IL269196A (en) | Novel inhibitors | |
| EP3541932A4 (fr) | Inhibiteurs de crispr-cas9 | |
| DK3497103T3 (da) | Pyridopyrimdinon-cdk2/4/6-inhibitorer | |
| DK3442972T3 (da) | Bromdomænehæmmere | |
| LT3303334T (lt) | Tirozinkinazės inhibitoriai | |
| DK3571192T3 (da) | Jak1-selektive inhibitorer | |
| EP3347008A4 (fr) | Inhibiteurs de bêta-lactamases | |
| HUE042335T2 (hu) | ROR-gamma dihidropirrolopiridin inhibitorai | |
| CU20160125A7 (es) | Inhibidores de diacilglicerol aciltransferasa 2 | |
| MA53944A (fr) | Inhibiteurs de la glycosidase | |
| EP3313828A4 (fr) | Inhibiteurs de métallo-bêta-lactamases | |
| MA46855A (fr) | Inhibiteurs de magl | |
| MA46857A (fr) | Inhibiteurs de magl | |
| EP3541822A4 (fr) | Inhibiteurs de magl | |
| DK3335532T3 (da) | Tandharve | |
| DK3186242T3 (da) | Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere | |
| DK3630744T3 (da) | Pyrazol-magl-inhibitorer | |
| MA43367A (fr) | Inhibiteurs de métallo-bêta-lactamases | |
| DK3114120T3 (da) | Tetrazolon-substituerede dihydropyridinon-mgat2-hæmmere | |
| MA46280A (fr) | Inhibiteurs de la dopamine-b-hydroxylase | |
| EP3600301A4 (fr) | Inhibiteurs de kdm4 | |
| DK3481826T3 (da) | Tyrosinkinaseinhibitorer | |
| EP3519429A4 (fr) | Inhibiteurs bactériens | |
| MA44607A (fr) | Inhibiteurs de kinase |