DK3514157T3 - Fremgangsmåde til fremstilling af glucosylceramidsynthase-hæmmere - Google Patents
Fremgangsmåde til fremstilling af glucosylceramidsynthase-hæmmere Download PDFInfo
- Publication number
- DK3514157T3 DK3514157T3 DK19153389.2T DK19153389T DK3514157T3 DK 3514157 T3 DK3514157 T3 DK 3514157T3 DK 19153389 T DK19153389 T DK 19153389T DK 3514157 T3 DK3514157 T3 DK 3514157T3
- Authority
- DK
- Denmark
- Prior art keywords
- production
- synthase inhibitors
- glucosylceramide synthase
- glucosylceramide
- inhibitors
- Prior art date
Links
- 239000003892 ceramide glucosyltransferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791913P | 2013-03-15 | 2013-03-15 | |
| EP14718835.3A EP2970251B1 (en) | 2013-03-15 | 2014-03-13 | Method of preparing glucosylceramide synthase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3514157T3 true DK3514157T3 (da) | 2023-11-27 |
Family
ID=50543333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19153389.2T DK3514157T3 (da) | 2013-03-15 | 2014-03-13 | Fremgangsmåde til fremstilling af glucosylceramidsynthase-hæmmere |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US9682975B2 (da) |
| EP (2) | EP2970251B1 (da) |
| JP (2) | JP6543242B2 (da) |
| KR (1) | KR20150130386A (da) |
| CN (2) | CN105189491B (da) |
| AR (1) | AR095436A1 (da) |
| AU (2) | AU2014235132B2 (da) |
| BR (1) | BR112015020667A2 (da) |
| CA (2) | CA2906581C (da) |
| CY (1) | CY1121859T1 (da) |
| DK (1) | DK3514157T3 (da) |
| ES (2) | ES2727869T3 (da) |
| HU (2) | HUE043394T2 (da) |
| IL (2) | IL240617B (da) |
| MX (2) | MX365464B (da) |
| RU (1) | RU2015144035A (da) |
| SG (2) | SG11201506415XA (da) |
| TW (2) | TW201900625A (da) |
| UY (1) | UY35438A (da) |
| WO (1) | WO2014151291A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| TW201900625A (zh) | 2013-03-15 | 2019-01-01 | 美商健臻公司 | 製備葡糖基神經醯胺合成酶抑制劑之方法 |
| WO2018149823A1 (de) * | 2017-02-17 | 2018-08-23 | Westfälische Wilhelms-Universität Münster | Elektrolyt-zusatz für lithium-ionen-batterien |
| JP2021506920A (ja) | 2017-12-21 | 2021-02-22 | リソソーマル・セラピューティクス・インコーポレイテッドＬｙｓｏｓｏｍａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 結晶性の置換シクロヘキシルピラゾロ［１，５−ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
| US10519157B2 (en) * | 2018-02-09 | 2019-12-31 | X-Cutag Therapeutics, Inc. | Deuterated compounds for treating Fabry, Gaucher, Parkinson's and related diseases and conditions, and compositions and methods thereof |
| PT3920912T (pt) | 2019-02-04 | 2025-09-09 | Genzyme Corp | Tratamento de ciliopatias usando inibidores da glucosilceramida sintase (gcs) |
| IL295255A (en) | 2020-02-03 | 2022-10-01 | Genzyme Corp | Methods for treating neurological symptoms associated with lysosomal storage diseases |
| WO2021221953A1 (en) | 2020-04-28 | 2021-11-04 | The Regents Of The University Of Michigan | Pyridine inhibitors of glucosylceramide synthase and therapeutic methods using the same |
| IL300090A (en) | 2020-07-24 | 2023-03-01 | Genzyme Corp | Pharmaceutical preparations containing VENGLUSTAT |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB725226A (en) * | 1952-06-03 | 1955-03-02 | Berger Brothers Co | Improvements in or relating to an inflatable surgical pad |
| GB725228A (en) * | 1952-06-19 | 1955-03-02 | Roche Products Ltd | Substituted carbamic acid esters and process for the manufacture thereof |
| NL130759C (da) * | 1965-10-07 | |||
| DE4326510A1 (de) * | 1993-08-06 | 1995-02-09 | Bayer Ag | Verfahren zur Herstellung von Cyclohexen-Derivaten |
| AU685225B2 (en) * | 1994-02-10 | 1998-01-15 | Yamanouchi Pharmaceutical Co., Ltd. | Novel carbamate derivative and medicinal composition containing the same |
| JPH08198751A (ja) * | 1995-01-19 | 1996-08-06 | Yamanouchi Pharmaceut Co Ltd | カルバメート誘導体 |
| SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
| BRPI0517701A8 (pt) | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
| JP5285643B2 (ja) * | 2010-03-15 | 2013-09-11 | シャープ株式会社 | 半導体集積回路および電子情報機器 |
| AU2011327113B9 (en) | 2010-11-12 | 2015-07-30 | Shionogi & Co., Ltd. | Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same |
| LT2685986T (lt) * | 2011-03-18 | 2020-03-10 | Genzyme Corporation | Gliukozilceramido sintazės slopiklis |
| US20140228575A1 (en) | 2011-06-22 | 2014-08-14 | Isochem | Process for the Preparation of Solifenacin and Salts Thereof |
| JP2013053228A (ja) * | 2011-09-02 | 2013-03-21 | Asahi Kasei E-Materials Corp | エポキシ樹脂用硬化剤及びマイクロカプセル型エポキシ樹脂用硬化剤 |
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| TW201900625A (zh) * | 2013-03-15 | 2019-01-01 | 美商健臻公司 | 製備葡糖基神經醯胺合成酶抑制劑之方法 |
-
2014
- 2014-03-13 TW TW107132577A patent/TW201900625A/zh unknown
- 2014-03-13 DK DK19153389.2T patent/DK3514157T3/da active
- 2014-03-13 SG SG11201506415XA patent/SG11201506415XA/en unknown
- 2014-03-13 MX MX2015012842A patent/MX365464B/es active IP Right Grant
- 2014-03-13 KR KR1020157027836A patent/KR20150130386A/ko not_active Ceased
- 2014-03-13 AU AU2014235132A patent/AU2014235132B2/en not_active Ceased
- 2014-03-13 WO PCT/US2014/025384 patent/WO2014151291A1/en not_active Ceased
- 2014-03-13 SG SG10201706575UA patent/SG10201706575UA/en unknown
- 2014-03-13 EP EP14718835.3A patent/EP2970251B1/en active Active
- 2014-03-13 US US14/776,443 patent/US9682975B2/en active Active
- 2014-03-13 RU RU2015144035A patent/RU2015144035A/ru not_active Application Discontinuation
- 2014-03-13 MX MX2019000914A patent/MX389168B/es unknown
- 2014-03-13 CN CN201480026302.4A patent/CN105189491B/zh active Active
- 2014-03-13 BR BR112015020667A patent/BR112015020667A2/pt not_active Application Discontinuation
- 2014-03-13 CA CA2906581A patent/CA2906581C/en active Active
- 2014-03-13 HU HUE14718835A patent/HUE043394T2/hu unknown
- 2014-03-13 JP JP2016501840A patent/JP6543242B2/ja active Active
- 2014-03-13 ES ES14718835T patent/ES2727869T3/es active Active
- 2014-03-13 CN CN201810630738.4A patent/CN108658970A/zh active Pending
- 2014-03-13 ES ES19153389T patent/ES2968073T3/es active Active
- 2014-03-13 EP EP19153389.2A patent/EP3514157B1/en active Active
- 2014-03-13 AR ARP140100982A patent/AR095436A1/es unknown
- 2014-03-13 TW TW103108899A patent/TWI649317B/zh not_active IP Right Cessation
- 2014-03-13 HU HUE19153389A patent/HUE064200T2/hu unknown
- 2014-03-13 CA CA3092901A patent/CA3092901C/en active Active
- 2014-03-14 UY UY0001035438A patent/UY35438A/es not_active Application Discontinuation
-
2015
- 2015-08-17 IL IL240617A patent/IL240617B/en active IP Right Grant
-
2017
- 2017-05-12 US US15/593,440 patent/US10065949B2/en active Active
-
2018
- 2018-06-03 IL IL259770A patent/IL259770B/en active IP Right Grant
- 2018-08-01 US US16/051,892 patent/US10604518B2/en active Active
-
2019
- 2019-01-18 AU AU2019200350A patent/AU2019200350A1/en not_active Abandoned
- 2019-05-27 CY CY20191100562T patent/CY1121859T1/el unknown
- 2019-06-13 JP JP2019109986A patent/JP6813626B2/ja active Active
-
2020
- 2020-02-14 US US16/791,854 patent/US10954230B2/en active Active
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